Mutagenetix > Incidental Mutation

Incidental Mutation 'R9284:Or5d37'

703792

Institutional Source

Beutler Lab

Gene Symbol

Or5d37

Ensembl Gene

ENSMUSG00000075136

Gene Name

olfactory receptor family 5 subfamily D member 37

Synonyms

GA_x6K02T2Q125-49585842-49584862, Olfr1164, MOR174-11

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.096) question?

Stock #

R9284 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

87923199-87924310 bp(-) (GRCm39)

Type of Mutation

start codon destroyed

DNA Base Change (assembly)

T to A at 87924278 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Leucine at position 1 (M1L)

Ref Sequence

ENSEMBL: ENSMUSP00000097422 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000099834]

AlphaFold

A2AVT5

Predicted Effect

probably benign
Transcript: ENSMUST00000099834
AA Change: M1L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000097422
Gene: ENSMUSG00000075136
AA Change: M1L

Domain	Start	End	E-Value	Type
Pfam:7tm_4	43	320	3.8e-47	PFAM
Pfam:7tm_1	53	302	2.9e-15	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.0%

Validation Efficiency

100% (63/63)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 61 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aadacl4fm5	T	G	4: 144,504,191 (GRCm39)	Q320P	probably damaging	Het
Adamtsl2	G	A	2: 26,994,055 (GRCm39)		probably benign	Het
Adgrl3	T	A	5: 81,657,568 (GRCm39)		probably benign	Het
Angptl3	A	G	4: 98,919,480 (GRCm39)	Q80R	probably benign	Het
Atmin	G	A	8: 117,684,019 (GRCm39)	V560M	probably benign	Het
Bbx	A	G	16: 50,045,023 (GRCm39)	S513P	probably benign	Het
Cacng8	C	A	7: 3,459,746 (GRCm39)	Y112*	probably null	Het
Catsperg2	A	G	7: 29,405,006 (GRCm39)		probably null	Het
Ccdc12	A	C	9: 110,540,203 (GRCm39)	T131P	probably damaging	Het
Cdh23	G	A	10: 60,143,306 (GRCm39)	A3005V	possibly damaging	Het
Cep95	A	T	11: 106,704,624 (GRCm39)	H493L	probably benign	Het
Cntnap1	A	G	11: 101,068,137 (GRCm39)	T50A	probably benign	Het
Cyp3a16	T	A	5: 145,377,304 (GRCm39)	I428F	probably damaging	Het
Dnhd1	G	T	7: 105,301,091 (GRCm39)	L149F	probably damaging	Het
Dop1b	T	A	16: 93,557,196 (GRCm39)	V497E	probably damaging	Het
Erich3	A	T	3: 154,404,308 (GRCm39)	N55I		Het
Fbxw26	A	T	9: 109,550,962 (GRCm39)		probably benign	Het
Gm4841	A	G	18: 60,403,895 (GRCm39)	I66T	probably damaging	Het
Gp5	G	A	16: 30,127,094 (GRCm39)	L527F	probably damaging	Het
Gpatch2l	G	A	12: 86,290,883 (GRCm39)	G22D	probably benign	Het
Isg20l2	T	A	3: 87,838,991 (GRCm39)	D67E	probably benign	Het
Itgae	G	A	11: 73,012,752 (GRCm39)	V695I	probably benign	Het
Itpr2	A	T	6: 146,256,174 (GRCm39)	N1006K	probably benign	Het
Iws1	G	A	18: 32,213,213 (GRCm39)	E214K	possibly damaging	Het
Lama3	C	T	18: 12,583,541 (GRCm39)	Q710*	probably null	Het
Loxhd1	C	T	18: 77,501,826 (GRCm39)	A1715V	probably damaging	Het
Map3k20	C	T	2: 72,228,755 (GRCm39)	Q325*	probably null	Het
Med1	A	T	11: 98,046,366 (GRCm39)	S1477T	unknown	Het
Mr1	T	A	1: 155,013,274 (GRCm39)	H101L	probably benign	Het
Mtor	T	A	4: 148,543,537 (GRCm39)	S405T	probably benign	Het
Nme9	G	C	9: 99,338,321 (GRCm39)		probably null	Het
Nom1	T	A	5: 29,647,532 (GRCm39)	I589N	probably damaging	Het
Nr6a1	A	T	2: 38,638,890 (GRCm39)	D148E	probably damaging	Het
Nup160	T	C	2: 90,548,375 (GRCm39)	V1006A	possibly damaging	Het
Or2ag1b	A	T	7: 106,288,416 (GRCm39)	I174N	possibly damaging	Het
Or2aj4	A	G	16: 19,385,357 (GRCm39)	I92T	probably damaging	Het
Or4d10b	A	T	19: 12,036,273 (GRCm39)	L281Q	probably damaging	Het
Or6c200-ps1	G	A	10: 128,869,821 (GRCm39)	P297S	probably damaging	Het
Phyhd1	G	T	2: 30,156,879 (GRCm39)	G7*	probably null	Het
Pla2g4e	T	C	2: 120,004,730 (GRCm39)		probably benign	Het
Ppfia3	A	G	7: 45,011,222 (GRCm39)	C3R	probably damaging	Het
Pramel1	T	C	4: 143,123,769 (GRCm39)	V148A	probably benign	Het
Ptpdc1	A	T	13: 48,740,167 (GRCm39)	D421E	probably benign	Het
Rapgef2	A	T	3: 79,000,010 (GRCm39)	D579E	probably damaging	Het
Rbpj	T	G	5: 53,810,724 (GRCm39)	V448G	probably damaging	Het
Rif1	T	C	2: 51,998,564 (GRCm39)	V1067A	probably benign	Het
Scfd1	A	T	12: 51,439,024 (GRCm39)	N162I	probably benign	Het
Sh2b1	TGGGGACCAGCTCAGCCACGGGGACCAGCTC	TGGGGACCAGCTCAGCCACGGGGACCAGCTCAGCCACGGGGACCAGCTC	7: 126,066,742 (GRCm39)		probably benign	Het
Sp110	A	T	1: 85,507,363 (GRCm39)		probably null	Het
Sparcl1	A	T	5: 104,236,345 (GRCm39)	C469*	probably null	Het
Srebf2	G	A	15: 82,066,357 (GRCm39)	R635Q	probably benign	Het
Stard7	T	G	2: 127,132,956 (GRCm39)	S250A	probably damaging	Het
Stxbp5l	A	C	16: 37,028,442 (GRCm39)	Y540*	probably null	Het
Tlr5	T	C	1: 182,801,377 (GRCm39)	V227A	probably benign	Het
Tmem132b	T	C	5: 125,864,711 (GRCm39)	I939T	possibly damaging	Het
Tnik	G	T	3: 28,593,570 (GRCm39)	S142I	unknown	Het
Trim6	A	G	7: 103,882,116 (GRCm39)	T482A	probably damaging	Het
Tssk5	A	G	15: 76,257,168 (GRCm39)	I238T	probably benign	Het
Ugt2b35	A	G	5: 87,156,140 (GRCm39)	T411A	probably benign	Het
Zc2hc1b	C	A	10: 13,043,562 (GRCm39)	R111L	probably benign	Het
Zfp266	A	T	9: 20,411,300 (GRCm39)	C292*	probably null	Het

