Incidental Mutation 'R9287:Myo16'
ID 704017
Institutional Source Beutler Lab
Gene Symbol Myo16
Ensembl Gene ENSMUSG00000039057
Gene Name myosin XVI
Synonyms C230040D10Rik, BM140241, Nyap3
MMRRC Submission
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.325) question?
Stock # R9287 (G1)
Quality Score 225.009
Status Validated
Chromosome 8
Chromosomal Location 10203911-10684742 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 10526114 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Methionine at position 885 (V885M)
Ref Sequence ENSEMBL: ENSMUSP00000146677 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000042103] [ENSMUST00000207204] [ENSMUST00000207477]
AlphaFold Q5DU14
Predicted Effect probably benign
Transcript: ENSMUST00000042103
AA Change: V885M

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000049345
Gene: ENSMUSG00000039057
AA Change: V885M

DomainStartEndE-ValueType
ANK 92 121 1.65e-1 SMART
ANK 125 154 3.46e-4 SMART
ANK 158 189 2.11e2 SMART
ANK 221 250 2.85e-5 SMART
ANK 254 283 3.51e-5 SMART
low complexity region 333 349 N/A INTRINSIC
MYSc 394 1144 2.27e-144 SMART
IQ 1144 1166 4.06e-2 SMART
Pfam:NYAP_N 1207 1591 4.1e-135 PFAM
low complexity region 1670 1690 N/A INTRINSIC
low complexity region 1841 1860 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000207204
AA Change: V829M
Predicted Effect unknown
Transcript: ENSMUST00000207477
AA Change: V885M
Meta Mutation Damage Score 0.0852 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 100% (109/109)
MGI Phenotype PHENOTYPE: Triple KO of Nyap1, Nyap2 and Myo16 results in decreased brain weight and cortex and striatum size and reduced neurite length in cortical neurons. [provided by MGI curators]
Allele List at MGI

All alleles(3) : Targeted(2) Gene trapped(1)

Other mutations in this stock
Total: 108 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9430097D07Rik T A 2: 32,465,178 (GRCm39) probably benign Het
Aadacl2 C A 3: 59,932,573 (GRCm39) H363N probably damaging Het
Ace3 T G 11: 105,888,246 (GRCm39) S319A probably damaging Het
Amer3 C T 1: 34,627,900 (GRCm39) P713L possibly damaging Het
Aoah T C 13: 21,186,879 (GRCm39) L453P probably damaging Het
Asz1 A T 6: 18,051,290 (GRCm39) L463Q possibly damaging Het
Bpifb6 T A 2: 153,746,535 (GRCm39) V143D probably damaging Het
Cad T A 5: 31,230,000 (GRCm39) M1499K possibly damaging Het
Casp9 T A 4: 141,534,471 (GRCm39) C294S probably benign Het
Ccdc7b T A 8: 129,890,321 (GRCm39) S65T probably benign Het
Cdh23 G A 10: 60,143,306 (GRCm39) A3005V possibly damaging Het
Cfap54 T C 10: 92,805,565 (GRCm39) Y1515C possibly damaging Het
Chrm5 A C 2: 112,309,610 (GRCm39) F502C probably damaging Het
Cnst A T 1: 179,407,108 (GRCm39) T52S possibly damaging Het
Cntn6 T C 6: 104,809,471 (GRCm39) I502T possibly damaging Het
Col7a1 G A 9: 108,787,457 (GRCm39) V617M unknown Het
Ctsb A G 14: 63,370,875 (GRCm39) D29G probably benign Het
Cyp3a44 T A 5: 145,725,202 (GRCm39) Q333L possibly damaging Het
Dnajc27 T C 12: 4,146,256 (GRCm39) V95A possibly damaging Het
Eea1 T A 10: 95,831,445 (GRCm39) Y179N probably damaging Het
Erbb2 T C 11: 98,326,107 (GRCm39) M961T probably damaging Het
Fat4 G A 3: 38,945,781 (GRCm39) G1558D probably damaging Het
