Incidental Mutation 'R9284:Nme9'
ID 703823
Institutional Source Beutler Lab
Gene Symbol Nme9
Ensembl Gene ENSMUSG00000046242
Gene Name NME/NM23 family member 9
Synonyms Txndc6
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.126) question?
Stock # R9284 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 99333528-99356804 bp(+) (GRCm39)
Type of Mutation critical splice donor site (1 bp from exon)
DNA Base Change (assembly) G to C at 99338321 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000150820 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000163199]
AlphaFold A0A1L1SUL6
Predicted Effect probably null
Transcript: ENSMUST00000163199
SMART Domains Protein: ENSMUSP00000127845
Gene: ENSMUSG00000046242

DomainStartEndE-ValueType
Pfam:Thioredoxin 1 76 6.3e-9 PFAM
NDK 97 241 9.98e-55 SMART
Predicted Effect probably null
Transcript: ENSMUST00000163199
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 100% (63/63)
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl4fm5 T G 4: 144,504,191 (GRCm39) Q320P probably damaging Het
Adamtsl2 G A 2: 26,994,055 (GRCm39) probably benign Het
Adgrl3 T A 5: 81,657,568 (GRCm39) probably benign Het
Angptl3 A G 4: 98,919,480 (GRCm39) Q80R probably benign Het
Atmin G A 8: 117,684,019 (GRCm39) V560M probably benign Het
Bbx A G 16: 50,045,023 (GRCm39) S513P probably benign Het
Cacng8 C A 7: 3,459,746 (GRCm39) Y112* probably null Het
Catsperg2 A G 7: 29,405,006 (GRCm39) probably null Het
Ccdc12 A C 9: 110,540,203 (GRCm39) T131P probably damaging Het
Cdh23 G A 10: 60,143,306 (GRCm39) A3005V possibly damaging Het
Cep95 A T 11: 106,704,624 (GRCm39) H493L probably benign Het
Cntnap1 A G 11: 101,068,137 (GRCm39) T50A probably benign Het
Cyp3a16 T A 5: 145,377,304 (GRCm39) I428F probably damaging Het
Dnhd1 G T 7: 105,301,091 (GRCm39) L149F probably damaging Het
Dop1b T A 16: 93,557,196 (GRCm39) V497E probably damaging Het
Erich3 A T 3: 154,404,308 (GRCm39) N55I Het
Fbxw26 A T 9: 109,550,962 (GRCm39) probably benign Het
Gm4841 A G 18: 60,403,895 (GRCm39) I66T probably damaging Het
Gp5 G A 16: 30,127,094 (GRCm39) L527F probably damaging Het
Gpatch2l G A 12: 86,290,883 (GRCm39) G22D probably benign Het
Isg20l2 T A 3: 87,838,991 (GRCm39) D67E probably benign Het
Itgae G A 11: 73,012,752 (GRCm39) V695I probably benign Het
Itpr2 A T 6: 146,256,174 (GRCm39) N1006K probably benign Het
Iws1 G A 18: 32,213,213 (GRCm39) E214K possibly damaging Het
Lama3 C T 18: 12,583,541 (GRCm39) Q710* probably null Het
Loxhd1 C T 18: 77,501,826 (GRCm39) A1715V probably damaging Het
Map3k20 C T 2: 72,228,755 (GRCm39) Q325* probably null Het
Med1 A T 11: 98,046,366 (GRCm39) S1477T unknown Het
Mr1 T A 1: 155,013,274 (GRCm39) H101L probably benign Het
Mtor T A 4: 148,543,537 (GRCm39) S405T probably benign Het
Nom1 T A 5: 29,647,532 (GRCm39) I589N probably damaging Het
Nr6a1 A T 2: 38,638,890 (GRCm39) D148E probably damaging Het
