Incidental Mutation 'R9271:Tiam2'
| ID |
702983 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tiam2
|
| Ensembl Gene |
ENSMUSG00000023800 |
| Gene Name |
T cell lymphoma invasion and metastasis 2 |
| Synonyms |
STEF, 3000002F19Rik |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R9271 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
3376675-3569672 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 3465011 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Histidine
at position 247
(Y247H)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000072020
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000072156]
[ENSMUST00000169838]
|
| AlphaFold |
Q6ZPF3 |
| PDB Structure |
Crystal structure of the Tiam2 PHCCEx domain [X-RAY DIFFRACTION]
Low-resolution crystal structure of the Tiam2 PHCCEx domain [X-RAY DIFFRACTION]
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000072156
AA Change: Y247H
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000072020
Gene: ENSMUSG00000023800
AA Change: Y247H
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
230 |
245 |
N/A |
INTRINSIC |
|
low complexity region
|
267 |
281 |
N/A |
INTRINSIC |
|
low complexity region
|
471 |
492 |
N/A |
INTRINSIC |
|
PH
|
505 |
620 |
7.82e-16 |
SMART |
|
RBD
|
831 |
902 |
1.32e-26 |
SMART |
|
PDZ
|
921 |
995 |
2.38e-7 |
SMART |
|
RhoGEF
|
1124 |
1313 |
2.23e-61 |
SMART |
|
PH
|
1347 |
1478 |
2.86e0 |
SMART |
|
low complexity region
|
1522 |
1532 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000169838
AA Change: Y247H
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000125842
Gene: ENSMUSG00000023800
AA Change: Y247H
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
230 |
245 |
N/A |
INTRINSIC |
|
low complexity region
|
267 |
281 |
N/A |
INTRINSIC |
|
low complexity region
|
471 |
492 |
N/A |
INTRINSIC |
|
PH
|
505 |
620 |
7.82e-16 |
SMART |
|
RBD
|
831 |
902 |
1.32e-26 |
SMART |
|
PDZ
|
921 |
995 |
2.38e-7 |
SMART |
|
RhoGEF
|
1124 |
1313 |
2.23e-61 |
SMART |
|
PH
|
1347 |
1478 |
2.86e0 |
SMART |
|
low complexity region
|
1522 |
1532 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
100% (107/107) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (GTPase) from a guanosine diphosphate-bound inactive state to a guanosine triphosphate-bound active state. The encoded protein may play a role in neural cell development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 111 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aatk |
A |
T |
11: 119,901,940 (GRCm39) |
S819T |
probably damaging |
Het |
| Abca13 |
A |
T |
11: 9,241,698 (GRCm39) |
D1187V |
probably damaging |
Het |
| Ak9 |
C |
A |
10: 41,300,623 (GRCm39) |
T1611K |
unknown |
Het |
| Als2 |
G |
T |
1: 59,242,189 (GRCm39) |
T622K |
probably benign |
Het |
| Ankrd40 |
G |
A |
11: 94,225,262 (GRCm39) |
A98T |
probably benign |
Het |
| Ap1b1 |
T |
C |
11: 4,973,174 (GRCm39) |
L339P |
probably damaging |
Het |
| Appl1 |
A |
C |
14: 26,669,084 (GRCm39) |
H363Q |
probably benign |
Het |
| Atf6 |
T |
C |
1: 170,622,245 (GRCm39) |
N459D |
probably damaging |
Het |
| Ccdc6 |
A |
T |
10: 70,024,993 (GRCm39) |
Q432L |
unknown |
Het |
| Ccl21a |
T |
A |
4: 42,773,486 (GRCm39) |
Q84L |
probably damaging |
Het |
| Cct4 |
A |
G |
11: 22,951,389 (GRCm39) |
I348V |
probably benign |
Het |
| Cd300ld2 |
A |
G |
11: 114,904,550 (GRCm39) |
Y106H |
probably damaging |
Het |
| Cdh19 |
C |
T |
1: 110,876,947 (GRCm39) |
E131K |
probably damaging |
Het |
| Cdon |
A |
G |
9: 35,403,175 (GRCm39) |
D1095G |
probably damaging |
Het |
| Cep85l |
T |
A |
10: 53,157,670 (GRCm39) |
R678* |
