Mutagenetix > Incidental Mutation

Incidental Mutation 'R9294:Hdac10'

704499

Institutional Source

Beutler Lab

Gene Symbol

Hdac10

Ensembl Gene

ENSMUSG00000062906

Gene Name

histone deacetylase 10

Synonyms

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

R9294 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

89123307-89128700 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 89126277 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Arginine at position 281 (C281R)

Ref Sequence

ENSEMBL: ENSMUSP00000080832 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000041656] [ENSMUST00000082197] [ENSMUST00000088827] [ENSMUST00000109347] [ENSMUST00000109353]

AlphaFold

Q6P3E7

Predicted Effect

probably benign
Transcript: ENSMUST00000041656

SMART Domains

Protein: ENSMUSP00000040132
Gene: ENSMUSG00000051786

Domain	Start	End	E-Value	Type
Pfam:Spc97_Spc98	355	1667	3.3e-119	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000082197
AA Change: C281R

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000080832
Gene: ENSMUSG00000062906
AA Change: C281R

Domain	Start	End	E-Value	Type
Pfam:Hist_deacetyl	13	322	2.1e-85	PFAM
low complexity region	478	489	N/A	INTRINSIC
low complexity region	583	595	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000088827

SMART Domains

Protein: ENSMUSP00000086207
Gene: ENSMUSG00000022610

Domain	Start	End	E-Value	Type
S_TKc	27	311	1.63e-96	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000109347

SMART Domains

Protein: ENSMUSP00000104971
Gene: ENSMUSG00000062906

Domain	Start	End	E-Value	Type
Pfam:Hist_deacetyl	13	251	6.1e-66	PFAM
low complexity region	270	282	N/A	INTRINSIC
low complexity region	398	409	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000109353

SMART Domains

Protein: ENSMUSP00000104977
Gene: ENSMUSG00000051786

Domain	Start	End	E-Value	Type
Pfam:Spc97_Spc98	355	1675	2.8e-94	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 98.8%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the histone deacetylase family, members of which deacetylate lysine residues on the N-terminal part of the core histones. Histone deacetylation modulates chromatin structure, and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Allele List at MGI

