Incidental Mutation 'R9276:Vmn2r79'
| ID |
703296 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r79
|
| Ensembl Gene |
ENSMUSG00000090362 |
| Gene Name |
vomeronasal 2, receptor 79 |
| Synonyms |
EG621430 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.093)
|
| Stock # |
R9276 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
86645673-86687176 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 86687045 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Valine
at position 809
(I809V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000132478
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000164462]
|
| AlphaFold |
E9Q067 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000164462
AA Change: I809V
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000132478
Gene: ENSMUSG00000090362
AA Change: I809V
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
75 |
464 |
1.9e-31 |
PFAM |
|
Pfam:NCD3G
|
506 |
559 |
3.1e-21 |
PFAM |
|
Pfam:7tm_3
|
592 |
827 |
2.8e-53 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.7%
|
| Validation Efficiency |
99% (83/84) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 84 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 9630041A04Rik |
A |
T |
9: 101,819,887 (GRCm39) |
R102S |
probably benign |
Het |
| Abitram |
A |
T |
4: 56,806,141 (GRCm39) |
K184N |
probably benign |
Het |
| Acvr2b |
C |
T |
9: 119,231,616 (GRCm39) |
T2M |
probably benign |
Het |
| Adamtsl3 |
A |
G |
7: 82,206,710 (GRCm39) |
|
probably benign |
Het |
| Adcy7 |
A |
G |
8: 89,052,014 (GRCm39) |
Y894C |
probably damaging |
Het |
| Afdn |
T |
A |
17: 14,024,270 (GRCm39) |
C59S |
probably damaging |
Het |
| Amt |
C |
A |
9: 108,178,410 (GRCm39) |
T339K |
probably benign |
Het |
| Ankrd27 |
G |
T |
7: 35,319,995 (GRCm39) |
V639L |
probably benign |
Het |
| Anxa10 |
G |
T |
8: 62,549,753 (GRCm39) |
Q31K |
probably damaging |
Het |
| Ap1g2 |
T |
C |
14: 55,339,818 (GRCm39) |
T454A |
probably benign |
Het |
| Boll |
A |
T |
1: 55,399,812 (GRCm39) |
I43N |
possibly damaging |
Het |
| Cacna1c |
T |
C |
6: 118,601,394 (GRCm39) |
D1472G |
|
Het |
| Calcrl |
T |
C |
2: 84,205,643 (GRCm39) |
N16S |
probably benign |
Het |
| Ccdc191 |
C |
T |
16: 43,764,041 (GRCm39) |
Q501* |
probably null |
Het |
| Cchcr1 |
T |
C |
17: 35,841,105 (GRCm39) |
L658P |
probably damaging |
Het |
| Cfap46 |
A |
T |
7: 139,201,207 (GRCm39) |
C1919S |
unknown |
Het |
| Col6a3 |
G |
A |
1: 90,735,403 (GRCm39) |
L1356F |
possibly damaging |
Het |
| Dlc1 |
A |
G |
8: 37,046,558 (GRCm39) |
S680P |
possibly damaging |
Het |
| Dock4 |
T |
G |
12: 40,699,404 (GRCm39) |
M206R |
possibly damaging |
Het |
| Eml5 |
T |
C |
12: 98,765,060 (GRCm39) |
K1630E |
probably damaging |
Het |
| Fat1 |
A |
G |
8: 45,488,514 (GRCm39) |
T3432A |
probably damaging |
Het |
| Fcrl5 |
G |
T |
3: 87,343,138 (GRCm39) |
|
probably benign |
Het |
| Fcrla |
A |
G |
1: 170,755,135 (GRCm39) |
|
probably benign |
Het |
| Fut4 |
C |
A |
9: 14,662,572 (GRCm39) |
D241Y |
probably benign |
Het |
| Fzd6 |
A |
G |
15: 38,870,962 (GRCm39) |
|
probably benign |
Het |
| Gjc2 |
T |
C |
11: 59,068,453 (GRCm39) |
T10A |
probably damaging |
Het |
| Gle1 |
C |
T |
2: 29,829,514 (GRCm39) |
H203Y |
possibly damaging |
Het |
| Gm5565 |
A |
T |
5: 146,096,917 (GRCm39) |
I74N |
probably damaging |
Het |
| Gnl2 |
T |
A |
4: 124,947,250 (GRCm39) |
I624K |
possibly damaging |
Het |
| Gnpat |
C |
A |
8: 125,614,524 (GRCm39) |
N653K |
probably benign |
Het |
| Gstcd |
A |
G |
3: 132,777,665 (GRCm39) |
L382S |
probably damaging |
Het |
| Ipcef1 |
A |
G |
10: 6,857,936 (GRCm39) |
|
probably benign |
Het |
| Jmjd7 |
T |
C |
2: 119,860,895 (GRCm39) |
V115A |
possibly damaging |
Het |
| Ltbp2 |
G |
A |
12: 84,837,864 (GRCm39) |
P1192L |
probably benign |
Het |
| Ltbp2 |
T |
G |
12: 84,876,885 (GRCm39) |
