Incidental Mutation 'R9272:Or9g4b'
ID 702999
Institutional Source Beutler Lab
Gene Symbol Or9g4b
Ensembl Gene ENSMUSG00000033850
Gene Name olfactory receptor family 9 subfamily G member 4B
Synonyms GA_x6K02T2Q125-47264151-47265089, Olfr1015, MOR213-3
MMRRC Submission
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.262) question?
Stock # R9272 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 85615818-85616833 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 85616088 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Leucine at position 78 (I78L)
Ref Sequence ENSEMBL: ENSMUSP00000148957 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000047870] [ENSMUST00000215945]
AlphaFold Q7TR94
Predicted Effect probably benign
Transcript: ENSMUST00000047870
AA Change: I78L

PolyPhen 2 Score 0.092 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000046301
Gene: ENSMUSG00000033850
AA Change: I78L

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 4.5e-49 PFAM
Pfam:7tm_1 41 290 4.2e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215945
AA Change: I78L

PolyPhen 2 Score 0.092 (Sensitivity: 0.93; Specificity: 0.85)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 100% (67/67)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700034J05Rik A G 6: 146,854,499 (GRCm39) V181A probably damaging Het
Abca16 T A 7: 120,076,993 (GRCm39) D686E probably benign Het
Abca8a C A 11: 109,953,908 (GRCm39) C844F probably damaging Het
Acd G A 8: 106,424,952 (GRCm39) P396L probably damaging Het
Adamtsl3 A G 7: 82,189,753 (GRCm39) Y659C probably damaging Het
Ankfn1 C T 11: 89,413,875 (GRCm39) V167M probably benign Het
Ankrd13c T A 3: 157,700,358 (GRCm39) L393Q possibly damaging Het
Arid1b G A 17: 5,386,879 (GRCm39) G1391D possibly damaging Het
Arid5b T A 10: 67,937,882 (GRCm39) D415V probably damaging Het
Arl13b G T 16: 62,647,774 (GRCm39) H45N probably benign Het
Atp13a4 A T 16: 29,268,797 (GRCm39) I519N Het
Atrnl1 T C 19: 57,643,420 (GRCm39) I436T probably benign Het
Bbx A G 16: 50,022,935 (GRCm39) I675T probably damaging Het
Bcas1 A T 2: 170,190,040 (GRCm39) V619E probably damaging Het
Cad T C 5: 31,218,576 (GRCm39) V501A possibly damaging Het
Car8 T A 4: 8,169,686 (GRCm39) N274I probably damaging Het
Ccdc3 A G 2: 5,146,143 (GRCm39) Q159R probably damaging Het
Ccdc7b A T 8: 129,893,459 (GRCm39) E95D possibly damaging Het
Cdh12 G T 15: 21,492,801 (GRCm39) probably benign Het
Col11a1 G T 3: 113,901,948 (GRCm39) G548* probably null Het
Cpb2 A G 14: 75,520,803 (GRCm39) E406G probably damaging Het
Crocc T C 4: 140,747,132 (GRCm39) S1723G probably benign Het
Ctu2 T C 8: 123,206,045 (GRCm39) V262A probably benign Het
Dmxl2 A T 9: 54,311,404 (GRCm39) N1772K possibly damaging Het
Dock3 A T 9: 106,774,569 (GRCm39) M62K probably benign Het
Dok7 G A 5: 35,214,239 (GRCm39) probably benign Het
E2f3 A G 13: 30,102,629 (GRCm39) Y211H probably damaging Het
Elapor2 T C 5: 9,460,699 (GRCm39) Y207H probably damaging Het
Fam53c T A 18: 34,895,774 (GRCm39) S25R probably damaging Het
Fhod3 T G 18: 25,030,681 (GRCm39) probably benign Het
Foxp4 A G 17: 48,180,033 (GRCm39) Y623H unknown Het
Ggt1 A T 10: 75,421,749 (GRCm39) H532L probably benign Het
Gm10775 A C 13: 65,407,770 (GRCm39) T24P unknown Het
Hinfp A G 9: 44,213,872 (GRCm39) S2P probably benign Het
Hs3st4 A G 7: 123,582,749 (GRCm39) T116A probably benign Het
Ighv5-9-1 A T 12: 113,699,818 (GRCm39) I98N probably damaging Het
Ipo11 A T 13: 107,046,713 (GRCm39) Y171N probably benign Het
