Incidental Mutation 'R9272:Lrp8'
| ID |
703005 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Lrp8
|
| Ensembl Gene |
ENSMUSG00000028613 |
| Gene Name |
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor |
| Synonyms |
4932703M08Rik, Lr8b, apoER2 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.477)
|
| Stock # |
R9272 (G1)
|
| Quality Score |
209.009 |
|
Status
|
Validated
|
| Chromosome |
4 |
| Chromosomal Location |
107659337-107734037 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to A
at 107717158 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Proline to Threonine
at position 603
(P603T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000102343
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000030356]
[ENSMUST00000106732]
[ENSMUST00000106733]
[ENSMUST00000126573]
[ENSMUST00000143601]
|
| AlphaFold |
Q924X6 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000030356
AA Change: P688T
PolyPhen 2
Score 0.178 (Sensitivity: 0.92; Specificity: 0.87)
|
| SMART Domains |
Protein: ENSMUSP00000030356
Gene: ENSMUSG00000028613
AA Change: P688T
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
27 |
N/A |
INTRINSIC |
|
LDLa
|
40 |
77 |
3.24e-13 |
SMART |
|
EGF_like
|
79 |
117 |
3.29e1 |
SMART |
|
LDLa
|
79 |
118 |
2.45e-13 |
SMART |
|
LDLa
|
120 |
159 |
1.19e-11 |
SMART |
|
LDLa
|
160 |
197 |
3.52e-14 |
SMART |
|
LDLa
|
199 |
239 |
8.09e-14 |
SMART |
|
LDLa
|
250 |
288 |
4.05e-14 |
SMART |
|
LDLa
|
290 |
327 |
4.58e-13 |
SMART |
|
EGF
|
331 |
367 |
2.83e-5 |
SMART |
|
EGF_CA
|
368 |
407 |
9.91e-10 |
SMART |
|
LY
|
434 |
476 |
8.44e-4 |
SMART |
|
LY
|
481 |
523 |
2.29e-14 |
SMART |
|
LY
|
524 |
567 |
5.96e-13 |
SMART |
|
LY
|
568 |
610 |
4.21e-13 |
SMART |
|
LY
|
612 |
654 |
7.24e-3 |
SMART |
|
EGF
|
681 |
727 |
1.56e1 |
SMART |
|
low complexity region
|
729 |
745 |
N/A |
INTRINSIC |
|
low complexity region
|
783 |
798 |
N/A |
INTRINSIC |
|
transmembrane domain
|
818 |
840 |
N/A |
INTRINSIC |
|
low complexity region
|
863 |
869 |
N/A |
INTRINSIC |
|
| Predicted Effect |
|
| SMART Domains |
Protein: ENSMUSP00000102342
Gene: ENSMUSG00000028613
AA Change: P490T
| Domain | Start | End | E-Value | Type |
|---|
|
EGF_like
|
9 |
47 |
3.29e1 |
SMART |
|
LDLa
|
9 |
48 |
2.45e-13 |
SMART |
|
LDLa
|
50 |
89 |
1.19e-11 |
SMART |
|
LDLa
|
93 |
130 |
4.58e-13 |
SMART |
|
EGF
|
134 |
170 |
2.83e-5 |
SMART |
|
EGF_CA
|
171 |
210 |
9.91e-10 |
SMART |
|
LY
|
237 |
279 |
8.44e-4 |
SMART |
|
LY
|
284 |
326 |
2.29e-14 |
SMART |
|
LY
|
327 |
370 |
5.96e-13 |
SMART |
|
LY
|
371 |
413 |
4.21e-13 |
SMART |
|
LY
|
415 |
457 |
7.24e-3 |
SMART |
|
EGF
|
484 |
530 |
1.56e1 |
SMART |
|
low complexity region
|
532 |
548 |
N/A |
INTRINSIC |
|
low complexity region
|
586 |
601 |
N/A |
INTRINSIC |
|
transmembrane domain
|
621 |
643 |
N/A |
INTRINSIC |
|
low complexity region
|
666 |
