Incidental Mutation 'R9282:Vmn2r104'
ID 703713
Institutional Source Beutler Lab
Gene Symbol Vmn2r104
Ensembl Gene ENSMUSG00000090315
Gene Name vomeronasal 2, receptor 104
Synonyms V2r7
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.108) question?
Stock # R9282 (G1)
Quality Score 225.009
Status Not validated
Chromosome 17
Chromosomal Location 20249687-20268467 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 20261098 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Isoleucine at position 442 (F442I)
Ref Sequence ENSEMBL: ENSMUSP00000129895 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000168050]
AlphaFold E9Q2J5
Predicted Effect probably damaging
Transcript: ENSMUST00000168050
AA Change: F442I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000129895
Gene: ENSMUSG00000090315
AA Change: F442I

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 85 457 4e-38 PFAM
Pfam:NCD3G 512 565 2.1e-20 PFAM
Pfam:7tm_3 598 833 1.7e-52 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abi3bp G A 16: 56,440,867 (GRCm39) V701M unknown Het
Adam2 G A 14: 66,267,238 (GRCm39) P674S probably benign Het
Adam24 T A 8: 41,133,674 (GRCm39) Y381N probably damaging Het
Adgrv1 A G 13: 81,251,491 (GRCm39) S6209P probably damaging Het
Aox4 A T 1: 58,285,028 (GRCm39) K593N possibly damaging Het
Aqp3 A G 4: 41,093,640 (GRCm39) V258A possibly damaging Het
Atg16l1 T A 1: 87,707,906 (GRCm39) F390I possibly damaging Het
B4galt6 T A 18: 20,825,509 (GRCm39) Y239F possibly damaging Het
Cmtr2 T C 8: 110,948,977 (GRCm39) M429T probably benign Het
Col5a2 C G 1: 45,478,029 (GRCm39) probably null Het
Dcc T C 18: 71,815,249 (GRCm39) D375G possibly damaging Het
Dnah14 T C 1: 181,642,077 (GRCm39) Y31H Het
Fam131a G A 16: 20,520,243 (GRCm39) R232H possibly damaging Het
Fam186a A G 15: 99,839,879 (GRCm39) Y2122H probably damaging Het
Focad A T 4: 88,115,059 (GRCm39) I421F unknown Het
Fscb T G 12: 64,520,097 (GRCm39) E456D possibly damaging Het
Furin C A 7: 80,040,846 (GRCm39) S664I probably benign Het
Ganc A G 2: 120,290,381 (GRCm39) E906G probably benign Het
Gdf5 C G 2: 155,783,915 (GRCm39) D346H probably damaging Het
Golga4 T C 9: 118,385,893 (GRCm39) L1005P probably damaging Het
Ifit1bl1 T C 19: 34,571,908 (GRCm39) N183S probably benign Het
Itpr1 T A 6: 108,370,984 (GRCm39) F1084I probably damaging Het
Katnal1 A T 5: 148,831,021 (GRCm39) Y184* probably null Het
Lrrc37a A G 11: 103,391,633 (GRCm39) I1264T probably benign Het
Map3k2 T A 18: 32,342,805 (GRCm39) M234K probably damaging Het
Mcm3ap T A 10: 76,342,352 (GRCm39) V1615E probably damaging Het
Mkrn2 A G 6: 115,591,534 (GRCm39) probably null Het
Nicn1 C T 9: 108,171,708 (GRCm39) R163C possibly damaging Het
Nradd T A 9: 110,450,751 (GRCm39) Q142L possibly damaging Het
Ophn1 G A X: 97,622,145 (GRCm39) T668M probably benign Het
Or56b35 T C 7: 104,963,781 (GRCm39) I190T probably benign Het
Pdzd7 A G 19: 45,028,622 (GRCm39) F174L probably damaging Het
Pi4k2b C T 5: 52,900,879 (GRCm39) T99I probably benign Het
Pigv A T 4: 133,391,973 (GRCm39) V399D probably damaging Het
Pla2g4a C A 1: 149,747,207 (GRCm39) L326F probably damaging Het
Psmg1 T C 16: 95,790,717 (GRCm39) I73M probably damaging Het
Rcl1 T C 19: 29,093,170 (GRCm39) S62P probably damaging Het
Slc23a4 T A 6: 34,955,861 (GRCm39) I58F probably damaging Het
