Mutagenetix > Incidental Mutation

Incidental Mutation 'R9279:Vmn1r238'

703526

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r238

Ensembl Gene

ENSMUSG00000091539

Gene Name

vomeronasal 1 receptor, 238

Synonyms

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.057) question?

Stock #

R9279 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

3122492-3123412 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 3122994 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Glutamic Acid at position 140 (V140E)

Ref Sequence

ENSEMBL: ENSMUSP00000129804 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000165255]

AlphaFold

E9Q373

Predicted Effect

probably damaging
Transcript: ENSMUST00000165255
AA Change: V140E

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000129804
Gene: ENSMUSG00000091539
AA Change: V140E

Domain	Start	End	E-Value	Type
Pfam:TAS2R	7	302	5.3e-8	PFAM
Pfam:7tm_1	27	292	8.8e-7	PFAM
Pfam:V1R	34	298	1.9e-33	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.6%

Validation Efficiency

100% (50/50)

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Akr7a5	A	T	4: 139,044,079 (GRCm39)	H225L	possibly damaging	Het
Arhgap32	C	A	9: 32,168,655 (GRCm39)	H879Q	probably benign	Het
Axin2	A	G	11: 108,833,128 (GRCm39)	I438V	possibly damaging	Het
Btbd18	T	A	2: 84,491,920 (GRCm39)	C34S	probably damaging	Het
Carns1	G	T	19: 4,216,256 (GRCm39)	T642N	possibly damaging	Het
Casp8	T	C	1: 58,883,542 (GRCm39)	I283T	probably benign	Het
Ccdc136	T	A	6: 29,421,982 (GRCm39)		probably benign	Het
Ccnk	C	A	12: 108,161,946 (GRCm39)	Q284K	unknown	Het
Ceacam12	T	A	7: 17,801,177 (GRCm39)	L52H	probably damaging	Het
Cit	G	A	5: 116,065,970 (GRCm39)	D540N	probably damaging	Het
Cntnap1	T	C	11: 101,072,121 (GRCm39)	V458A	probably damaging	Het
Col6a5	T	A	9: 105,758,976 (GRCm39)	I2077F	probably damaging	Het
Dnah2	T	C	11: 69,409,104 (GRCm39)	K425E	probably benign	Het
Eya2	A	G	2: 165,529,631 (GRCm39)	S125G	probably benign	Het
Gabrg1	T	G	5: 70,934,599 (GRCm39)	M260L	probably benign	Het
Greb1	T	C	12: 16,732,153 (GRCm39)	S1603G	probably damaging	Het
Isx	A	G	8: 75,600,434 (GRCm39)	T56A	probably benign	Het
Kif2b	A	T	11: 91,467,975 (GRCm39)	S103T	probably benign	Het
Krtap26-1	T	C	16: 88,444,342 (GRCm39)	H93R	probably benign	Het
Ltbp2	G	A	12: 84,837,864 (GRCm39)	P1192L	probably benign	Het
Mdm4	G	A	1: 132,924,416 (GRCm39)	T236M	probably damaging	Het
Mgat5	T	A	1: 127,325,348 (GRCm39)	L405Q	probably damaging	Het
Msantd1	A	G	5: 35,080,885 (GRCm39)	I272V	probably benign	Het
Ocstamp	A	G	2: 165,237,768 (GRCm39)	*499Q	probably null	Het
Or11h6	A	G	14: 50,880,493 (GRCm39)	K252E	possibly damaging	Het
Or1e16	G	A	11: 73,279,789 (GRCm39)	P21L	probably benign	Het
Or2n1d	G	A	17: 38,646,414 (GRCm39)	R122Q	probably damaging	Het
Or4c100	A	G	2: 88,356,211 (GRCm39)	M95V	probably benign	Het
Or5b12	A	T	19: 12,897,309 (GRCm39)	Y121*	probably null	Het
Pcdh15	T	A	10: 74,461,756 (GRCm39)		probably benign	Het
Pkdrej	C	T	15: 85,700,834 (GRCm39)	G1701S	probably damaging	Het
Ppp1r9a	A	G	6: 5,113,757 (GRCm39)	T754A	probably damaging	Het
Prss8	C	A	7: 127,527,082 (GRCm39)	Q55H	probably damaging	Het
Psg20	G	T	7: 18,416,670 (GRCm39)	R149S	probably benign	Het
Ptprz1	T	G	6: 23,002,444 (GRCm39)	N1511K	probably benign	Het
Rbbp8nl	C	T	2: 179,920,894 (GRCm39)		probably null	Het
Sgk2	A	G	2: 162,854,975 (GRCm39)	D362G	probably benign	Het
Sim1	T	C	10: 50,859,796 (GRCm39)	Y553H	probably damaging	Het
Sipa1l2	T	C	8: 126,208,896 (GRCm39)	D504G	probably damaging	Het
Smad7	T	C	18: 75,502,547 (GRCm39)	V174A	possibly damaging	Het
Smarcc1	T	A	9: 109,996,792 (GRCm39)	N303K	possibly damaging	Het
Snai3	T	C	8: 123,183,038 (GRCm39)	H169R	possibly damaging	Het
Tecpr2	T	A	12: 110,895,505 (GRCm39)	S331T	possibly damaging	Het
Tenm2	G	A	11: 35,959,303 (GRCm39)	T1082I	probably benign	Het
Tle4	A	T	19: 14,429,890 (GRCm39)	I627N	probably damaging	Het
Tnxb	A	T	17: 34,898,088 (GRCm39)	N912I	possibly damaging	Het
Ube2q2l	A	G	6: 136,377,978 (GRCm39)	V284A	probably damaging	Het
Vmn1r65	G	A	7: 6,011,988 (GRCm39)	T82I	probably benign	Het
Vps13b	A	G	15: 35,572,290 (GRCm39)	K969R	probably damaging	Het
Zfp943	A	G	17: 22,209,832 (GRCm39)	R35G	possibly damaging	Het

