Mutagenetix > Incidental Mutation

Incidental Mutation 'R9267:Lrrk2'

702644

Institutional Source

Beutler Lab

Gene Symbol

Lrrk2

Ensembl Gene

ENSMUSG00000036273

Gene Name

leucine-rich repeat kinase 2

Synonyms

9330188B09Rik, 4921513O20Rik, LOC381026, cI-46, D630001M17Rik

MMRRC Submission

Accession Numbers

Genbank: NM_025730; MGI: 1913975

Essential gene?

Possibly essential (E-score: 0.520) question?

Stock #

R9267 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

91673175-91816120 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 91700426 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Phenylalanine at position 349 (L349F)

Ref Sequence

ENSEMBL: ENSMUSP00000052584 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000060642]

AlphaFold

Q5S006

Predicted Effect

probably damaging
Transcript: ENSMUST00000060642
AA Change: L349F

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000052584
Gene: ENSMUSG00000036273
AA Change: L349F

Domain	Start	End	E-Value	Type
low complexity region	138	156	N/A	INTRINSIC
low complexity region	332	347	N/A	INTRINSIC
ANK	708	737	3.95e1	SMART
ANK	770	800	4.58e2	SMART
low complexity region	890	901	N/A	INTRINSIC
low complexity region	953	966	N/A	INTRINSIC
low complexity region	971	979	N/A	INTRINSIC
LRR	1010	1033	9.96e-1	SMART
LRR	1034	1057	8.01e0	SMART
LRR	1082	1105	2.45e0	SMART
LRR	1128	1151	9.3e-1	SMART
LRR	1195	1219	3.24e0	SMART
LRR	1244	1266	3.87e1	SMART
LRR	1267	1291	4.98e1	SMART
Pfam:Roc	1336	1456	4.9e-32	PFAM
Pfam:Ras	1336	1489	3.3e-17	PFAM
Pfam:COR	1524	1740	4e-28	PFAM
Pfam:Pkinase	1881	2132	4.7e-40	PFAM
Pfam:Pkinase_Tyr	1882	2132	6.8e-39	PFAM
WD40	2231	2276	3.09e-1	SMART
WD40	2401	2438	1.37e2	SMART

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.7%

Validation Efficiency

98% (79/81)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-in allele exhibit impaired response to dopamine, amphetamine, and quinpirole. Mice homozygous for one knock-out allele exhibit increased neurite growth. Mice homozygous for different knock-out alleles exhibit alopecia due to excessive grooming or kdiney atrophy. [provided by MGI curators]

Allele List at MGI

All alleles(7) : Targeted, knock-out(6) Targeted, other(1)

