Incidental Mutation 'R9293:Olfr918'
ID 704398
Institutional Source Beutler Lab
Gene Symbol Olfr918
Ensembl Gene ENSMUSG00000046150
Gene Name olfactory receptor 918
Synonyms GA_x6K02T2PVTD-32375756-32374818, MOR164-3
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.161) question?
Stock # R9293 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 38669861-38674601 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 38673118 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 109 (I109V)
Ref Sequence ENSEMBL: ENSMUSP00000150182 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055099] [ENSMUST00000215461]
AlphaFold E9PVZ7
Predicted Effect probably damaging
Transcript: ENSMUST00000055099
AA Change: I122V

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000057210
Gene: ENSMUSG00000046150
AA Change: I122V

DomainStartEndE-ValueType
transmembrane domain 9 31 N/A INTRINSIC
Pfam:7tm_4 44 319 6.5e-48 PFAM
Pfam:7tm_1 54 301 3.9e-22 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000215461
AA Change: I109V

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.8%
Validation Efficiency 95% (54/57)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002E22Rik T C 3: 138,066,078 S343P possibly damaging Het
1700007G11Rik C T 5: 98,498,303 A86V probably benign Het
4930563M21Rik T A 9: 56,009,284 E36D unknown Het
Abcc8 T G 7: 46,106,668 K1450T probably benign Het
Aox2 A T 1: 58,322,794 N720Y possibly damaging Het
AW549877 T C 15: 3,991,854 D73G probably damaging Het
BC034090 T C 1: 155,225,772 T249A probably benign Het
Brf2 A T 8: 27,123,993 S388R probably damaging Het
Ccdc180 A T 4: 45,944,461 Q1437L probably damaging Het
Cdc42ep1 A C 15: 78,849,825 D375A probably benign Het
Cep85l T C 10: 53,298,186 Y487C probably damaging Het
Chd3 C T 11: 69,353,201 R1346H possibly damaging Het
Cltc T A 11: 86,712,620 R793S possibly damaging Het
Crat A G 2: 30,408,202 F162L probably benign Het
Cyp3a44 C A 5: 145,774,377 V495L probably benign Het
Dchs2 C T 3: 83,282,054 T1575I possibly damaging Het
Ddx60 A G 8: 62,009,960 T1292A possibly damaging Het
Dnah12 C T 14: 26,773,059 A109V probably benign Het
Foxo3 C T 10: 42,197,025 V499M probably damaging Het
Fry T C 5: 150,495,832 S546P Het
Hfe T C 13: 23,706,809 K204E probably benign Het
Hibch T A 1: 52,913,827 Y329N probably damaging Het
Irf9 T G 14: 55,608,790 I426S probably damaging Het
Kif26a C A 12: 112,146,401 P13T probably damaging Het
Lhx5 A C 5: 120,432,386 K36Q probably benign Het
Mdn1 T C 4: 32,707,579 S1623P probably damaging Het
Mre11a T C 9: 14,799,588 F193L probably damaging Het
Mybl2 G A 2: 163,068,215 G187E probably damaging Het
Myh1 A T 11: 67,209,103 Q613L probably benign Het
Myo5a T A 9: 75,180,030 M1056K probably benign Het
Olfr1 T C 11: 73,395,129 K298E probably damaging Het
Olfr1197 G A 2: 88,729,455 T48I probably benign Het
Olfr610 C T 7: 103,506,520 R142H probably benign Het
Pcdhga12 G A 18: 37,767,887 V591M probably damaging Het
Phyhipl A G 10: 70,565,286 S161P probably damaging Het
Pmfbp1 A G 8: 109,536,573 T775A probably benign Het
Pou3f3 T C 1: 42,697,522 V126A unknown Het
Reg4 A C 3: 98,236,315 K142Q possibly damaging Het
Sec22c G T 9: 121,688,248 A199E probably damaging Het
Sema3d C T 5: 12,553,214 P395S probably damaging Het