probably null |
Het |
| Chst3 |
T |
A |
10: 60,021,465 (GRCm39) |
S461C |
probably damaging |
Het |
| Clk1 |
A |
G |
1: 58,459,312 (GRCm39) |
I149T |
possibly damaging |
Het |
| Clvs2 |
T |
A |
10: 33,389,301 (GRCm39) |
D313V |
possibly damaging |
Het |
| Dap3 |
T |
C |
3: 88,840,913 (GRCm39) |
T75A |
probably benign |
Het |
| Dnaaf1 |
T |
A |
8: 120,324,392 (GRCm39) |
F631L |
probably benign |
Het |
| Dnah14 |
A |
T |
1: 181,597,325 (GRCm39) |
N3549I |
probably benign |
Het |
| Dnah17 |
A |
T |
11: 117,931,870 (GRCm39) |
Y3701N |
probably damaging |
Het |
| Dock6 |
A |
G |
9: 21,752,796 (GRCm39) |
V339A |
possibly damaging |
Het |
| Dpp6 |
T |
A |
5: 27,803,832 (GRCm39) |
C259* |
probably null |
Het |
| Dqx1 |
A |
G |
6: 83,036,024 (GRCm39) |
T119A |
probably benign |
Het |
| Dync1h1 |
G |
T |
12: 110,583,310 (GRCm39) |
R469L |
probably benign |
Het |
| Eno4 |
C |
T |
19: 58,951,260 (GRCm39) |
A424V |
probably benign |
Het |
| Entrep1 |
A |
T |
19: 23,972,221 (GRCm39) |
I161N |
possibly damaging |
Het |
| Fads1 |
T |
A |
19: 10,163,162 (GRCm39) |
D146E |
probably damaging |
Het |
| Fam171a1 |
C |
T |
2: 3,224,543 (GRCm39) |
T303M |
probably damaging |
Het |
| Fbxw20 |
C |
T |
9: 109,050,423 (GRCm39) |
D401N |
probably benign |
Het |
| Fcho1 |
T |
A |
8: 72,163,068 (GRCm39) |
T654S |
possibly damaging |
Het |
| Flad1 |
C |
A |
3: 89,315,858 (GRCm39) |
E235* |
probably null |
Het |
| Flrt2 |
G |
T |
12: 95,745,907 (GRCm39) |
A82S |
probably benign |
Het |
| Gabrg3 |
A |
T |
7: 56,829,386 (GRCm39) |
S124T |
probably benign |
Het |
| Galt |
C |
T |
4: 41,756,777 (GRCm39) |
T139I |
probably benign |
Het |
| Garin4 |
A |
G |
1: 190,895,153 (GRCm39) |
S497P |
probably damaging |
Het |
| Gfod1 |
T |
C |
13: 43,456,861 (GRCm39) |
E38G |
possibly damaging |
Het |
| Gm10330 |
A |
G |
12: 23,829,992 (GRCm39) |
I63T |
possibly damaging |
Het |
| Gm3033 |
A |
T |
14: 3,846,968 (GRCm38) |
N28I |
|
Het |
| Gm49359 |
A |
G |
13: 62,602,867 (GRCm39) |
V111A |
probably benign |
Het |
| Gpank1 |
C |
T |
17: 35,340,734 (GRCm39) |
|
probably benign |
Het |
| Hck |
T |
C |
2: 152,973,185 (GRCm39) |
L156P |
probably damaging |
Het |
| Hcn3 |
G |
T |
3: 89,057,267 (GRCm39) |
R444S |
probably damaging |
Het |
| Hephl1 |
T |
C |
9: 14,988,236 (GRCm39) |
N624S |
probably damaging |
Het |
| Hmcn1 |
A |
G |
1: 150,632,309 (GRCm39) |
I876T |
probably damaging |
Het |
| Itga9 |
T |
A |
9: 118,500,859 (GRCm39) |
D377E |
possibly damaging |
Het |
| Itpr3 |
G |
A |
17: 27,337,651 (GRCm39) |
|
probably benign |
Het |
| Itprid1 |
G |
T |
6: 55,944,051 (GRCm39) |
R417L |
probably benign |
Het |
| Kcnk1 |
T |
A |
8: 126,752,152 (GRCm39) |
|
probably null |
Het |
| Klk1b11 |
C |
T |
7: 43,425,954 (GRCm39) |
L32F |
probably benign |
Het |
| Lta4h |
A |
G |
10: 93,310,412 (GRCm39) |
S427G |
probably benign |
Het |
| Lxn |
T |
A |
3: 67,368,651 (GRCm39) |
I122F |
probably damaging |
Het |
| Lyz1 |
A |
G |
10: 117,124,492 (GRCm39) |
V148A |
possibly damaging |
Het |
| Mael |
G |
T |
1: 166,032,424 (GRCm39) |
Q326K |
probably benign |
Het |
| Magi3 |
T |
C |
3: 103,923,264 (GRCm39) |
D1151G |
possibly damaging |
Het |
| Map3k9 |
C |
A |
12: 81,769,261 (GRCm39) |
G929V |
probably benign |
Het |
| Mcoln1 |
A |
G |
8: 3,555,771 (GRCm39) |
Y22C |
probably damaging |
Het |
| Mier3 |
G |
T |
13: 111,827,870 (GRCm39) |
M45I |
probably benign |
Het |
| Mrpl1 |
T |
C |
5: 96,371,746 (GRCm39) |
V91A |
probably damaging |
Het |
| Msra |
T |
C |
14: 64,471,269 (GRCm39) |
|
probably null |
Het |
| Myo7a |
T |
C |
7: 97,740,281 (GRCm39) |
H571R |
probably benign |
Het |
| Myom1 |
T |
