Incidental Mutation 'R9259:Zfp658'
ID 702098
Institutional Source Beutler Lab
Gene Symbol Zfp658
Ensembl Gene ENSMUSG00000056592
Gene Name zinc finger protein 658
Synonyms
MMRRC Submission
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9259 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 43211680-43224885 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 43224280 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Valine at position 852 (M852V)
Ref Sequence ENSEMBL: ENSMUSP00000005597 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000005597] [ENSMUST00000058104] [ENSMUST00000107972] [ENSMUST00000205769]
AlphaFold Q5PPQ4
Predicted Effect probably benign
Transcript: ENSMUST00000005597
AA Change: M852V

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000005597
Gene: ENSMUSG00000056592
AA Change: M852V

DomainStartEndE-ValueType
KRAB 23 83 3.7e-27 SMART
ZnF_C2H2 276 295 8.84e1 SMART
ZnF_C2H2 301 323 5.81e-2 SMART
ZnF_C2H2 328 350 1.5e-4 SMART
ZnF_C2H2 356 378 1.84e-4 SMART
ZnF_C2H2 384 406 3.16e-3 SMART
ZnF_C2H2 412 434 1.45e-2 SMART
ZnF_C2H2 440 462 4.87e-4 SMART
ZnF_C2H2 468 490 4.87e-4 SMART
ZnF_C2H2 496 518 6.88e-4 SMART
ZnF_C2H2 524 546 1.69e-3 SMART
ZnF_C2H2 552 574 9.73e-4 SMART
ZnF_C2H2 580 602 1.82e-3 SMART
ZnF_C2H2 608 630 3.16e-3 SMART
ZnF_C2H2 636 658 8.94e-3 SMART
ZnF_C2H2 664 686 3.74e-5 SMART
ZnF_C2H2 692 714 2.99e-4 SMART
ZnF_C2H2 720 742 5.21e-4 SMART
ZnF_C2H2 748 770 2.79e-4 SMART
ZnF_C2H2 776 798 1.58e-3 SMART
ZnF_C2H2 804 826 3.44e-4 SMART
ZnF_C2H2 832 854 5.59e-4 SMART
ZnF_C2H2 860 882 5.81e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000058104
SMART Domains Protein: ENSMUSP00000050968
Gene: ENSMUSG00000030469

DomainStartEndE-ValueType
KRAB 49 109 1.18e-20 SMART
ZnF_C2H2 285 305 4.16e1 SMART
ZnF_C2H2 341 363 1.2e-3 SMART
ZnF_C2H2 369 391 9.08e-4 SMART
ZnF_C2H2 397 419 6.67e-2 SMART
ZnF_C2H2 425 447 7.9e-4 SMART
ZnF_C2H2 453 475 3.34e-2 SMART
ZnF_C2H2 481 503 1.38e-3 SMART
ZnF_C2H2 509 531 5.42e-2 SMART
ZnF_C2H2 537 559 3.78e-1 SMART
ZnF_C2H2 565 587 2.43e-4 SMART
ZnF_C2H2 593 615 4.54e-4 SMART
ZnF_C2H2 621 643 4.24e-4 SMART
ZnF_C2H2 649 671 6.42e-4 SMART
ZnF_C2H2 677 699 1.47e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000107972
AA Change: M852V

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000103606
Gene: ENSMUSG00000056592
AA Change: M852V