672 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000106732
AA Change: P603T
PolyPhen 2
Score 0.185 (Sensitivity: 0.92; Specificity: 0.87)
|
| SMART Domains |
Protein: ENSMUSP00000102343
Gene: ENSMUSG00000028613
AA Change: P603T
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
27 |
N/A |
INTRINSIC |
|
LDLa
|
40 |
77 |
3.24e-13 |
SMART |
|
EGF_like
|
79 |
117 |
3.29e1 |
SMART |
|
LDLa
|
79 |
118 |
2.45e-13 |
SMART |
|
LDLa
|
120 |
159 |
1.19e-11 |
SMART |
|
LDLa
|
164 |
201 |
4.58e-13 |
SMART |
|
LDLa
|
204 |
244 |
1.4e-8 |
SMART |
|
EGF
|
246 |
282 |
2.83e-5 |
SMART |
|
EGF_CA
|
283 |
322 |
9.91e-10 |
SMART |
|
LY
|
349 |
391 |
8.44e-4 |
SMART |
|
LY
|
396 |
438 |
2.29e-14 |
SMART |
|
LY
|
439 |
482 |
5.96e-13 |
SMART |
|
LY
|
483 |
525 |
4.21e-13 |
SMART |
|
LY
|
527 |
569 |
7.24e-3 |
SMART |
|
EGF
|
596 |
642 |
1.56e1 |
SMART |
|
low complexity region
|
644 |
660 |
N/A |
INTRINSIC |
|
low complexity region
|
698 |
713 |
N/A |
INTRINSIC |
|
transmembrane domain
|
733 |
755 |
N/A |
INTRINSIC |
|
low complexity region
|
778 |
784 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000106733
AA Change: P688T
PolyPhen 2
Score 0.135 (Sensitivity: 0.92; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000102344
Gene: ENSMUSG00000028613
AA Change: P688T
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
27 |
N/A |
INTRINSIC |
|
LDLa
|
40 |
77 |
3.24e-13 |
SMART |
|
EGF_like
|
79 |
117 |
3.29e1 |
SMART |
|
LDLa
|
79 |
118 |
2.45e-13 |
SMART |
|
LDLa
|
120 |
159 |
1.19e-11 |
SMART |
|
LDLa
|
160 |
197 |
3.52e-14 |
SMART |
|
LDLa
|
199 |
239 |
8.09e-14 |
SMART |
|
LDLa
|
250 |
288 |
4.05e-14 |
SMART |
|
LDLa
|
290 |
327 |
4.58e-13 |
SMART |
|
EGF
|
331 |
367 |
2.83e-5 |
SMART |
|
EGF_CA
|
368 |
407 |
9.91e-10 |
SMART |
|
LY
|
434 |
476 |
8.44e-4 |
SMART |
|
LY
|
481 |
523 |
2.29e-14 |
SMART |
|
LY
|
524 |
567 |
5.96e-13 |
SMART |
|
LY
|
568 |
610 |
4.21e-13 |
SMART |
|
LY
|
612 |
654 |
7.24e-3 |
SMART |
|
EGF
|
681 |
727 |
1.56e1 |
SMART |
|
low complexity region
|
729 |
745 |
N/A |
INTRINSIC |
|
low complexity region
|
783 |
798 |
N/A |
INTRINSIC |
|
transmembrane domain
|
818 |
840 |
N/A |
INTRINSIC |
|
low complexity region
|
863 |
869 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000126573
AA Change: P561T
PolyPhen 2
Score 0.190 (Sensitivity: 0.92; Specificity: 0.87)
|
| SMART Domains |
Protein: ENSMUSP00000118020
Gene: ENSMUSG00000028613
AA Change: P561T
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
27 |
N/A |
INTRINSIC |
|
LDLa
|
40 |
77 |
3.24e-13 |
SMART |
|
EGF_like
|
79 |
117 |
3.29e1 |
SMART |
|
LDLa
|
79 |
118 |
2.45e-13 |
SMART |
|
LDLa
|
120 |
159 |
1.19e-11 |
SMART |
|
LDLa
|
163 |
200 |
4.58e-13 |
SMART |
|
EGF
|
204 |
240 |
2.83e-5 |
SMART |
|
EGF_CA
|
241 |
280 |
9.91e-10 |
SMART |
|
LY
|
307 |
349 |
8.44e-4 |
SMART |
|
LY
|
354 |
396 |
2.29e-14 |
