Incidental Mutation 'R9276:Dlc1'
| ID |
703301 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dlc1
|
| Ensembl Gene |
ENSMUSG00000031523 |
| Gene Name |
deleted in liver cancer 1 |
| Synonyms |
p122-RhoGAP, Arhgap7, A730069N07Rik, STARD12 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R9276 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
8 |
| Chromosomal Location |
37034905-37420297 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 37046558 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Proline
at position 680
(S680P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000033923
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000033923]
[ENSMUST00000098826]
[ENSMUST00000163663]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000033923
AA Change: S680P
PolyPhen 2
Score 0.832 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000033923
Gene: ENSMUSG00000031523
AA Change: S680P
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:SAM_2
|
15 |
76 |
2.2e-7 |
PFAM |
|
low complexity region
|
154 |
174 |
N/A |
INTRINSIC |
|
low complexity region
|
238 |
250 |
N/A |
INTRINSIC |
|
low complexity region
|
298 |
325 |
N/A |
INTRINSIC |
|
low complexity region
|
427 |
441 |
N/A |
INTRINSIC |
|
RhoGAP
|
653 |
845 |
8.82e-59 |
SMART |
|
START
|
887 |
1088 |
3.93e-59 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000098826
AA Change: S714P
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000096425
Gene: ENSMUSG00000031523
AA Change: S714P
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:SAM_2
|
49 |
110 |
5.9e-8 |
PFAM |
|
low complexity region
|
188 |
208 |
N/A |
INTRINSIC |
|
low complexity region
|
272 |
284 |
N/A |
INTRINSIC |
|
low complexity region
|
332 |
359 |
N/A |
INTRINSIC |
|
low complexity region
|
461 |
475 |
N/A |
INTRINSIC |
|
RhoGAP
|
687 |
879 |
8.82e-59 |
SMART |
|
START
|
921 |
1122 |
3.93e-59 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000163663
AA Change: S1131P
PolyPhen 2
Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000132812
Gene: ENSMUSG00000031523
AA Change: S1131P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
353 |
369 |
N/A |
INTRINSIC |
|
low complexity region
|
388 |
403 |
N/A |
INTRINSIC |
|
Pfam:SAM_2
|
466 |
527 |
1.2e-7 |
PFAM |
|
low complexity region
|
605 |
625 |
N/A |
INTRINSIC |
|
low complexity region
|
689 |
701 |
N/A |
INTRINSIC |
|
low complexity region
|
749 |
776 |
N/A |
INTRINSIC |
|
low complexity region
|
878 |
892 |
N/A |
INTRINSIC |
|
RhoGAP
|
1104 |
1296 |
8.82e-59 |
SMART |
|
START
|
1338 |
1539 |
3.93e-59 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.7%
|
| Validation Efficiency |
99% (83/84) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.[provided by RefSeq, Apr 2010]
PHENOTYPE: Homozygous mutants die by E10.5 with variable defects in the neural tube, heart, brain and placenta. Mouse embryonic fibroblasts homozygous for an activated conditional allele exhibti increased sensitivity to Ras-induced transformation. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 84 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 9630041A04Rik |
A |
T |
9: 101,819,887 (GRCm39) |
R102S |
probably benign |
Het |
| Abitram |
A |
T |
4: 56,806,141 (GRCm39) |
K184N |
probably benign |
Het |
| Acvr2b |
C |
T |