Foxh1 T C 15: 76,553,126 (GRCm39) E196G probably damaging Het
Gcc2 T A 10: 58,105,217 (GRCm39) L151* probably null Het
Gcdh C T 8: 85,616,313 (GRCm39) G294D probably damaging Het
Gcnt3 A T 9: 69,941,693 (GRCm39) F292I probably damaging Het
Glod4 T C 11: 76,128,510 (GRCm39) S131G probably benign Het
Gpc2 G A 5: 138,272,586 (GRCm39) L576F unknown Het
Gphn G A 12: 78,609,646 (GRCm39) S330N possibly damaging Het
Heatr5a C T 12: 51,967,260 (GRCm39) C872Y probably damaging Het
Hephl1 G A 9: 14,995,775 (GRCm39) S449L probably benign Het
Hrh2 G T 13: 54,368,358 (GRCm39) M111I probably benign Het
Igfn1 A G 1: 135,925,544 (GRCm39) V70A probably benign Het
Il2 G A 3: 37,179,988 (GRCm39) T23I probably damaging Het
Irak4 A G 15: 94,460,917 (GRCm39) T382A possibly damaging Het
Itih2 A G 2: 10,128,297 (GRCm39) S135P possibly damaging Het
Kansl3 C T 1: 36,388,497 (GRCm39) D457N probably damaging Het
Kcns3 A G 12: 11,141,601 (GRCm39) I366T probably damaging Het
Kif26a C A 12: 112,145,719 (GRCm39) Y1743* probably null Het
Lama4 A T 10: 38,981,960 (GRCm39) I1730F probably damaging Het
Lax1 T C 1: 133,607,931 (GRCm39) N270S probably benign Het
Lrp1 G T 10: 127,403,233 (GRCm39) D2113E probably damaging Het
Lrp6 A G 6: 134,483,259 (GRCm39) V482A probably benign Het
Luzp2 A G 7: 54,914,108 (GRCm39) probably benign Het
Mc5r C A 18: 68,472,200 (GRCm39) D186E probably damaging Het
Mcph1 A T 8: 18,657,293 (GRCm39) probably null Het
Mgam A G 6: 40,705,905 (GRCm39) probably benign Het
Mmrn1 A C 6: 60,952,939 (GRCm39) T407P probably damaging Het
Mrpl1 T C 5: 96,386,806 (GRCm39) V265A probably benign Het
Mrpl15 C T 1: 4,846,856 (GRCm39) G240D probably damaging Het
Msx1 A T 5: 37,978,795 (GRCm39) M240K probably damaging Het
Mtf1 T C 4: 124,724,934 (GRCm39) L337P probably damaging Het
Muc5ac T A 7: 141,361,626 (GRCm39) C1646S probably damaging Het
Mvb12a C A 8: 71,999,638 (GRCm39) T219N probably damaging Het
N4bp2 T A 5: 65,960,855 (GRCm39) S509T probably benign Het
Nckap1 A G 2: 80,383,750 (GRCm39) V144A possibly damaging Het
Nkx2-6 G T 14: 69,412,404 (GRCm39) G191C possibly damaging Het
Nmnat2 T C 1: 152,962,138 (GRCm39) I126T probably damaging Het
Nrp2 C T 1: 62,835,014 (GRCm39) R863W probably damaging Het
Nup188 C T 2: 30,226,726 (GRCm39) R1168C probably damaging Het
Oas3 T A 5: 120,892,754 (GRCm39) D1091V probably damaging Het
Optn T A 2: 5,036,126 (GRCm39) Q452L probably damaging Het
Or8b47 C T 9: 38,435,082 (GRCm39) T18I probably damaging Het
Pcca G A 14: 122,854,178 (GRCm39) V157I probably benign Het
Pcdha9 A G 18: 37,132,281 (GRCm39) D450G probably benign Het
Pcnx1 T A 12: 82,042,323 (GRCm39) S38T probably benign Het
Phrf1 C G 7: 140,840,055 (GRCm39) D1083E probably benign Het
Plaat5 T A 19: 7,596,691 (GRCm39) Y159* probably null Het
Plcb4 G A 2: 135,829,817 (GRCm39) A947T probably benign Het
Ppp1r3g G A 13: 36,152,834 (GRCm39) D85N possibly damaging Het
Pramel34 G A 5: 93,785,969 (GRCm39) H104Y possibly damaging Het
Prom2 A C 2: 127,380,185 (GRCm39) V349G probably damaging Het
Prrc2c C T 1: 162,541,843 (GRCm39) S382N probably benign Het
Rai14 A T 15: 10,592,204 (GRCm39) N230K probably benign Het
Rexo5 A T 7: 119,402,025 (GRCm39) K142I probably damaging Het
Rgs22 T C 15: 36,098,409 (GRCm39) H484R probably damaging Het