SMART |
|
LY
|
397 |
440 |
5.96e-13 |
SMART |
|
LY
|
441 |
483 |
4.21e-13 |
SMART |
|
LY
|
485 |
527 |
7.24e-3 |
SMART |
|
EGF
|
554 |
600 |
1.56e1 |
SMART |
|
transmembrane domain
|
616 |
638 |
N/A |
INTRINSIC |
|
low complexity region
|
661 |
667 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000143601
AA Change: P729T
PolyPhen 2
Score 0.178 (Sensitivity: 0.92; Specificity: 0.87)
|
| SMART Domains |
Protein: ENSMUSP00000115854
Gene: ENSMUSG00000028613
AA Change: P729T
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
27 |
N/A |
INTRINSIC |
|
LDLa
|
40 |
77 |
3.24e-13 |
SMART |
|
EGF_like
|
79 |
117 |
3.29e1 |
SMART |
|
LDLa
|
79 |
118 |
2.45e-13 |
SMART |
|
LDLa
|
120 |
159 |
1.19e-11 |
SMART |
|
LDLa
|
160 |
197 |
3.52e-14 |
SMART |
|
LDLa
|
199 |
239 |
8.09e-14 |
SMART |
|
LDLa
|
250 |
288 |
4.05e-14 |
SMART |
|
LDLa
|
290 |
327 |
4.58e-13 |
SMART |
|
LDLa
|
330 |
370 |
1.4e-8 |
SMART |
|
EGF
|
372 |
408 |
2.83e-5 |
SMART |
|
EGF_CA
|
409 |
448 |
9.91e-10 |
SMART |
|
LY
|
475 |
517 |
8.44e-4 |
SMART |
|
LY
|
522 |
564 |
2.29e-14 |
SMART |
|
LY
|
565 |
608 |
5.96e-13 |
SMART |
|
LY
|
609 |
651 |
4.21e-13 |
SMART |
|
LY
|
653 |
695 |
7.24e-3 |
SMART |
|
EGF
|
722 |
768 |
1.56e1 |
SMART |
|
low complexity region
|
770 |
786 |
N/A |
INTRINSIC |
|
low complexity region
|
824 |
839 |
N/A |
INTRINSIC |
|
transmembrane domain
|
859 |
881 |
N/A |
INTRINSIC |
|
low complexity region
|
904 |
910 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
100% (67/67) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the low density lipoprotein receptor (LDLR) family. Low density lipoprotein receptors are cell surface proteins that play roles in both signal transduction and receptor-mediated endocytosis of specific ligands for lysosomal degradation. The encoded protein plays a critical role in the migration of neurons during development by mediating Reelin signaling, and also functions as a receptor for the cholesterol transport protein apolipoprotein E. Expression of this gene may be a marker for major depressive disorder. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2011]
PHENOTYPE: Homozygotes for a targeted null mutation exhibit impaired granule cell migration, radial glial scaffold formation, contextual fear conditioning, and long-term potentiation. Mutant males have abnormal sperm and are sterile. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 66 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700034J05Rik |
A |
G |
6: 146,854,499 (GRCm39) |
V181A |
probably damaging |
Het |
| Abca16 |
T |
A |
7: 120,076,993 (GRCm39) |
D686E |
probably benign |
Het |
| Abca8a |
C |
A |
11: 109,953,908 (GRCm39) |
C844F |
probably damaging |
Het |
| Acd |
G |
A |
8: 106,424,952 (GRCm39) |
P396L |
probably damaging |
Het |
| Adamtsl3 |
A |
G |
7: 82,189,753 (GRCm39) |
Y659C |
probably damaging |
