Mutagenetix > Incidental Mutation

Incidental Mutation 'R0751:Or1e26'

70344

Institutional Source

Beutler Lab

Gene Symbol

Or1e26

Ensembl Gene

ENSMUSG00000095095

Gene Name

olfactory receptor family 1 subfamily E member 26

Synonyms

Olfr385, GA_x6K02T2P1NL-3760313-3759375, MOR135-3

MMRRC Submission

038931-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.150) question?

Stock #

R0751 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

73479624-73480562 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 73479970 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Lysine at position 198 (T198K)

Ref Sequence

ENSEMBL: ENSMUSP00000149293 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000071553] [ENSMUST00000215689]

AlphaFold

Q8VGT1

Predicted Effect

probably benign
Transcript: ENSMUST00000071553
AA Change: T198K

PolyPhen 2 Score 0.019 (Sensitivity: 0.95; Specificity: 0.80)

SMART Domains

Protein: ENSMUSP00000071484
Gene: ENSMUSG00000095095
AA Change: T198K

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	6.1e-55	PFAM
Pfam:7TM_GPCR_Srsx	35	305	1.7e-6	PFAM
Pfam:7tm_1	41	290	2.2e-23	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000215689
AA Change: T198K

PolyPhen 2 Score 0.019 (Sensitivity: 0.95; Specificity: 0.80)

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.3%
3x: 98.7%
10x: 97.2%
20x: 94.4%

