Incidental Mutation 'R9295:Vmn2r60'
| ID |
704551 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r60
|
| Ensembl Gene |
ENSMUSG00000090619 |
| Gene Name |
vomeronasal 2, receptor 60 |
| Synonyms |
Casr-rs3, EG637898, Gprc2a-rs3 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.112)
|
| Stock # |
R9295 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
41765895-41845200 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 41785955 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Isoleucine
at position 253
(F253I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000128493
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000166447]
|
| AlphaFold |
A0A3B2WBC8 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000166447
AA Change: F253I
PolyPhen 2
Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
|
| SMART Domains |
Protein: ENSMUSP00000128493
Gene: ENSMUSG00000090619
AA Change: F253I
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
78 |
471 |
1.2e-44 |
PFAM |
|
Pfam:NCD3G
|
514 |
567 |
5.1e-23 |
PFAM |
|
Pfam:7tm_3
|
600 |
835 |
1.4e-51 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.7%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 67 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2410002F23Rik |
T |
A |
7: 43,900,116 (GRCm39) |
V7E |
probably benign |
Het |
| Adam17 |
A |
G |
12: 21,399,938 (GRCm39) |
V156A |
probably benign |
Het |
| Ankrd6 |
A |
T |
4: 32,822,160 (GRCm39) |
V236E |
probably damaging |
Het |
| Apcdd1 |
C |
T |
18: 63,055,731 (GRCm39) |
|
probably benign |
Het |
| C2cd3 |
C |
A |
7: 100,081,734 (GRCm39) |
D1125E |
|
Het |
| Cacna2d2 |
A |
G |
9: 107,386,419 (GRCm39) |
E182G |
probably benign |
Het |
| Cct3 |
A |
G |
3: 88,212,430 (GRCm39) |
K139E |
probably benign |
Het |
| Cd96 |
G |
T |
16: 45,938,244 (GRCm39) |
Q74K |
probably benign |
Het |
| Cdk5rap1 |
A |
T |
2: 154,194,186 (GRCm39) |
I373N |
probably damaging |
Het |
| Cep350 |
A |
T |
1: 155,738,051 (GRCm39) |
Y2597* |
probably null |
Het |
| Chst13 |
G |
A |
6: 90,286,506 (GRCm39) |
P152L |
probably damaging |
Het |
| Clcn1 |
G |
A |
6: 42,290,883 (GRCm39) |
G919E |
probably benign |
Het |
| Col6a4 |
G |
A |
9: 105,957,734 (GRCm39) |
A30V |
probably damaging |
Het |
| Copa |
T |
C |
1: 171,939,823 (GRCm39) |
C655R |
probably damaging |
Het |
| Cpt1a |
T |
A |
19: 3,428,441 (GRCm39) |
V605E |
probably damaging |
Het |
| Ddx46 |
T |
C |
13: 55,811,599 (GRCm39) |
I600T |
possibly damaging |
Het |
| Dhx9 |
C |
A |
1: 153,340,673 (GRCm39) |
V656L |
probably damaging |
Het |
| Dnhd1 |
T |
A |
7: 105,363,348 (GRCm39) |
M3970K |
probably benign |
Het |
| Ercc5 |
G |
T |
1: 44,198,017 (GRCm39) |
V145F |
probably damaging |
Het |
| Erv3 |
T |
C |
2: 131,697,979 (GRCm39) |
T127A |
possibly damaging |
Het |
| Fcer1a |
T |
C |
1: 173,050,174 (GRCm39) |
Y172C |
probably damaging |
Het |
| Gabra1 |
A |
G |
11: 42,044,217 (GRCm39) |
M167T |
probably damaging |
Het |
| Ggt1 |
A |
G |
10: 75,421,743 (GRCm39) |
H530R |
probably benign |
Het |
| Gli2 |
C |
A |
1: 118,764,996 (GRCm39) |
V1052L |
probably damaging |
Het |
| Gm4491 |
A |
C |
14: 57,351,140 (GRCm39) |
F84C |
unknown |
Het |
| Irf2bp1 |
C |
T |
7: 18,739,740 (GRCm39) |
T460I |
probably benign |
Het |
| Klf3 |
A |
G |
5: 64,980,240 (GRCm39) |
Y187C |
possibly damaging |
Het |
| Krt80 |
T |
C |
15: 101,249,652 (GRCm39) |
E287G |
probably benign |
Het |
| Lama4 |
G |
T |
10: 38,948,747 (GRCm39) |
V837F |
probably damaging |
Het |
| Lrig3 |
G |
T |