9: 119,231,616 (GRCm39) |
T2M |
probably benign |
Het |
| Adamtsl3 |
A |
G |
7: 82,206,710 (GRCm39) |
|
probably benign |
Het |
| Adcy7 |
A |
G |
8: 89,052,014 (GRCm39) |
Y894C |
probably damaging |
Het |
| Afdn |
T |
A |
17: 14,024,270 (GRCm39) |
C59S |
probably damaging |
Het |
| Amt |
C |
A |
9: 108,178,410 (GRCm39) |
T339K |
probably benign |
Het |
| Ankrd27 |
G |
T |
7: 35,319,995 (GRCm39) |
V639L |
probably benign |
Het |
| Anxa10 |
G |
T |
8: 62,549,753 (GRCm39) |
Q31K |
probably damaging |
Het |
| Ap1g2 |
T |
C |
14: 55,339,818 (GRCm39) |
T454A |
probably benign |
Het |
| Boll |
A |
T |
1: 55,399,812 (GRCm39) |
I43N |
possibly damaging |
Het |
| Cacna1c |
T |
C |
6: 118,601,394 (GRCm39) |
D1472G |
|
Het |
| Calcrl |
T |
C |
2: 84,205,643 (GRCm39) |
N16S |
probably benign |
Het |
| Ccdc191 |
C |
T |
16: 43,764,041 (GRCm39) |
Q501* |
probably null |
Het |
| Cchcr1 |
T |
C |
17: 35,841,105 (GRCm39) |
L658P |
probably damaging |
Het |
| Cfap46 |
A |
T |
7: 139,201,207 (GRCm39) |
C1919S |
unknown |
Het |
| Col6a3 |
G |
A |
1: 90,735,403 (GRCm39) |
L1356F |
possibly damaging |
Het |
| Dock4 |
T |
G |
12: 40,699,404 (GRCm39) |
M206R |
possibly damaging |
Het |
| Eml5 |
T |
C |
12: 98,765,060 (GRCm39) |
K1630E |
probably damaging |
Het |
| Fat1 |
A |
G |
8: 45,488,514 (GRCm39) |
T3432A |
probably damaging |
Het |
| Fcrl5 |
G |
T |
3: 87,343,138 (GRCm39) |
|
probably benign |
Het |
| Fcrla |
A |
G |
1: 170,755,135 (GRCm39) |
|
probably benign |
Het |
| Fut4 |
C |
A |
9: 14,662,572 (GRCm39) |
D241Y |
probably benign |
Het |
| Fzd6 |
A |
G |
15: 38,870,962 (GRCm39) |
|
probably benign |
Het |
| Gjc2 |
T |
C |
11: 59,068,453 (GRCm39) |
T10A |
probably damaging |
Het |
| Gle1 |
C |
T |
2: 29,829,514 (GRCm39) |
H203Y |
possibly damaging |
Het |
| Gm5565 |
A |
T |
5: 146,096,917 (GRCm39) |
I74N |
probably damaging |
Het |
| Gnl2 |
T |
A |
4: 124,947,250 (GRCm39) |
I624K |
possibly damaging |
Het |
| Gnpat |
C |
A |
8: 125,614,524 (GRCm39) |
N653K |
probably benign |
Het |
| Gstcd |
A |
G |
3: 132,777,665 (GRCm39) |
L382S |
probably damaging |
Het |
| Ipcef1 |
A |
G |
10: 6,857,936 (GRCm39) |
|
probably benign |
Het |
| Jmjd7 |
T |
C |
2: 119,860,895 (GRCm39) |
V115A |
possibly damaging |
Het |
| Ltbp2 |
G |
A |
12: 84,837,864 (GRCm39) |
P1192L |
probably benign |
Het |
| Ltbp2 |
T |
G |
12: 84,876,885 (GRCm39) |
D440A |
possibly damaging |
Het |
| Macf1 |
T |
G |
4: 123,328,501 (GRCm39) |
D4744A |
probably damaging |
Het |
| Mapk11 |
T |
C |
15: 89,029,372 (GRCm39) |
D230G |
probably damaging |
Het |
| Mfsd6 |
A |
C |
1: 52,747,514 (GRCm39) |
Y450* |
probably null |
Het |
| Mtmr9 |
A |
G |
14: 63,781,001 (GRCm39) |
C30R |
probably damaging |
Het |
| Ncf1 |
G |
A |
5: 134,250,693 (GRCm39) |
Q376* |
probably null |
Het |
| Ncor2 |
C |
A |
5: 125,113,150 (GRCm39) |
R296M |
|
Het |
| Or51ah3 |
A |
T |
7: 103,210,004 (GRCm39) |
T107S |
probably damaging |
Het |
| Or5d37 |
A |
G |
2: 87,923,806 (GRCm39) |
V158A |
probably benign |
Het |
| Or5k8 |
A |
G |
16: 58,644,734 (GRCm39) |
F113L |
probably benign |
Het |
| Or8b57 |
A |
T |
9: 40,003,632 (GRCm39) |
I210K |
possibly damaging |
Het |
| Or8b8 |
C |
A |
9: 37,809,415 (GRCm39) |
S238R |
probably benign |
Het |
| Or8k31-ps1 |
A |
T |
2: 86,356,392 (GRCm39) |
L43* |
probably null |
Het |