A |
17: 71,374,325 (GRCm39) |
W601R |
probably damaging |
Het |
| Myom3 |
C |
T |
4: 135,505,479 (GRCm39) |
T456I |
probably benign |
Het |
| Nags |
A |
T |
11: 102,037,584 (GRCm39) |
H225L |
probably benign |
Het |
| Ncaph |
C |
A |
2: 126,958,554 (GRCm39) |
K488N |
probably damaging |
Het |
| Nkain3 |
C |
T |
4: 20,484,897 (GRCm39) |
R60H |
probably damaging |
Het |
| Nlrp9a |
A |
T |
7: 26,261,944 (GRCm39) |
M698L |
probably benign |
Het |
| Nmur2 |
A |
C |
11: 55,931,308 (GRCm39) |
I134M |
probably benign |
Het |
| Nrp2 |
A |
C |
1: 62,784,670 (GRCm39) |
E273A |
probably benign |
Het |
| Nup85 |
A |
G |
11: 115,468,787 (GRCm39) |
D210G |
possibly damaging |
Het |
| Obscn |
A |
G |
11: 59,006,643 (GRCm39) |
F1173S |
probably damaging |
Het |
| Or5ac24 |
A |
T |
16: 59,165,145 (GRCm39) |
C306* |
probably null |
Het |
| Otogl |
T |
A |
10: 107,652,974 (GRCm39) |
E1126V |
probably null |
Het |
| Pfkl |
T |
C |
10: 77,833,426 (GRCm39) |
I259V |
probably benign |
Het |
| Phkg1 |
A |
T |
5: 129,893,863 (GRCm39) |
Y291N |
probably benign |
Het |
| Piezo2 |
T |
G |
18: 63,163,450 (GRCm39) |
H2156P |
probably damaging |
Het |
| Piezo2 |
C |
A |
18: 63,208,790 (GRCm39) |
V1408L |
probably damaging |
Het |
| Pira13 |
T |
A |
7: 3,819,997 (GRCm39) |
E640V |
unknown |
Het |
| Pkd2 |
A |
G |
5: 104,626,959 (GRCm39) |
|
probably null |
Het |
| Plekhg3 |
A |
G |
12: 76,622,694 (GRCm39) |
T646A |
probably benign |
Het |
| Plk5 |
C |
G |
10: 80,193,830 (GRCm39) |
R40G |
probably damaging |
Het |
| Ppp1r12a |
T |
C |
10: 108,098,224 (GRCm39) |
S838P |
probably damaging |
Het |
| Rarb |
A |
T |
14: 16,435,235 (GRCm38) |
Y270* |
probably null |
Het |
| Rbm15 |
T |
C |
3: 107,239,312 (GRCm39) |
E362G |
possibly damaging |
Het |
| Rcan1 |
A |
G |
16: 92,262,741 (GRCm39) |
F76L |
|
Het |
| Rdh19 |
T |
C |
10: 127,696,142 (GRCm39) |
L298P |
probably damaging |
Het |
| Rims1 |
T |
A |
1: 22,498,773 (GRCm39) |
H57L |
|
Het |
| Rlf |
T |
C |
4: 121,004,751 (GRCm39) |
T1520A |
probably benign |
Het |
| Rnase1 |
T |
A |
14: 51,382,964 (GRCm39) |
H130L |
possibly damaging |
Het |
| Samd8 |
T |
A |
14: 21,842,569 (GRCm39) |
M360K |
probably damaging |
Het |
| Samhd1 |
A |
G |
2: 156,956,205 (GRCm39) |
L329P |
probably damaging |
Het |
| Scube1 |
C |
T |
15: 83,494,394 (GRCm39) |
E878K |
probably damaging |
Het |
| Sema3b |
T |
C |
9: 107,476,154 (GRCm39) |
Y689C |
probably damaging |
Het |
| Semp2l2a |
T |
C |
8: 13,886,697 (GRCm39) |
T465A |
possibly damaging |
Het |
| Sgo1 |
T |
C |
17: 53,983,931 (GRCm39) |
|
probably benign |
Het |
| Sh3pxd2b |
A |
T |
11: 32,373,361 (GRCm39) |
N843Y |
possibly damaging |
Het |
| Slco1a6 |
C |
T |
6: 142,035,575 (GRCm39) |
C583Y |
probably damaging |
Het |
| Smg1 |
A |
C |
7: 117,811,786 (GRCm39) |
V88G |
unknown |
Het |
| Spata24 |
T |
A |
18: 35,790,054 (GRCm39) |
N146Y |
probably damaging |
Het |
| Tcf3 |
C |
A |
10: 80,253,191 (GRCm39) |
V258L |
probably benign |
Het |
| Thap1 |
CAGCATCTGCTCGGAGCA |
CAGCA |
8: 26,650,884 (GRCm39) |
|
probably null |
Het |
| Ticrr |
T |
C |
7: 79,310,604 (GRCm39) |
F173L |
possibly damaging |
Het |
| Tpp2 |
A |
G |
1: 43,993,811 (GRCm39) |
E232G |
probably damaging |
Het |
| Trank1 |
T |
A |
9: 111,174,547 (GRCm39) |
V138E |
probably damaging |
Het |
| Ttll3 |
T |
C |
6: 113,369,596 (GRCm39) |
S47P |
probably benign |
Het |
| Utp4 |
C |
T |
8: 107,632,857 (GRCm39) |
T280M |
probably damaging |
Het |
| Vmn1r123 |
A |
T |
7: 20,896,794 (GRCm39) |
N229Y |
probably benign |
Het |
| Vmn1r85 |
A |
T |
7: 12,818,942 (GRCm39) |
Y67* |
probably null |
Het |
| Zbtb12 |
T |
A |
17: 35,114,320 (GRCm39) |