Validation Efficiency

99% (73/74)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 75 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ahdc1	T	A	4: 132,792,707 (GRCm39)	M1316K	probably benign	Het
Alox12	T	C	11: 70,137,776 (GRCm39)	I455V	probably benign	Het
Ankrd28	A	G	14: 31,486,225 (GRCm39)	L89P	probably damaging	Het
Aqp9	A	T	9: 71,045,487 (GRCm39)	C41S	probably damaging	Het
Arhgap17	T	C	7: 122,913,913 (GRCm39)	Y199C	probably damaging	Het
Aspm	A	T	1: 139,384,636 (GRCm39)		probably benign	Het
Cacfd1	T	C	2: 26,908,993 (GRCm39)		probably null	Het
Cd33	T	C	7: 43,181,545 (GRCm39)	D205G	probably damaging	Het
Chadl	T	C	15: 81,577,258 (GRCm39)	S198G	probably benign	Het
Chtf8	A	G	8: 107,613,109 (GRCm39)		probably null	Het
Clec4a4	G	T	6: 122,989,671 (GRCm39)	W104L	probably benign	Het
Clock	A	T	5: 76,377,208 (GRCm39)	I696K	possibly damaging	Het
Crtc2	T	A	3: 90,169,940 (GRCm39)	Y445*	probably null	Het
Dapk1	A	T	13: 60,844,112 (GRCm39)	I44F	probably damaging	Het
Dcbld2	T	A	16: 58,270,204 (GRCm39)		probably null	Het
Derl2	T	C	11: 70,905,373 (GRCm39)		probably null	Het
Dnah7c	A	G	1: 46,505,065 (GRCm39)	T154A	probably benign	Het
Dnmt3b	T	A	2: 153,516,762 (GRCm39)		probably null	Het
Dusp3	A	T	11: 101,872,554 (GRCm39)	S106T	probably benign	Het
Eftud2	A	G	11: 102,730,079 (GRCm39)	V897A	probably damaging	Het
Eif3l	T	A	15: 78,959,966 (GRCm39)		probably null	Het
Fbxo33	A	C	12: 59,265,878 (GRCm39)	F130V	probably damaging	Het
Ffar3	T	A	7: 30,554,529 (GRCm39)	N264Y	probably damaging	Het
Fig4	T	C	10: 41,148,978 (GRCm39)	D158G	probably damaging	Het
Fyco1	A	G	9: 123,648,218 (GRCm39)	F1239L	probably damaging	Het
Gabra2	A	G	5: 71,249,442 (GRCm39)		probably benign	Het
Gabra6	C	A	11: 42,205,844 (GRCm39)	R336S	probably benign	Het
Hkdc1	T	C	10: 62,234,452 (GRCm39)	D581G	probably damaging	Het
Ift70a2	C	T	2: 75,808,375 (GRCm39)	A46T	probably damaging	Het
Iqgap1	A	G	7: 80,375,321 (GRCm39)		probably benign	Het
Larp4b	T	C	13: 9,216,345 (GRCm39)		probably benign	Het
Lcp1	A	T	14: 75,436,827 (GRCm39)	M58L	probably benign	Het
Lrrc8a	T	C	2: 30,146,362 (GRCm39)	V392A	possibly damaging	Het
Mavs	A	T	2: 131,088,684 (GRCm39)	Y496F	probably damaging	Het
Mpi	A	T	9: 57,457,897 (GRCm39)	S102T	probably damaging	Het
Mroh9	G	A	1: 162,893,693 (GRCm39)	R161W	possibly damaging	Het
Myo1h	A	T	5: 114,458,747 (GRCm39)	S161C	probably damaging	Het
Napg	T	G	18: 63,127,409 (GRCm39)	H204Q	probably benign	Het
Nelfcd	C	A	2: 174,264,807 (GRCm39)	A182D	probably benign	Het
Ntsr2	G	T	12: 16,704,031 (GRCm39)	K91N	probably damaging	Het
Obscn	A	G	11: 58,972,645 (GRCm39)	S2134P	probably damaging	Het
Ogfod2	G	A	5: 124,251,539 (GRCm39)		probably benign	Het
Or13a19	G	A	7: 139,903,238 (GRCm39)	V209I	probably benign	Het
Pcdha8	T	C	18: 37,127,123 (GRCm39)	V535A	probably damaging	Het
Pdlim2	C	T	14: 70,402,228 (GRCm39)	R296H	probably damaging	Het
Pik3r1	T	C	13: 101,822,866 (GRCm39)		probably null	Het
Pimreg	C	A	11: 71,933,939 (GRCm39)	Q22K	probably benign	Het
Pld5	A	G	1: 175,872,462 (GRCm39)	I225T	probably damaging	Het
Plxnc1	T	C	10: 94,667,195 (GRCm39)		probably benign	Het
Ppip5k2	A	T	1: 97,677,377 (GRCm39)	C306*	probably null	Het
Ptprc	A	G	1: 138,020,668 (GRCm39)	Y588H	probably damaging	Het
Rac2	T	G	15: 78,450,145 (GRCm39)	D65A	possibly damaging	Het
Rgl3	A	G	9: 21,888,676 (GRCm39)		probably null	Het
Serpinb1a	T	C	13: 33,027,199 (GRCm39)	K248E	probably benign	Het
Serpinb9e	A	C	13: 33,443,757 (GRCm39)	E259A	probably benign	Het
Slc12a4	A	T	8: 106,678,532 (GRCm39)	V266E	probably damaging	Het
Slc8b1	A	G	5: 120,662,260 (GRCm39)		probably benign	Het
Spink6	T	C	18: 44,204,605 (GRCm39)		probably benign	Het
Spta1	G	A	1: 174,012,256 (GRCm39)	R354H	probably damaging	Het
Ssb	T	A	2: 69,700,909 (GRCm39)	S330T	probably benign	Het
Stard9	G	T	2: 120,527,966 (GRCm39)	V1408F	probably benign	Het
Sumf2	A	T	5: 129,878,846 (GRCm39)	T61S	probably benign	Het
Sypl2	T	C	3: 108,124,072 (GRCm39)	T157A	probably damaging	Het
Tgfbr3	A	T	5: 107,287,749 (GRCm39)	D483E	probably damaging	Het
Tnrc6a	A	G	7: 122,769,563 (GRCm39)	N451S	possibly damaging	Het
Tradd	T	C	8: 105,986,403 (GRCm39)	E123G	probably damaging	Het
Trim36	T	C	18: 46,329,318 (GRCm39)	T41A	probably damaging	Het
Ttll7	C	T	3: 146,645,746 (GRCm39)	P535S	probably damaging	Het
Ubr4	C	T	4: 139,164,509 (GRCm39)		probably benign	Het
Uqcc5	G	T	14: 30,810,953 (GRCm39)		probably benign	Het
Vmn1r195	A	G	13: 22,463,181 (GRCm39)	Y217C	probably damaging	Het
Vmn2r63	A	C	7: 42,577,459 (GRCm39)	F360V	probably damaging	Het
Vmn2r78	G	A	7: 86,603,588 (GRCm39)	V589M	possibly damaging	Het
Vmn2r-ps158	A	G	7: 42,696,833 (GRCm39)	Y630C	probably damaging	Het
Vrk2	A	G	11: 26,433,331 (GRCm39)		probably benign	Het