Other mutations in this stock

Total: 83 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc4	G	T	14: 118,632,245		probably benign	Het
Abcd2	T	A	15: 91,179,220	T422S	possibly damaging	Het
Acsl3	T	G	1: 78,696,906	I390S	probably damaging	Het
Adad1	T	A	3: 37,084,925		probably benign	Het
Adam3	A	G	8: 24,681,589	V742A	probably benign	Het
Adgra3	A	T	5: 49,998,276	I450K	possibly damaging	Het
Adgrb2	T	C	4: 129,992,108	S14P	possibly damaging	Het
Arfgef3	T	A	10: 18,599,280	I1553F	probably damaging	Het
Btbd16	C	T	7: 130,815,786	R344C	probably damaging	Het
Ccdc27	A	G	4: 154,032,984	L502P	probably damaging	Het
Ccdc50	T	A	16: 27,389,950	L5Q		Het
Cdh16	C	T	8: 104,615,202	G777D	probably damaging	Het
Cntn2	C	A	1: 132,521,283	V663L	probably benign	Het
Cpne4	T	A	9: 105,007,634	V343E	probably damaging	Het
Dctpp1	A	T	7: 127,257,103	I149N	probably benign	Het
Dlg5	T	C	14: 24,154,677	N1266S	probably damaging	Het
Dst	A	G	1: 34,193,064	D3246G	probably benign	Het
Efcab8	G	C	2: 153,804,941	V397L	unknown	Het
Erbin	T	C	13: 103,850,784	T423A	probably damaging	Het
Erich5	C	T	15: 34,471,417	P264L	possibly damaging	Het
Fam90a1a	A	G	8: 21,963,075	M149V	probably benign	Het
Fbxl18	C	T	5: 142,895,115	G62R	possibly damaging	Het
Fech	A	G	18: 64,458,196	S386P	possibly damaging	Het
Fhl3	T	A	4: 124,707,705		probably null	Het
Fkbp5	A	G	17: 28,410,584	S256P	probably benign	Het
Frem2	A	G	3: 53,657,083	M1T	probably null	Het
Galnt5	T	C	2: 58,035,208	F834L	possibly damaging	Het
Gm3618	G	T	14: 6,314,964	T99N	unknown	Het
Gm884	A	T	11: 103,604,580	D2804E	unknown	Het
Gm9195	T	A	14: 72,463,106	Q1127L	possibly damaging	Het
Gpsm1	A	G	2: 26,346,823	D643G	probably damaging	Het
Grm4	A	G	17: 27,435,209	V589A	possibly damaging	Het
Gskip	T	A	12: 105,698,793	F30L	probably benign	Het
Haus3	T	A	5: 34,154,108		probably null	Het
Heatr1	T	C	13: 12,406,608	F463S	probably damaging	Het
Hmcn1	G	A	1: 150,597,989	S4851F	probably benign	Het
Il16	A	C	7: 83,722,549	F16L	probably benign	Het
Itga1	C	A	13: 115,049,388	C26F	possibly damaging	Het
Itga6	A	G	2: 71,838,412	E565G	probably benign	Het
Itgb4	A	G	11: 115,979,639	H98R	probably benign	Het
Kidins220	T	A	12: 24,988,559	S37T	probably benign	Het
Malrd1	T	G	2: 16,255,266	I2099S	unknown	Het
Mapk8ip1	A	G	2: 92,386,369	I492T	possibly damaging	Het
Mest	T	A	6: 30,742,142	D68E		Het
Mthfd1l	A	G	10: 3,984,154	D162G	probably benign	Het
Nalcn	A	T	14: 123,281,155	D1657E	probably benign	Het
Nbeal2	C	A	9: 110,633,047	V1475F	probably damaging	Het
Nf1	C	A	11: 79,440,890	Q684K	possibly damaging	Het
Olfr1116	T	C	2: 87,268,982	L67P	possibly damaging	Het
Olfr1354	A	G	10: 78,916,969	N43S	probably damaging	Het
Olfr1411	A	T	1: 92,597,274	M252L	probably benign	Het
Olfr1411	A	T	1: 92,597,272	H251L	probably damaging	Het
Olfr348	A	T	2: 36,786,518		probably benign	Het
Opn5	T	A	17: 42,592,902	T181S	probably damaging	Het
Orc4	T	A	2: 48,937,522	R20*	probably null	Het
Pik3ca	T	C	3: 32,438,062	Y270H	probably damaging	Het
Pkn2	T	C	3: 142,811,915	E474G	probably null	Het
Pnmal2	A	T	7: 16,945,234	N48Y	unknown	Het
Pnpla2	A	C	7: 141,456,590		probably benign	Het
Polr1a	G	A	6: 71,965,558	M1127I	probably benign	Het
Ptpre	A	C	7: 135,672,820	D507A	probably damaging	Het
Rab3gap2	T	C	1: 185,251,134	V490A	probably damaging	Het
Rab44	A	T	17: 29,135,364		probably benign	Het
Rchy1	G	T	5: 91,957,972	T39N	probably benign	Het
Ripor1	A	G	8: 105,621,431	D1146G	unknown	Het
Sh3yl1	A	T	12: 30,922,336	I35F	possibly damaging	Het
Slc22a5	A	G	11: 53,873,793	F276L	probably benign	Het
Slc8a3	T	A	12: 81,314,434	D537V	possibly damaging	Het
Smc4	T	A	3: 69,034,453	I1263N	probably damaging	Het
Snai2	A	T	16: 14,707,256	T209S	possibly damaging	Het
Stam2	A	T	2: 52,714,891	Y211N	probably damaging	Het
Stxbp1	A	G	2: 32,818,505	S83P	probably damaging	Het
Susd4	T	C	1: 182,888,824	F325L	probably benign	Het
Tmem245	A	G	4: 56,947,236	V59A	probably benign	Het
Tnk2	A	G	16: 32,675,671	D469G	probably damaging	Het
Tpx2	A	G	2: 152,890,597	D597G	probably damaging	Het
Ube2w	A	T	1: 16,541,787	S170R		Het
Vmn2r102	A	T	17: 19,676,666	I92F	probably damaging	Het
Vmn2r11	T	A	5: 109,052,063	E508V	possibly damaging	Het
Vmn2r30	T	A	7: 7,337,433	I21F	possibly damaging	Het
Yipf2	G	A	9: 21,590,193	T187M	possibly damaging	Het
Zbtb8a	T	A	4: 129,354,474	K335*	probably null	Het
Zfp609	T	C	9: 65,701,046	D1184G	possibly damaging	Het

