Incidental Mutation 'R9264:Olfr1198'
ID 702407
Institutional Source Beutler Lab
Gene Symbol Olfr1198
Ensembl Gene ENSMUSG00000075117
Gene Name olfactory receptor 1198
Synonyms GA_x6K02T2Q125-50221692-50220766, MOR225-13
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.060) question?
Stock # R9264 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 88743970-88751370 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 88746432 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Histidine to Arginine at position 152 (H152R)
Ref Sequence ENSEMBL: ENSMUSP00000149844 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099814] [ENSMUST00000215179] [ENSMUST00000215529]
AlphaFold Q7TR12
Predicted Effect probably damaging
Transcript: ENSMUST00000099814
AA Change: H152R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000097402
Gene: ENSMUSG00000075117
AA Change: H152R

DomainStartEndE-ValueType
Pfam:7tm_4 28 302 1.1e-49 PFAM
Pfam:7tm_1 38 284 1e-16 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000215179
AA Change: H152R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000215529
AA Change: H152R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Meta Mutation Damage Score 0.8537 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 100% (58/58)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700017D01Rik T A 19: 11,116,466 M1L probably benign Het
Abca15 A T 7: 120,401,833 I1531L probably benign Het
Adam28 T C 14: 68,607,465 Y791C probably benign Het
Ankrd40 T A 11: 94,338,361 I262N probably damaging Het
BC067074 G A 13: 113,319,480 V687M Het
Catsperg2 A T 7: 29,698,188 N1033K possibly damaging Het
Cdh10 A T 15: 18,963,995 D81V probably damaging Het
Cep290 T C 10: 100,498,016 V310A possibly damaging Het
Cep78 T C 19: 15,974,466 Y325C probably damaging Het
Clstn3 T A 6: 124,459,768 D197V probably damaging Het
Col11a1 T C 3: 114,212,160 I1647T unknown Het
Col5a1 G A 2: 27,964,111 R569K unknown Het
Cyp4a10 T C 4: 115,524,278 S180P probably benign Het
D630045J12Rik T C 6: 38,158,238 I1336V probably benign Het
Dchs2 G A 3: 83,270,477 V946M probably damaging Het
Dnah10 A G 5: 124,736,836 R347G probably damaging Het
Dnah11 T A 12: 118,027,527 D2368V probably damaging Het
Ganab T C 19: 8,912,864 I719T possibly damaging Het
Gm10944 C A 10: 10,681,839 A11D unknown Het
Gmcl1 T C 6: 86,714,213 M267V probably benign Het
Inhbe T A 10: 127,350,558 D251V probably damaging Het
Kcnj1 G A 9: 32,396,358 R26Q probably benign Het
Lama5 A G 2: 180,196,478 probably benign Het
Lin9 T A 1: 180,667,347 D251E probably damaging Het
Magel2 T A 7: 62,378,596 I416N possibly damaging Het
Mdga2 T C 12: 66,513,283 N772S probably damaging Het
Msh3 G T 13: 92,349,304 Q171K probably benign Het
Mslnl T G 17: 25,742,532 probably benign Het
Mtpn A G 6: 35,512,241 L116P possibly damaging Het
Myh7 T C 14: 54,975,997 T1351A probably benign Het
Nectin3 A T 16: 46,454,635 I353N probably damaging Het
Nprl3 A T 11: 32,233,948 N500K probably benign Het
Nup93 T A 8: 94,292,720 I181N probably benign Het
Olfr362 G A 2: 37,104,789 T287I probably damaging Het
Optc T C 1: 133,905,240 I41V probably benign Het
Pcdh7 C A 5: 58,129,321 N1246K probably benign Het
Pcdhb3 T A 18: 37,302,113 D377E probably benign Het
Pnpla6 C T 8: 3,523,294 P386L probably benign Het
Polr3a T C 14: 24,470,831 T587A probably benign Het
Pramel1 T G 4: 143,398,529 L341R probably damaging Het
Rhot2 A T 17: 25,841,766 N210K probably damaging Het
Slc37a1 A G 17: 31,300,485 I12V probably benign Het
Spata48 T A 11: 11,464,678 D141E Het
Sstr3 G T 15: 78,539,592 N318K probably damaging Het
Ssx2ip T C 3: 146,437,200 V511A probably benign Het
Stfa1 G A 16: 36,280,568 V57I unknown Het
Syne1 T G 10: 5,262,793 R3265S probably damaging Het
Tacc2 G T 7: 130,626,803 K1739N probably damaging Het
Tas2r143 A T 6: 42,400,739 M168L probably benign Het
Tm4sf1 A T 3: 57,294,610 probably null Het
Ttc16 A G 2: 32,763,005 I604T possibly damaging Het
Ugt1a10 T A 1: 88,055,671 W64R possibly damaging Het
Usp34 A T 11: 23,489,064 H3561L Het
Vasp C T 7: 19,259,451 V276I unknown Het
Vwa3a A G 7: 120,775,464 N333S probably benign Het
Wipf3 A G 6: 54,483,881 N105D probably benign Het
Zfp760 T C 17: 21,723,682 S613P possibly damaging Het
Other mutations in Olfr1198
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02290:Olfr1198 APN 2 88746385 missense probably benign
IGL02316:Olfr1198 APN 2 88746843 missense probably damaging 0.97
R0726:Olfr1198 UTSW 2 88746008 missense probably benign 0.15
R1439:Olfr1198 UTSW 2 88746834 missense possibly damaging 0.57
R1706:Olfr1198 UTSW 2 88746138 missense probably damaging 1.00
R1757:Olfr1198 UTSW 2 88746017 missense probably benign 0.15
R2202:Olfr1198 UTSW 2 88746609 missense probably benign 0.00
R2203:Olfr1198 UTSW 2 88746609 missense probably benign 0.00
R2204:Olfr1198 UTSW 2 88746609 missense probably benign 0.00
R3085:Olfr1198 UTSW 2 88746144 missense probably damaging 1.00
R4901:Olfr1198 UTSW 2 88746887 splice site probably null
R4934:Olfr1198 UTSW 2 88746054 nonsense probably null
R5687:Olfr1198 UTSW 2 88746750 missense probably damaging 1.00
R6074:Olfr1198 UTSW 2 88746222 missense probably damaging 1.00
R6105:Olfr1198 UTSW 2 88746840 missense probably benign 0.01
R6781:Olfr1198 UTSW 2 88746830 missense probably benign 0.01
R8745:Olfr1198 UTSW 2 88746064 missense possibly damaging 0.79
R9058:Olfr1198 UTSW 2 88746686 missense
R9355:Olfr1198 UTSW 2 88746405 missense probably damaging 0.97
R9660:Olfr1198 UTSW 2 88746528 missense probably damaging 1.00
Z1088:Olfr1198 UTSW 2 88746578 missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGTCCTCAGGATGGACAAAATG -3'
(R):5'- AATCTCCTACAATGGCTGCATAG -3'

Sequencing Primer
(F):5'- TGACCAAGGCAAGAAAGGTC -3'
(R):5'- GCATAGCCCAGATGTTTTATGCAC -3'
Posted On 2022-03-25