Het |
| Ankfn1 |
C |
T |
11: 89,413,875 (GRCm39) |
V167M |
probably benign |
Het |
| Ankrd13c |
T |
A |
3: 157,700,358 (GRCm39) |
L393Q |
possibly damaging |
Het |
| Arid1b |
G |
A |
17: 5,386,879 (GRCm39) |
G1391D |
possibly damaging |
Het |
| Arid5b |
T |
A |
10: 67,937,882 (GRCm39) |
D415V |
probably damaging |
Het |
| Arl13b |
G |
T |
16: 62,647,774 (GRCm39) |
H45N |
probably benign |
Het |
| Atp13a4 |
A |
T |
16: 29,268,797 (GRCm39) |
I519N |
|
Het |
| Atrnl1 |
T |
C |
19: 57,643,420 (GRCm39) |
I436T |
probably benign |
Het |
| Bbx |
A |
G |
16: 50,022,935 (GRCm39) |
I675T |
probably damaging |
Het |
| Bcas1 |
A |
T |
2: 170,190,040 (GRCm39) |
V619E |
probably damaging |
Het |
| Cad |
T |
C |
5: 31,218,576 (GRCm39) |
V501A |
possibly damaging |
Het |
| Car8 |
T |
A |
4: 8,169,686 (GRCm39) |
N274I |
probably damaging |
Het |
| Ccdc3 |
A |
G |
2: 5,146,143 (GRCm39) |
Q159R |
probably damaging |
Het |
| Ccdc7b |
A |
T |
8: 129,893,459 (GRCm39) |
E95D |
possibly damaging |
Het |
| Cdh12 |
G |
T |
15: 21,492,801 (GRCm39) |
|
probably benign |
Het |
| Col11a1 |
G |
T |
3: 113,901,948 (GRCm39) |
G548* |
probably null |
Het |
| Cpb2 |
A |
G |
14: 75,520,803 (GRCm39) |
E406G |
probably damaging |
Het |
| Crocc |
T |
C |
4: 140,747,132 (GRCm39) |
S1723G |
probably benign |
Het |
| Ctu2 |
T |
C |
8: 123,206,045 (GRCm39) |
V262A |
probably benign |
Het |
| Dmxl2 |
A |
T |
9: 54,311,404 (GRCm39) |
N1772K |
possibly damaging |
Het |
| Dock3 |
A |
T |
9: 106,774,569 (GRCm39) |
M62K |
probably benign |
Het |
| Dok7 |
G |
A |
5: 35,214,239 (GRCm39) |
|
probably benign |
Het |
| E2f3 |
A |
G |
13: 30,102,629 (GRCm39) |
Y211H |
probably damaging |
Het |
| Elapor2 |
T |
C |
5: 9,460,699 (GRCm39) |
Y207H |
probably damaging |
Het |
| Fam53c |
T |
A |
18: 34,895,774 (GRCm39) |
S25R |
probably damaging |
Het |
| Fhod3 |
T |
G |
18: 25,030,681 (GRCm39) |
|
probably benign |
Het |
| Foxp4 |
A |
G |
17: 48,180,033 (GRCm39) |
Y623H |
unknown |
Het |
| Ggt1 |
A |
T |
10: 75,421,749 (GRCm39) |
H532L |
probably benign |
Het |
| Gm10775 |
A |
C |
13: 65,407,770 (GRCm39) |
T24P |
unknown |
Het |
| Hinfp |
A |
G |
9: 44,213,872 (GRCm39) |
S2P |
probably benign |
Het |
| Hs3st4 |
A |
G |
7: 123,582,749 (GRCm39) |
T116A |
probably benign |
Het |
| Ighv5-9-1 |
A |
T |
12: 113,699,818 (GRCm39) |
I98N |
probably damaging |
Het |
| Ipo11 |
A |
T |
13: 107,046,713 (GRCm39) |
Y171N |
probably benign |
Het |
| Jph1 |
C |
A |
1: 17,161,838 (GRCm39) |
A275S |
probably damaging |
Het |
| Kcnh6 |
C |
G |
11: 105,924,860 (GRCm39) |
H941Q |
possibly damaging |
Het |
| Kcnh7 |
A |
T |
2: 62,618,097 (GRCm39) |
I464K |
probably damaging |
Het |
| Man1c1 |
C |
A |
4: 134,291,118 (GRCm39) |
D593Y |
probably damaging |
Het |
| Mdm4 |
A |
T |
1: 132,929,169 (GRCm39) |
I176K |
possibly damaging |
Het |
| Mpo |
T |
C |
11: 87,686,693 (GRCm39) |