Other mutations in Lrrk2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00159:Lrrk2	APN	15	91,747,799 (GRCm38)	missense	possibly damaging	0.90
IGL00542:Lrrk2	APN	15	91,699,943 (GRCm38)	missense	probably benign
IGL00770:Lrrk2	APN	15	91,801,833 (GRCm38)	splice site	probably benign
IGL00774:Lrrk2	APN	15	91,801,833 (GRCm38)	splice site	probably benign
IGL00791:Lrrk2	APN	15	91,779,841 (GRCm38)	missense	probably damaging	1.00
IGL00827:Lrrk2	APN	15	91,755,790 (GRCm38)	missense	probably damaging	1.00
IGL00843:Lrrk2	APN	15	91,757,058 (GRCm38)	missense	possibly damaging	0.58
IGL01109:Lrrk2	APN	15	91,738,832 (GRCm38)	missense	probably damaging	1.00
IGL01293:Lrrk2	APN	15	91,726,137 (GRCm38)	missense	probably benign	0.21
IGL01296:Lrrk2	APN	15	91,683,142 (GRCm38)	missense	probably benign
IGL01301:Lrrk2	APN	15	91,767,339 (GRCm38)	missense	probably damaging	1.00
IGL01360:Lrrk2	APN	15	91,700,569 (GRCm38)	splice site	probably null
IGL01465:Lrrk2	APN	15	91,728,925 (GRCm38)	missense	probably benign	0.21
IGL01529:Lrrk2	APN	15	91,812,313 (GRCm38)	missense	possibly damaging	0.92
IGL01557:Lrrk2	APN	15	91,699,989 (GRCm38)	missense	probably damaging	1.00
IGL01560:Lrrk2	APN	15	91,774,988 (GRCm38)	missense	probably benign	0.33
IGL01991:Lrrk2	APN	15	91,779,946 (GRCm38)	missense	probably damaging	0.99
IGL02003:Lrrk2	APN	15	91,731,491 (GRCm38)	missense	probably damaging	0.99
IGL02325:Lrrk2	APN	15	91,726,308 (GRCm38)	critical splice donor site	probably null
IGL02711:Lrrk2	APN	15	91,685,822 (GRCm38)	missense	possibly damaging	0.71
IGL02869:Lrrk2	APN	15	91,750,277 (GRCm38)	missense	probably damaging	1.00
IGL03104:Lrrk2	APN	15	91,747,755 (GRCm38)	missense	possibly damaging	0.68
IGL03179:Lrrk2	APN	15	91,700,578 (GRCm38)	missense	probably damaging	1.00
IGL03395:Lrrk2	APN	15	91,797,414 (GRCm38)	splice site	probably null
horned	UTSW	15	91,772,858 (GRCm38)	missense	probably damaging	1.00
R1312_Lrrk2_980	UTSW	15	91,699,895 (GRCm38)	missense	probably damaging	1.00
R4710_lrrk2_232	UTSW	15	91,699,927 (GRCm38)	missense	possibly damaging	0.88
R5245_Lrrk2_127	UTSW	15	91,796,089 (GRCm38)	missense	probably damaging	1.00
spree	UTSW	15	91,702,247 (GRCm38)	missense	probably benign	0.00
Spur	UTSW	15	91,774,995 (GRCm38)	nonsense	probably null
3-1:Lrrk2	UTSW	15	91,801,934 (GRCm38)	missense	probably benign	0.01
ANU18:Lrrk2	UTSW	15	91,767,339 (GRCm38)	missense	probably damaging	1.00
H8562:Lrrk2	UTSW	15	91,673,358 (GRCm38)	missense	probably benign
H8786:Lrrk2	UTSW	15	91,673,358 (GRCm38)	missense	probably benign