| Pate9 |
A |
T |
9: 36,445,727 (GRCm39) |
C75S |
probably damaging |
Het |
| Pcsk6 |
A |
T |
7: 65,559,950 (GRCm39) |
I92F |
probably damaging |
Het |
| Plec |
A |
G |
15: 76,060,445 (GRCm39) |
V3164A |
probably benign |
Het |
| Prss16 |
A |
G |
13: 22,190,175 (GRCm39) |
|
probably benign |
Het |
| Ptch2 |
T |
A |
4: 116,967,505 (GRCm39) |
H724Q |
probably damaging |
Het |
| Pzp |
A |
T |
6: 128,499,077 (GRCm39) |
F190Y |
probably damaging |
Het |
| Rab6a |
A |
G |
7: 100,275,809 (GRCm39) |
T41A |
probably benign |
Het |
| Rbm6 |
A |
G |
9: 107,660,926 (GRCm39) |
L879P |
probably damaging |
Het |
| Rem1 |
T |
A |
2: 152,469,969 (GRCm39) |
|
probably benign |
Het |
| Rnf17 |
T |
C |
14: 56,719,554 (GRCm39) |
S935P |
probably damaging |
Het |
| Ryr1 |
C |
A |
7: 28,802,254 (GRCm39) |
V789L |
probably damaging |
Het |
| Scgb2b3 |
A |
T |
7: 31,059,528 (GRCm39) |
M82K |
possibly damaging |
Het |
| Sgce |
T |
A |
6: 4,674,585 (GRCm39) |
L451F |
probably damaging |
Het |
| Slc25a17 |
A |
C |
15: 81,207,814 (GRCm39) |
V258G |
probably benign |
Het |
| Spidr |
G |
A |
16: 15,784,712 (GRCm39) |
T452I |
probably benign |
Het |
| Tas2r129 |
A |
G |
6: 132,928,576 (GRCm39) |
N171S |
probably benign |
Het |
| Tbc1d24 |
A |
T |
17: 24,405,114 (GRCm39) |
V10E |
probably damaging |
Het |
| Tdo2 |
T |
G |
3: 81,876,885 (GRCm39) |
M115L |
probably benign |
Het |
| Tdrd9 |
T |
C |
12: 111,980,935 (GRCm39) |
|
probably null |
Het |
| Tead1 |
T |
A |
7: 112,493,601 (GRCm39) |
I376N |
probably damaging |
Het |
| Tmem26 |
A |
G |
10: 68,614,488 (GRCm39) |
H301R |
possibly damaging |
Het |
| Tnxb |
A |
G |
17: 34,929,134 (GRCm39) |
T2726A |
possibly damaging |
Het |
| Trim43c |
T |
C |
9: 88,723,966 (GRCm39) |
M164T |
probably benign |
Het |
| Trpc1 |
G |
A |
9: 95,590,288 (GRCm39) |
S723L |
probably benign |
Het |
| Txndc15 |
A |
G |
13: 55,865,914 (GRCm39) |
D126G |
probably benign |
Het |
| Urb1 |
C |
T |
16: 90,569,463 (GRCm39) |
|
probably benign |
Het |
| Usp25 |
C |
T |
16: 76,910,721 (GRCm39) |
H926Y |
probably benign |
Het |
| Uvssa |
T |
A |
5: 33,572,180 (GRCm39) |
M700K |
possibly damaging |
Het |
| Vdac1 |
T |
A |
11: 52,274,789 (GRCm39) |
Y146N |
probably damaging |
Het |
| Vmn1r231 |
A |
T |
17: 21,110,560 (GRCm39) |
S118R |
probably benign |
Het |
| Vmn1r41 |
A |
G |
6: 89,724,080 (GRCm39) |
Y207C |
probably damaging |
Het |
| Vmn2r79 |
A |
G |
7: 86,687,045 (GRCm39) |
I809V |
probably damaging |
Het |
| Vnn1 |
G |
A |
10: 23,776,794 (GRCm39) |
G382R |
probably damaging |
Het |
| Xcr1 |
A |
T |
9: 123,685,680 (GRCm39) |
H27Q |
probably benign |
Het |
| Yeats2 |
T |
A |
16: 19,975,786 (GRCm39) |
N94K |
probably benign |
Het |
| Zfp28 |
C |
T |
7: 6,397,440 (GRCm39) |
T625M |
probably damaging |
Het |
| Zfp521 |
T |
C |
18: 13,977,698 (GRCm39) |
Q905R |
probably benign |
Het |
| Zfp804b |
T |
C |
5: 6,821,398 (GRCm39) |
D555G |
probably damaging |
Het |
|
| Other mutations in Dlc1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00493:Dlc1
|
APN |
8 |
37,037,436 (GRCm39) |
utr 3 prime |
probably benign |
|
|
IGL00807:Dlc1
|
APN |
8 |
37,040,002 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL00924:Dlc1
|
APN |
8 |
37,405,368 (GRCm39) |
missense |
probably benign |
|
|
IGL01349:Dlc1
|
APN |
8 |