V35E |
possibly damaging |
Het |
| Zmym6 |
T |
A |
4: 127,017,854 (GRCm39) |
F1212I |
probably damaging |
Het |
|
| Other mutations in Tiam2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01011:Tiam2
|
APN |
17 |
3,465,303 (GRCm39) |
missense |
probably benign |
0.21 |
|
IGL01320:Tiam2
|
APN |
17 |
3,556,020 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01384:Tiam2
|
APN |
17 |
3,477,477 (GRCm39) |
missense |
probably benign |
0.08 |
|
IGL01575:Tiam2
|
APN |
17 |
3,504,591 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01769:Tiam2
|
APN |
17 |
3,477,565 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02395:Tiam2
|
APN |
17 |
3,471,756 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
IGL02652:Tiam2
|
APN |
17 |
3,489,971 (GRCm39) |
splice site |
probably benign |
|
|
IGL03102:Tiam2
|
APN |
17 |
3,559,823 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03222:Tiam2
|
APN |
17 |
3,488,983 (GRCm39) |
missense |
probably damaging |
0.97 |
|
Feste_burg
|
UTSW |
17 |
3,464,897 (GRCm39) |
frame shift |
probably null |
|
|
R0257:Tiam2
|
UTSW |
17 |
3,501,088 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R0420:Tiam2
|
UTSW |
17 |
3,553,193 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0528:Tiam2
|
UTSW |
17 |
3,561,346 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0532:Tiam2
|
UTSW |
17 |
3,471,921 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0551:Tiam2
|
UTSW |
17 |
3,479,229 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0554:Tiam2
|
UTSW |
17 |
3,488,956 (GRCm39) |
nonsense |
probably null |
|
|
R0645:Tiam2
|
UTSW |
17 |
3,564,973 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R0726:Tiam2
|
UTSW |
17 |
3,563,108 (GRCm39) |
unclassified |
probably benign |
|
|
R1139:Tiam2
|
UTSW |
17 |
3,527,542 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R1392:Tiam2
|
UTSW |
17 |
3,464,472 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1392:Tiam2
|
UTSW |
17 |
3,464,472 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1529:Tiam2
|
UTSW |
17 |
3,566,978 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1671:Tiam2
|
UTSW |
17 |
3,557,109 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1731:Tiam2
|
UTSW |
17 |
3,568,698 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1759:Tiam2
|
UTSW |
17 |
3,566,278 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1850:Tiam2
|
UTSW |
17 |
3,487,510 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1853:Tiam2
|
UTSW |
17 |
3,465,410 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1855:Tiam2
|
UTSW |
17 |
3,465,410 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1931:Tiam2
|
UTSW |
17 |
3,565,000 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1932:Tiam2
|
UTSW |
17 |
3,565,000 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1993:Tiam2
|
UTSW |
17 |
3,465,401 (GRCm39) |
nonsense |
probably null |
|
|
R2211:Tiam2
|
UTSW |
17 |
3,465,193 (GRCm39) |
nonsense |
probably null |
|
|
R2217:Tiam2
|
UTSW |
17 |
3,465,389 (GRCm39) |
missense |
probably benign |
0.34 |
|
R2278:Tiam2
|
UTSW |
17 |
3,477,495 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2407:Tiam2
|
UTSW |
17 |
3,527,536 (GRCm39) |
missense |
probably benign |
0.14 |
|
R2516:Tiam2
|
UTSW |
17 |
3,503,657 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2991:Tiam2
|
UTSW |
17 |
3,568,525 (GRCm39) |
missense |
probably benign |
|
|
R3086:Tiam2
|
UTSW |
17 |
3,471,857 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3121:Tiam2
|
UTSW |
17 |
3,489,977 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3686:Tiam2
|
UTSW |
