Incidental Mutation 'R9293:Or8b3b'
ID 704398
Institutional Source Beutler Lab
Gene Symbol Or8b3b
Ensembl Gene ENSMUSG00000046150
Gene Name olfactory receptor family 8 subfamily B member 3B
Synonyms GA_x6K02T2PVTD-32375756-32374818, MOR164-3, Olfr918
MMRRC Submission 068991-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.259) question?
Stock # R9293 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 38583800-38584777 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 38584414 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 109 (I109V)
Ref Sequence ENSEMBL: ENSMUSP00000150182 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055099] [ENSMUST00000215461]
AlphaFold E9PVZ7
Predicted Effect probably damaging
Transcript: ENSMUST00000055099
AA Change: I122V

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000057210
Gene: ENSMUSG00000046150
AA Change: I122V

DomainStartEndE-ValueType
transmembrane domain 9 31 N/A INTRINSIC
Pfam:7tm_4 44 319 6.5e-48 PFAM
Pfam:7tm_1 54 301 3.9e-22 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000215461
AA Change: I109V

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.8%
Validation Efficiency 95% (54/57)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002E22Rik T C 3: 137,771,839 (GRCm39) S343P possibly damaging Het
4930563M21Rik T A 9: 55,916,568 (GRCm39) E36D unknown Het
Abcc8 T G 7: 45,756,092 (GRCm39) K1450T probably benign Het
Aox1 A T 1: 58,361,953 (GRCm39) N720Y possibly damaging Het
BC034090 T C 1: 155,101,518 (GRCm39) T249A probably benign Het
Brf2 A T 8: 27,614,021 (GRCm39) S388R probably damaging Het
Ccdc180 A T 4: 45,944,461 (GRCm39) Q1437L probably damaging Het
Cdc42ep1 A C 15: 78,734,025 (GRCm39) D375A probably benign Het
Cep85l T C 10: 53,174,282 (GRCm39) Y487C probably damaging Het
Cfap299 C T 5: 98,646,162 (GRCm39) A86V probably benign Het
Chd3 C T 11: 69,244,027 (GRCm39) R1346H possibly damaging Het
Cltc T A 11: 86,603,446 (GRCm39) R793S possibly damaging Het
Crat A G 2: 30,298,214 (GRCm39) F162L probably benign Het
Cyp3a44 C A 5: 145,711,187 (GRCm39) V495L probably benign Het
Dchs2 C T 3: 83,189,361 (GRCm39) T1575I possibly damaging Het
Ddx60 A G 8: 62,462,994 (GRCm39) T1292A possibly damaging Het
Dnah12 C T 14: 26,495,016 (GRCm39) A109V probably benign Het
Foxo3 C T 10: 42,073,021 (GRCm39) V499M probably damaging Het
Fry T C 5: 150,419,297 (GRCm39) S546P Het
Hfe T C 13: 23,890,792 (GRCm39) K204E probably benign Het
Hibch T A 1: 52,952,986 (GRCm39) Y329N probably damaging Het
Irf9 T G 14: 55,846,247 (GRCm39) I426S probably damaging Het
Kif26a C A 12: 112,112,835 (GRCm39) P13T probably damaging Het
Lhx5 A C 5: 120,570,451 (GRCm39) K36Q probably benign Het
Mdn1 T C 4: 32,707,579 (GRCm39) S1623P probably damaging Het
Mre11a T C 9: 14,710,884 (GRCm39) F193L probably damaging Het
Mybl2 G A 2: 162,910,135 (GRCm39) G187E probably damaging Het
Myh1 A T 11: 67,099,929 (GRCm39) Q613L probably benign Het
Myo5a T A 9: 75,087,312 (GRCm39) M1056K probably benign Het
Or1e16 T C 11: 73,285,955 (GRCm39) K298E probably damaging Het
Or4a27 G A 2: 88,559,799 (GRCm39) T48I probably benign Het
Or51ag1 C T 7: 103,155,727 (GRCm39) R142H probably benign Het
Pcdhga12 G A 18: 37,900,940 (GRCm39) V591M probably damaging Het
Phyhipl A G 10: 70,401,116 (GRCm39) S161P probably damaging Het
Pmfbp1 A G 8: 110,263,205 (GRCm39) T775A probably benign Het
Pou3f3 T C 1: 42,736,682 (GRCm39) V126A unknown Het
Reg4 A C 3: 98,143,631 (GRCm39) K142Q possibly damaging Het
Rimoc1 T C 15: 4,021,336 (GRCm39) D73G probably damaging Het
Sec22c G T 9: 121,517,314 (GRCm39) A199E probably damaging Het
Sema3d C T 5: 12,603,181 (GRCm39) P395S probably damaging Het