D440A |
possibly damaging |
Het |
| Macf1 |
T |
G |
4: 123,328,501 (GRCm39) |
D4744A |
probably damaging |
Het |
| Mapk11 |
T |
C |
15: 89,029,372 (GRCm39) |
D230G |
probably damaging |
Het |
| Mfsd6 |
A |
C |
1: 52,747,514 (GRCm39) |
Y450* |
probably null |
Het |
| Mtmr9 |
A |
G |
14: 63,781,001 (GRCm39) |
C30R |
probably damaging |
Het |
| Ncf1 |
G |
A |
5: 134,250,693 (GRCm39) |
Q376* |
probably null |
Het |
| Ncor2 |
C |
A |
5: 125,113,150 (GRCm39) |
R296M |
|
Het |
| Or51ah3 |
A |
T |
7: 103,210,004 (GRCm39) |
T107S |
probably damaging |
Het |
| Or5d37 |
A |
G |
2: 87,923,806 (GRCm39) |
V158A |
probably benign |
Het |
| Or5k8 |
A |
G |
16: 58,644,734 (GRCm39) |
F113L |
probably benign |
Het |
| Or8b57 |
A |
T |
9: 40,003,632 (GRCm39) |
I210K |
possibly damaging |
Het |
| Or8b8 |
C |
A |
9: 37,809,415 (GRCm39) |
S238R |
probably benign |
Het |
| Or8k31-ps1 |
A |
T |
2: 86,356,392 (GRCm39) |
L43* |
probably null |
Het |
| Pate9 |
A |
T |
9: 36,445,727 (GRCm39) |
C75S |
probably damaging |
Het |
| Pcsk6 |
A |
T |
7: 65,559,950 (GRCm39) |
I92F |
probably damaging |
Het |
| Plec |
A |
G |
15: 76,060,445 (GRCm39) |
V3164A |
probably benign |
Het |
| Prss16 |
A |
G |
13: 22,190,175 (GRCm39) |
|
probably benign |
Het |
| Ptch2 |
T |
A |
4: 116,967,505 (GRCm39) |
H724Q |
probably damaging |
Het |
| Pzp |
A |
T |
6: 128,499,077 (GRCm39) |
F190Y |
probably damaging |
Het |
| Rab6a |
A |
G |
7: 100,275,809 (GRCm39) |
T41A |
probably benign |
Het |
| Rbm6 |
A |
G |
9: 107,660,926 (GRCm39) |
L879P |
probably damaging |
Het |
| Rem1 |
T |
A |
2: 152,469,969 (GRCm39) |
|
probably benign |
Het |
| Rnf17 |
T |
C |
14: 56,719,554 (GRCm39) |
S935P |
probably damaging |
Het |
| Ryr1 |
C |
A |
7: 28,802,254 (GRCm39) |
V789L |
probably damaging |
Het |
| Scgb2b3 |
A |
T |
7: 31,059,528 (GRCm39) |
M82K |
possibly damaging |
Het |
| Sgce |
T |
A |
6: 4,674,585 (GRCm39) |
L451F |
probably damaging |
Het |
| Slc25a17 |
A |
C |
15: 81,207,814 (GRCm39) |
V258G |
probably benign |
Het |
| Spidr |
G |
A |
16: 15,784,712 (GRCm39) |
T452I |
probably benign |
Het |
| Tas2r129 |
A |
G |
6: 132,928,576 (GRCm39) |
N171S |
probably benign |
Het |
| Tbc1d24 |
A |
T |
17: 24,405,114 (GRCm39) |
V10E |
probably damaging |
Het |
| Tdo2 |
T |
G |
3: 81,876,885 (GRCm39) |
M115L |
probably benign |
Het |
| Tdrd9 |
T |
C |
12: 111,980,935 (GRCm39) |
|
probably null |
Het |
| Tead1 |
T |
A |
7: 112,493,601 (GRCm39) |
I376N |
probably damaging |
Het |
| Tmem26 |
A |
G |
10: 68,614,488 (GRCm39) |
H301R |
possibly damaging |
Het |
| Tnxb |
A |
G |
17: 34,929,134 (GRCm39) |
T2726A |
possibly damaging |
Het |
| Trim43c |
T |
C |
9: 88,723,966 (GRCm39) |
M164T |
probably benign |
Het |
| Trpc1 |
G |
A |
9: 95,590,288 (GRCm39) |
S723L |
probably benign |
Het |
| Txndc15 |
A |
G |
13: 55,865,914 (GRCm39) |
D126G |
probably benign |
Het |
| Urb1 |
C |
T |
16: 90,569,463 (GRCm39) |
|
probably benign |
Het |
| Usp25 |
C |
T |
16: 76,910,721 (GRCm39) |
H926Y |
probably benign |
Het |
| Uvssa |
T |
A |
5: 33,572,180 (GRCm39) |
M700K |
possibly damaging |
Het |
| Vdac1 |
T |
A |
11: 52,274,789 (GRCm39) |
Y146N |
probably damaging |
Het |
| Vmn1r231 |
A |
T |
17: 21,110,560 (GRCm39) |
S118R |
probably benign |
Het |
| Vmn1r41 |
A |
G |
6: 89,724,080 (GRCm39) |
Y207C |
probably damaging |
Het |
| Vnn1 |
G |
A |
10: 23,776,794 (GRCm39) |
G382R |
probably damaging |
Het |
| Xcr1 |
A |
T |
9: 123,685,680 (GRCm39) |
H27Q |
probably benign |
Het |
| Yeats2 |
T |
A |
16: 19,975,786 (GRCm39) |
N94K |
probably benign |
Het |
| Zfp28 |
C |
T |
7: 6,397,440 (GRCm39) |
T625M |
probably damaging |
Het |
| Zfp521 |
T |
C |
18: 13,977,698 (GRCm39) |
Q905R |
probably benign |
Het |
| Zfp804b |
T |
C |
5: 6,821,398 (GRCm39) |
D555G |
probably damaging |
Het |
|
| Other mutations in Vmn2r79 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01401:Vmn2r79