17 |
3,471,959 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R3740:Tiam2
|
UTSW |
17 |
3,464,388 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R3742:Tiam2
|
UTSW |
17 |
3,464,388 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R3826:Tiam2
|
UTSW |
17 |
3,557,976 (GRCm39) |
splice site |
probably benign |
|
|
R3829:Tiam2
|
UTSW |
17 |
3,557,976 (GRCm39) |
splice site |
probably benign |
|
|
R3844:Tiam2
|
UTSW |
17 |
3,471,926 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3970:Tiam2
|
UTSW |
17 |
3,479,106 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4060:Tiam2
|
UTSW |
17 |
3,479,255 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4296:Tiam2
|
UTSW |
17 |
3,501,120 (GRCm39) |
missense |
probably benign |
|
|
R4357:Tiam2
|
UTSW |
17 |
3,501,128 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4368:Tiam2
|
UTSW |
17 |
3,464,958 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4369:Tiam2
|
UTSW |
17 |
3,464,242 (GRCm39) |
start gained |
probably benign |
|
|
R4524:Tiam2
|
UTSW |
17 |
3,564,986 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4619:Tiam2
|
UTSW |
17 |
3,568,617 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4715:Tiam2
|
UTSW |
17 |
3,504,443 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4723:Tiam2
|
UTSW |
17 |
3,500,592 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4979:Tiam2
|
UTSW |
17 |
3,555,985 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5182:Tiam2
|
UTSW |
17 |
3,488,996 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5451:Tiam2
|
UTSW |
17 |
3,479,271 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5728:Tiam2
|
UTSW |
17 |
3,465,231 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5827:Tiam2
|
UTSW |
17 |
3,498,764 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5879:Tiam2
|
UTSW |
17 |
3,487,540 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5960:Tiam2
|
UTSW |
17 |
3,488,915 (GRCm39) |
missense |
probably benign |
0.24 |
|
R5974:Tiam2
|
UTSW |
17 |
3,465,084 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R6198:Tiam2
|
UTSW |
17 |
3,464,396 (GRCm39) |
missense |
probably benign |
0.06 |
|
R6222:Tiam2
|
UTSW |
17 |
3,503,613 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6295:Tiam2
|
UTSW |
17 |
3,559,831 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6355:Tiam2
|
UTSW |
17 |
3,464,897 (GRCm39) |
frame shift |
probably null |
|
|
R6356:Tiam2
|
UTSW |
17 |
3,464,897 (GRCm39) |
frame shift |
probably null |
|
|
R6454:Tiam2
|
UTSW |
17 |
3,488,938 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6497:Tiam2
|
UTSW |
17 |
3,557,102 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6579:Tiam2
|
UTSW |
17 |
3,464,897 (GRCm39) |
frame shift |
probably null |
|
|
R6580:Tiam2
|
UTSW |
17 |
3,464,897 (GRCm39) |
frame shift |
probably null |
|
|
R6581:Tiam2
|
UTSW |
17 |
3,464,897 (GRCm39) |
frame shift |
probably null |
|
|
R6582:Tiam2
|
UTSW |
17 |
3,464,897 (GRCm39) |
frame shift |
probably null |
|
|
R6648:Tiam2
|
UTSW |
17 |
3,557,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6705:Tiam2
|
UTSW |
17 |
3,568,518 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6758:Tiam2
|
UTSW |
17 |
3,568,678 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6836:Tiam2
|
UTSW |
17 |
3,464,655 (GRCm39) |
missense |
probably benign |
0.17 |
|
R6924:Tiam2
|
UTSW |
17 |
3,558,070 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6977:Tiam2
|
UTSW |
17 |
3,568,934 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7051:Tiam2
|
UTSW |
17 |
3,498,758 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7151:Tiam2