IGL02835:Lrrk2	UTSW	15	91,814,660 (GRCm38)	critical splice acceptor site	probably null
R0014:Lrrk2	UTSW	15	91,802,045 (GRCm38)	splice site	probably benign
R0014:Lrrk2	UTSW	15	91,802,045 (GRCm38)	splice site	probably benign
R0078:Lrrk2	UTSW	15	91,734,009 (GRCm38)	missense	probably benign	0.01
R0100:Lrrk2	UTSW	15	91,745,796 (GRCm38)	missense	probably damaging	1.00
R0282:Lrrk2	UTSW	15	91,778,414 (GRCm38)	splice site	probably benign
R0448:Lrrk2	UTSW	15	91,709,305 (GRCm38)	missense	probably damaging	0.99
R0449:Lrrk2	UTSW	15	91,750,275 (GRCm38)	missense	probably damaging	1.00
R0610:Lrrk2	UTSW	15	91,815,416 (GRCm38)	missense	probably benign
R0617:Lrrk2	UTSW	15	91,752,278 (GRCm38)	missense	probably benign	0.00
R0632:Lrrk2	UTSW	15	91,796,028 (GRCm38)	missense	probably damaging	0.98
R0639:Lrrk2	UTSW	15	91,772,996 (GRCm38)	missense	probably benign	0.03
R0661:Lrrk2	UTSW	15	91,787,016 (GRCm38)	missense	probably damaging	1.00
R0666:Lrrk2	UTSW	15	91,757,070 (GRCm38)	critical splice donor site	probably null
R0764:Lrrk2	UTSW	15	91,775,046 (GRCm38)	splice site	probably null
R0766:Lrrk2	UTSW	15	91,699,895 (GRCm38)	missense	probably damaging	1.00
R0845:Lrrk2	UTSW	15	91,755,962 (GRCm38)	missense	probably benign	0.22
R0940:Lrrk2	UTSW	15	91,729,081 (GRCm38)	missense	possibly damaging	0.83
R0970:Lrrk2	UTSW	15	91,729,169 (GRCm38)	missense	probably benign	0.22
R1080:Lrrk2	UTSW	15	91,673,689 (GRCm38)	missense	probably benign	0.01
R1114:Lrrk2	UTSW	15	91,700,468 (GRCm38)	nonsense	probably null
R1223:Lrrk2	UTSW	15	91,673,635 (GRCm38)	missense	probably benign	0.00
R1289:Lrrk2	UTSW	15	91,812,360 (GRCm38)	missense	probably benign	0.00
R1296:Lrrk2	UTSW	15	91,728,920 (GRCm38)	missense	probably damaging	1.00
R1312:Lrrk2	UTSW	15	91,699,895 (GRCm38)	missense	probably damaging	1.00
R1637:Lrrk2	UTSW	15	91,734,058 (GRCm38)	missense	probably benign
R1773:Lrrk2	UTSW	15	91,779,981 (GRCm38)	missense	possibly damaging	0.96
R1809:Lrrk2	UTSW	15	91,699,892 (GRCm38)	missense	possibly damaging	0.86
R1839:Lrrk2	UTSW	15	91,683,134 (GRCm38)	missense	probably benign	0.00
R1946:Lrrk2	UTSW	15	91,736,661 (GRCm38)	splice site	probably null
R2160:Lrrk2	UTSW	15	91,796,060 (GRCm38)	missense	probably damaging	1.00
R2232:Lrrk2	UTSW	15	91,764,716 (GRCm38)	missense	probably benign	0.05
R2419:Lrrk2	UTSW	15	91,797,526 (GRCm38)	splice site	probably benign
R2516:Lrrk2	UTSW	15	91,755,927 (GRCm38)	missense	probably benign
R3110:Lrrk2	UTSW	15	91,814,695 (GRCm38)	missense	probably benign	0.02