Other mutations in Vmn1r238

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00427:Vmn1r238	APN	18	3,123,243 (GRCm39)	missense	probably benign	0.01
IGL01385:Vmn1r238	APN	18	3,122,770 (GRCm39)	missense	possibly damaging	0.83
IGL02716:Vmn1r238	APN	18	3,123,124 (GRCm39)	missense	probably damaging	1.00
R1219:Vmn1r238	UTSW	18	3,123,135 (GRCm39)	missense	possibly damaging	0.81
R1568:Vmn1r238	UTSW	18	3,123,358 (GRCm39)	missense	probably benign	0.00
R1864:Vmn1r238	UTSW	18	3,123,040 (GRCm39)	nonsense	probably null
R3024:Vmn1r238	UTSW	18	3,123,305 (GRCm39)	missense	probably benign	0.13
R4291:Vmn1r238	UTSW	18	3,123,214 (GRCm39)	nonsense	probably null
R4304:Vmn1r238	UTSW	18	3,123,040 (GRCm39)	nonsense	probably null
R4586:Vmn1r238	UTSW	18	3,123,294 (GRCm39)	missense	probably damaging	1.00
R4664:Vmn1r238	UTSW	18	3,123,300 (GRCm39)	missense	probably damaging	0.99
R5123:Vmn1r238	UTSW	18	3,123,243 (GRCm39)	missense	probably benign
R5430:Vmn1r238	UTSW	18	3,122,521 (GRCm39)	missense	possibly damaging	0.63
R5834:Vmn1r238	UTSW	18	3,123,168 (GRCm39)	missense	probably benign
R7186:Vmn1r238	UTSW	18	3,122,661 (GRCm39)	missense	probably damaging	0.99
R7206:Vmn1r238	UTSW	18	3,122,623 (GRCm39)	missense	possibly damaging	0.94
R7308:Vmn1r238	UTSW	18	3,122,875 (GRCm39)	missense	probably benign	0.09
R7346:Vmn1r238	UTSW	18	3,123,151 (GRCm39)	missense	probably damaging	1.00
R7467:Vmn1r238	UTSW	18	3,123,393 (GRCm39)	missense	probably benign	0.10
R7571:Vmn1r238	UTSW	18	3,122,721 (GRCm39)	missense	probably damaging	1.00
R7808:Vmn1r238	UTSW	18	3,123,033 (GRCm39)	missense	probably benign	0.03
R8085:Vmn1r238	UTSW	18	3,123,151 (GRCm39)	missense	probably damaging	1.00
R8086:Vmn1r238	UTSW	18	3,123,250 (GRCm39)	missense	probably damaging	1.00
R8325:Vmn1r238	UTSW	18	3,122,529 (GRCm39)	missense	probably benign	0.00
R8423:Vmn1r238	UTSW	18	3,123,365 (GRCm39)	nonsense	probably null
R8747:Vmn1r238	UTSW	18	3,123,232 (GRCm39)	missense	possibly damaging	0.87
R8930:Vmn1r238	UTSW	18	3,123,127 (GRCm39)	missense	probably benign	0.03
R8932:Vmn1r238	UTSW	18	3,123,127 (GRCm39)	missense	probably benign	0.03
R9382:Vmn1r238	UTSW	18	3,122,676 (GRCm39)	missense	probably damaging	0.99
R9644:Vmn1r238	UTSW	18	3,122,635 (GRCm39)	missense	probably benign	0.10
R9725:Vmn1r238	UTSW	18	3,122,577 (GRCm39)	missense	probably benign	0.00
Z1177:Vmn1r238	UTSW	18	3,122,505 (GRCm39)	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- TACTTGAGCAGGCCATGAGAC -3'
(R):5'- CCACAGACAATGTCATATTTTGGG -3'

Sequencing Primer
(F):5'- GGCCATGAGACCCAGACAG -3'
(R):5'- AAGAATTTCCTAGATGACATGGAATG -3'

Posted On

2022-03-25