|
UTSW |
17 |
3,498,660 (GRCm39) |
missense |
probably benign |
0.36 |
|
R7214:Tiam2
|
UTSW |
17 |
3,568,687 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R7332:Tiam2
|
UTSW |
17 |
3,503,644 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7334:Tiam2
|
UTSW |
17 |
3,553,283 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7414:Tiam2
|
UTSW |
17 |
3,464,388 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R7660:Tiam2
|
UTSW |
17 |
3,532,880 (GRCm39) |
start codon destroyed |
probably null |
0.66 |
|
R7743:Tiam2
|
UTSW |
17 |
3,568,431 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R7755:Tiam2
|
UTSW |
17 |
3,471,591 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7805:Tiam2
|
UTSW |
17 |
3,559,685 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7813:Tiam2
|
UTSW |
17 |
3,487,522 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7842:Tiam2
|
UTSW |
17 |
3,568,399 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7989:Tiam2
|
UTSW |
17 |
3,568,524 (GRCm39) |
nonsense |
probably null |
|
|
R8011:Tiam2
|
UTSW |
17 |
3,498,671 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8221:Tiam2
|
UTSW |
17 |
3,568,860 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8260:Tiam2
|
UTSW |
17 |
3,568,594 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8292:Tiam2
|
UTSW |
17 |
3,557,142 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8406:Tiam2
|
UTSW |
17 |
3,558,065 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8424:Tiam2
|
UTSW |
17 |
3,566,317 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8424:Tiam2
|
UTSW |
17 |
3,566,316 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8430:Tiam2
|
UTSW |
17 |
3,568,537 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8530:Tiam2
|
UTSW |
17 |
3,501,087 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8692:Tiam2
|
UTSW |
17 |
3,479,082 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8902:Tiam2
|
UTSW |
17 |
3,527,471 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9067:Tiam2
|
UTSW |
17 |
3,561,407 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9080:Tiam2
|
UTSW |
17 |
3,464,519 (GRCm39) |
missense |
probably benign |
|
|
R9090:Tiam2
|
UTSW |
17 |
3,465,011 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9211:Tiam2
|
UTSW |
17 |
3,498,729 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9347:Tiam2
|
UTSW |
17 |
3,471,923 (GRCm39) |
missense |
probably benign |
0.37 |
|
R9353:Tiam2
|
UTSW |
17 |
3,558,074 (GRCm39) |
nonsense |
probably null |
|
|
R9407:Tiam2
|
UTSW |
17 |
3,553,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9460:Tiam2
|
UTSW |
17 |
3,487,585 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9550:Tiam2
|
UTSW |
17 |
3,559,706 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9748:Tiam2
|
UTSW |
17 |
3,561,440 (GRCm39) |
missense |
probably benign |
0.20 |
|
X0027:Tiam2
|
UTSW |
17 |
3,464,275 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
|
X0060:Tiam2
|
UTSW |
17 |
3,500,629 (GRCm39) |
splice site |
probably null |
|
|
X0065:Tiam2
|
UTSW |
17 |
3,555,983 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Tiam2
|
UTSW |
17 |
3,465,294 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1176:Tiam2
|
UTSW |
17 |
3,556,051 (GRCm39) |
missense |
probably null |
1.00 |
|
Z1177:Tiam2
|
UTSW |
17 |
3,477,538 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TAAGAGTCGAGTTCCACAACGG -3'
(R):5'- GGGATCTTTGTACAATTCCCGGAG -3'
Sequencing Primer
(F):5'- GGACCCCAGTGGACCTGTAC -3'
(R):5'- GGGAGGAGAGGGAAGAGCTTTG -3'
|
| Posted On |
2022-03-25 |
Incidental Mutation