Mutagenetix > Incidental Mutation

Incidental Mutation 'R9282:Vmn2r104'

703713

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r104

Ensembl Gene

ENSMUSG00000090315

Gene Name

vomeronasal 2, receptor 104

Synonyms

V2r7

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.097) question?

Stock #

R9282 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

20029425-20048205 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 20040836 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Isoleucine at position 442 (F442I)

Ref Sequence

ENSEMBL: ENSMUSP00000129895 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168050]

AlphaFold

E9Q2J5

Predicted Effect

probably damaging
Transcript: ENSMUST00000168050
AA Change: F442I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000129895
Gene: ENSMUSG00000090315
AA Change: F442I

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	85	457	4e-38	PFAM
Pfam:NCD3G	512	565	2.1e-20	PFAM
Pfam:7tm_3	598	833	1.7e-52	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 98.9%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 54 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abi3bp	G	A	16: 56,620,504	V701M	unknown	Het
Adam2	G	A	14: 66,029,789	P674S	probably benign	Het
Adam24	T	A	8: 40,680,635	Y381N	probably damaging	Het
Adgrv1	A	G	13: 81,103,372	S6209P	probably damaging	Het
Aox4	A	T	1: 58,245,869	K593N	possibly damaging	Het
Aqp3	A	G	4: 41,093,640	V258A	possibly damaging	Het
Atg16l1	T	A	1: 87,780,184	F390I	possibly damaging	Het
B4galt6	T	A	18: 20,692,452	Y239F	possibly damaging	Het
Cmtr2	T	C	8: 110,222,345	M429T	probably benign	Het
Col5a2	C	G	1: 45,438,869		probably null	Het
Dcc	T	C	18: 71,682,178	D375G	possibly damaging	Het
Dnah14	T	C	1: 181,814,512	Y31H		Het
Fam131a	G	A	16: 20,701,493	R232H	possibly damaging	Het
Fam186a	A	G	15: 99,941,998	Y2122H	probably damaging	Het
Focad	A	T	4: 88,196,822	I421F	unknown	Het
Fscb	T	G	12: 64,473,323	E456D	possibly damaging	Het
Furin	C	A	7: 80,391,098	S664I	probably benign	Het
Ganc	A	G	2: 120,459,900	E906G	probably benign	Het
Gdf5	C	G	2: 155,941,995	D346H	probably damaging	Het
Golga4	T	C	9: 118,556,825	L1005P	probably damaging	Het
Ifit1bl1	T	C	19: 34,594,508	N183S	probably benign	Het
Itpr1	T	A	6: 108,394,023	F1084I	probably damaging	Het
Katnal1	A	T	5: 148,894,211	Y184*	probably null	Het
Lrrc37a	A	G	11: 103,500,807	I1264T	probably benign	Het
Map3k2	T	A	18: 32,209,752	M234K	probably damaging	Het
Mcm3ap	T	A	10: 76,506,518	V1615E	probably damaging	Het
Mkrn2	A	G	6: 115,614,573		probably null	Het
Nicn1	C	T	9: 108,294,509	R163C	possibly damaging	Het
Nradd	T	A	9: 110,621,683	Q142L	possibly damaging	Het
Olfr689	T	C	7: 105,314,574	I190T	probably benign	Het
Ophn1	G	A	X: 98,578,539	T668M	probably benign	Het
Pdzd7	A	G	19: 45,040,183	F174L	probably damaging	Het
Pi4k2b	C	T	5: 52,743,537	T99I	probably benign	Het
Pigv	A	T	4: 133,664,662	V399D	probably damaging	Het
Pla2g4a	C	A	1: 149,871,456	L326F	probably damaging	Het
Psmg1	T	C	16: 95,989,517	I73M	probably damaging	Het
Rcl1	T	C	19: 29,115,770	S62P	probably damaging	Het
Slc23a4	T	A	6: 34,978,926	I58F	probably damaging	Het
Slc36a2	G	T	11: 55,170,011	T191K	probably benign	Het
Sorbs2	T	G	8: 45,795,737	V675G	probably benign	Het
Tbc1d30	T	C	10: 121,306,223		probably null	Het
Tbc1d4	A	G	14: 101,608,180	V94A	possibly damaging	Het
Tdrd5	T	C	1: 156,277,460	Y532C	probably benign	Het
Tll2	T	A	19: 41,086,333	I931L	probably benign	Het
Tlr3	T	C	8: 45,398,606	N418S	probably benign	Het
Tmco1	C	T	1: 167,308,563		probably benign	Het
Tshr	T	A	12: 91,507,744	M164K	possibly damaging	Het
Ttc21b	A	G	2: 66,226,005	V679A	possibly damaging	Het
Ttn	A	G	2: 76,900,517	Y4951H	unknown	Het
Usf1	T	A	1: 171,415,805	V50D	possibly damaging	Het
Utp6	A	T	11: 79,936,025	M575K	probably benign	Het
Vmn1r197	A	T	13: 22,328,438	R176S	possibly damaging	Het
Vmn2r94	A	G	17: 18,277,489	F7S	possibly damaging	Het
Vps41	G	T	13: 18,829,231	E340*	probably null	Het