|
APN |
7 |
86,686,481 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01675:Vmn2r79
|
APN |
7 |
86,645,856 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01760:Vmn2r79
|
APN |
7 |
86,651,366 (GRCm39) |
missense |
probably benign |
|
|
IGL01834:Vmn2r79
|
APN |
7 |
86,686,354 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01843:Vmn2r79
|
APN |
7 |
86,686,485 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01914:Vmn2r79
|
APN |
7 |
86,686,571 (GRCm39) |
missense |
probably benign |
0.14 |
|
IGL01980:Vmn2r79
|
APN |
7 |
86,686,290 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
IGL02438:Vmn2r79
|
APN |
7 |
86,651,744 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02740:Vmn2r79
|
APN |
7 |
86,653,366 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03052:Vmn2r79
|
UTSW |
7 |
86,652,799 (GRCm39) |
missense |
probably benign |
0.00 |
|
PIT4445001:Vmn2r79
|
UTSW |
7 |
86,651,408 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R0096:Vmn2r79
|
UTSW |
7 |
86,686,527 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0096:Vmn2r79
|
UTSW |
7 |
86,686,527 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0270:Vmn2r79
|
UTSW |
7 |
86,652,594 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0336:Vmn2r79
|
UTSW |
7 |
86,651,287 (GRCm39) |
missense |
probably benign |
0.15 |
|
R0418:Vmn2r79
|
UTSW |
7 |
86,651,611 (GRCm39) |
missense |
probably benign |
0.18 |
|
R1070:Vmn2r79
|
UTSW |
7 |
86,652,681 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1234:Vmn2r79
|
UTSW |
7 |
86,653,307 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1459:Vmn2r79
|
UTSW |
7 |
86,687,002 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1513:Vmn2r79
|
UTSW |
7 |
86,686,652 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1624:Vmn2r79
|
UTSW |
7 |
86,653,247 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R1633:Vmn2r79
|
UTSW |
7 |
86,687,042 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R1676:Vmn2r79
|
UTSW |
7 |
86,651,839 (GRCm39) |
missense |
probably benign |
|
|
R1781:Vmn2r79
|
UTSW |
7 |
86,651,555 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1794:Vmn2r79
|
UTSW |
7 |
86,650,621 (GRCm39) |
missense |
probably benign |
0.37 |
|
R1823:Vmn2r79
|
UTSW |
7 |
86,687,080 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2013:Vmn2r79
|
UTSW |
7 |
86,653,289 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R2018:Vmn2r79
|
UTSW |
7 |
86,651,634 (GRCm39) |
missense |
probably benign |
0.07 |
|
R2019:Vmn2r79
|
UTSW |
7 |
86,651,634 (GRCm39) |
missense |
probably benign |
0.07 |
|
R2177:Vmn2r79
|
UTSW |
7 |
86,645,839 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2984:Vmn2r79
|
UTSW |
7 |
86,651,099 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R3719:Vmn2r79
|
UTSW |
7 |
86,651,245 (GRCm39) |
missense |
probably benign |
0.05 |
|
R3798:Vmn2r79
|
UTSW |
7 |
86,651,402 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R3969:Vmn2r79
|
UTSW |
7 |
86,652,801 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4182:Vmn2r79
|
UTSW |
7 |
86,651,099 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4183:Vmn2r79
|
UTSW |
7 |
86,651,099 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4245:Vmn2r79
|
UTSW |
7 |
86,651,624 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R4301:Vmn2r79
|
UTSW |
7 |
86,651,099 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4391:Vmn2r79
|
UTSW |
7 |
86,651,099 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4393:Vmn2r79
|
UTSW |
7 |
86,651,099 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4394:Vmn2r79
|
UTSW |
7 |
86,651,099 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4396:Vmn2r79
|
UTSW |
7 |
86,651,099 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4397:Vmn2r79
|
UTSW |
7 |
