Incidental Mutation 'R9296:Mapk3'
ID 704603
Institutional Source Beutler Lab
Gene Symbol Mapk3
Ensembl Gene ENSMUSG00000063065
Gene Name mitogen-activated protein kinase 3
Synonyms p44 MAP kinase, p44erk1, Erk1, Prkm3, Erk-1, Mtap2k, p44mapk, Esrk1
MMRRC Submission
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9296 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 126358798-126364988 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 126363518 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 297 (F297L)
Ref Sequence ENSEMBL: ENSMUSP00000051619 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000032944] [ENSMUST00000050201] [ENSMUST00000057669] [ENSMUST00000091328]
AlphaFold Q63844
Predicted Effect probably benign
Transcript: ENSMUST00000032944
SMART Domains Protein: ENSMUSP00000032944
Gene: ENSMUSG00000030703

DomainStartEndE-ValueType
transmembrane domain 4 23 N/A INTRINSIC
Pfam:GDPD 44 202 1.1e-23 PFAM
low complexity region 208 216 N/A INTRINSIC
low complexity region 311 321 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000050201
AA Change: F297L

PolyPhen 2 Score 0.939 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000101969
Gene: ENSMUSG00000063065
AA Change: F297L

DomainStartEndE-ValueType
low complexity region 2 32 N/A INTRINSIC
S_TKc 43 331 3.3e-97 SMART
Predicted Effect
SMART Domains Protein: ENSMUSP00000051619
Gene: ENSMUSG00000063065
AA Change: F297L

DomainStartEndE-ValueType
low complexity region 2 32 N/A INTRINSIC
S_TKc 43 331 3.3e-97 SMART
Blast:S_TKc 335 372 1e-15 BLAST
Predicted Effect
SMART Domains Protein: ENSMUSP00000088880
Gene: ENSMUSG00000063065
AA Change: F182L

DomainStartEndE-ValueType
Pfam:Pkinase_Tyr 1 213 2.5e-24 PFAM
Pfam:Pkinase 1 216 2.2e-58 PFAM
Pfam:APH 17 108 7.6e-7 PFAM
Blast:S_TKc 220 257 4e-16 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000205657
Predicted Effect possibly damaging
Transcript: ENSMUST00000206272
AA Change: F194L