Rims2 C T 15: 39,543,086 (GRCm39) A1440V probably damaging Het
Serpinb1a T C 13: 33,026,946 (GRCm39) E332G probably damaging Het
Sh2b1 TGGGGACCAGCTCAGCCACGGGGACCAGCTC TGGGGACCAGCTCAGCCACGGGGACCAGCTCAGCCACGGGGACCAGCTC 7: 126,066,742 (GRCm39) probably benign Het
Slc26a7 C T 4: 14,516,165 (GRCm39) G555S possibly damaging Het
Slc4a2 A T 5: 24,639,123 (GRCm39) D386V probably damaging Het
Slc6a17 C T 3: 107,384,551 (GRCm39) V350M probably damaging Het
Smc2 A G 4: 52,449,361 (GRCm39) Y174C probably damaging Het
Smoc2 A G 17: 14,619,686 (GRCm39) Y355C probably damaging Het
Smpd1 T A 7: 105,204,442 (GRCm39) V107E probably benign Het
Snapc1 T C 12: 74,018,773 (GRCm39) probably benign Het
Spata31e2 T C 1: 26,722,426 (GRCm39) D918G possibly damaging Het
Steap4 T G 5: 8,026,683 (GRCm39) F215L probably benign Het
Tbc1d1 T A 5: 64,435,364 (GRCm39) S501T probably damaging Het
Tec A G 5: 72,926,117 (GRCm39) Y312H probably damaging Het
Ticrr C A 7: 79,343,516 (GRCm39) T1127K possibly damaging Het
Tlk2 A G 11: 105,147,722 (GRCm39) D438G probably benign Het
Tln2 C A 9: 67,277,980 (GRCm39) V343L probably benign Het
Tmem156 T A 5: 65,231,148 (GRCm39) I241F probably damaging Het
Tmtc1 G T 6: 148,186,390 (GRCm39) N559K probably benign Het
Trbv4 A T 6: 41,036,696 (GRCm39) I74F probably benign Het
Trmt1l C T 1: 151,328,899 (GRCm39) P524S probably damaging Het
Trpa1 A T 1: 14,956,040 (GRCm39) C776* probably null Het
Ttc41 T A 10: 86,599,830 (GRCm39) S1043R probably benign Het
Ttn A G 2: 76,576,646 (GRCm39) L24749S probably damaging Het
Ube2o C T 11: 116,471,942 (GRCm39) G100R probably damaging Het
Unc5b T C 10: 60,609,532 (GRCm39) E588G possibly damaging Het
Usp43 G T 11: 67,770,922 (GRCm39) Q571K probably damaging Het
Vmn1r127 G A 7: 21,052,927 (GRCm39) P287L possibly damaging Het
Wasf3 T A 5: 146,397,857 (GRCm39) M208K possibly damaging Het
Xab2 A G 8: 3,663,000 (GRCm39) F527S possibly damaging Het
Zfp644 T G 5: 106,785,774 (GRCm39) N258H possibly damaging Het
Zfp947 A C 17: 22,364,594 (GRCm39) F360C probably damaging Het
Other mutations in Myo16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00421:Myo16 APN 8 10,488,889 (GRCm39) missense probably damaging 1.00
IGL00567:Myo16 APN 8 10,512,154 (GRCm39) missense probably damaging 1.00
IGL00671:Myo16 APN 8 10,411,067 (GRCm39) missense probably damaging 1.00
IGL00897:Myo16 APN 8 10,365,518 (GRCm39) missense probably damaging 1.00
IGL01458:Myo16 APN 8 10,485,853 (GRCm39) missense probably damaging 1.00
IGL01523:Myo16 APN 8 10,420,908 (GRCm39) missense probably damaging 1.00
IGL01532:Myo16 APN 8 10,450,551 (GRCm39) missense probably benign 0.00
IGL01680:Myo16 APN 8 10,322,630 (GRCm39) missense probably damaging 1.00
IGL01747:Myo16 APN 8 10,654,877 (GRCm39) missense probably damaging 1.00
IGL02084:Myo16 APN 8 10,411,088 (GRCm39) missense probably damaging 0.99
IGL02203:Myo16 APN 8 10,620,132 (GRCm39) missense possibly damaging 0.52
IGL02506:Myo16 APN 8 10,440,217 (GRCm39) missense probably damaging 1.00
IGL02819:Myo16 APN 8 10,372,600 (GRCm39) missense probably damaging 1.00
IGL02935:Myo16 APN 8 10,582,990 (GRCm39) missense probably benign 0.41
IGL02943:Myo16 APN 8 10,450,595 (GRCm39) splice site probably benign
IGL03347:Myo16 APN 8 10,426,120 (GRCm39) critical splice acceptor site probably null