Other mutations in Or1e26

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01570:Or1e26	APN	11	73,480,209 (GRCm39)	missense	probably benign	0.34
IGL02045:Or1e26	APN	11	73,480,058 (GRCm39)	missense	probably damaging	1.00
IGL02324:Or1e26	APN	11	73,480,081 (GRCm39)	missense	probably benign	0.02
IGL02328:Or1e26	APN	11	73,480,081 (GRCm39)	missense	probably benign	0.02
IGL02562:Or1e26	APN	11	73,480,237 (GRCm39)	missense	probably benign
IGL02715:Or1e26	APN	11	73,479,947 (GRCm39)	missense	probably benign	0.00
IGL03182:Or1e26	APN	11	73,480,268 (GRCm39)	missense	probably benign	0.04
IGL03048:Or1e26	UTSW	11	73,479,831 (GRCm39)	missense	possibly damaging	0.56
R0346:Or1e26	UTSW	11	73,480,283 (GRCm39)	missense	probably damaging	1.00
R0675:Or1e26	UTSW	11	73,480,078 (GRCm39)	missense	probably damaging	1.00
R1220:Or1e26	UTSW	11	73,480,203 (GRCm39)	nonsense	probably null
R1389:Or1e26	UTSW	11	73,480,369 (GRCm39)	missense	possibly damaging	0.88
R1484:Or1e26	UTSW	11	73,480,187 (GRCm39)	missense	possibly damaging	0.91
R1619:Or1e26	UTSW	11	73,480,118 (GRCm39)	missense	probably damaging	1.00
R2290:Or1e26	UTSW	11	73,479,745 (GRCm39)	missense	probably benign	0.37
R3713:Or1e26	UTSW	11	73,479,731 (GRCm39)	missense	probably damaging	1.00
R3781:Or1e26	UTSW	11	73,480,194 (GRCm39)	nonsense	probably null
R3781:Or1e26	UTSW	11	73,479,839 (GRCm39)	missense	probably damaging	1.00
R3782:Or1e26	UTSW	11	73,480,194 (GRCm39)	nonsense	probably null
R3782:Or1e26	UTSW	11	73,479,839 (GRCm39)	missense	probably damaging	1.00
R4402:Or1e26	UTSW	11	73,480,081 (GRCm39)	missense	probably benign	0.02
R4721:Or1e26	UTSW	11	73,480,273 (GRCm39)	missense	probably damaging	1.00
R5157:Or1e26	UTSW	11	73,480,549 (GRCm39)	missense	probably damaging	1.00
R5995:Or1e26	UTSW	11	73,480,076 (GRCm39)	missense	probably benign
R6373:Or1e26	UTSW	11	73,479,724 (GRCm39)	missense	probably benign	0.42
R6658:Or1e26	UTSW	11	73,479,874 (GRCm39)	missense	probably damaging	0.99
R7046:Or1e26	UTSW	11	73,480,558 (GRCm39)	missense	probably benign
R7096:Or1e26	UTSW	11	73,480,463 (GRCm39)	missense	probably benign	0.03
R7238:Or1e26	UTSW	11	73,480,561 (GRCm39)	start codon destroyed	probably null	0.99
R7537:Or1e26	UTSW	11	73,480,094 (GRCm39)	missense	probably benign	0.04
R7548:Or1e26	UTSW	11	73,479,802 (GRCm39)	missense	possibly damaging	0.56
R7888:Or1e26	UTSW	11	73,480,354 (GRCm39)	missense	probably damaging	0.99
R7968:Or1e26	UTSW	11	73,480,154 (GRCm39)	missense	probably benign	0.05
R8923:Or1e26	UTSW	11	73,480,076 (GRCm39)	missense	probably benign
R9006:Or1e26	UTSW	11	73,480,036 (GRCm39)	missense	probably benign	0.40
R9281:Or1e26	UTSW	11	73,480,133 (GRCm39)	missense	probably benign
R9689:Or1e26	UTSW	11	73,479,686 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- CATGGCAGTGTCCTTCACAGTAGAG -3'
(R):5'- TCTTATGTTCATGGCCTATGACCGC -3'

Sequencing Primer
(F):5'- AGTGTCCTTCACAGTAGAGTTATTAG -3'
(R):5'- CGTTATACCAGCATCATGAGTC -3'

Posted On

2013-09-30