Mutagenetix > Incidental Mutation

Incidental Mutation 'R9269:Vmn2r112'

702800

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r112

Ensembl Gene

ENSMUSG00000094921

Gene Name

vomeronasal 2, receptor 112

Synonyms

EG628185

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.111) question?

Stock #

R9269 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

22601148-22619133 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 22601232 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Leucine at position 29 (M29L)

Ref Sequence

ENSEMBL: ENSMUSP00000094994 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000097381]

AlphaFold

L7N221

Predicted Effect

probably benign
Transcript: ENSMUST00000097381
AA Change: M29L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000094994
Gene: ENSMUSG00000094921
AA Change: M29L

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	73	471	2.8e-32	PFAM
Pfam:NCD3G	512	565	5.8e-21	PFAM
Pfam:7tm_3	598	833	6.5e-54	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.6%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 90 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2410089E03Rik	A	C	15: 8,219,016 (GRCm38)	Q1683P	probably damaging	Het
A2m	T	C	6: 121,660,906 (GRCm38)	S845P	probably benign	Het
Actn1	T	A	12: 80,172,971 (GRCm38)	N709Y	probably benign	Het
Alox5ap	A	G	5: 149,279,196 (GRCm38)	Y64C	probably damaging	Het
Anapc4	T	A	5: 52,861,278 (GRCm38)	S521T	possibly damaging	Het
Ap3b1	C	A	13: 94,404,062 (GRCm38)	P164Q	probably damaging	Het
Arhgef26	A	G	3: 62,340,499 (GRCm38)	N335D	probably damaging	Het
Arrdc2	G	A	8: 70,836,329 (GRCm38)	A354V	probably benign	Het
Atg2b	A	G	12: 105,652,100 (GRCm38)	S898P	probably damaging	Het
Atxn1	T	A	13: 45,557,204 (GRCm38)	T751S	probably benign	Het
Begain	T	A	12: 109,033,193 (GRCm38)	R551W	possibly damaging	Het
Borcs8	C	A	8: 70,141,871 (GRCm38)	D15E	probably benign	Het
Btbd16	C	T	7: 130,815,786 (GRCm38)	R344C	probably damaging	Het
Card11	A	T	5: 140,906,761 (GRCm38)	M183K	probably damaging	Het
Cldn3	T	C	5: 134,986,725 (GRCm38)	L94P	probably damaging	Het
Clvs2	A	T	10: 33,543,426 (GRCm38)	Y211N	probably damaging	Het
Col15a1	G	C	4: 47,288,200 (GRCm38)		probably benign	Het
Cop1	C	T	1: 159,288,983 (GRCm38)	P409L	probably benign	Het
Crhbp	C	A	13: 95,436,516 (GRCm38)	A241S	probably benign	Het
Cyfip1	C	A	7: 55,907,431 (GRCm38)	S794*	probably null	Het
D17Wsu92e	A	C	17: 27,786,075 (GRCm38)	Y169*	probably null	Het
Dlg5	T	A	14: 24,192,813 (GRCm38)	H172L	probably damaging	Het
Doc2a	T	A	7: 126,850,987 (GRCm38)	I199N	probably benign	Het
Dock3	T	C	9: 106,941,323 (GRCm38)	T1191A	probably benign	Het
Efcab8	G	C	2: 153,804,941 (GRCm38)	V397L	unknown	Het
Fcgr1	C	T	3: 96,285,838 (GRCm38)	R281H	probably benign	Het
Fndc10	T	C	4: 155,694,748 (GRCm38)	V83A	possibly damaging	Het
Galnt2	T	A	8: 124,338,463 (GRCm38)	I444K	probably benign	Het
Gcnt3	T	C	9: 70,034,008 (GRCm38)	Y426C	probably damaging	Het
Gm5580	C	T	6: 116,552,356 (GRCm38)	T398I	probably damaging	Het
Gtpbp1	C	T	15: 79,717,654 (GRCm38)	R533C	probably damaging	Het
Hid1	T	C	11: 115,361,676 (GRCm38)	E60G	probably damaging	Het
Ighv1-81	A	T	12: 115,920,541 (GRCm38)	L30Q	possibly damaging	Het
Ighv5-8	TATATATATATATATATATATA	TATATATATATATATATATATATA	12: 113,654,945 (GRCm38)		probably null	Het
Klf10	A	G	15: 38,297,758 (GRCm38)	L44P	probably damaging	Het
Lamc3	C	A	2: 31,928,896 (GRCm38)	S1211*	probably null	Het