3-1:Myo16 UTSW 8 10,488,869 (GRCm39) missense probably damaging 0.99
P0016:Myo16 UTSW 8 10,450,596 (GRCm39) splice site probably benign
R0006:Myo16 UTSW 8 10,525,988 (GRCm39) missense probably damaging 0.98
R0006:Myo16 UTSW 8 10,525,988 (GRCm39) missense probably damaging 0.98
R0033:Myo16 UTSW 8 10,420,955 (GRCm39) missense probably damaging 1.00
R0033:Myo16 UTSW 8 10,420,955 (GRCm39) missense probably damaging 1.00
R0142:Myo16 UTSW 8 10,619,790 (GRCm39) missense probably benign 0.01
R0195:Myo16 UTSW 8 10,365,538 (GRCm39) splice site probably benign
R0418:Myo16 UTSW 8 10,619,918 (GRCm39) missense probably benign 0.01
R0576:Myo16 UTSW 8 10,612,318 (GRCm39) critical splice donor site probably null
R0627:Myo16 UTSW 8 10,489,689 (GRCm39) missense probably benign 0.15
R0826:Myo16 UTSW 8 10,426,285 (GRCm39) splice site probably benign
R0835:Myo16 UTSW 8 10,322,766 (GRCm39) missense probably damaging 1.00
R1015:Myo16 UTSW 8 10,440,183 (GRCm39) missense probably benign 0.17
R1052:Myo16 UTSW 8 10,620,181 (GRCm39) missense possibly damaging 0.92
R1180:Myo16 UTSW 8 10,446,908 (GRCm39) missense probably damaging 1.00
R1185:Myo16 UTSW 8 10,683,624 (GRCm39) missense probably damaging 1.00
R1185:Myo16 UTSW 8 10,683,624 (GRCm39) missense probably damaging 1.00
R1474:Myo16 UTSW 8 10,552,796 (GRCm39) missense probably damaging 1.00
R1484:Myo16 UTSW 8 10,610,145 (GRCm39) missense probably damaging 1.00
R1503:Myo16 UTSW 8 10,552,817 (GRCm39) missense probably benign 0.44
R1733:Myo16 UTSW 8 10,492,283 (GRCm39) missense probably damaging 0.98
R1873:Myo16 UTSW 8 10,322,789 (GRCm39) missense probably damaging 1.00
R1885:Myo16 UTSW 8 10,372,656 (GRCm39) missense probably damaging 1.00
R1943:Myo16 UTSW 8 10,644,905 (GRCm39) missense possibly damaging 0.63
R2013:Myo16 UTSW 8 10,552,796 (GRCm39) missense probably damaging 1.00
R2019:Myo16 UTSW 8 10,426,260 (GRCm39) missense probably benign 0.05
R2022:Myo16 UTSW 8 10,322,633 (GRCm39) missense probably benign 0.08
R2214:Myo16 UTSW 8 10,488,803 (GRCm39) missense probably damaging 1.00
R2228:Myo16 UTSW 8 10,644,905 (GRCm39) missense possibly damaging 0.63
R2351:Myo16 UTSW 8 10,644,905 (GRCm39) missense possibly damaging 0.63
R2352:Myo16 UTSW 8 10,644,905 (GRCm39) missense possibly damaging 0.63
R2357:Myo16 UTSW 8 10,644,905 (GRCm39) missense possibly damaging 0.63
R2566:Myo16 UTSW 8 10,644,820 (GRCm39) missense probably benign 0.43
R3402:Myo16 UTSW 8 10,434,719 (GRCm39) missense probably benign
R3870:Myo16 UTSW 8 10,492,239 (GRCm39) missense probably benign 0.25
R4080:Myo16 UTSW 8 10,612,240 (GRCm39) missense probably damaging 1.00
R4498:Myo16 UTSW 8 10,485,869 (GRCm39) missense probably benign 0.01
R4631:Myo16 UTSW 8 10,556,984 (GRCm39) missense probably damaging 1.00
R4689:Myo16 UTSW 8 10,488,890 (GRCm39) missense probably damaging 1.00
R4736:Myo16 UTSW 8 10,423,527 (GRCm39) missense probably damaging 1.00
R4738:Myo16 UTSW 8 10,423,527 (GRCm39) missense probably damaging 1.00
R4739:Myo16 UTSW 8 10,423,527 (GRCm39) missense probably damaging 1.00
R4764:Myo16 UTSW 8 10,485,880 (GRCm39) missense probably damaging 1.00
R4778:Myo16 UTSW 8 10,619,694 (GRCm39) missense probably damaging 0.97
R4852:Myo16 UTSW 8 10,423,474 (GRCm39) missense probably damaging 1.00