Other mutations in this stock

Total: 87 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
0610009O20Rik	T	G	18: 38,261,076	L442R	probably damaging	Het
1700067K01Rik	A	G	8: 84,003,379	Y165C	probably damaging	Het
2410089E03Rik	T	C	15: 8,203,327	V1110A	probably benign	Het
2810474O19Rik	T	A	6: 149,326,432	N325K	probably benign	Het
4930452B06Rik	A	G	14: 8,578,361	I127T	possibly damaging	Het
Abcb11	T	A	2: 69,265,496	K833N	possibly damaging	Het
Abcb1a	T	A	5: 8,686,171	M188K	probably benign	Het
Akap1	A	T	11: 88,837,140	V672D	probably damaging	Het
Anapc4	A	G	5: 52,864,525	T650A	possibly damaging	Het
Ash1l	C	A	3: 88,982,990	S725R	possibly damaging	Het
Axdnd1	T	A	1: 156,420,347	K28*	probably null	Het
C8b	C	A	4: 104,786,995	H286Q	probably benign	Het
Cacna2d1	A	G	5: 16,012,398	K34E	probably damaging	Het
Ccdc14	T	A	16: 34,697,358	H154Q	probably damaging	Het
Ccdc184	A	G	15: 98,168,512	D66G	probably damaging	Het
Ccdc62	A	G	5: 123,954,709	I586V	possibly damaging	Het
Chadl	A	T	15: 81,694,490	C313S	probably damaging	Het
Clec14a	C	A	12: 58,268,750	A29S	probably damaging	Het
Col26a1	C	T	5: 136,757,754	G161D	probably benign	Het
Ctbp2	A	G	7: 133,014,232	S325P	probably damaging	Het
Dcaf13	A	G	15: 39,130,292	D260G	possibly damaging	Het
Dhx37	G	A	5: 125,422,672	P575L	probably benign	Het
Dnajc6	T	C	4: 101,550,857		probably null	Het
Eapp	T	C	12: 54,690,276	T145A	unknown	Het
Efcab5	A	G	11: 77,121,238	M730T	probably benign	Het
Eif4g3	T	A	4: 138,190,657	D1305E	probably damaging	Het
Endou	A	T	15: 97,712,065	V450E	probably benign	Het
F10	A	T	8: 13,048,177	K127*	probably null	Het
Fbxw21	A	G	9: 109,143,762	F368S	probably damaging	Het
Fezf1	A	T	6: 23,245,798	L456Q	possibly damaging	Het
Foxo3	C	T	10: 42,197,025	V499M	probably damaging	Het
Fyco1	A	C	9: 123,794,813	C1384G	probably damaging	Het
Galnt6	G	T	15: 100,704,151	S258R	possibly damaging	Het
Gemin5	A	G	11: 58,137,748	V882A	probably benign	Het
Gm10750	A	G	2: 149,016,187	L48P	unknown	Het
Gm11639	A	G	11: 104,831,300	I1913V	probably benign	Het
Gm16503	T	A	4: 147,541,114	F22I	unknown	Het
Hikeshi	T	C	7: 89,935,760	S79G	probably damaging	Het
Ifitm2	AG	A	7: 140,955,901		probably null	Het
Itpr3	A	G	17: 27,111,217	E1603G	probably damaging	Het
Lrrc37a	A	T	11: 103,504,533	V22E	probably benign	Het
Man1a	C	T	10: 53,933,491		probably null	Het
Mdga1	A	G	17: 29,839,897	L5P	probably damaging	Het
Mettl7a1	A	G	15: 100,313,133	E213G	probably damaging	Het
Mup6	A	G	4: 60,004,838	I76M	probably benign	Het
Nbea	A	T	3: 56,091,092	M98K	probably benign	Het
Nckap1l	A	G	15: 103,473,539	E454G	probably damaging	Het
Notch3	A	T	17: 32,143,691	L1320Q	probably benign	Het
Nrn1	A	T	13: 36,726,674	L128H	probably damaging	Het
Numa1	T	C	7: 101,995,416	S200P	possibly damaging	Het
Numa1	A	G	7: 102,012,796	D1898G	probably damaging	Het
Olfr1124	G	A	2: 87,434,666	A60T	probably benign	Het
Olfr152	A	C	2: 87,782,523		probably null	Het
Olfr366	T	C	2: 37,220,110	I207T	possibly damaging	Het
Olfr700	A	T	7: 106,806,398	S21R	possibly damaging	Het
P2ry6	A	T	7: 100,938,926	Y75*	probably null	Het
Pbrm1	T	A	14: 31,084,803	C1062*	probably null	Het
Pcdh15	A	G	10: 74,643,728	E557G	unknown	Het
Pcdh7	T	C	5: 57,721,335	L744P	probably benign	Het
Plekhg3	A	T	12: 76,562,278	I142L	possibly damaging	Het
Plk4	C	T	3: 40,811,891	H695Y	probably damaging	Het
Pms1	T	C	1: 53,208,057	H243R	probably benign	Het
Prdm14	T	C	1: 13,122,483	D344G	possibly damaging	Het
R3hdml	A	G	2: 163,502,332	I214V	probably benign	Het
Rab11fip5	T	C	6: 85,348,710	N238S	probably benign	Het
Sacs	T	A	14: 61,240,319	Y732N	possibly damaging	Het
Scfd1	T	A	12: 51,393,866	M187K	possibly damaging	Het
Serpina1d	A	G	12: 103,767,998	C16R	probably damaging	Het
Slc2a12	T	C	10: 22,665,095	I283T	possibly damaging	Het
Smarca5	A	G	8: 80,719,803	Y423H	probably damaging	Het
Srrm3	C	A	5: 135,868,261	A366E	unknown	Het
St7	A	T	6: 17,844,914	K134*	probably null	Het
St8sia5	T	G	18: 77,254,829	C412G	probably damaging	Het
Tanc2	A	T	11: 105,886,458	I821F	probably damaging	Het
Tbrg4	A	G	11: 6,624,204	M6T	probably benign	Het
Tcf20	A	T	15: 82,852,696	I1518N	probably benign	Het
Tctn3	A	G	19: 40,607,276	V355A	probably benign	Het
Tenm2	A	T	11: 36,024,500	F2070Y	probably damaging	Het
Tex2	A	G	11: 106,568,535	V23A	probably damaging	Het
Thrsp	C	G	7: 97,417,074	E144Q	probably damaging	Het
Top2a	A	C	11: 99,001,078	S1114A	probably benign	Het
Tpm1	A	G	9: 67,029,716	Y267H	probably benign	Het
Txndc2	G	T	17: 65,639,024	P53T	unknown	Het
Ugt2b36	A	T	5: 87,081,017	I389N	probably damaging	Het
Virma	C	T	4: 11,513,507	R454*	probably null	Het
Vwa3b	T	A	1: 37,035,801	H16Q	probably damaging	Het
Zbp1	A	G	2: 173,210,643	M240T	possibly damaging	Het

