Incidental Mutation 'R9275:Trim34a'
ID 703223
Institutional Source Beutler Lab
Gene Symbol Trim34a
Ensembl Gene ENSMUSG00000056144
Gene Name tripartite motif-containing 34A
Synonyms Trim34-1, Trim34
Accession Numbers
Essential gene? Probably non essential (E-score: 0.093) question?
Stock # R9275 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 103893664-103911441 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 103910201 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 334 (N334K)
Ref Sequence ENSEMBL: ENSMUSP00000055058 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051795] [ENSMUST00000060315] [ENSMUST00000098179] [ENSMUST00000106848] [ENSMUST00000106849]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000051795
SMART Domains Protein: ENSMUSP00000050084
Gene: ENSMUSG00000060441

DomainStartEndE-ValueType
RING 15 58 3.64e-7 SMART
BBOX 91 132 4.83e-12 SMART
coiled coil region 172 232 N/A INTRINSIC
Pfam:SPRY 349 485 9.2e-22 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000060315
AA Change: N334K

PolyPhen 2 Score 0.958 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000055058
Gene: ENSMUSG00000056144
AA Change: N334K

DomainStartEndE-ValueType
RING 15 58 6.79e-7 SMART
BBOX 91 132 1.08e-9 SMART
coiled coil region 194 238 N/A INTRINSIC
Blast:PRY 299 343 2e-21 BLAST
Pfam:SPRY 347 474 1e-12 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000098179
SMART Domains Protein: ENSMUSP00000095781
Gene: ENSMUSG00000060441

DomainStartEndE-ValueType
RING 15 58 3.64e-7 SMART
BBOX 91 132 4.83e-12 SMART
Pfam:SPRY 351 493 1.6e-13 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000106848
AA Change: N334K

PolyPhen 2 Score 0.958 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000102461
Gene: ENSMUSG00000056144
AA Change: N334K

DomainStartEndE-ValueType
RING 15 58 6.79e-7 SMART
BBOX 91 132 1.08e-9 SMART
coiled coil region 194 238 N/A INTRINSIC
Blast:PRY 299 343 2e-21 BLAST
Pfam:SPRY 345 484 6.5e-21 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000106849
AA Change: N334K

PolyPhen 2 Score 0.958 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000102462
Gene: ENSMUSG00000056144
AA Change: N334K