Lamc3	T	C	2: 31,923,005 (GRCm38)	V1001A	probably benign	Het
Lmx1a	T	A	1: 167,830,625 (GRCm38)	H192Q	probably benign	Het
Nkx2-4	T	C	2: 147,084,264 (GRCm38)	H226R	possibly damaging	Het
Olfr1046	T	C	2: 86,216,903 (GRCm38)	H269R	probably damaging	Het
Olfr1179	G	A	2: 88,402,242 (GRCm38)	R231C	probably benign	Het
Olfr1240	T	A	2: 89,439,932 (GRCm38)	M116L	probably damaging	Het
Olfr1281	T	C	2: 111,328,952 (GRCm38)	F178L	probably damaging	Het
Olfr1453	T	C	19: 13,027,630 (GRCm38)	H233R	probably benign	Het
Olfr1468-ps1	A	T	19: 13,375,640 (GRCm38)	N226I	unknown	Het
Olfr472	T	A	7: 107,903,320 (GRCm38)	I201N	possibly damaging	Het
Olfr715	T	C	7: 107,128,626 (GRCm38)	I256V	probably benign	Het
Olfr869	T	C	9: 20,137,461 (GRCm38)	M115T	probably damaging	Het
Orai3	G	T	7: 127,774,022 (GRCm38)	A232S	probably benign	Het
Pak1ip1	G	A	13: 41,009,251 (GRCm38)	G177R	probably benign	Het
Pcp4l1	T	C	1: 171,174,406 (GRCm38)	R62G	possibly damaging	Het
Phox2b	T	A	5: 67,098,721 (GRCm38)	Q74L	probably benign	Het
Pi4kb	A	G	3: 94,984,486 (GRCm38)	Y159C	probably damaging	Het
Pkd1l3	GACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCA	GACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCA	8: 109,624,195 (GRCm38)		probably benign	Het
Plxna1	T	C	6: 89,329,559 (GRCm38)	R1430G	probably null	Het
Plxna4	T	C	6: 32,178,380 (GRCm38)	H1543R	probably benign	Het
Prcc	A	T	3: 87,869,731 (GRCm38)	F312Y	probably damaging	Het
Ranbp6	A	G	19: 29,809,988 (GRCm38)	L988P	probably damaging	Het
Rbm27	A	G	18: 42,327,507 (GRCm38)	T840A	probably benign	Het
Rchy1	G	T	5: 91,957,972 (GRCm38)	T39N	probably benign	Het
Rmi1	C	T	13: 58,409,026 (GRCm38)	T363I	probably benign	Het
Rnpc3	A	C	3: 113,611,246 (GRCm38)	I420S	probably damaging	Het
Rsph4a	T	A	10: 33,909,398 (GRCm38)	V435E	probably benign	Het
Rwdd1	T	C	10: 34,012,099 (GRCm38)	T38A	probably damaging	Het
S100a13	G	T	3: 90,515,863 (GRCm38)	D54Y	unknown	Het
Sel1l3	T	C	5: 53,154,286 (GRCm38)	Y619C	probably damaging	Het
Sf3b3	T	C	8: 110,812,026 (GRCm38)	T1121A	probably damaging	Het
Sgk3	T	C	1: 9,872,309 (GRCm38)	V102A	probably benign	Het
Sh2b1	T	C	7: 126,469,182 (GRCm38)	T486A	probably damaging	Het
Slc22a5	C	T	11: 53,876,155 (GRCm38)	R169H	probably damaging	Het
Slc4a5	T	C	6: 83,289,241 (GRCm38)	V889A	possibly damaging	Het
Spast	C	A	17: 74,339,074 (GRCm38)	S13*	probably null	Het
Srek1	T	C	13: 103,753,146 (GRCm38)		probably null	Het
Sugp1	G	T	8: 70,056,570 (GRCm38)	E164D	probably benign	Het
Synpo2	T	C	3: 123,117,324 (GRCm38)	D224G	probably benign	Het
Tanc1	A	G	2: 59,800,088 (GRCm38)	D804G	probably damaging	Het
Tep1	C	T	14: 50,844,309 (GRCm38)	C1228Y	probably damaging	Het
Tes	T	A	6: 17,100,342 (GRCm38)	C325S	probably benign	Het
Themis	T	C	10: 28,863,394 (GRCm38)	V620A	probably benign	Het
Trim17	T	C	11: 58,971,431 (GRCm38)	S430P	probably damaging	Het
Tubgcp5	T	C	7: 55,795,945 (GRCm38)	I65T	possibly damaging	Het
Unc13b	T	C	4: 43,171,955 (GRCm38)	S928P	unknown	Het
Vat1l	C	T	8: 114,289,432 (GRCm38)	A354V	probably damaging	Het
Vmn1r170	T	A	7: 23,606,838 (GRCm38)	S222T	probably benign	Het
Vmn2r72	T	C	7: 85,751,203 (GRCm38)	I213V	probably benign	Het
Wdr89	T	A	12: 75,632,790 (GRCm38)	Q230L	possibly damaging	Het
Zfp386	A	G	12: 116,059,663 (GRCm38)	T334A	probably benign	Het
Zfp442	T	A	2: 150,409,367 (GRCm38)	H205L	probably benign	Het
Zfyve26	A	T	12: 79,276,302 (GRCm38)	I890N	possibly damaging	Het
Zic1	T	C	9: 91,364,320 (GRCm38)	E233G	probably damaging	Het