Nup160 T C 2: 90,548,375 (GRCm39) V1006A possibly damaging Het
Or2ag1b A T 7: 106,288,416 (GRCm39) I174N possibly damaging Het
Or2aj4 A G 16: 19,385,357 (GRCm39) I92T probably damaging Het
Or4d10b A T 19: 12,036,273 (GRCm39) L281Q probably damaging Het
Or5d37 T A 2: 87,924,278 (GRCm39) M1L probably benign Het
Or6c200-ps1 G A 10: 128,869,821 (GRCm39) P297S probably damaging Het
Phyhd1 G T 2: 30,156,879 (GRCm39) G7* probably null Het
Pla2g4e T C 2: 120,004,730 (GRCm39) probably benign Het
Ppfia3 A G 7: 45,011,222 (GRCm39) C3R probably damaging Het
Pramel1 T C 4: 143,123,769 (GRCm39) V148A probably benign Het
Ptpdc1 A T 13: 48,740,167 (GRCm39) D421E probably benign Het
Rapgef2 A T 3: 79,000,010 (GRCm39) D579E probably damaging Het
Rbpj T G 5: 53,810,724 (GRCm39) V448G probably damaging Het
Rif1 T C 2: 51,998,564 (GRCm39) V1067A probably benign Het
Scfd1 A T 12: 51,439,024 (GRCm39) N162I probably benign Het
Sh2b1 TGGGGACCAGCTCAGCCACGGGGACCAGCTC TGGGGACCAGCTCAGCCACGGGGACCAGCTCAGCCACGGGGACCAGCTC 7: 126,066,742 (GRCm39) probably benign Het
Sp110 A T 1: 85,507,363 (GRCm39) probably null Het
Sparcl1 A T 5: 104,236,345 (GRCm39) C469* probably null Het
Srebf2 G A 15: 82,066,357 (GRCm39) R635Q probably benign Het
Stard7 T G 2: 127,132,956 (GRCm39) S250A probably damaging Het
Stxbp5l A C 16: 37,028,442 (GRCm39) Y540* probably null Het
Tlr5 T C 1: 182,801,377 (GRCm39) V227A probably benign Het
Tmem132b T C 5: 125,864,711 (GRCm39) I939T possibly damaging Het
Tnik G T 3: 28,593,570 (GRCm39) S142I unknown Het
Trim6 A G 7: 103,882,116 (GRCm39) T482A probably damaging Het
Tssk5 A G 15: 76,257,168 (GRCm39) I238T probably benign Het
Ugt2b35 A G 5: 87,156,140 (GRCm39) T411A probably benign Het
Zc2hc1b C A 10: 13,043,562 (GRCm39) R111L probably benign Het
Zfp266 A T 9: 20,411,300 (GRCm39) C292* probably null Het
Other mutations in Nme9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02496:Nme9 APN 9 99,351,684 (GRCm39) missense probably damaging 0.97
IGL02573:Nme9 APN 9 99,352,908 (GRCm39) missense probably benign 0.45
R1900:Nme9 UTSW 9 99,341,827 (GRCm39) missense probably damaging 0.96
R4091:Nme9 UTSW 9 99,346,580 (GRCm39) missense possibly damaging 0.71
R5079:Nme9 UTSW 9 99,341,755 (GRCm39) missense probably damaging 1.00
R6400:Nme9 UTSW 9 99,351,760 (GRCm39) missense possibly damaging 0.88
R7611:Nme9 UTSW 9 99,352,843 (GRCm39) missense probably benign 0.19
R7659:Nme9 UTSW 9 99,352,910 (GRCm39) missense possibly damaging 0.73
R8791:Nme9 UTSW 9 99,350,301 (GRCm39) missense probably damaging 1.00
R9361:Nme9 UTSW 9 99,341,775 (GRCm39) missense probably damaging 1.00
Z1176:Nme9 UTSW 9 99,352,848 (GRCm39) missense possibly damaging 0.73
Predicted Primers PCR Primer
(F):5'- AAGCAGCCTCCTCTATGATTCC -3'
(R):5'- AAGAAGGTGGACCACTGTGC -3'

Sequencing Primer
(F):5'- CACTTTTAATGTCTGAGGATGGCAC -3'
(R):5'- CATTTTGAAACAGAGTCACGGTAGCC -3'
Posted On 2022-03-25