Other mutations in Vmn2r104

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00427:Vmn2r104	APN	17	20038239	missense	probably damaging	0.98
IGL01098:Vmn2r104	APN	17	20048096	missense	probably benign	0.27
IGL01333:Vmn2r104	APN	17	20042793	missense	probably benign	0.17
IGL01527:Vmn2r104	APN	17	20042896	missense	possibly damaging	0.82
IGL01773:Vmn2r104	APN	17	20040668	missense	probably benign	0.10
IGL01939:Vmn2r104	APN	17	20029925	missense	probably damaging	0.99
IGL02121:Vmn2r104	APN	17	20041794	nonsense	probably null
IGL02305:Vmn2r104	APN	17	20042856	missense	probably benign	0.09
IGL02374:Vmn2r104	APN	17	20042786	missense	probably benign	0.34
IGL03260:Vmn2r104	APN	17	20042821	missense	probably benign	0.05
IGL03366:Vmn2r104	APN	17	20029604	missense	probably damaging	1.00
R0091:Vmn2r104	UTSW	17	20041813	missense	possibly damaging	0.79
R0125:Vmn2r104	UTSW	17	20029807	missense	probably damaging	0.98
R0257:Vmn2r104	UTSW	17	20029627	missense	probably damaging	1.00
R0381:Vmn2r104	UTSW	17	20048002	nonsense	probably null
R0709:Vmn2r104	UTSW	17	20042904	missense	probably damaging	1.00
R0786:Vmn2r104	UTSW	17	20042725	missense	probably benign
R1575:Vmn2r104	UTSW	17	20042215	missense	probably damaging	1.00
R1827:Vmn2r104	UTSW	17	20042235	missense	probably damaging	0.97
R1932:Vmn2r104	UTSW	17	20040769	missense	probably damaging	1.00
R1956:Vmn2r104	UTSW	17	20042051	missense	probably damaging	0.98
R2203:Vmn2r104	UTSW	17	20029821	missense	probably benign	0.05
R2205:Vmn2r104	UTSW	17	20029821	missense	probably benign	0.05
R2859:Vmn2r104	UTSW	17	20048193	missense	possibly damaging	0.82
R3701:Vmn2r104	UTSW	17	20029556	missense	probably damaging	1.00
R3834:Vmn2r104	UTSW	17	20029921	missense	probably benign	0.02
R4151:Vmn2r104	UTSW	17	20029885	missense	probably damaging	1.00
R4470:Vmn2r104	UTSW	17	20042241	missense	probably damaging	1.00
R4625:Vmn2r104	UTSW	17	20048181	missense	probably benign	0.00
R4754:Vmn2r104	UTSW	17	20040768	nonsense	probably null
R4911:Vmn2r104	UTSW	17	20030026	missense	probably benign	0.00
R5270:Vmn2r104	UTSW	17	20038266	missense	probably damaging	1.00
R5279:Vmn2r104	UTSW	17	20041884	missense	probably benign	0.07
R5311:Vmn2r104	UTSW	17	20029901	missense	probably damaging	1.00
R5370:Vmn2r104	UTSW	17	20030188	missense	probably damaging	0.97
R5461:Vmn2r104	UTSW	17	20030081	missense	probably damaging	1.00
R5683:Vmn2r104	UTSW	17	20040719	nonsense	probably null