10: 125,850,722 (GRCm39) |
C1096F |
probably benign |
Het |
| Mtrr |
T |
C |
13: 68,719,258 (GRCm39) |
R328G |
possibly damaging |
Het |
| Nln |
TGGTCCAGGTAAAACTGCCCCAGCCAATCAGGTACCTTGGATAGAGGTCCAGGTAAAACTGCCCCAGCCAATCAGGTACCTTGGATAGAGGTCCAGGTAGAACTGCCCCAGC |
TGGTCCAGGTAAAACTGCCCCAGCCAATCAGGTACCTTGGATAGAGGTCCAGGTAGAACTGCCCCAGC |
13: 104,186,924 (GRCm39) |
|
probably null |
Het |
| Obsl1 |
A |
T |
1: 75,476,721 (GRCm39) |
D744E |
probably damaging |
Het |
| Or2n1d |
A |
T |
17: 38,646,320 (GRCm39) |
T91S |
possibly damaging |
Het |
| Or4x13 |
G |
A |
2: 90,231,441 (GRCm39) |
M145I |
probably benign |
Het |
| Pde4b |
A |
G |
4: 102,112,478 (GRCm39) |
T21A |
probably damaging |
Het |
| Phf20l1 |
G |
A |
15: 66,513,752 (GRCm39) |
G1003D |
probably damaging |
Het |
| Phtf1 |
A |
G |
3: 103,904,893 (GRCm39) |
T514A |
probably benign |
Het |
| Phykpl |
A |
G |
11: 51,482,231 (GRCm39) |
E115G |
possibly damaging |
Het |
| Pramel20 |
A |
G |
4: 143,298,704 (GRCm39) |
T216A |
possibly damaging |
Het |
| Pxmp2 |
C |
A |
5: 110,433,944 (GRCm39) |
|
probably benign |
Het |
| Reln |
A |
G |
5: 22,209,209 (GRCm39) |
L1123P |
possibly damaging |
Het |
| Rusc2 |
T |
C |
4: 43,416,382 (GRCm39) |
S563P |
probably damaging |
Het |
| Secisbp2 |
T |
G |
13: 51,808,483 (GRCm39) |
S83A |
probably damaging |
Het |
| Sema3c |
T |
A |
5: 17,932,495 (GRCm39) |
M666K |
probably benign |
Het |
| Serbp1 |
G |
T |
6: 67,248,208 (GRCm39) |
D114Y |
probably damaging |
Het |
| Sh3d21 |
T |
A |
4: 126,045,276 (GRCm39) |
T468S |
possibly damaging |
Het |
| Shroom3 |
T |
A |
5: 93,098,478 (GRCm39) |
D1319E |
probably benign |
Het |
| Skida1 |
T |
C |
2: 18,051,386 (GRCm39) |
R502G |
unknown |
Het |
| Slc25a12 |
C |
A |
2: 71,128,986 (GRCm39) |
G314C |
possibly damaging |
Het |
| Smg8 |
A |
G |
11: 86,968,789 (GRCm39) |
V989A |
probably benign |
Het |
| Spon2 |
G |
A |
5: 33,373,844 (GRCm39) |
P156S |
probably damaging |
Het |
| Stx1a |
A |
G |
5: 135,066,370 (GRCm39) |
N50S |
probably benign |
Het |
| Tmem151b |
C |
A |
17: 45,857,806 (GRCm39) |
V147L |
probably benign |
Het |
| Trim12c |
C |
T |
7: 103,990,391 (GRCm39) |
G362D |
unknown |
Het |
| Tsr1 |
T |
C |
11: 74,799,135 (GRCm39) |
V772A |
probably damaging |
Het |
| Tti2 |
A |
T |
8: 31,643,550 (GRCm39) |
K222* |
probably null |
Het |
| Usp48 |
G |
A |
4: 137,340,996 (GRCm39) |
G332E |
probably benign |
Het |
| Vmn1r60 |
A |
G |
7: 5,547,218 (GRCm39) |
M294T |
probably null |
Het |
| Vmn2r6 |
T |
C |
3: 64,463,484 (GRCm39) |
E450G |
probably benign |
Het |
| Wnk4 |
A |
T |
11: 101,160,078 (GRCm39) |
D649V |
probably damaging |
Het |
| Zfhx4 |
T |
C |
3: 5,394,525 (GRCm39) |
S1040P |
probably benign |
Het |
| Zfp112 |
C |
T |
7: 23,824,805 (GRCm39) |
R262C |
probably benign |
Het |
| Zfp287 |
T |
A |
11: 62,606,115 (GRCm39) |
D264V |
probably benign |
Het |
| Zfp46 |
T |
C |
4: 136,017,876 (GRCm39) |
C237R |
probably damaging |
Het |
| Zfp773 |
C |
T |
7: 7,135,694 (GRCm39) |
E301K |
probably benign |
Het |
| Zswim2 |
A |
C |
2: 83,748,304 (GRCm39) |
V292G |
probably benign |
Het |
|
| Other mutations in Vmn2r60 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01622:Vmn2r60
|
APN |
7 |
41,785,910 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL01623:Vmn2r60
|
APN |
7 |
41,785,910 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL02363:Vmn2r60
|
APN |
7 |
41,844,578 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02485:Vmn2r60
|
APN |
7 |
41,844,890 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