V139A |
probably benign |
Het |
| Niban3 |
A |
C |
8: 72,055,520 (GRCm39) |
D310A |
probably damaging |
Het |
| Nicn1 |
C |
T |
9: 108,171,708 (GRCm39) |
R163C |
possibly damaging |
Het |
| Nup98 |
C |
A |
7: 101,788,037 (GRCm39) |
R1011L |
probably benign |
Het |
| Or1f12 |
A |
G |
13: 21,721,864 (GRCm39) |
S89P |
possibly damaging |
Het |
| Or4k51 |
G |
A |
2: 111,584,965 (GRCm39) |
V124M |
probably damaging |
Het |
| Or9g4b |
A |
T |
2: 85,616,088 (GRCm39) |
I78L |
probably benign |
Het |
| Pcdh7 |
A |
G |
5: 57,878,779 (GRCm39) |
D778G |
possibly damaging |
Het |
| Pcdhb12 |
T |
C |
18: 37,570,675 (GRCm39) |
F607S |
probably damaging |
Het |
| Pcolce |
A |
G |
5: 137,606,333 (GRCm39) |
F157L |
probably benign |
Het |
| Pogk |
T |
C |
1: 166,226,780 (GRCm39) |
Y457C |
probably damaging |
Het |
| Ppp1r21 |
G |
A |
17: 88,866,086 (GRCm39) |
E323K |
possibly damaging |
Het |
| Prkn |
T |
A |
17: 11,456,527 (GRCm39) |
V117E |
probably damaging |
Het |
| Prr12 |
A |
C |
7: 44,692,811 (GRCm39) |
F1574V |
probably damaging |
Het |
| Rasl2-9 |
A |
T |
7: 5,128,448 (GRCm39) |
F161I |
probably damaging |
Het |
| Rb1 |
A |
G |
14: 73,517,602 (GRCm39) |
I268T |
possibly damaging |
Het |
| Rin3 |
A |
T |
12: 102,335,691 (GRCm39) |
D534V |
probably damaging |
Het |
| Scn5a |
C |
T |
9: 119,315,717 (GRCm39) |
G1664S |
probably damaging |
Het |
| Sin3b |
T |
C |
8: 73,471,168 (GRCm39) |
S372P |
probably benign |
Het |
| Snx32 |
T |
A |
19: 5,548,485 (GRCm39) |
H65L |
probably damaging |
Het |
| Spidr |
T |
A |
16: 15,855,544 (GRCm39) |
I324F |
probably damaging |
Het |
| Stab1 |
A |
T |
14: 30,867,298 (GRCm39) |
F1687L |
probably benign |
Het |
| Taar6 |
T |
C |
10: 23,860,903 (GRCm39) |
I214M |
probably benign |
Het |
| Vmn2r105 |
T |
A |
17: 20,447,685 (GRCm39) |
N380Y |
probably damaging |
Het |
|
| Other mutations in Lrp8 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01308:Lrp8
|
APN |
4 |
107,721,273 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL01514:Lrp8
|
APN |
4 |
107,712,881 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02058:Lrp8
|
APN |
4 |
107,727,306 (GRCm39) |
missense |
probably benign |
0.25 |
|
IGL02398:Lrp8
|
APN |
4 |
107,726,245 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02398:Lrp8
|
APN |
4 |
107,704,691 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02706:Lrp8
|
APN |
4 |
107,660,516 (GRCm39) |
nonsense |
probably null |
|
|
IGL02754:Lrp8
|
APN |
4 |
107,691,952 (GRCm39) |
splice site |
probably null |
|
|
IGL02967:Lrp8
|
APN |
4 |
107,718,431 (GRCm39) |
missense |
probably benign |
0.21 |
|
IGL03080:Lrp8
|
APN |
4 |
107,712,996 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02837:Lrp8
|
UTSW |
4 |
107,718,478 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0312:Lrp8
|
UTSW |
4 |
107,664,052 (GRCm39) |
intron |