DomainStartEndE-ValueType
RING 15 58 6.79e-7 SMART
BBOX 91 132 1.08e-9 SMART
coiled coil region 194 238 N/A INTRINSIC
Blast:PRY 299 343 2e-21 BLAST
Pfam:SPRY 345 484 6.5e-21 PFAM
Meta Mutation Damage Score 0.1963 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.6%
Validation Efficiency 100% (66/66)
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abr A G 11: 76,355,108 (GRCm39) Y249H probably damaging Het
Afdn T A 17: 14,024,270 (GRCm39) C59S probably damaging Het
Akap11 C A 14: 78,751,149 (GRCm39) V413F Het
Ank3 T C 10: 69,822,662 (GRCm39) S444P probably damaging Het
Ankrd12 C T 17: 66,344,599 (GRCm39) E91K possibly damaging Het
Arhgap10 A G 8: 78,137,665 (GRCm39) S309P probably damaging Het
Arpc2 C A 1: 74,276,041 (GRCm39) F19L probably benign Het
Atp5f1a C T 18: 77,868,997 (GRCm39) T457I probably damaging Het
Bsn C T 9: 107,988,819 (GRCm39) R2311H probably damaging Het
C1ra A G 6: 124,494,383 (GRCm39) T277A probably benign Het
Celsr3 C G 9: 108,715,689 (GRCm39) L2124V probably benign Het
Cenpv T C 11: 62,415,989 (GRCm39) *253W probably null Het
Cfap54 A T 10: 92,875,048 (GRCm39) V479E possibly damaging Het
Clec1a T C 6: 129,428,564 (GRCm39) probably benign Het
Cmpk2 A T 12: 26,519,568 (GRCm39) Y73F probably benign Het
Cpne2 T C 8: 95,281,643 (GRCm39) I226T possibly damaging Het
Cyp2c67 C T 19: 39,597,699 (GRCm39) R433Q probably damaging Het
Dagla A G 19: 10,232,220 (GRCm39) Y489H probably damaging Het
Dennd4a C A 9: 64,749,906 (GRCm39) P166T probably damaging Het
Dnm2 C T 9: 21,416,977 (GRCm39) R837W possibly damaging Het
Enpp2 C T 15: 54,713,484 (GRCm39) R658Q probably benign Het
Gm10521 G A 1: 171,724,030 (GRCm39) V114I unknown Het
H2-T24 T A 17: 36,328,276 (GRCm39) E69V probably damaging Het
H6pd T A 4: 150,080,307 (GRCm39) K179N probably damaging Het
Hsf2bp C T 17: 32,206,336 (GRCm39) W265* probably null Het
Igfn1 C A 1: 135,901,185 (GRCm39) R431L probably damaging Het
Kcng2 T C 18: 80,339,074 (GRCm39) S405G possibly damaging Het
Leng9 T C 7: 4,151,447 (GRCm39) T410A probably benign Het
Lrp1b T C 2: 40,487,076 (GRCm39) Y4557C Het
Ltbp2 G A 12: 84,837,864 (GRCm39) P1192L probably benign Het
Mlkl A G 8: 112,043,055 (GRCm39) V364A probably benign Het
Mns1 T A 9: 72,356,507 (GRCm39) F254Y probably benign Het
Naip1 T A 13: 100,562,684 (GRCm39) N827I probably damaging Het
Neb C T 2: 52,146,190 (GRCm39) R2929H probably damaging Het
Or5m13 A G 2: 85,749,046 (GRCm39) Y259C probably benign Het
Or5v1b T A 17: 37,841,819 (GRCm39) M317K probably benign Het
Pde10a A G 17: 9,200,488 (GRCm39) *797W probably null Het
Pirb T G 7: 3,719,859 (GRCm39) H429P probably benign Het
Plbd1 A G 6: 136,594,286 (GRCm39) L321P probably damaging Het
Pmfbp1 A G 8: 110,262,471 (GRCm39) I722V probably benign Het
Polr2b A G 5: 77,471,485 (GRCm39) R274G probably damaging Het
Prune2 C T 19: 17,101,144 (GRCm39) T2216I probably benign Het
Psma3 A T 12: 71,041,156 (GRCm39) D252V probably benign Het
Ptpn1 C T 2: 167,816,176 (GRCm39) T230I probably damaging Het
Rhpn1 T C 15: 75,585,120 (GRCm39) V519A possibly damaging Het
Rnf213 T C 11: 119,326,768 (GRCm39) V1586A Het
Rrp36 T A 17: 46,983,306 (GRCm39) K103* probably null Het
Ryr2 T C 13: 11,897,976 (GRCm39) T140A probably benign Het
Scn1a T A 2: 66,130,026 (GRCm39) Y243F probably damaging Het
Sdk1 A G 5: 141,941,953 (GRCm39) T534A possibly damaging Het
Slc27a5 T C 7: 12,731,640 (GRCm39) D117G probably damaging Het
Slc2a1 A T 4: 118,990,607 (GRCm39) E246D probably benign Het
Smpd2 T C 10: 41,363,685 (GRCm39) D289G probably benign Het