Slc36a2 G T 11: 55,060,837 (GRCm39) T191K probably benign Het
Sorbs2 T G 8: 46,248,774 (GRCm39) V675G probably benign Het
Tbc1d30 T C 10: 121,142,128 (GRCm39) probably null Het
Tbc1d4 A G 14: 101,845,616 (GRCm39) V94A possibly damaging Het
Tdrd5 T C 1: 156,105,030 (GRCm39) Y532C probably benign Het
Tll2 T A 19: 41,074,772 (GRCm39) I931L probably benign Het
Tlr3 T C 8: 45,851,643 (GRCm39) N418S probably benign Het
Tmco1 C T 1: 167,136,132 (GRCm39) probably benign Het
Tshr T A 12: 91,474,518 (GRCm39) M164K possibly damaging Het
Ttc21b A G 2: 66,056,349 (GRCm39) V679A possibly damaging Het
Ttn A G 2: 76,730,861 (GRCm39) Y4951H unknown Het
Usf1 T A 1: 171,243,373 (GRCm39) V50D possibly damaging Het
Utp6 A T 11: 79,826,851 (GRCm39) M575K probably benign Het
Vmn1r197 A T 13: 22,512,608 (GRCm39) R176S possibly damaging Het
Vmn2r94 A G 17: 18,497,751 (GRCm39) F7S possibly damaging Het
Vps41 G T 13: 19,013,401 (GRCm39) E340* probably null Het
Other mutations in Vmn2r104
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00427:Vmn2r104 APN 17 20,258,501 (GRCm39) missense probably damaging 0.98
IGL01098:Vmn2r104 APN 17 20,268,358 (GRCm39) missense probably benign 0.27
IGL01333:Vmn2r104 APN 17 20,263,055 (GRCm39) missense probably benign 0.17
IGL01527:Vmn2r104 APN 17 20,263,158 (GRCm39) missense possibly damaging 0.82
IGL01773:Vmn2r104 APN 17 20,260,930 (GRCm39) missense probably benign 0.10
IGL01939:Vmn2r104 APN 17 20,250,187 (GRCm39) missense probably damaging 0.99
IGL02121:Vmn2r104 APN 17 20,262,056 (GRCm39) nonsense probably null
IGL02305:Vmn2r104 APN 17 20,263,118 (GRCm39) missense probably benign 0.09
IGL02374:Vmn2r104 APN 17 20,263,048 (GRCm39) missense probably benign 0.34
IGL03260:Vmn2r104 APN 17 20,263,083 (GRCm39) missense probably benign 0.05
IGL03366:Vmn2r104 APN 17 20,249,866 (GRCm39) missense probably damaging 1.00
R0091:Vmn2r104 UTSW 17 20,262,075 (GRCm39) missense possibly damaging 0.79
R0125:Vmn2r104 UTSW 17 20,250,069 (GRCm39) missense probably damaging 0.98
R0257:Vmn2r104 UTSW 17 20,249,889 (GRCm39) missense probably damaging 1.00
R0381:Vmn2r104 UTSW 17 20,268,264 (GRCm39) nonsense probably null
R0709:Vmn2r104 UTSW 17 20,263,166 (GRCm39) missense probably damaging 1.00
R0786:Vmn2r104 UTSW 17 20,262,987 (GRCm39) missense probably benign
R1575:Vmn2r104 UTSW 17 20,262,477 (GRCm39) missense probably damaging 1.00
R1827:Vmn2r104 UTSW 17 20,262,497 (GRCm39) missense probably damaging 0.97
R1932:Vmn2r104 UTSW 17 20,261,031 (GRCm39) missense probably damaging 1.00
R1956:Vmn2r104 UTSW 17 20,262,313 (GRCm39) missense probably damaging 0.98
R2203:Vmn2r104 UTSW 17 20,250,083 (GRCm39) missense probably benign 0.05
R2205:Vmn2r104 UTSW 17 20,250,083 (GRCm39) missense probably benign 0.05
R2859:Vmn2r104 UTSW 17 20,268,455 (GRCm39) missense possibly damaging 0.82
R3701:Vmn2r104 UTSW 17 20,249,818 (GRCm39) missense probably damaging 1.00
R3834:Vmn2r104 UTSW 17 20,250,183 (GRCm39) missense probably benign 0.02
R4151:Vmn2r104 UTSW 17 20,250,147 (GRCm39) missense probably damaging 1.00
R4470:Vmn2r104 UTSW 17 20,262,503 (GRCm39) missense probably damaging 1.00
R4625:Vmn2r104 UTSW 17 20,268,443 (GRCm39) missense probably benign 0.00
R4754:Vmn2r104 UTSW 17 20,261,030 (GRCm39) nonsense probably null