R5795:Vmn2r104	UTSW	17	20030110	missense	probably benign	0.02
R5795:Vmn2r104	UTSW	17	20030282	missense	possibly damaging	0.89
R5970:Vmn2r104	UTSW	17	20029471	missense	probably benign	0.01
R5983:Vmn2r104	UTSW	17	20041708	missense	probably damaging	1.00
R5992:Vmn2r104	UTSW	17	20029485	missense	probably damaging	1.00
R6066:Vmn2r104	UTSW	17	20038311	missense	possibly damaging	0.69
R6156:Vmn2r104	UTSW	17	20041647	missense	probably damaging	1.00
R6182:Vmn2r104	UTSW	17	20030245	missense	probably benign	0.16
R6245:Vmn2r104	UTSW	17	20041567	missense	possibly damaging	0.69
R6333:Vmn2r104	UTSW	17	20029586	missense	probably benign	0.30
R6573:Vmn2r104	UTSW	17	20042225	missense	probably damaging	1.00
R7101:Vmn2r104	UTSW	17	20030096	missense	possibly damaging	0.65
R7123:Vmn2r104	UTSW	17	20040826	missense	probably benign	0.12
R7485:Vmn2r104	UTSW	17	20029475	missense	probably benign	0.01
R7514:Vmn2r104	UTSW	17	20029529	missense	probably damaging	1.00
R7634:Vmn2r104	UTSW	17	20041709	missense	possibly damaging	0.48
R7958:Vmn2r104	UTSW	17	20042726	missense	probably benign
R8031:Vmn2r104	UTSW	17	20042786	missense	probably benign	0.34
R8094:Vmn2r104	UTSW	17	20030221	missense	possibly damaging	0.77
R8191:Vmn2r104	UTSW	17	20030203	missense	possibly damaging	0.89
R8308:Vmn2r104	UTSW	17	20040778	missense	possibly damaging	0.55
R8691:Vmn2r104	UTSW	17	20041848	missense	probably damaging	0.98
R8795:Vmn2r104	UTSW	17	20042726	missense	probably benign
R8900:Vmn2r104	UTSW	17	20041662	missense	probably damaging	0.99
R8913:Vmn2r104	UTSW	17	20029706	missense	probably damaging	1.00
R9180:Vmn2r104	UTSW	17	20042825	missense	probably benign	0.00
R9199:Vmn2r104	UTSW	17	20041835	missense	probably damaging	0.99
R9303:Vmn2r104	UTSW	17	20048177	missense	possibly damaging	0.90
R9305:Vmn2r104	UTSW	17	20048177	missense	possibly damaging	0.90
R9322:Vmn2r104	UTSW	17	20042825	missense	probably benign	0.00
R9325:Vmn2r104	UTSW	17	20048171	missense	possibly damaging	0.95
R9414:Vmn2r104	UTSW	17	20029988	missense	probably damaging	0.99
R9785:Vmn2r104	UTSW	17	20048147	missense	probably benign
RF007:Vmn2r104	UTSW	17	20048040	missense	probably benign	0.36
Z1177:Vmn2r104	UTSW	17	20029789	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GTTCAGATAAAGACAACTGTTGACCC -3'
(R):5'- CAGTAGTGATTGATTGCTTACTTGAGC -3'

Sequencing Primer
(F):5'- ACAACTGTTGACCCTGAGGAGC -3'
(R):5'- TTCAGAAGCAGAATGGTAGTTTG -3'

Posted On

2022-03-25