R4885:Myo16 UTSW 8 10,488,892 (GRCm39) missense probably damaging 0.98
R4993:Myo16 UTSW 8 10,526,094 (GRCm39) missense probably damaging 0.99
R5077:Myo16 UTSW 8 10,372,658 (GRCm39) missense probably damaging 1.00
R5135:Myo16 UTSW 8 10,526,114 (GRCm39) missense probably benign
R5170:Myo16 UTSW 8 10,619,745 (GRCm39) missense probably benign 0.30
R5203:Myo16 UTSW 8 10,410,995 (GRCm39) missense probably damaging 1.00
R5246:Myo16 UTSW 8 10,612,212 (GRCm39) nonsense probably null
R5517:Myo16 UTSW 8 10,610,226 (GRCm39) missense probably benign 0.22
R5567:Myo16 UTSW 8 10,372,676 (GRCm39) missense probably damaging 1.00
R5694:Myo16 UTSW 8 10,619,606 (GRCm39) missense probably benign 0.01
R5749:Myo16 UTSW 8 10,463,245 (GRCm39) missense probably benign 0.01
R6131:Myo16 UTSW 8 10,619,877 (GRCm39) missense probably benign
R6213:Myo16 UTSW 8 10,420,963 (GRCm39) critical splice donor site probably null
R6216:Myo16 UTSW 8 10,365,494 (GRCm39) missense probably benign 0.01
R6240:Myo16 UTSW 8 10,420,930 (GRCm39) missense probably damaging 1.00
R6628:Myo16 UTSW 8 10,620,638 (GRCm39) missense probably damaging 0.99
R6935:Myo16 UTSW 8 10,619,820 (GRCm39) missense probably benign 0.37
R6996:Myo16 UTSW 8 10,619,496 (GRCm39) missense probably damaging 1.00
R7103:Myo16 UTSW 8 10,619,673 (GRCm39) missense unknown
R7164:Myo16 UTSW 8 10,619,585 (GRCm39) missense unknown
R7255:Myo16 UTSW 8 10,549,169 (GRCm39) missense unknown
R7266:Myo16 UTSW 8 10,322,687 (GRCm39) missense unknown
R7319:Myo16 UTSW 8 10,526,185 (GRCm39) splice site probably null
R7398:Myo16 UTSW 8 10,612,183 (GRCm39) missense unknown
R7442:Myo16 UTSW 8 10,322,537 (GRCm39) missense probably damaging 1.00
R7498:Myo16 UTSW 8 10,450,589 (GRCm39) missense unknown
R7539:Myo16 UTSW 8 10,411,095 (GRCm39) critical splice donor site probably null
R7622:Myo16 UTSW 8 10,426,238 (GRCm39) missense unknown
R7794:Myo16 UTSW 8 10,619,913 (GRCm39) missense unknown
R7903:Myo16 UTSW 8 10,426,265 (GRCm39) missense probably null
R8055:Myo16 UTSW 8 10,612,186 (GRCm39) missense unknown
R8078:Myo16 UTSW 8 10,612,078 (GRCm39) missense unknown
R8081:Myo16 UTSW 8 10,372,743 (GRCm39) missense unknown
R8679:Myo16 UTSW 8 10,411,042 (GRCm39) missense unknown
R8700:Myo16 UTSW 8 10,463,172 (GRCm39) missense unknown
R8939:Myo16 UTSW 8 10,524,679 (GRCm39) missense probably damaging 0.99
R8955:Myo16 UTSW 8 10,426,175 (GRCm39) missense probably damaging 1.00
R8968:Myo16 UTSW 8 10,619,700 (GRCm39) missense unknown
R9187:Myo16 UTSW 8 10,492,233 (GRCm39) missense unknown
R9219:Myo16 UTSW 8 10,492,236 (GRCm39) missense unknown
R9327:Myo16 UTSW 8 10,489,705 (GRCm39) critical splice donor site probably null
R9763:Myo16 UTSW 8 10,450,528 (GRCm39) missense unknown
R9765:Myo16 UTSW 8 10,620,401 (GRCm39) missense probably damaging 0.97
R9790:Myo16 UTSW 8 10,619,925 (GRCm39) missense unknown
R9791:Myo16 UTSW 8 10,619,925 (GRCm39) missense unknown
X0066:Myo16 UTSW 8 10,426,185 (GRCm39) missense probably damaging 1.00
Z1177:Myo16 UTSW 8 10,524,691 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- AGAGCGTATGTCAAGGATGCC -3'
(R):5'- TGACTGCAGGCTGTTCATG -3'

Sequencing Primer
(F):5'- CGTATGTCAAGGATGCCAAGTG -3'
(R):5'- GGCCTTTGAATGTGGAATAGTAACAC -3'
Posted On 2022-03-25