Incidental Mutation 'R9261:Gstt2'
ID 702265
Institutional Source Beutler Lab
Gene Symbol Gstt2
Ensembl Gene ENSMUSG00000033318
Gene Name glutathione S-transferase, theta 2
Synonyms Yrs, mGSTT2
MMRRC Submission 068990-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9261 (G1)
Quality Score 225.009
Status Validated
Chromosome 10
Chromosomal Location 75667676-75673253 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 75669511 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Asparagine at position 59 (D59N)
Ref Sequence ENSEMBL: ENSMUSP00000046324 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000038257] [ENSMUST00000218500] [ENSMUST00000220195] [ENSMUST00000220440]
AlphaFold Q61133
Predicted Effect possibly damaging
Transcript: ENSMUST00000038257
AA Change: D59N

PolyPhen 2 Score 0.768 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000046324
Gene: ENSMUSG00000033318
AA Change: D59N

DomainStartEndE-ValueType
Pfam:GST_N 1 76 4.6e-12 PFAM
Pfam:GST_N_3 5 84 1.4e-11 PFAM
Pfam:GST_N_2 11 77 3.5e-10 PFAM
Pfam:GST_C 73 199 1.5e-10 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000218500
AA Change: D59N

PolyPhen 2 Score 0.962 (Sensitivity: 0.78; Specificity: 0.95)
Predicted Effect probably damaging
Transcript: ENSMUST00000220195
AA Change: D59N

PolyPhen 2 Score 0.969 (Sensitivity: 0.77; Specificity: 0.95)
Predicted Effect possibly damaging
Transcript: ENSMUST00000220440
AA Change: D59N