37,050,978 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01419:Dlc1
|
APN |
8 |
37,317,371 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01871:Dlc1
|
APN |
8 |
37,317,334 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01937:Dlc1
|
APN |
8 |
37,317,345 (GRCm39) |
missense |
probably benign |
0.25 |
|
IGL02525:Dlc1
|
APN |
8 |
37,046,800 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02696:Dlc1
|
APN |
8 |
37,041,326 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
IGL02826:Dlc1
|
APN |
8 |
37,037,429 (GRCm39) |
utr 3 prime |
probably benign |
|
|
IGL03029:Dlc1
|
APN |
8 |
37,038,416 (GRCm39) |
splice site |
probably null |
|
|
BB001:Dlc1
|
UTSW |
8 |
37,038,570 (GRCm39) |
missense |
probably benign |
0.03 |
|
BB011:Dlc1
|
UTSW |
8 |
37,038,570 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02835:Dlc1
|
UTSW |
8 |
37,051,055 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0068:Dlc1
|
UTSW |
8 |
37,404,875 (GRCm39) |
missense |
probably benign |
|
|
R0068:Dlc1
|
UTSW |
8 |
37,404,875 (GRCm39) |
missense |
probably benign |
|
|
R0164:Dlc1
|
UTSW |
8 |
37,066,594 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0164:Dlc1
|
UTSW |
8 |
37,066,594 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0218:Dlc1
|
UTSW |
8 |
37,317,383 (GRCm39) |
missense |
probably benign |
|
|
R0419:Dlc1
|
UTSW |
8 |
37,050,740 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R0513:Dlc1
|
UTSW |
8 |
37,051,164 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0645:Dlc1
|
UTSW |
8 |
37,041,203 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R0646:Dlc1
|
UTSW |
8 |
37,325,205 (GRCm39) |
missense |
probably benign |
|
|
R0727:Dlc1
|
UTSW |
8 |
37,039,828 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0792:Dlc1
|
UTSW |
8 |
37,405,702 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1061:Dlc1
|
UTSW |
8 |
37,325,205 (GRCm39) |
missense |
probably benign |
|
|
R1221:Dlc1
|
UTSW |
8 |
37,051,985 (GRCm39) |
missense |
probably benign |
|
|
R1440:Dlc1
|
UTSW |
8 |
37,060,617 (GRCm39) |
splice site |
probably benign |
|
|
R1501:Dlc1
|
UTSW |
8 |
37,405,302 (GRCm39) |
missense |
probably benign |
0.06 |
|
R1606:Dlc1
|
UTSW |
8 |
37,317,406 (GRCm39) |
missense |
probably benign |
|
|
R1707:Dlc1
|
UTSW |
8 |
37,404,763 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1750:Dlc1
|
UTSW |
8 |
37,325,244 (GRCm39) |
splice site |
probably null |
|
|
R1762:Dlc1
|
UTSW |
8 |
37,404,739 (GRCm39) |
missense |
probably benign |
0.25 |
|
R2041:Dlc1
|
UTSW |
8 |
37,049,922 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2055:Dlc1
|
UTSW |
8 |
37,060,535 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2091:Dlc1
|
UTSW |
8 |
37,404,763 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2987:Dlc1
|
UTSW |
8 |
37,041,306 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4285:Dlc1
|
UTSW |
8 |
37,041,282 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R4294:Dlc1
|
UTSW |
8 |
37,051,907 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R4631:Dlc1
|
UTSW |
8 |
37,404,712 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4828:Dlc1
|
UTSW |
8 |
37,317,400 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R4867:Dlc1
|
UTSW |
8 |
37,051,799 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4902:Dlc1
|
UTSW |
8 |