86,651,099 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4592:Vmn2r79
|
UTSW |
7 |
86,653,319 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4697:Vmn2r79
|
UTSW |
7 |
86,687,168 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4897:Vmn2r79
|
UTSW |
7 |
86,650,675 (GRCm39) |
missense |
probably benign |
|
|
R5016:Vmn2r79
|
UTSW |
7 |
86,686,548 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5058:Vmn2r79
|
UTSW |
7 |
86,651,423 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5177:Vmn2r79
|
UTSW |
7 |
86,651,177 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6078:Vmn2r79
|
UTSW |
7 |
86,653,319 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R6079:Vmn2r79
|
UTSW |
7 |
86,653,319 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R6138:Vmn2r79
|
UTSW |
7 |
86,653,319 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R6257:Vmn2r79
|
UTSW |
7 |
86,651,778 (GRCm39) |
missense |
probably benign |
0.27 |
|
R6260:Vmn2r79
|
UTSW |
7 |
86,686,365 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6307:Vmn2r79
|
UTSW |
7 |
86,686,976 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6323:Vmn2r79
|
UTSW |
7 |
86,650,522 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6374:Vmn2r79
|
UTSW |
7 |
86,651,498 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6530:Vmn2r79
|
UTSW |
7 |
86,651,252 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R6546:Vmn2r79
|
UTSW |
7 |
86,652,741 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6682:Vmn2r79
|
UTSW |
7 |
86,653,370 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R6858:Vmn2r79
|
UTSW |
7 |
86,686,580 (GRCm39) |
missense |
probably benign |
|
|
R6965:Vmn2r79
|
UTSW |
7 |
86,651,100 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7130:Vmn2r79
|
UTSW |
7 |
86,651,474 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7156:Vmn2r79
|
UTSW |
7 |
86,686,851 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7604:Vmn2r79
|
UTSW |
7 |
86,652,592 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7691:Vmn2r79
|
UTSW |
7 |
86,687,111 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8055:Vmn2r79
|
UTSW |
7 |
86,686,541 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8070:Vmn2r79
|
UTSW |
7 |
86,651,336 (GRCm39) |
missense |
probably benign |
|
|
R8073:Vmn2r79
|
UTSW |
7 |
86,651,462 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8145:Vmn2r79
|
UTSW |
7 |
86,686,862 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8263:Vmn2r79
|
UTSW |
7 |
86,686,726 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R8350:Vmn2r79
|
UTSW |
7 |
86,686,741 (GRCm39) |
nonsense |
probably null |
|
|
R8400:Vmn2r79
|
UTSW |
7 |
86,651,308 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8814:Vmn2r79
|
UTSW |
7 |
86,651,714 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8862:Vmn2r79
|
UTSW |
7 |
86,645,712 (GRCm39) |
missense |
probably benign |
0.23 |
|
R9146:Vmn2r79
|
UTSW |
7 |
86,650,681 (GRCm39) |
nonsense |
probably null |
|
|
R9361:Vmn2r79
|
UTSW |
7 |
86,652,822 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9676:Vmn2r79
|
UTSW |
7 |
86,686,452 (GRCm39) |
missense |
probably damaging |
1.00 |
|
U15987:Vmn2r79
|
UTSW |
7 |
86,653,319 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
X0054:Vmn2r79
|
UTSW |
7 |
86,653,270 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1088:Vmn2r79
|
UTSW |
7 |
86,651,549 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Vmn2r79
|
UTSW |
7 |
86,686,377 (GRCm39) |
missense |
probably benign |
|
|
Z1176:Vmn2r79
|
UTSW |
7 |
86,651,526 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CTTGCAAGTTTCACTGTGGC -3'
(R):5'- CCAGGAGGTTATCTACATTTTCAATGG -3'
Sequencing Primer
(F):5'- CAAGTTTCACTGTGGCTTTCCTGG -3'
(R):5'- CATGCATTTTCCTAAACTCATG -3'
|
| Posted On |
2022-03-25 |
Incidental Mutation