R3112:Lrrk2	UTSW	15	91,814,695 (GRCm38)	missense	probably benign	0.02
R3801:Lrrk2	UTSW	15	91,737,111 (GRCm38)	missense	probably benign
R3842:Lrrk2	UTSW	15	91,755,916 (GRCm38)	missense	probably benign	0.01
R3903:Lrrk2	UTSW	15	91,747,701 (GRCm38)	missense	probably damaging	1.00
R3903:Lrrk2	UTSW	15	91,747,700 (GRCm38)	missense	probably damaging	1.00
R3930:Lrrk2	UTSW	15	91,767,461 (GRCm38)	critical splice donor site	probably null
R3937:Lrrk2	UTSW	15	91,778,504 (GRCm38)	missense	probably damaging	0.98
R3938:Lrrk2	UTSW	15	91,778,504 (GRCm38)	missense	probably damaging	0.98
R3938:Lrrk2	UTSW	15	91,712,780 (GRCm38)	missense	possibly damaging	0.69
R3982:Lrrk2	UTSW	15	91,709,284 (GRCm38)	missense	probably benign	0.22
R4125:Lrrk2	UTSW	15	91,815,483 (GRCm38)	missense	probably benign	0.01
R4130:Lrrk2	UTSW	15	91,755,794 (GRCm38)	missense	probably benign	0.19
R4296:Lrrk2	UTSW	15	91,699,895 (GRCm38)	missense	probably damaging	1.00
R4465:Lrrk2	UTSW	15	91,747,820 (GRCm38)	missense	probably damaging	0.96
R4478:Lrrk2	UTSW	15	91,723,188 (GRCm38)	missense	probably damaging	1.00
R4517:Lrrk2	UTSW	15	91,705,120 (GRCm38)	missense	probably benign
R4539:Lrrk2	UTSW	15	91,729,142 (GRCm38)	missense	possibly damaging	0.86
R4654:Lrrk2	UTSW	15	91,765,681 (GRCm38)	missense	probably damaging	0.96
R4710:Lrrk2	UTSW	15	91,699,927 (GRCm38)	missense	possibly damaging	0.88
R4722:Lrrk2	UTSW	15	91,688,901 (GRCm38)	missense	probably damaging	1.00
R4723:Lrrk2	UTSW	15	91,764,759 (GRCm38)	missense	probably damaging	1.00
R4732:Lrrk2	UTSW	15	91,765,747 (GRCm38)	missense	probably damaging	1.00
R4732:Lrrk2	UTSW	15	91,688,849 (GRCm38)	missense	probably damaging	1.00
R4733:Lrrk2	UTSW	15	91,765,747 (GRCm38)	missense	probably damaging	1.00
R4733:Lrrk2	UTSW	15	91,688,849 (GRCm38)	missense	probably damaging	1.00
R4787:Lrrk2	UTSW	15	91,712,828 (GRCm38)	missense	probably benign
R4945:Lrrk2	UTSW	15	91,804,920 (GRCm38)	missense	probably benign	0.02
R4948:Lrrk2	UTSW	15	91,803,389 (GRCm38)	missense	probably benign	0.20
R5000:Lrrk2	UTSW	15	91,749,878 (GRCm38)	missense	probably damaging	1.00
R5031:Lrrk2	UTSW	15	91,700,619 (GRCm38)	missense	possibly damaging	0.50
R5067:Lrrk2	UTSW	15	91,765,790 (GRCm38)	missense	probably benign	0.01
R5245:Lrrk2	UTSW	15	91,796,089 (GRCm38)	missense	probably damaging	1.00
R5341:Lrrk2	UTSW	15	91,772,858 (GRCm38)	missense	probably damaging	1.00
R5460:Lrrk2	UTSW	15	91,814,644 (GRCm38)	splice site	probably null
R5551:Lrrk2	UTSW	15	91,812,350 (GRCm38)	missense	probably benign