PolyPhen 2 Score 0.910 (Sensitivity: 0.81; Specificity: 0.94)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 98% (56/57)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a targeted null mutation are hyperactive with impaired T cell maturation and proliferation. Mice homozygous for a knock-out allele on a CD-1 background exhibit normal Mendelian ratios, growth, and no obvious abnormalities. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Antxr1 T G 6: 87,114,409 (GRCm39) probably benign Het
Aox1 A T 1: 58,124,612 (GRCm39) Y951F probably damaging Het
Arhgap44 G T 11: 64,957,933 (GRCm39) A83E probably damaging Het
Bmpr2 T C 1: 59,906,502 (GRCm39) S532P probably damaging Het
Brd7 T C 8: 89,059,560 (GRCm39) I617V possibly damaging Het
Brsk2 A C 7: 141,552,375 (GRCm39) S620R probably benign Het
C3 T C 17: 57,511,291 (GRCm39) M1604V probably benign Het
Cacna2d1 G A 5: 16,564,068 (GRCm39) R917H probably damaging Het
Ccdc17 T A 4: 116,456,586 (GRCm39) F452I probably damaging Het
Cfap221 T C 1: 119,883,467 (GRCm39) I235V probably null Het
Chst13 G A 6: 90,286,506 (GRCm39) P152L probably damaging Het
Ciita G A 16: 10,321,812 (GRCm39) probably null Het
Cxcl10 T C 5: 92,495,997 (GRCm39) K47E probably damaging Het
Cyp2d12 C T 15: 82,440,435 (GRCm39) Q75* probably null Het
Cyp4f18 C T 8: 72,756,301 (GRCm39) V92M probably benign Het
D930020B18Rik A G 10: 121,497,011 (GRCm39) R149G possibly damaging Het
Dlgap4 G T 2: 156,546,514 (GRCm39) R394L possibly damaging Het
Dmtf1 A C 5: 9,190,467 (GRCm39) D82E probably benign Het
Dnah1 T C 14: 30,996,011 (GRCm39) probably null Het
Eps15 T G 4: 109,173,089 (GRCm39) D183E possibly damaging Het
Fbln5 A T 12: 101,780,853 (GRCm39) I7K probably benign Het
Fermt3 C T 19: 6,980,865 (GRCm39) E289K possibly damaging Het
Gm10762 T A 2: 128,809,149 (GRCm39) R67W unknown Het
Gm5089 A G 14: 122,673,554 (GRCm39) S56P unknown Het
H2-T5 C T 17: 36,479,169 (GRCm39) G27R unknown Het
Itih1 A G 14: 30,653,251 (GRCm39) F730L probably benign Het
Macf1 T C 4: 123,400,246 (GRCm39) H683R probably damaging Het
Mfap3l G A 8: 61,124,615 (GRCm39) V286I possibly damaging Het
Myh4 A G 11: 67,146,130 (GRCm39) K1396R possibly damaging Het
Mylk3 A T 8: 86,085,561 (GRCm39) S324R probably benign Het
Ndufv3 T C 17: 31,739,197 (GRCm39) S4P probably benign Het
Nebl A T 2: 17,429,451 (GRCm39) probably benign Het
Nol4 A T 18: 22,956,388 (GRCm39) S119T Het
Or6k4 A T 1: 173,964,835 (GRCm39) H175L probably benign Het
Pcdhgb4 T A 18: 37,853,777 (GRCm39) S57R probably benign Het
Pcyox1 A G 6: 86,368,735 (GRCm39) L261P probably damaging Het
Plekhm3 G T 1: 64,961,639 (GRCm39) H206N probably benign Het
Polr2a T C 11: 69,625,562 (GRCm39) T1863A probably benign Het
Prl7c1 T A 13: 27,962,812 (GRCm39) I64L probably benign Het
Psg17 A T 7: 18,553,991 (GRCm39) N86K probably benign Het
Rab37 A G 11: 115,045,065 (GRCm39) E14G probably benign Het
Rad54l2 T A 9: 106,579,942 (GRCm39) K976N probably damaging Het
Rnf213 A T 11: 119,334,621 (GRCm39) probably benign Het
Sdha A T 13: 74,472,062 (GRCm39) D602E probably damaging Het
Slc22a30 T A 19: 8,364,119 (GRCm39) T186S probably benign Het
Slc22a4 A T 11: 53,888,217 (GRCm39) C270* probably null Het
Slc6a4 T C 11: 76,909,110 (GRCm39) V374A probably benign Het
Spg11 T C 2: 121,945,175 (GRCm39) D115G probably benign Het
Susd1 T C 4: 59,427,865 (GRCm39) probably benign Het
Tor1a A T 2: 30,851,104 (GRCm39) M286K probably damaging Het
Trim12c G T 7: 103,994,185 (GRCm39) A223D Het
Usp32 A G 11: 84,908,478 (GRCm39) I1076T probably damaging Het
Usp48 G A 4: 137,340,996 (GRCm39) G332E probably benign Het
Vmn2r101 G A 17: 19,810,047 (GRCm39) D278N probably damaging Het
Zan C T 5: 137,387,138 (GRCm39) V4972I unknown Het
Other mutations in Mapk3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01024:Mapk3 APN 7 126,363,946 (GRCm39) nonsense probably null
IGL02412:Mapk3 APN 7 126,362,210 (GRCm39) nonsense probably null
wabasha UTSW 7 126,362,684 (GRCm39) nonsense probably null
R0078:Mapk3 UTSW 7 126,358,977 (GRCm39) missense probably damaging 1.00
R0532:Mapk3 UTSW 7 126,362,558 (GRCm39) intron probably benign
R1549:Mapk3 UTSW 7 126,362,684 (GRCm39) nonsense probably null
R2913:Mapk3 UTSW 7 126,359,978 (GRCm39) nonsense probably null
R5220:Mapk3 UTSW 7 126,363,408 (GRCm39) missense probably benign
R5408:Mapk3 UTSW 7 126,363,007 (GRCm39) missense probably damaging 1.00
R5729:Mapk3 UTSW 7 126,363,979 (GRCm39) missense probably benign 0.01
R5929:Mapk3 UTSW 7 126,359,030 (GRCm39) unclassified probably benign
R6307:Mapk3 UTSW 7 126,363,454 (GRCm39) missense probably benign 0.03
R6359:Mapk3 UTSW 7 126,359,928 (GRCm39) missense probably benign
R7356:Mapk3 UTSW 7 126,360,087 (GRCm39) critical splice donor site probably null
R7380:Mapk3 UTSW 7 126,363,967 (GRCm39) missense
R7384:Mapk3 UTSW 7 126,363,463 (GRCm39) missense
R8177:Mapk3 UTSW 7 126,362,937 (GRCm39) missense probably null
R9362:Mapk3 UTSW 7 126,363,444 (GRCm39) missense
X0017:Mapk3 UTSW 7 126,363,420 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTCCTGACCTGTTGCCAGAAG -3'
(R):5'- TGGGTTGAAGGTTAACATCCGG -3'

Sequencing Primer
(F):5'- GGAGGACTGATCTTCTCACCAAG -3'
(R):5'- TTGAAGGTTAACATCCGGTCCAG -3'
Posted On 2022-03-25