37,044,285 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5067:Dlc1
|
UTSW |
8 |
37,051,647 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5068:Dlc1
|
UTSW |
8 |
37,405,184 (GRCm39) |
missense |
probably benign |
|
|
R5198:Dlc1
|
UTSW |
8 |
37,405,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5471:Dlc1
|
UTSW |
8 |
37,051,879 (GRCm39) |
missense |
probably benign |
0.26 |
|
R5668:Dlc1
|
UTSW |
8 |
37,404,655 (GRCm39) |
unclassified |
probably benign |
|
|
R5915:Dlc1
|
UTSW |
8 |
37,405,829 (GRCm39) |
utr 5 prime |
probably benign |
|
|
R6323:Dlc1
|
UTSW |
8 |
37,405,537 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R6655:Dlc1
|
UTSW |
8 |
37,039,870 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6908:Dlc1
|
UTSW |
8 |
37,404,841 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6914:Dlc1
|
UTSW |
8 |
37,405,364 (GRCm39) |
missense |
probably benign |
|
|
R6942:Dlc1
|
UTSW |
8 |
37,405,364 (GRCm39) |
missense |
probably benign |
|
|
R7269:Dlc1
|
UTSW |
8 |
37,046,407 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7271:Dlc1
|
UTSW |
8 |
37,049,954 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7462:Dlc1
|
UTSW |
8 |
37,405,118 (GRCm39) |
missense |
unknown |
|
|
R7548:Dlc1
|
UTSW |
8 |
37,051,809 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7649:Dlc1
|
UTSW |
8 |
37,049,894 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7924:Dlc1
|
UTSW |
8 |
37,038,570 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7960:Dlc1
|
UTSW |
8 |
37,404,989 (GRCm39) |
missense |
probably benign |
|
|
R7984:Dlc1
|
UTSW |
8 |
37,405,472 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8227:Dlc1
|
UTSW |
8 |
37,039,825 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8491:Dlc1
|
UTSW |
8 |
37,052,000 (GRCm39) |
missense |
probably benign |
|
|
R8526:Dlc1
|
UTSW |
8 |
37,404,968 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8715:Dlc1
|
UTSW |
8 |
37,405,795 (GRCm39) |
start gained |
probably benign |
|
|
R8887:Dlc1
|
UTSW |
8 |
37,051,481 (GRCm39) |
missense |
probably benign |
0.34 |
|
R8972:Dlc1
|
UTSW |
8 |
37,405,394 (GRCm39) |
nonsense |
probably null |
|
|
R8988:Dlc1
|
UTSW |
8 |
37,039,997 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9031:Dlc1
|
UTSW |
8 |
37,405,055 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9080:Dlc1
|
UTSW |
8 |
37,052,006 (GRCm39) |
missense |
probably benign |
|
|
R9092:Dlc1
|
UTSW |
8 |
37,199,860 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9096:Dlc1
|
UTSW |
8 |
37,080,721 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9097:Dlc1
|
UTSW |
8 |
37,080,721 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9166:Dlc1
|
UTSW |
8 |
37,066,589 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9187:Dlc1
|
UTSW |
8 |
37,405,786 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
|
R9240:Dlc1
|
UTSW |
8 |
37,052,005 (GRCm39) |
missense |
probably benign |
|
|
R9325:Dlc1
|
UTSW |
8 |
37,038,518 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
Z1176:Dlc1
|
UTSW |
8 |
37,051,365 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GATCTGCAGGAAGGTTTCGG -3'
(R):5'- ACTGACTGTGAACGTGCAGC -3'
Sequencing Primer
(F):5'- CAGGAAGGTTTCGGAGAGTTTGTTC -3'
(R):5'- TGAACGTGCAGCGCTCAG -3'
|
| Posted On |
2022-03-25 |
Incidental Mutation