Other mutations in Or5d37

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01522:Or5d37	APN	2	87,923,360 (GRCm39)	missense	possibly damaging	0.48
IGL02894:Or5d37	APN	2	87,924,107 (GRCm39)	missense	possibly damaging	0.79
IGL02977:Or5d37	APN	2	87,923,915 (GRCm39)	missense	probably benign
R0234:Or5d37	UTSW	2	87,923,366 (GRCm39)	nonsense	probably null
R0234:Or5d37	UTSW	2	87,923,366 (GRCm39)	nonsense	probably null
R0480:Or5d37	UTSW	2	87,923,972 (GRCm39)	missense	probably benign
R0644:Or5d37	UTSW	2	87,923,633 (GRCm39)	missense	probably benign	0.02
R1479:Or5d37	UTSW	2	87,923,630 (GRCm39)	missense	probably benign	0.05
R2047:Or5d37	UTSW	2	87,924,237 (GRCm39)	missense	probably benign	0.01
R2311:Or5d37	UTSW	2	87,924,178 (GRCm39)	missense	probably benign	0.00
R2973:Or5d37	UTSW	2	87,923,458 (GRCm39)	missense	probably benign	0.00
R3683:Or5d37	UTSW	2	87,923,603 (GRCm39)	missense	probably damaging	1.00
R3685:Or5d37	UTSW	2	87,923,603 (GRCm39)	missense	probably damaging	1.00
R4258:Or5d37	UTSW	2	87,923,362 (GRCm39)	missense	probably damaging	1.00
R4811:Or5d37	UTSW	2	87,923,876 (GRCm39)	missense	probably benign	0.08
R4970:Or5d37	UTSW	2	87,923,353 (GRCm39)	missense	probably damaging	1.00
R5112:Or5d37	UTSW	2	87,923,353 (GRCm39)	missense	probably damaging	1.00
R5258:Or5d37	UTSW	2	87,923,762 (GRCm39)	missense	probably benign	0.22
R5884:Or5d37	UTSW	2	87,924,140 (GRCm39)	missense	probably damaging	1.00
R6329:Or5d37	UTSW	2	87,924,008 (GRCm39)	missense	probably damaging	1.00
R6597:Or5d37	UTSW	2	87,923,413 (GRCm39)	missense	probably damaging	1.00
R7018:Or5d37	UTSW	2	87,923,600 (GRCm39)	missense	probably benign	0.00
R7055:Or5d37	UTSW	2	87,924,045 (GRCm39)	missense	probably damaging	1.00
R7314:Or5d37	UTSW	2	87,923,458 (GRCm39)	missense	probably benign	0.00
R7350:Or5d37	UTSW	2	87,923,542 (GRCm39)	missense	probably benign	0.01
R7527:Or5d37	UTSW	2	87,923,954 (GRCm39)	missense	probably damaging	1.00
R8003:Or5d37	UTSW	2	87,923,589 (GRCm39)	nonsense	probably null
R8814:Or5d37	UTSW	2	87,923,315 (GRCm39)	missense	probably benign
R9072:Or5d37	UTSW	2	87,924,172 (GRCm39)	missense	probably benign	0.25
R9073:Or5d37	UTSW	2	87,924,172 (GRCm39)	missense	probably benign	0.25
R9189:Or5d37	UTSW	2	87,924,194 (GRCm39)	missense	probably damaging	1.00
R9276:Or5d37	UTSW	2	87,923,806 (GRCm39)	missense	probably benign
Z1176:Or5d37	UTSW	2	87,923,678 (GRCm39)	missense	probably damaging	0.99

Predicted Primers

PCR Primer
(F):5'- AGGTCTAACAGCTTTGGTGC -3'
(R):5'- TTTCCAGATGAGAGGCATGAG -3'

Sequencing Primer
(F):5'- GGTCTAACAGCTTTGGTGCAATTAC -3'
(R):5'- GTGACTCAGTGAAAAAACAC -3'

Posted On

2022-03-25