Spag6 A C 2: 18,703,985 (GRCm39) E11A probably benign Het
Stard3 G A 11: 98,262,931 (GRCm39) probably benign Het
Tcf19 A G 17: 35,825,899 (GRCm39) V86A probably damaging Het
Tcstv7a T C 13: 120,289,993 (GRCm39) S68G possibly damaging Het
Tigit A T 16: 43,479,833 (GRCm39) M154K probably benign Het
Tsen15 T C 1: 152,259,098 (GRCm39) I87V probably damaging Het
Ttn A T 2: 76,738,218 (GRCm39) M4153K unknown Het
Uchl3 A T 14: 101,905,963 (GRCm39) probably null Het
Usp1 A G 4: 98,819,578 (GRCm39) K347E probably damaging Het
Vmn1r73 T C 7: 11,490,479 (GRCm39) M99T probably benign Het
Vmn2r20 A G 6: 123,362,394 (GRCm39) W797R probably damaging Het
Vwa7 A G 17: 35,238,712 (GRCm39) T267A probably damaging Het
Zpld2 A G 4: 133,922,770 (GRCm39) L521P probably damaging Het
Other mutations in Trim34a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00503:Trim34a APN 7 103,910,538 (GRCm39) missense probably damaging 1.00
IGL00826:Trim34a APN 7 103,910,140 (GRCm39) splice site probably null
IGL01526:Trim34a APN 7 103,909,706 (GRCm39) missense probably damaging 1.00
IGL01859:Trim34a APN 7 103,910,149 (GRCm39) missense probably damaging 0.96
IGL02052:Trim34a APN 7 103,897,038 (GRCm39) missense probably benign 0.33
IGL02192:Trim34a APN 7 103,896,939 (GRCm39) start codon destroyed probably null 1.00
IGL02351:Trim34a APN 7 103,910,441 (GRCm39) nonsense probably null
IGL02358:Trim34a APN 7 103,910,441 (GRCm39) nonsense probably null
IGL03326:Trim34a APN 7 103,910,587 (GRCm39) missense probably benign 0.03
IGL03366:Trim34a APN 7 103,910,140 (GRCm39) splice site probably null
Gold_belt UTSW 7 103,910,271 (GRCm39) nonsense probably null
PIT4472001:Trim34a UTSW 7 103,897,155 (GRCm39) missense probably damaging 1.00
PIT4791001:Trim34a UTSW 7 103,909,691 (GRCm39) missense probably benign 0.15
R0115:Trim34a UTSW 7 103,897,109 (GRCm39) missense probably damaging 1.00
R0848:Trim34a UTSW 7 103,910,331 (GRCm39) missense probably benign
R1016:Trim34a UTSW 7 103,897,167 (GRCm39) missense probably benign 0.10
R1477:Trim34a UTSW 7 103,897,287 (GRCm39) missense possibly damaging 0.81
R1622:Trim34a UTSW 7 103,910,545 (GRCm39) splice site probably null
R2287:Trim34a UTSW 7 103,910,262 (GRCm39) missense probably damaging 1.00
R3685:Trim34a UTSW 7 103,909,333 (GRCm39) splice site probably null
R4166:Trim34a UTSW 7 103,910,223 (GRCm39) missense probably benign 0.02
R4967:Trim34a UTSW 7 103,910,271 (GRCm39) nonsense probably null
R4979:Trim34a UTSW 7 103,897,069 (GRCm39) missense probably benign 0.00
R5194:Trim34a UTSW 7 103,910,200 (GRCm39) missense possibly damaging 0.70
R5443:Trim34a UTSW 7 103,909,420 (GRCm39) missense possibly damaging 0.80
R5631:Trim34a UTSW 7 103,897,946 (GRCm39) missense probably damaging 1.00
R5902:Trim34a UTSW 7 103,910,328 (GRCm39) nonsense probably null
R6147:Trim34a UTSW 7 103,910,398 (GRCm39) missense probably damaging 0.99
R6644:Trim34a UTSW 7 103,910,244 (GRCm39) missense probably damaging 1.00
R7971:Trim34a UTSW 7 103,897,025 (GRCm39) missense probably damaging 0.98
R8060:Trim34a UTSW 7 103,910,183 (GRCm39) missense probably damaging 1.00
R8278:Trim34a UTSW 7 103,898,623 (GRCm39) missense probably damaging 0.99
R8356:Trim34a UTSW 7 103,910,178 (GRCm39) missense probably damaging 0.99
R9563:Trim34a UTSW 7 103,910,328 (GRCm39) nonsense probably null
X0023:Trim34a UTSW 7 103,908,622 (GRCm39) missense probably benign 0.43
Predicted Primers PCR Primer
(F):5'- CCAGTGTTGGCTTTTCACAG -3'
(R):5'- TTCGATCCATGCTGTAACCC -3'

Sequencing Primer
(F):5'- GGCTTTTCACAGTGTTTCACAAAC -3'
(R):5'- ATAACCCAGTAGCCATTCTGTG -3'
Posted On 2022-03-25