IGL02651:Vmn2r60
|
APN |
7 |
41,845,010 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02660:Vmn2r60
|
APN |
7 |
41,791,720 (GRCm39) |
nonsense |
probably null |
|
|
IGL03135:Vmn2r60
|
APN |
7 |
41,786,018 (GRCm39) |
missense |
probably benign |
0.13 |
|
IGL03307:Vmn2r60
|
APN |
7 |
41,765,971 (GRCm39) |
missense |
probably benign |
0.14 |
|
R0310:Vmn2r60
|
UTSW |
7 |
41,844,564 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R0314:Vmn2r60
|
UTSW |
7 |
41,784,985 (GRCm39) |
splice site |
probably benign |
|
|
R0328:Vmn2r60
|
UTSW |
7 |
41,791,744 (GRCm39) |
splice site |
probably benign |
|
|
R0464:Vmn2r60
|
UTSW |
7 |
41,785,255 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0755:Vmn2r60
|
UTSW |
7 |
41,844,869 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1119:Vmn2r60
|
UTSW |
7 |
41,844,365 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1162:Vmn2r60
|
UTSW |
7 |
41,845,195 (GRCm39) |
missense |
probably benign |
0.29 |
|
R1241:Vmn2r60
|
UTSW |
7 |
41,786,476 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1404:Vmn2r60
|
UTSW |
7 |
41,786,211 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1404:Vmn2r60
|
UTSW |
7 |
41,786,211 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1488:Vmn2r60
|
UTSW |
7 |
41,786,137 (GRCm39) |
missense |
probably benign |
0.17 |
|
R1623:Vmn2r60
|
UTSW |
7 |
41,785,279 (GRCm39) |
nonsense |
probably null |
|
|
R1628:Vmn2r60
|
UTSW |
7 |
41,785,830 (GRCm39) |
nonsense |
probably null |
|
|
R1883:Vmn2r60
|
UTSW |
7 |
41,786,094 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1884:Vmn2r60
|
UTSW |
7 |
41,786,094 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2182:Vmn2r60
|
UTSW |
7 |
41,844,931 (GRCm39) |
missense |
probably benign |
0.06 |
|
R2275:Vmn2r60
|
UTSW |
7 |
41,786,251 (GRCm39) |
nonsense |
probably null |
|
|
R2847:Vmn2r60
|
UTSW |
7 |
41,785,857 (GRCm39) |
missense |
probably benign |
0.07 |
|
R2885:Vmn2r60
|
UTSW |
7 |
41,790,403 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R2894:Vmn2r60
|
UTSW |
7 |
41,785,220 (GRCm39) |
missense |
probably benign |
|
|
R2921:Vmn2r60
|
UTSW |
7 |
41,790,459 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2922:Vmn2r60
|
UTSW |
7 |
41,790,459 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3772:Vmn2r60
|
UTSW |
7 |
41,765,980 (GRCm39) |
missense |
probably benign |
0.35 |
|
R3820:Vmn2r60
|
UTSW |
7 |
41,785,125 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3822:Vmn2r60
|
UTSW |
7 |
41,785,125 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3872:Vmn2r60
|
UTSW |
7 |
41,785,878 (GRCm39) |
missense |
probably benign |
0.19 |
|
R4222:Vmn2r60
|
UTSW |
7 |
41,765,952 (GRCm39) |
missense |
probably benign |
0.08 |
|
R4223:Vmn2r60
|
UTSW |
7 |
41,765,952 (GRCm39) |
missense |
probably benign |
0.08 |
|
R4224:Vmn2r60
|
UTSW |
7 |
41,765,952 (GRCm39) |
missense |
probably benign |
0.08 |
|
R4526:Vmn2r60
|
UTSW |
7 |
41,844,667 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4547:Vmn2r60
|
UTSW |
7 |
41,785,087 (GRCm39) |
missense |
probably null |
0.54 |
|
R4840:Vmn2r60
|
UTSW |
7 |
41,785,285 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5173:Vmn2r60
|
UTSW |
7 |
41,844,935 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5231:Vmn2r60
|
UTSW |
7 |
41,786,448 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5480:Vmn2r60
|
UTSW |
7 |
41,785,154 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5521:Vmn2r60
|
UTSW |
7 |