DomainStartEndE-ValueType
KRAB 23 83 3.7e-27 SMART
ZnF_C2H2 276 295 8.84e1 SMART
ZnF_C2H2 301 323 5.81e-2 SMART
ZnF_C2H2 328 350 1.5e-4 SMART
ZnF_C2H2 356 378 1.84e-4 SMART
ZnF_C2H2 384 406 3.16e-3 SMART
ZnF_C2H2 412 434 1.45e-2 SMART
ZnF_C2H2 440 462 4.87e-4 SMART
ZnF_C2H2 468 490 4.87e-4 SMART
ZnF_C2H2 496 518 6.88e-4 SMART
ZnF_C2H2 524 546 1.69e-3 SMART
ZnF_C2H2 552 574 9.73e-4 SMART
ZnF_C2H2 580 602 1.82e-3 SMART
ZnF_C2H2 608 630 3.16e-3 SMART
ZnF_C2H2 636 658 8.94e-3 SMART
ZnF_C2H2 664 686 3.74e-5 SMART
ZnF_C2H2 692 714 2.99e-4 SMART
ZnF_C2H2 720 742 5.21e-4 SMART
ZnF_C2H2 748 770 2.79e-4 SMART
ZnF_C2H2 776 798 1.58e-3 SMART
ZnF_C2H2 804 826 3.44e-4 SMART
ZnF_C2H2 832 854 5.59e-4 SMART
ZnF_C2H2 860 882 5.81e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000205769
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 100% (65/65)
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acot6 A G 12: 84,155,816 (GRCm39) I255V possibly damaging Het
Adcy8 A T 15: 64,576,604 (GRCm39) I986N probably damaging Het
Agr2 T A 12: 36,053,863 (GRCm39) M164K probably damaging Het
Akap11 G A 14: 78,749,949 (GRCm39) H813Y Het
Alas1 A T 9: 106,118,835 (GRCm39) S195T probably benign Het
Aldoart1 T C 4: 72,770,680 (GRCm39) T43A probably benign Het
Alms1 A G 6: 85,644,873 (GRCm39) D2537G possibly damaging Het
Alpk3 A G 7: 80,743,302 (GRCm39) T1040A probably damaging Het
Ankrd16 T C 2: 11,784,532 (GRCm39) I120T probably damaging Het
Anks4b A G 7: 119,773,278 (GRCm39) E46G probably benign Het
Ap3d1 A T 10: 80,559,661 (GRCm39) V199E probably damaging Het
Atp1a3 A G 7: 24,696,956 (GRCm39) S236P probably damaging Het
Atp5mc2 T A 15: 102,571,561 (GRCm39) N110I probably damaging Het
Cabin1 A G 10: 75,582,576 (GRCm39) M280T probably benign Het
Cdc5l T C 17: 45,736,817 (GRCm39) T134A possibly damaging Het
Clec4n C A 6: 123,212,424 (GRCm39) P80Q probably damaging Het
Clip3 A G 7: 29,998,375 (GRCm39) K274E probably benign Het
Cntrob A T 11: 69,211,665 (GRCm39) D186E possibly damaging Het
Cplane1 T C 15: 8,232,787 (GRCm39) V1102A possibly damaging Het
Dcun1d3 A G 7: 119,457,052 (GRCm39) V220A probably benign Het
Emsy A T 7: 98,242,757 (GRCm39) N1127K probably benign Het
Entpd2 C T 2: 25,288,614 (GRCm39) S206L probably damaging Het
Fgd4 T C 16: 16,295,325 (GRCm39) E218G probably damaging Het
Fkbp2 G T 19: 6,955,960 (GRCm39) Q82K probably benign Het
Gpr161 T C 1: 165,138,025 (GRCm39) Y204H probably damaging Het
Grip1 G A 10: 119,874,569 (GRCm39) E778K possibly damaging Het
Gstt2 C T 10: 75,669,511 (GRCm39) D59N possibly damaging Het
Havcr1 A T 11: 46,661,318 (GRCm39) D206V probably damaging Het
Hoxb9 G A 11: 96,162,762 (GRCm39) G132D probably damaging Het
Ifi44 C T 3: 151,454,875 (GRCm39) V117M possibly damaging Het
Inhbe A G 10: 127,186,844 (GRCm39) F112S probably damaging Het
Iqgap2 A T 13: 95,766,561 (GRCm39) Y1481N probably damaging Het
Irak4 A T 15: 94,456,726 (GRCm39) H303L probably damaging Het
Kdm5d A G Y: 942,640 (GRCm39) E1435G possibly damaging Het
Kifc1 G T 17: 34,101,165 (GRCm39) T599K possibly damaging Het
Klhl38 T C 15: 58,186,471 (GRCm39) E86G probably benign Het
Mcub G C 3: 129,720,070 (GRCm39) T141R probably benign Het
Moxd2 A T 6: 40,860,969 (GRCm39) V274D probably damaging Het
Nol6 C T 4: 41,118,229 (GRCm39) V803M possibly damaging Het
Or8b51 C T 9: 38,569,642 (GRCm39) probably benign Het
Ovgp1 T C 3: 105,893,883 (GRCm39) probably benign Het
Pbld1 A G 10: 62,897,436 (GRCm39) T46A possibly damaging Het
Peli3 T C 19: 4,984,486 (GRCm39) D192G probably benign Het