R5574:Lrrk2	UTSW	15	91,787,016 (GRCm38)	missense	probably damaging	1.00
R5577:Lrrk2	UTSW	15	91,765,745 (GRCm38)	missense	probably damaging	1.00
R5685:Lrrk2	UTSW	15	91,803,301 (GRCm38)	nonsense	probably null
R5712:Lrrk2	UTSW	15	91,702,222 (GRCm38)	nonsense	probably null
R5728:Lrrk2	UTSW	15	91,774,974 (GRCm38)	missense	probably benign	0.36
R5782:Lrrk2	UTSW	15	91,702,183 (GRCm38)	missense	probably damaging	1.00
R5788:Lrrk2	UTSW	15	91,764,648 (GRCm38)	missense	possibly damaging	0.55
R5821:Lrrk2	UTSW	15	91,709,390 (GRCm38)	critical splice donor site	probably null
R5852:Lrrk2	UTSW	15	91,755,949 (GRCm38)	missense	probably damaging	1.00
R5934:Lrrk2	UTSW	15	91,734,046 (GRCm38)	missense	probably benign	0.00
R5935:Lrrk2	UTSW	15	91,745,831 (GRCm38)	missense	probably benign	0.14
R5979:Lrrk2	UTSW	15	91,772,945 (GRCm38)	missense	possibly damaging	0.47
R6101:Lrrk2	UTSW	15	91,723,135 (GRCm38)	missense	probably benign	0.10
R6114:Lrrk2	UTSW	15	91,747,826 (GRCm38)	missense	probably benign	0.33
R6259:Lrrk2	UTSW	15	91,702,247 (GRCm38)	missense	probably benign	0.00
R6376:Lrrk2	UTSW	15	91,742,266 (GRCm38)	missense	possibly damaging	0.89
R6417:Lrrk2	UTSW	15	91,812,346 (GRCm38)	missense	probably benign	0.03
R6420:Lrrk2	UTSW	15	91,812,346 (GRCm38)	missense	probably benign	0.03
R6737:Lrrk2	UTSW	15	91,723,218 (GRCm38)	missense	possibly damaging	0.50
R7056:Lrrk2	UTSW	15	91,774,995 (GRCm38)	nonsense	probably null
R7072:Lrrk2	UTSW	15	91,801,920 (GRCm38)	missense	probably benign	0.03
R7109:Lrrk2	UTSW	15	91,764,782 (GRCm38)	missense	probably damaging	1.00
R7128:Lrrk2	UTSW	15	91,801,885 (GRCm38)	missense	probably benign
R7144:Lrrk2	UTSW	15	91,734,055 (GRCm38)	missense	possibly damaging	0.54
R7187:Lrrk2	UTSW	15	91,757,001 (GRCm38)	missense	possibly damaging	0.92
R7270:Lrrk2	UTSW	15	91,700,441 (GRCm38)	missense	probably benign	0.01
R7356:Lrrk2	UTSW	15	91,738,744 (GRCm38)	missense	probably benign	0.07
R7360:Lrrk2	UTSW	15	91,731,655 (GRCm38)	critical splice donor site	probably null
R7373:Lrrk2	UTSW	15	91,700,004 (GRCm38)	critical splice donor site	probably null
R7465:Lrrk2	UTSW	15	91,767,340 (GRCm38)	missense	probably damaging	1.00
R7477:Lrrk2	UTSW	15	91,812,325 (GRCm38)	missense	probably damaging	0.98
R7614:Lrrk2	UTSW	15	91,772,858 (GRCm38)	missense	probably damaging	1.00
R7622:Lrrk2	UTSW	15	91,812,323 (GRCm38)	missense	probably damaging	1.00
R7658:Lrrk2	UTSW	15	91,700,358 (GRCm38)	missense	possibly damaging	0.91
R7679:Lrrk2	UTSW	15	91,726,186 (GRCm38)	missense	possibly damaging	0.58