Other mutations in Vmn2r112

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00341:Vmn2r112	APN	17	22,618,936 (GRCm38)	missense	probably benign	0.13
IGL01021:Vmn2r112	APN	17	22,618,904 (GRCm38)	missense	probably damaging	1.00
IGL01122:Vmn2r112	APN	17	22,603,007 (GRCm38)	missense	probably benign	0.00
IGL01360:Vmn2r112	APN	17	22,618,622 (GRCm38)	missense	probably benign	0.03
IGL01536:Vmn2r112	APN	17	22,605,155 (GRCm38)	missense	probably damaging	1.00
IGL02148:Vmn2r112	APN	17	22,619,032 (GRCm38)	missense	probably damaging	1.00
IGL02465:Vmn2r112	APN	17	22,614,994 (GRCm38)	missense	probably damaging	1.00
PIT4576001:Vmn2r112	UTSW	17	22,614,931 (GRCm38)	missense	probably benign	0.00
R0278:Vmn2r112	UTSW	17	22,603,006 (GRCm38)	missense	probably benign	0.44
R0328:Vmn2r112	UTSW	17	22,605,270 (GRCm38)	missense	probably benign	0.01
R0583:Vmn2r112	UTSW	17	22,618,949 (GRCm38)	missense	probably damaging	1.00
R0831:Vmn2r112	UTSW	17	22,614,999 (GRCm38)	missense	probably damaging	0.99
R1080:Vmn2r112	UTSW	17	22,618,999 (GRCm38)	missense	probably damaging	1.00
R1245:Vmn2r112	UTSW	17	22,603,247 (GRCm38)	missense	probably benign	0.03
R1321:Vmn2r112	UTSW	17	22,618,519 (GRCm38)	nonsense	probably null
R1381:Vmn2r112	UTSW	17	22,618,486 (GRCm38)	missense	probably damaging	1.00
R1514:Vmn2r112	UTSW	17	22,602,844 (GRCm38)	missense	probably benign	0.40
R1519:Vmn2r112	UTSW	17	22,618,903 (GRCm38)	missense	possibly damaging	0.83
R1572:Vmn2r112	UTSW	17	22,603,144 (GRCm38)	missense	possibly damaging	0.61
R1590:Vmn2r112	UTSW	17	22,615,008 (GRCm38)	critical splice donor site	probably null
R1640:Vmn2r112	UTSW	17	22,605,116 (GRCm38)	missense	probably benign	0.01
R2221:Vmn2r112	UTSW	17	22,601,233 (GRCm38)	missense	possibly damaging	0.86
R2223:Vmn2r112	UTSW	17	22,601,233 (GRCm38)	missense	possibly damaging	0.86
R2310:Vmn2r112	UTSW	17	22,603,115 (GRCm38)	missense	probably damaging	0.98
R2312:Vmn2r112	UTSW	17	22,603,115 (GRCm38)	missense	probably damaging	0.98
R2337:Vmn2r112	UTSW	17	22,603,115 (GRCm38)	missense	probably damaging	0.98
R2339:Vmn2r112	UTSW	17	22,603,115 (GRCm38)	missense	probably damaging	0.98
R2340:Vmn2r112	UTSW	17	22,603,115 (GRCm38)	missense	probably damaging	0.98
R2341:Vmn2r112	UTSW	17	22,603,115 (GRCm38)	missense	probably damaging	0.98
R2342:Vmn2r112	UTSW	17	22,603,115 (GRCm38)	missense	probably damaging	0.98
R2401:Vmn2r112	UTSW	17	22,603,115 (GRCm38)	missense	probably damaging	0.98
R2860:Vmn2r112	UTSW	17	22,603,115 (GRCm38)	missense	probably damaging	0.98
R2861:Vmn2r112	UTSW	17	22,603,115 (GRCm38)	missense	probably damaging	0.98
R2926:Vmn2r112	UTSW	17	22,615,003 (GRCm38)	missense	possibly damaging	0.90
R3236:Vmn2r112	UTSW	17	22,603,115 (GRCm38)	missense	probably damaging	0.98
R3237:Vmn2r112	UTSW	17	22,603,115 (GRCm38)	missense	probably damaging	0.98
R3977:Vmn2r112	UTSW	17	22,603,115 (GRCm38)	missense	probably damaging	0.98
R3979:Vmn2r112	UTSW	17	22,603,115 (GRCm38)	missense	probably damaging	0.98