Sh2b2 C T 5: 136,260,893 (GRCm39) E108K possibly damaging Het
Slfn3 A G 11: 83,105,616 (GRCm39) K538E possibly damaging Het
Spatc1l A T 10: 76,405,200 (GRCm39) D194V probably damaging Het
Stoml3 T C 3: 53,408,185 (GRCm39) V77A possibly damaging Het
Taco1 A G 11: 105,963,930 (GRCm39) I230V probably benign Het
Tfcp2 T C 15: 100,411,934 (GRCm39) T346A probably benign Het
Tmem8b C T 4: 43,686,188 (GRCm39) T273M probably damaging Het
Trav6-1 A G 14: 52,876,299 (GRCm39) N73S probably benign Het
Trav6d-5 A G 14: 53,033,060 (GRCm39) D103G probably damaging Het
Ttll5 T A 12: 85,937,806 (GRCm39) L379Q probably damaging Het
Ube3c T A 5: 29,803,846 (GRCm39) probably benign Het
Ubr3 A C 2: 69,727,769 (GRCm39) D44A probably benign Het
Upp2 G T 2: 58,457,443 (GRCm39) R5L unknown Het
Vmn1r43 G A 6: 89,846,877 (GRCm39) T203M probably damaging Het
Vmn2r17 C T 5: 109,600,712 (GRCm39) T670I probably damaging Het
Zfp433 A T 10: 81,556,122 (GRCm39) H208L probably damaging Het
Zfp616 A T 11: 73,974,744 (GRCm39) I429F possibly damaging Het
Other mutations in Or8b3b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00958:Or8b3b APN 9 38,584,320 (GRCm39) missense probably benign 0.01
IGL01388:Or8b3b APN 9 38,584,379 (GRCm39) nonsense probably null
IGL01516:Or8b3b APN 9 38,584,159 (GRCm39) missense probably benign 0.09
IGL02121:Or8b3b APN 9 38,584,711 (GRCm39) missense probably damaging 0.98
IGL02209:Or8b3b APN 9 38,584,342 (GRCm39) missense possibly damaging 0.84
IGL02256:Or8b3b APN 9 38,584,776 (GRCm39) start codon destroyed probably null
IGL02517:Or8b3b APN 9 38,584,209 (GRCm39) missense probably damaging 1.00
IGL02648:Or8b3b APN 9 38,584,312 (GRCm39) missense probably benign
IGL02747:Or8b3b APN 9 38,584,380 (GRCm39) missense probably benign 0.11
IGL02971:Or8b3b APN 9 38,584,564 (GRCm39) missense probably damaging 0.96
E0370:Or8b3b UTSW 9 38,583,857 (GRCm39) missense probably damaging 0.99
R0616:Or8b3b UTSW 9 38,584,776 (GRCm39) start codon destroyed probably null
R2173:Or8b3b UTSW 9 38,584,240 (GRCm39) missense probably benign 0.03
R2989:Or8b3b UTSW 9 38,583,831 (GRCm39) missense probably benign
R3430:Or8b3b UTSW 9 38,584,435 (GRCm39) missense probably damaging 1.00
R3809:Or8b3b UTSW 9 38,584,159 (GRCm39) missense probably benign 0.09
R4688:Or8b3b UTSW 9 38,584,659 (GRCm39) missense probably damaging 1.00
R4702:Or8b3b UTSW 9 38,584,776 (GRCm39) start codon destroyed probably null
R5548:Or8b3b UTSW 9 38,584,600 (GRCm39) missense probably benign 0.00
R5590:Or8b3b UTSW 9 38,584,261 (GRCm39) missense probably damaging 1.00
R6082:Or8b3b UTSW 9 38,583,866 (GRCm39) missense probably damaging 1.00
R6214:Or8b3b UTSW 9 38,584,510 (GRCm39) missense probably benign 0.13
R6215:Or8b3b UTSW 9 38,584,510 (GRCm39) missense probably benign 0.13
R6893:Or8b3b UTSW 9 38,584,355 (GRCm39) missense possibly damaging 0.95
R7215:Or8b3b UTSW 9 38,584,743 (GRCm39) missense probably benign 0.05
R7624:Or8b3b UTSW 9 38,583,919 (GRCm39) missense probably benign 0.18
R7862:Or8b3b UTSW 9 38,584,624 (GRCm39) missense probably benign 0.01
R8116:Or8b3b UTSW 9 38,584,464 (GRCm39) missense possibly damaging 0.93
R8897:Or8b3b UTSW 9 38,584,147 (GRCm39) missense probably damaging 1.00
R8899:Or8b3b UTSW 9 38,584,147 (GRCm39) missense probably damaging 1.00
R9114:Or8b3b UTSW 9 38,583,892 (GRCm39) missense probably benign
R9311:Or8b3b UTSW 9 38,583,925 (GRCm39) missense probably damaging 1.00
R9690:Or8b3b UTSW 9 38,584,477 (GRCm39) nonsense probably null
R9734:Or8b3b UTSW 9 38,584,239 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TTGCAGAAGATCAGTCGGAG -3'
(R):5'- TCACAGTGGTGGGAAACTTGG -3'

Sequencing Primer
(F):5'- ATCAGTCGGAGCATGCAGC -3'
(R):5'- GAAACTTGGGCTTGATCATCC -3'
Posted On 2022-03-25