Jph1 C A 1: 17,161,838 (GRCm39) A275S probably damaging Het
Kcnh6 C G 11: 105,924,860 (GRCm39) H941Q possibly damaging Het
Kcnh7 A T 2: 62,618,097 (GRCm39) I464K probably damaging Het
Lrp8 C A 4: 107,717,158 (GRCm39) P603T probably benign Het
Man1c1 C A 4: 134,291,118 (GRCm39) D593Y probably damaging Het
Mdm4 A T 1: 132,929,169 (GRCm39) I176K possibly damaging Het
Mpo T C 11: 87,686,693 (GRCm39) V139A probably benign Het
Niban3 A C 8: 72,055,520 (GRCm39) D310A probably damaging Het
Nicn1 C T 9: 108,171,708 (GRCm39) R163C possibly damaging Het
Nup98 C A 7: 101,788,037 (GRCm39) R1011L probably benign Het
Or1f12 A G 13: 21,721,864 (GRCm39) S89P possibly damaging Het
Or4k51 G A 2: 111,584,965 (GRCm39) V124M probably damaging Het
Pcdh7 A G 5: 57,878,779 (GRCm39) D778G possibly damaging Het
Pcdhb12 T C 18: 37,570,675 (GRCm39) F607S probably damaging Het
Pcolce A G 5: 137,606,333 (GRCm39) F157L probably benign Het
Pogk T C 1: 166,226,780 (GRCm39) Y457C probably damaging Het
Ppp1r21 G A 17: 88,866,086 (GRCm39) E323K possibly damaging Het
Prkn T A 17: 11,456,527 (GRCm39) V117E probably damaging Het
Prr12 A C 7: 44,692,811 (GRCm39) F1574V probably damaging Het
Rasl2-9 A T 7: 5,128,448 (GRCm39) F161I probably damaging Het
Rb1 A G 14: 73,517,602 (GRCm39) I268T possibly damaging Het
Rin3 A T 12: 102,335,691 (GRCm39) D534V probably damaging Het
Scn5a C T 9: 119,315,717 (GRCm39) G1664S probably damaging Het
Sin3b T C 8: 73,471,168 (GRCm39) S372P probably benign Het
Snx32 T A 19: 5,548,485 (GRCm39) H65L probably damaging Het
Spidr T A 16: 15,855,544 (GRCm39) I324F probably damaging Het
Stab1 A T 14: 30,867,298 (GRCm39) F1687L probably benign Het
Taar6 T C 10: 23,860,903 (GRCm39) I214M probably benign Het
Vmn2r105 T A 17: 20,447,685 (GRCm39) N380Y probably damaging Het
Other mutations in Or9g4b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00902:Or9g4b APN 2 85,616,461 (GRCm39) missense probably benign 0.21
IGL01716:Or9g4b APN 2 85,616,487 (GRCm39) missense probably damaging 0.97
IGL03196:Or9g4b APN 2 85,616,365 (GRCm39) missense possibly damaging 0.63
IGL03374:Or9g4b APN 2 85,616,053 (GRCm39) missense probably damaging 1.00
R0329:Or9g4b UTSW 2 85,616,147 (GRCm39) nonsense probably null
R0330:Or9g4b UTSW 2 85,616,147 (GRCm39) nonsense probably null
R0714:Or9g4b UTSW 2 85,616,743 (GRCm39) missense probably damaging 1.00
R0965:Or9g4b UTSW 2 85,616,643 (GRCm39) missense probably damaging 1.00
R1078:Or9g4b UTSW 2 85,616,437 (GRCm39) missense possibly damaging 0.53
R3826:Or9g4b UTSW 2 85,616,559 (GRCm39) nonsense probably null
R5031:Or9g4b UTSW 2 85,616,062 (GRCm39) nonsense probably null
R5239:Or9g4b UTSW 2 85,616,002 (GRCm39) missense probably damaging 1.00
R6120:Or9g4b UTSW 2 85,616,685 (GRCm39) missense probably damaging 1.00
R6177:Or9g4b UTSW 2 85,616,004 (GRCm39) missense probably damaging 0.99
R6726:Or9g4b UTSW 2 85,615,906 (GRCm39) missense possibly damaging 0.51
R6954:Or9g4b UTSW 2 85,616,726 (GRCm39) nonsense probably null
R7766:Or9g4b UTSW 2 85,616,002 (GRCm39) missense probably damaging 1.00
R8193:Or9g4b UTSW 2 85,616,305 (GRCm39) missense probably benign 0.34
R8245:Or9g4b UTSW 2 85,616,119 (GRCm39) missense probably benign 0.02
R8339:Or9g4b UTSW 2 85,615,876 (GRCm39) missense probably damaging 0.98
Z1176:Or9g4b UTSW 2 85,616,464 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CAATCGCACCATCCTGACTG -3'
(R):5'- GGACATGATGCTTGAATAGAGC -3'

Sequencing Primer
(F):5'- TCTCAGCAGACCCCCATTGG -3'
(R):5'- CAATGGGCTACAAATTGCAGC -3'
Posted On 2022-03-25