R4168:Vmn2r112	UTSW	17	22,603,088 (GRCm38)	missense	probably benign	0.01
R4256:Vmn2r112	UTSW	17	22,618,412 (GRCm38)	missense	probably damaging	1.00
R4386:Vmn2r112	UTSW	17	22,601,322 (GRCm38)	missense	probably benign	0.36
R4912:Vmn2r112	UTSW	17	22,603,382 (GRCm38)	missense	probably damaging	0.99
R4947:Vmn2r112	UTSW	17	22,602,879 (GRCm38)	missense	probably benign	0.02
R5446:Vmn2r112	UTSW	17	22,618,250 (GRCm38)	missense	probably damaging	1.00
R5870:Vmn2r112	UTSW	17	22,619,023 (GRCm38)	missense	probably benign	0.00
R6351:Vmn2r112	UTSW	17	22,601,278 (GRCm38)	missense	probably benign
R6384:Vmn2r112	UTSW	17	22,605,155 (GRCm38)	missense	probably damaging	1.00
R6390:Vmn2r112	UTSW	17	22,605,249 (GRCm38)	missense	probably benign	0.01
R6401:Vmn2r112	UTSW	17	22,603,551 (GRCm38)	nonsense	probably null
R6405:Vmn2r112	UTSW	17	22,618,235 (GRCm38)	missense	probably damaging	1.00
R6620:Vmn2r112	UTSW	17	22,603,101 (GRCm38)	missense	probably benign	0.00
R6648:Vmn2r112	UTSW	17	22,618,486 (GRCm38)	missense	probably damaging	1.00
R6649:Vmn2r112	UTSW	17	22,601,179 (GRCm38)	missense	probably null	1.00
R6653:Vmn2r112	UTSW	17	22,601,179 (GRCm38)	missense	probably null	1.00
R6654:Vmn2r112	UTSW	17	22,603,469 (GRCm38)	missense	possibly damaging	0.89
R6700:Vmn2r112	UTSW	17	22,603,481 (GRCm38)	missense	possibly damaging	0.53
R6993:Vmn2r112	UTSW	17	22,603,214 (GRCm38)	missense	probably benign	0.01
R7052:Vmn2r112	UTSW	17	22,602,526 (GRCm38)	missense	probably benign
R7454:Vmn2r112	UTSW	17	22,603,307 (GRCm38)	missense	probably benign	0.00
R7763:Vmn2r112	UTSW	17	22,603,118 (GRCm38)	missense	probably damaging	1.00
R8032:Vmn2r112	UTSW	17	22,603,394 (GRCm38)	missense	probably benign	0.21
R8177:Vmn2r112	UTSW	17	22,603,613 (GRCm38)	missense	possibly damaging	0.47
R8263:Vmn2r112	UTSW	17	22,605,159 (GRCm38)	missense	probably damaging	1.00
R8395:Vmn2r112	UTSW	17	22,618,606 (GRCm38)	missense	possibly damaging	0.94
R8492:Vmn2r112	UTSW	17	22,602,489 (GRCm38)	missense	probably benign	0.03
R8889:Vmn2r112	UTSW	17	22,618,631 (GRCm38)	missense	probably damaging	1.00
R8892:Vmn2r112	UTSW	17	22,618,631 (GRCm38)	missense	probably damaging	1.00
R9246:Vmn2r112	UTSW	17	22,605,107 (GRCm38)	missense	probably benign	0.21
R9273:Vmn2r112	UTSW	17	22,618,740 (GRCm38)	missense	probably damaging	1.00
R9288:Vmn2r112	UTSW	17	22,603,342 (GRCm38)	missense	probably damaging	1.00
R9352:Vmn2r112	UTSW	17	22,603,498 (GRCm38)	missense	probably damaging	0.98
R9406:Vmn2r112	UTSW	17	22,605,242 (GRCm38)	nonsense	probably null
R9432:Vmn2r112	UTSW	17	22,602,252 (GRCm38)	missense
R9728:Vmn2r112	UTSW	17	22,605,127 (GRCm38)	missense	probably damaging	0.96
Z1088:Vmn2r112	UTSW	17	22,605,078 (GRCm38)	missense	possibly damaging	0.89

Predicted Primers

PCR Primer
(F):5'- GGGACACAGTGTTAATAGTACATGG -3'
(R):5'- CCGTGCAAAAGCCTCATAGC -3'

Sequencing Primer
(F):5'- ATAGTACATGGGGCTATATTGGTACC -3'
(R):5'- AGCCTCATAGCTTTGCTGTTC -3'

Posted On

2022-03-25