Perm1 C T 4: 156,303,607 (GRCm39) T717I probably benign Het
Pim1 G A 17: 29,710,181 (GRCm39) A22T probably benign Het
Pkp2 C T 16: 16,043,714 (GRCm39) P156L probably damaging Het
Ppwd1 G A 13: 104,359,612 (GRCm39) R130C probably damaging Het
Prdm16 C A 4: 154,430,525 (GRCm39) W321L possibly damaging Het
Ptprd T A 4: 75,990,200 (GRCm39) D504V probably damaging Het
Pusl1 T C 4: 155,975,639 (GRCm39) T65A probably damaging Het
Rtcb A G 10: 85,774,925 (GRCm39) I490T probably damaging Het
Sec31b G T 19: 44,505,855 (GRCm39) L967I probably damaging Het
Sec63 A C 10: 42,699,937 (GRCm39) M666L probably benign Het
Sh3rf1 G C 8: 61,806,838 (GRCm39) A379P probably benign Het
Slc7a12 T A 3: 14,546,376 (GRCm39) L174I probably damaging Het
Sptbn4 C T 7: 27,067,124 (GRCm39) S1935N possibly damaging Het
Susd6 A T 12: 80,898,030 (GRCm39) Q55L probably benign Het
Tecpr2 A G 12: 110,897,867 (GRCm39) E373G possibly damaging Het
Tent5c T C 3: 100,379,640 (GRCm39) Y372C probably damaging Het
Tm6sf2 A T 8: 70,530,585 (GRCm39) I222L probably benign Het
Tsc22d1 T A 14: 76,654,484 (GRCm39) V321E probably damaging Het
Tspoap1 A G 11: 87,670,350 (GRCm39) N172S Het
Unc13d AATGCCTCCCATGCC AATGCCTCCCATGCCTCCCATGCC 11: 115,958,998 (GRCm39) probably benign Het
Vcan G A 13: 89,838,989 (GRCm39) S2185F probably damaging Het
Wapl G T 14: 34,463,052 (GRCm39) V1131L probably benign Het
Other mutations in Zfp658
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00465:Zfp658 APN 7 43,216,780 (GRCm39) missense probably benign 0.03
IGL00475:Zfp658 APN 7 43,223,500 (GRCm39) missense possibly damaging 0.68
IGL01972:Zfp658 APN 7 43,222,134 (GRCm39) nonsense probably null
IGL03223:Zfp658 APN 7 43,216,735 (GRCm39) missense possibly damaging 0.85
R0135:Zfp658 UTSW 7 43,223,019 (GRCm39) nonsense probably null
R1863:Zfp658 UTSW 7 43,223,323 (GRCm39) missense possibly damaging 0.78
R1962:Zfp658 UTSW 7 43,223,245 (GRCm39) missense possibly damaging 0.93
R2698:Zfp658 UTSW 7 43,222,969 (GRCm39) missense possibly damaging 0.53
R3781:Zfp658 UTSW 7 43,223,270 (GRCm39) missense probably benign
R4791:Zfp658 UTSW 7 43,223,890 (GRCm39) missense possibly damaging 0.93
R5392:Zfp658 UTSW 7 43,222,355 (GRCm39) missense probably benign 0.07
R6092:Zfp658 UTSW 7 43,223,951 (GRCm39) missense possibly damaging 0.73
R6594:Zfp658 UTSW 7 43,216,701 (GRCm39) missense possibly damaging 0.86
R7003:Zfp658 UTSW 7 43,224,172 (GRCm39) missense possibly damaging 0.85
R7008:Zfp658 UTSW 7 43,223,336 (GRCm39) missense possibly damaging 0.95
R7077:Zfp658 UTSW 7 43,223,413 (GRCm39) missense probably benign 0.32
R7689:Zfp658 UTSW 7 43,224,102 (GRCm39) missense probably benign 0.00
R7793:Zfp658 UTSW 7 43,224,108 (GRCm39) missense possibly damaging 0.74
R7939:Zfp658 UTSW 7 43,224,301 (GRCm39) missense possibly damaging 0.73
R8672:Zfp658 UTSW 7 43,222,919 (GRCm39) missense possibly damaging 0.52
R8828:Zfp658 UTSW 7 43,222,240 (GRCm39) missense probably benign
R8995:Zfp658 UTSW 7 43,222,798 (GRCm39) missense possibly damaging 0.93
R9021:Zfp658 UTSW 7 43,223,381 (GRCm39) missense possibly damaging 0.71
R9551:Zfp658 UTSW 7 43,222,567 (GRCm39) missense probably benign 0.00
R9552:Zfp658 UTSW 7 43,222,567 (GRCm39) missense probably benign 0.00
R9571:Zfp658 UTSW 7 43,222,139 (GRCm39) missense possibly damaging 0.85
Z1176:Zfp658 UTSW 7 43,222,641 (GRCm39) missense possibly damaging 0.72
Predicted Primers PCR Primer
(F):5'- AGGTCGTCTTTGCATAGACATCAG -3'
(R):5'- AGTGCTGCACATCCAGTTGG -3'

Sequencing Primer
(F):5'- CGTCTTTGCATAGACATCAGATAAC -3'
(R):5'- CCAGTTGGGATGCTCTCTGC -3'
Posted On 2022-03-25