probably benign |
|
|
R0440:Lrp8
|
UTSW |
4 |
107,726,295 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0598:Lrp8
|
UTSW |
4 |
107,714,434 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R1627:Lrp8
|
UTSW |
4 |
107,711,613 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1967:Lrp8
|
UTSW |
4 |
107,717,168 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2183:Lrp8
|
UTSW |
4 |
107,660,462 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2208:Lrp8
|
UTSW |
4 |
107,712,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2325:Lrp8
|
UTSW |
4 |
107,721,206 (GRCm39) |
missense |
probably benign |
0.03 |
|
R3712:Lrp8
|
UTSW |
4 |
107,705,499 (GRCm39) |
missense |
probably benign |
0.08 |
|
R4093:Lrp8
|
UTSW |
4 |
107,700,468 (GRCm39) |
nonsense |
probably null |
|
|
R4706:Lrp8
|
UTSW |
4 |
107,718,470 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4765:Lrp8
|
UTSW |
4 |
107,711,592 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4840:Lrp8
|
UTSW |
4 |
107,727,234 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R4900:Lrp8
|
UTSW |
4 |
107,664,006 (GRCm39) |
intron |
probably benign |
|
|
R5033:Lrp8
|
UTSW |
4 |
107,691,952 (GRCm39) |
splice site |
probably null |
|
|
R5280:Lrp8
|
UTSW |
4 |
107,711,518 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5381:Lrp8
|
UTSW |
4 |
107,726,307 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5935:Lrp8
|
UTSW |
4 |
107,714,493 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5972:Lrp8
|
UTSW |
4 |
107,726,267 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6076:Lrp8
|
UTSW |
4 |
107,704,656 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R6343:Lrp8
|
UTSW |
4 |
107,726,353 (GRCm39) |
splice site |
probably null |
|
|
R6805:Lrp8
|
UTSW |
4 |
107,711,517 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7100:Lrp8
|
UTSW |
4 |
107,659,647 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7262:Lrp8
|
UTSW |
4 |
107,704,661 (GRCm39) |
missense |
probably benign |
|
|
R7717:Lrp8
|
UTSW |
4 |
107,691,940 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7949:Lrp8
|
UTSW |
4 |
107,660,524 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8350:Lrp8
|
UTSW |
4 |
107,704,661 (GRCm39) |
missense |
probably benign |
|
|
R8371:Lrp8
|
UTSW |
4 |
107,726,268 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9461:Lrp8
|
UTSW |
4 |
107,700,515 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R9567:Lrp8
|
UTSW |
4 |
107,711,469 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1177:Lrp8
|
UTSW |
4 |
107,700,529 (GRCm39) |
missense |
probably benign |
0.02 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGACCGTAATACCCACTTCTCAG -3'
(R):5'- TGGAGCATACTGTGTCCTGG -3'
Sequencing Primer
(F):5'- AAGTCCCAAGTACTATGCTGG -3'
(R):5'- CATACTGTGTCCTGGGAGGC -3'
|
| Posted On |
2022-03-25 |
Incidental Mutation