41,845,049 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5834:Vmn2r60
|
UTSW |
7 |
41,765,932 (GRCm39) |
missense |
probably benign |
0.17 |
|
R6038:Vmn2r60
|
UTSW |
7 |
41,844,386 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6038:Vmn2r60
|
UTSW |
7 |
41,844,386 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6112:Vmn2r60
|
UTSW |
7 |
41,844,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6149:Vmn2r60
|
UTSW |
7 |
41,786,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6170:Vmn2r60
|
UTSW |
7 |
41,785,045 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6383:Vmn2r60
|
UTSW |
7 |
41,765,895 (GRCm39) |
start codon destroyed |
probably null |
0.04 |
|
R6811:Vmn2r60
|
UTSW |
7 |
41,844,310 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6876:Vmn2r60
|
UTSW |
7 |
41,785,087 (GRCm39) |
missense |
probably null |
0.54 |
|
R6997:Vmn2r60
|
UTSW |
7 |
41,791,716 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7040:Vmn2r60
|
UTSW |
7 |
41,791,666 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7116:Vmn2r60
|
UTSW |
7 |
41,786,487 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7128:Vmn2r60
|
UTSW |
7 |
41,844,536 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7232:Vmn2r60
|
UTSW |
7 |
41,786,166 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7296:Vmn2r60
|
UTSW |
7 |
41,785,826 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7376:Vmn2r60
|
UTSW |
7 |
41,844,631 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7526:Vmn2r60
|
UTSW |
7 |
41,845,158 (GRCm39) |
frame shift |
probably null |
|
|
R7527:Vmn2r60
|
UTSW |
7 |
41,845,158 (GRCm39) |
frame shift |
probably null |
|
|
R7528:Vmn2r60
|
UTSW |
7 |
41,845,158 (GRCm39) |
frame shift |
probably null |
|
|
R7764:Vmn2r60
|
UTSW |
7 |
41,844,535 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7843:Vmn2r60
|
UTSW |
7 |
41,844,511 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8080:Vmn2r60
|
UTSW |
7 |
41,790,521 (GRCm39) |
missense |
probably benign |
0.30 |
|
R8290:Vmn2r60
|
UTSW |
7 |
41,791,690 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8342:Vmn2r60
|
UTSW |
7 |
41,790,494 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R8362:Vmn2r60
|
UTSW |
7 |
41,844,954 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8418:Vmn2r60
|
UTSW |
7 |
41,844,850 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8848:Vmn2r60
|
UTSW |
7 |
41,786,169 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8860:Vmn2r60
|
UTSW |
7 |
41,791,654 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8882:Vmn2r60
|
UTSW |
7 |
41,790,518 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8913:Vmn2r60
|
UTSW |
7 |
41,785,778 (GRCm39) |
missense |
probably benign |
0.27 |
|
R9190:Vmn2r60
|
UTSW |
7 |
41,844,935 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9229:Vmn2r60
|
UTSW |
7 |
41,791,723 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9335:Vmn2r60
|
UTSW |
7 |
41,844,332 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9796:Vmn2r60
|
UTSW |
7 |
41,785,172 (GRCm39) |
missense |
probably benign |
|
|
RF024:Vmn2r60
|
UTSW |
7 |
41,790,363 (GRCm39) |
missense |
probably benign |
0.01 |
|
X0023:Vmn2r60
|
UTSW |
7 |
41,790,538 (GRCm39) |
missense |
probably benign |
0.01 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCTTGAATGACCGAGCTCAG -3'
(R):5'- GTGGCTATCAACATCCCATGAAG -3'
Sequencing Primer
(F):5'- GAAGACACATCTCTGCCATTTG -3'
(R):5'- TGAAGAGTTCAAGACCCAGACTTTC -3'
|
| Posted On |
2022-03-25 |
Incidental Mutation