R7737:Lrrk2	UTSW	15	91,815,446 (GRCm38)	missense	probably damaging	0.98
R7739:Lrrk2	UTSW	15	91,700,613 (GRCm38)	missense	probably damaging	1.00
R7740:Lrrk2	UTSW	15	91,767,324 (GRCm38)	missense	probably damaging	1.00
R7908:Lrrk2	UTSW	15	91,726,152 (GRCm38)	missense	probably damaging	1.00
R8299:Lrrk2	UTSW	15	91,673,240 (GRCm38)	start gained	probably benign
R8389:Lrrk2	UTSW	15	91,699,991 (GRCm38)	missense	probably damaging	1.00
R8462:Lrrk2	UTSW	15	91,731,477 (GRCm38)	missense	probably benign
R8698:Lrrk2	UTSW	15	91,752,197 (GRCm38)	missense	probably benign	0.38
R8947:Lrrk2	UTSW	15	91,702,270 (GRCm38)	nonsense	probably null
R9084:Lrrk2	UTSW	15	91,750,266 (GRCm38)	missense
R9086:Lrrk2	UTSW	15	91,755,848 (GRCm38)	missense	probably benign	0.01
R9096:Lrrk2	UTSW	15	91,673,256 (GRCm38)	start gained	probably benign
R9097:Lrrk2	UTSW	15	91,673,256 (GRCm38)	start gained	probably benign
R9285:Lrrk2	UTSW	15	91,778,483 (GRCm38)	missense	probably damaging	1.00
R9341:Lrrk2	UTSW	15	91,700,415 (GRCm38)	missense	probably benign	0.18
R9343:Lrrk2	UTSW	15	91,700,415 (GRCm38)	missense	probably benign	0.18
R9371:Lrrk2	UTSW	15	91,723,204 (GRCm38)	missense	probably damaging	1.00
R9424:Lrrk2	UTSW	15	91,752,185 (GRCm38)	nonsense	probably null
R9489:Lrrk2	UTSW	15	91,737,217 (GRCm38)	missense	probably benign	0.37
R9502:Lrrk2	UTSW	15	91,723,162 (GRCm38)	missense	probably damaging	0.98
R9563:Lrrk2	UTSW	15	91,749,840 (GRCm38)	missense	possibly damaging	0.90
R9576:Lrrk2	UTSW	15	91,752,185 (GRCm38)	nonsense	probably null
R9605:Lrrk2	UTSW	15	91,737,217 (GRCm38)	missense	probably benign	0.37
R9635:Lrrk2	UTSW	15	91,812,324 (GRCm38)	missense	probably benign	0.21
R9641:Lrrk2	UTSW	15	91,787,048 (GRCm38)	missense	possibly damaging	0.94
R9660:Lrrk2	UTSW	15	91,734,025 (GRCm38)	missense	probably benign	0.00
R9673:Lrrk2	UTSW	15	91,765,681 (GRCm38)	missense	probably damaging	1.00
R9708:Lrrk2	UTSW	15	91,750,279 (GRCm38)	nonsense	probably null
R9728:Lrrk2	UTSW	15	91,734,025 (GRCm38)	missense	probably benign	0.00
R9757:Lrrk2	UTSW	15	91,811,026 (GRCm38)	missense	probably benign	0.03
RF001:Lrrk2	UTSW	15	91,736,633 (GRCm38)	missense	probably benign	0.11
X0028:Lrrk2	UTSW	15	91,738,851 (GRCm38)	missense	probably benign	0.00
Z1088:Lrrk2	UTSW	15	91,726,240 (GRCm38)	missense	probably benign	0.12

Predicted Primers

PCR Primer
(F):5'- ACATGACGAGGCAGCAGTTATG -3'
(R):5'- GGTTATTTAGTGCCCAGCAGG -3'

Sequencing Primer
(F):5'- AAGTGGCTTCATGATTAGTGAAGG -3'
(R):5'- AGGCAGCCTCCTAGATCAG -3'

Posted On

2022-03-25