PolyPhen 2 Score 0.768 (Sensitivity: 0.85; Specificity: 0.92)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.8%
Validation Efficiency 100% (73/73)
MGI Phenotype PHENOTYPE: Mice homozygous for a disruption in this gene display a normal phenotype. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 73 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts7 A G 9: 90,075,397 (GRCm39) E1043G probably benign Het
Agps T G 2: 75,684,850 (GRCm39) probably benign Het
Ahnak A G 19: 8,993,503 (GRCm39) E4929G possibly damaging Het
Arl6ip4 T A 5: 124,256,146 (GRCm39) probably benign Het
Cdhr17 T C 5: 17,006,547 (GRCm39) L88P possibly damaging Het
Clca3a2 G T 3: 144,525,158 (GRCm39) H25N probably benign Het
Cubn C T 2: 13,283,262 (GRCm39) D3559N probably damaging Het
Dmac2 T A 7: 25,320,345 (GRCm39) W15R probably benign Het
Dzank1 T C 2: 144,355,344 (GRCm39) E117G probably benign Het
Eml2 A G 7: 18,913,743 (GRCm39) T187A probably benign Het
Eml5 A G 12: 98,822,287 (GRCm39) V747A probably damaging Het
Esr1 T A 10: 4,919,271 (GRCm39) S454T probably damaging Het
Evc2 A G 5: 37,537,895 (GRCm39) T528A probably benign Het
Fbxo5 T C 10: 5,752,325 (GRCm39) N96S probably damaging Het
Fcnb T C 2: 27,969,636 (GRCm39) T144A probably damaging Het
Fgf20 T A 8: 40,739,951 (GRCm39) probably benign Het
Gcg T C 2: 62,306,408 (GRCm39) probably benign Het
Gfm2 T A 13: 97,299,369 (GRCm39) Y363* probably null Het
Grwd1 C T 7: 45,475,381 (GRCm39) R387Q probably benign Het
Herc1 A G 9: 66,412,129 (GRCm39) N4783S probably damaging Het
Hydin C A 8: 110,994,047 (GRCm39) A27E unknown Het
Iigp1c T A 18: 60,353,820 (GRCm39) probably benign Het
Ikbip A G 10: 90,932,249 (GRCm39) T298A possibly damaging Het
Il1rap A G 16: 26,541,724 (GRCm39) N655S possibly damaging Het
Kif21b C T 1: 136,077,162 (GRCm39) R395C probably damaging Het
Kif3a ATTGACG A 11: 53,484,248 (GRCm39) probably benign Het
Klhl40 A G 9: 121,609,002 (GRCm39) D389G probably benign Het
Ly6g A G 15: 75,030,529 (GRCm39) T116A probably damaging Het
Mast2 A G 4: 116,165,900 (GRCm39) L1276P probably damaging Het
Mitf A G 6: 97,990,704 (GRCm39) Q369R possibly damaging Het
Mtus2 T A 5: 148,243,453 (GRCm39) Y192* probably null Het
Nav1 T A 1: 135,388,095 (GRCm39) E1109D unknown Het
Nav2 A G 7: 49,246,904 (GRCm39) E2143G probably damaging Het
Nedd4 A G 9: 72,584,656 (GRCm39) Q119R possibly damaging Het
Nek9 A G 12: 85,359,841 (GRCm39) V537A probably damaging Het
Notum G T 11: 120,550,974 (GRCm39) T64K Het
Nudcd2 A G 11: 40,630,026 (GRCm39) N144S probably damaging Het
Nup205 A G 6: 35,176,792 (GRCm39) E596G probably benign Het
Olfml1 T A 7: 107,167,007 (GRCm39) L12Q possibly damaging Het
Or4f60 T A 2: 111,902,718 (GRCm39) D70V probably damaging Het
Or51k1 C T 7: 103,661,336 (GRCm39) C191Y probably damaging Het
Or52n2c A T 7: 104,574,305 (GRCm39) M222K probably benign Het
Or56b2 T A 7: 104,337,260 (GRCm39) F13I probably benign Het
Or6b13 A G 7: 139,782,563 (GRCm39) V40A probably benign Het
Ovgp1 T C 3: 105,893,883 (GRCm39) probably benign Het
Padi4 T C 4: 140,479,926 (GRCm39) N409S probably damaging Het
Pam T A 1: 97,903,620 (GRCm39) T38S probably benign Het
Piezo2 T C 18: 63,208,868 (GRCm39) I1382V possibly damaging Het
Pla2g12a A T 3: 129,684,080 (GRCm39) Q153L possibly damaging Het
Pla2g4e T A 2: 120,019,910 (GRCm39) H180L probably benign Het
Pou2af2 T A 9: 51,202,998 (GRCm39) H52L probably benign Het
Pprc1 A G 19: 46,050,868 (GRCm39) T169A unknown Het
Prrc2c A G 1: 162,505,622 (GRCm39) I2592T possibly damaging Het
Ptchd3 T A 11: 121,722,956 (GRCm39) I348N probably damaging Het
Ralgps1 T C 2: 33,226,571 (GRCm39) D40G probably damaging Het
Rbm19 T C 5: 120,256,810 (GRCm39) F41S probably damaging Het
Rbsn T C 6: 92,166,797 (GRCm39) M616V probably benign Het
Ryr1 A T 7: 28,751,813 (GRCm39) M3660K possibly damaging Het
Sidt2 A T 9: 45,861,396 (GRCm39) V246E probably damaging Het
Slc4a4 T C 5: 89,347,568 (GRCm39) W770R probably damaging Het
Spata31d1c T A 13: 65,184,680 (GRCm39) S741T probably damaging Het
Stk19 T G 17: 35,051,432 (GRCm39) Y108S possibly damaging Het
Stox2 T C 8: 47,645,441 (GRCm39) E673G possibly damaging Het
Tax1bp1 T A 6: 52,714,116 (GRCm39) C271S probably benign Het
Tmem161a C A 8: 70,631,572 (GRCm39) R167S probably damaging Het
Tnrc6c T A 11: 117,605,105 (GRCm39) V80E probably damaging Het
Trpa1 G A 1: 14,963,465 (GRCm39) H586Y probably damaging Het
Tsr1 A G 11: 74,799,056 (GRCm39) T746A probably damaging Het
Uqcrfs1 T C 13: 30,724,794 (GRCm39) I249V probably damaging Het
Vmn2r84 C A 10: 130,229,976 (GRCm39) E45D probably benign Het
Vnn3 A G 10: 23,741,607 (GRCm39) E304G probably damaging Het
Zfp541 G A 7: 15,816,029 (GRCm39) V839M possibly damaging Het
Zfp62 A G 11: 49,108,350 (GRCm39) K814E probably benign Het
Other mutations in Gstt2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01571:Gstt2 APN 10 75,670,005 (GRCm39) splice site probably benign
IGL01710:Gstt2 APN 10 75,669,579 (GRCm39) splice site probably benign
IGL02642:Gstt2 APN 10 75,668,652 (GRCm39) missense probably benign 0.17
IGL03375:Gstt2 APN 10 75,668,655 (GRCm39) splice site probably null
R0389:Gstt2 UTSW 10 75,668,266 (GRCm39) missense probably damaging 1.00
R1751:Gstt2 UTSW 10 75,670,098 (GRCm39) missense probably damaging 1.00
R1767:Gstt2 UTSW 10 75,670,098 (GRCm39) missense probably damaging 1.00
R1971:Gstt2 UTSW 10 75,668,499 (GRCm39) missense probably benign 0.10
R2367:Gstt2 UTSW 10 75,668,524 (GRCm39) missense probably benign 0.44
R5027:Gstt2 UTSW 10 75,667,726 (GRCm39) missense probably damaging 0.99
R7457:Gstt2 UTSW 10 75,668,354 (GRCm39) missense probably damaging 1.00
R7579:Gstt2 UTSW 10 75,670,019 (GRCm39) missense probably benign 0.00
R7910:Gstt2 UTSW 10 75,667,736 (GRCm39) missense probably benign 0.25
R7912:Gstt2 UTSW 10 75,668,418 (GRCm39) missense probably benign 0.27
R8282:Gstt2 UTSW 10 75,668,291 (GRCm39) missense probably benign 0.00
R8348:Gstt2 UTSW 10 75,668,526 (GRCm39) missense probably damaging 0.98
R8448:Gstt2 UTSW 10 75,668,526 (GRCm39) missense probably damaging 0.98
R8488:Gstt2 UTSW 10 75,667,823 (GRCm39) missense possibly damaging 0.69
R9259:Gstt2 UTSW 10 75,669,511 (GRCm39) missense possibly damaging 0.77
Predicted Primers PCR Primer
(F):5'- ATCAGCCCTCTAGTCTTCCAGG -3'
(R):5'- GAGACACATAGCTGAGCCAC -3'

Sequencing Primer
(F):5'- GACCCCTTCCCACAGAGTCTG -3'
(R):5'- ACATAGCTGAGCCACCTCTGTG -3'
Posted On 2022-03-25