R4911:Vmn2r104 UTSW 17 20,250,288 (GRCm39) missense probably benign 0.00
R5270:Vmn2r104 UTSW 17 20,258,528 (GRCm39) missense probably damaging 1.00
R5279:Vmn2r104 UTSW 17 20,262,146 (GRCm39) missense probably benign 0.07
R5311:Vmn2r104 UTSW 17 20,250,163 (GRCm39) missense probably damaging 1.00
R5370:Vmn2r104 UTSW 17 20,250,450 (GRCm39) missense probably damaging 0.97
R5461:Vmn2r104 UTSW 17 20,250,343 (GRCm39) missense probably damaging 1.00
R5683:Vmn2r104 UTSW 17 20,260,981 (GRCm39) nonsense probably null
R5795:Vmn2r104 UTSW 17 20,250,544 (GRCm39) missense possibly damaging 0.89
R5795:Vmn2r104 UTSW 17 20,250,372 (GRCm39) missense probably benign 0.02
R5970:Vmn2r104 UTSW 17 20,249,733 (GRCm39) missense probably benign 0.01
R5983:Vmn2r104 UTSW 17 20,261,970 (GRCm39) missense probably damaging 1.00
R5992:Vmn2r104 UTSW 17 20,249,747 (GRCm39) missense probably damaging 1.00
R6066:Vmn2r104 UTSW 17 20,258,573 (GRCm39) missense possibly damaging 0.69
R6156:Vmn2r104 UTSW 17 20,261,909 (GRCm39) missense probably damaging 1.00
R6182:Vmn2r104 UTSW 17 20,250,507 (GRCm39) missense probably benign 0.16
R6245:Vmn2r104 UTSW 17 20,261,829 (GRCm39) missense possibly damaging 0.69
R6333:Vmn2r104 UTSW 17 20,249,848 (GRCm39) missense probably benign 0.30
R6573:Vmn2r104 UTSW 17 20,262,487 (GRCm39) missense probably damaging 1.00
R7101:Vmn2r104 UTSW 17 20,250,358 (GRCm39) missense possibly damaging 0.65
R7123:Vmn2r104 UTSW 17 20,261,088 (GRCm39) missense probably benign 0.12
R7485:Vmn2r104 UTSW 17 20,249,737 (GRCm39) missense probably benign 0.01
R7514:Vmn2r104 UTSW 17 20,249,791 (GRCm39) missense probably damaging 1.00
R7634:Vmn2r104 UTSW 17 20,261,971 (GRCm39) missense possibly damaging 0.48
R7958:Vmn2r104 UTSW 17 20,262,988 (GRCm39) missense probably benign
R8031:Vmn2r104 UTSW 17 20,263,048 (GRCm39) missense probably benign 0.34
R8094:Vmn2r104 UTSW 17 20,250,483 (GRCm39) missense possibly damaging 0.77
R8191:Vmn2r104 UTSW 17 20,250,465 (GRCm39) missense possibly damaging 0.89
R8308:Vmn2r104 UTSW 17 20,261,040 (GRCm39) missense possibly damaging 0.55
R8691:Vmn2r104 UTSW 17 20,262,110 (GRCm39) missense probably damaging 0.98
R8795:Vmn2r104 UTSW 17 20,262,988 (GRCm39) missense probably benign
R8900:Vmn2r104 UTSW 17 20,261,924 (GRCm39) missense probably damaging 0.99
R8913:Vmn2r104 UTSW 17 20,249,968 (GRCm39) missense probably damaging 1.00
R9180:Vmn2r104 UTSW 17 20,263,087 (GRCm39) missense probably benign 0.00
R9199:Vmn2r104 UTSW 17 20,262,097 (GRCm39) missense probably damaging 0.99
R9303:Vmn2r104 UTSW 17 20,268,439 (GRCm39) missense possibly damaging 0.90
R9305:Vmn2r104 UTSW 17 20,268,439 (GRCm39) missense possibly damaging 0.90
R9322:Vmn2r104 UTSW 17 20,263,087 (GRCm39) missense probably benign 0.00
R9325:Vmn2r104 UTSW 17 20,268,433 (GRCm39) missense possibly damaging 0.95
R9414:Vmn2r104 UTSW 17 20,250,250 (GRCm39) missense probably damaging 0.99
R9785:Vmn2r104 UTSW 17 20,268,409 (GRCm39) missense probably benign
RF007:Vmn2r104 UTSW 17 20,268,302 (GRCm39) missense probably benign 0.36
Z1177:Vmn2r104 UTSW 17 20,250,051 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTTCAGATAAAGACAACTGTTGACCC -3'
(R):5'- CAGTAGTGATTGATTGCTTACTTGAGC -3'

Sequencing Primer
(F):5'- ACAACTGTTGACCCTGAGGAGC -3'
(R):5'- TTCAGAAGCAGAATGGTAGTTTG -3'
Posted On 2022-03-25