Other mutations in Hdac10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00229:Hdac10	APN	15	89128442	missense	probably damaging	1.00
IGL01063:Hdac10	APN	15	89123868	missense	possibly damaging	0.68
IGL01577:Hdac10	APN	15	89126213	missense	possibly damaging	0.90
IGL01690:Hdac10	APN	15	89125991	missense	probably benign	0.00
IGL01724:Hdac10	APN	15	89124709	unclassified	probably benign
IGL01866:Hdac10	APN	15	89124533	missense	probably damaging	1.00
IGL01989:Hdac10	APN	15	89125343	missense	probably damaging	1.00
IGL01995:Hdac10	APN	15	89127598	missense	probably damaging	1.00
IGL02256:Hdac10	APN	15	89125894	unclassified	probably benign
IGL02668:Hdac10	APN	15	89125644	missense	probably benign	0.10
R0240:Hdac10	UTSW	15	89125882	missense	possibly damaging	0.65
R0240:Hdac10	UTSW	15	89125882	missense	possibly damaging	0.65
R0454:Hdac10	UTSW	15	89125758	splice site	probably null
R0723:Hdac10	UTSW	15	89126418	missense	probably damaging	1.00
R0924:Hdac10	UTSW	15	89125862	missense	probably benign
R1553:Hdac10	UTSW	15	89125515	missense	possibly damaging	0.51
R1608:Hdac10	UTSW	15	89125318	missense	probably benign	0.04
R1619:Hdac10	UTSW	15	89126675	missense	probably damaging	1.00
R1715:Hdac10	UTSW	15	89126709	splice site	probably null
R2284:Hdac10	UTSW	15	89127404	missense	probably benign	0.00
R2872:Hdac10	UTSW	15	89125856	missense	possibly damaging	0.46
R2872:Hdac10	UTSW	15	89125856	missense	possibly damaging	0.46
R3688:Hdac10	UTSW	15	89123564	critical splice donor site	probably null
R4283:Hdac10	UTSW	15	89125623	missense	possibly damaging	0.94
R4604:Hdac10	UTSW	15	89125397	critical splice acceptor site	probably null
R4654:Hdac10	UTSW	15	89126833	unclassified	probably benign
R4898:Hdac10	UTSW	15	89128447	start codon destroyed	probably null	1.00
R4998:Hdac10	UTSW	15	89123940	missense	possibly damaging	0.94
R5393:Hdac10	UTSW	15	89126684	missense	probably damaging	1.00
R5769:Hdac10	UTSW	15	89123616	missense	probably benign	0.00
R5785:Hdac10	UTSW	15	89126945	missense	probably benign
R6992:Hdac10	UTSW	15	89125331	missense	probably benign	0.01
R7149:Hdac10	UTSW	15	89127449	missense	probably damaging	1.00
R7237:Hdac10	UTSW	15	89125377	missense	probably benign
R7276:Hdac10	UTSW	15	89128285	missense	probably benign	0.01
R7395:Hdac10	UTSW	15	89128284	missense	probably benign	0.14

Predicted Primers

PCR Primer
(F):5'- TGCTAGGGACTCCAAGTGGTAG -3'
(R):5'- CACCGGATCCTGCCTATAGTTTG -3'

Sequencing Primer
(F):5'- TGGTAGCCACCCTAGGAAG -3'
(R):5'- GATCCTGCCTATAGTTTGATCCTGAG -3'

Posted On

2022-03-25