Sh2b2 C T 5: 136,232,039 E108K possibly damaging Het
Slfn3 A G 11: 83,214,790 K538E possibly damaging Het
Spatc1l A T 10: 76,569,366 D194V probably damaging Het
Stoml3 T C 3: 53,500,764 V77A possibly damaging Het
Taco1 A G 11: 106,073,104 I230V probably benign Het
Tfcp2 T C 15: 100,514,053 T346A probably benign Het
Tmem8b C T 4: 43,686,188 T273M probably damaging Het
Trav6-1 A G 14: 52,638,842 N73S probably benign Het
Trav6d-5 A G 14: 52,795,603 D103G probably damaging Het
Ttll5 T A 12: 85,891,032 L379Q probably damaging Het
Ube3c T A 5: 29,598,848 probably benign Het
Ubr3 A C 2: 69,897,425 D44A probably benign Het
Upp2 G T 2: 58,567,431 R5L unknown Het
Vmn1r43 G A 6: 89,869,895 T203M probably damaging Het
Vmn2r17 C T 5: 109,452,846 T670I probably damaging Het
Zfp433 A T 10: 81,720,288 H208L probably damaging Het
Zfp616 A T 11: 74,083,918 I429F possibly damaging Het
Other mutations in Olfr918
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00958:Olfr918 APN 9 38673024 missense probably benign 0.01
IGL01388:Olfr918 APN 9 38673083 nonsense probably null
IGL01516:Olfr918 APN 9 38672863 missense probably benign 0.09
IGL02121:Olfr918 APN 9 38673415 missense probably damaging 0.98
IGL02209:Olfr918 APN 9 38673046 missense possibly damaging 0.84
IGL02256:Olfr918 APN 9 38673480 start codon destroyed probably null
IGL02517:Olfr918 APN 9 38672913 missense probably damaging 1.00
IGL02648:Olfr918 APN 9 38673016 missense probably benign
IGL02747:Olfr918 APN 9 38673084 missense probably benign 0.11
IGL02971:Olfr918 APN 9 38673268 missense probably damaging 0.96
E0370:Olfr918 UTSW 9 38672561 missense probably damaging 0.99
R0616:Olfr918 UTSW 9 38673480 start codon destroyed probably null
R2173:Olfr918 UTSW 9 38672944 missense probably benign 0.03
R2989:Olfr918 UTSW 9 38672535 missense probably benign
R3430:Olfr918 UTSW 9 38673139 missense probably damaging 1.00
R3809:Olfr918 UTSW 9 38672863 missense probably benign 0.09
R4688:Olfr918 UTSW 9 38673363 missense probably damaging 1.00
R4702:Olfr918 UTSW 9 38673480 start codon destroyed probably null
R5548:Olfr918 UTSW 9 38673304 missense probably benign 0.00
R5590:Olfr918 UTSW 9 38672965 missense probably damaging 1.00
R6082:Olfr918 UTSW 9 38672570 missense probably damaging 1.00
R6214:Olfr918 UTSW 9 38673214 missense probably benign 0.13
R6215:Olfr918 UTSW 9 38673214 missense probably benign 0.13
R6893:Olfr918 UTSW 9 38673059 missense possibly damaging 0.95
R7215:Olfr918 UTSW 9 38673447 missense probably benign 0.05
R7624:Olfr918 UTSW 9 38672623 missense probably benign 0.18
R7862:Olfr918 UTSW 9 38673328 missense probably benign 0.01
R8116:Olfr918 UTSW 9 38673168 missense possibly damaging 0.93
R8897:Olfr918 UTSW 9 38672851 missense probably damaging 1.00
R8899:Olfr918 UTSW 9 38672851 missense probably damaging 1.00
R9114:Olfr918 UTSW 9 38672596 missense probably benign
R9311:Olfr918 UTSW 9 38672629 missense probably damaging 1.00
R9690:Olfr918 UTSW 9 38673181 nonsense probably null
R9734:Olfr918 UTSW 9 38672943 missense probably benign
Predicted Primers PCR Primer
(F):5'- TTGCAGAAGATCAGTCGGAG -3'
(R):5'- TCACAGTGGTGGGAAACTTGG -3'

Sequencing Primer
(F):5'- ATCAGTCGGAGCATGCAGC -3'
(R):5'- GAAACTTGGGCTTGATCATCC -3'
Posted On 2022-03-25