Incidental Mutation 'R0755:Vstm4'
ID 70462
Institutional Source Beutler Lab
Gene Symbol Vstm4
Ensembl Gene ENSMUSG00000050666
Gene Name V-set and transmembrane domain containing 4
Synonyms E130203B14Rik
MMRRC Submission 038935-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # R0755 (G1)
Quality Score 225
Status Not validated
Chromosome 14
Chromosomal Location 32578713-32661448 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 32614601 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 181 (V181A)
Ref Sequence ENSEMBL: ENSMUSP00000055178 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053175] [ENSMUST00000100721]
AlphaFold T1NXB5
Predicted Effect probably damaging
Transcript: ENSMUST00000053175
AA Change: V181A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000055178
Gene: ENSMUSG00000050666
AA Change: V181A

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
IG 31 153 2.11e-2 SMART
transmembrane domain 178 200 N/A INTRINSIC
low complexity region 245 261 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000100721
AA Change: V32A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000098287
Gene: ENSMUSG00000050666
AA Change: V32A

DomainStartEndE-ValueType
transmembrane domain 29 51 N/A INTRINSIC
low complexity region 96 112 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 93.8%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 94 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A730061H03Rik A T 14: 55,797,638 (GRCm39) probably benign Het
Acin1 A G 14: 54,889,292 (GRCm39) M1T probably null Het
Akp3 G A 1: 87,055,593 (GRCm39) G547R unknown Het
Aldh1a1 A G 19: 20,595,358 (GRCm39) M96V probably benign Het
Ankfn1 T A 11: 89,282,913 (GRCm39) M245L probably benign Het
Arhgap19 T C 19: 41,769,614 (GRCm39) K54E probably damaging Het
Atp1a2 T C 1: 172,116,948 (GRCm39) Q223R probably benign Het
Atp8a2 C T 14: 60,247,330 (GRCm39) V557I possibly damaging Het
AU041133 A T 10: 81,986,724 (GRCm39) K126* probably null Het
Axin1 T A 17: 26,401,480 (GRCm39) Y351N possibly damaging Het
Baiap2l1 T C 5: 144,221,367 (GRCm39) K176E probably damaging Het
Baz2a C T 10: 127,955,560 (GRCm39) T848I possibly damaging Het
Bbs2 A C 8: 94,808,708 (GRCm39) V333G probably benign Het
BC051019 G A 7: 109,315,302 (GRCm39) Q318* probably null Het
Bltp1 T C 3: 37,000,513 (GRCm39) S1231P probably damaging Het
Cdc37 C T 9: 21,051,160 (GRCm39) D362N probably damaging Het
Cep170 A T 1: 176,583,319 (GRCm39) V1020E probably damaging Het
Chrm4 T C 2: 91,758,747 (GRCm39) V385A probably benign Het
Cntrl G A 2: 35,035,151 (GRCm39) S373N probably damaging Het
Col23a1 G A 11: 51,467,706 (GRCm39) G19D probably damaging Het
Cyb5r4 G T 9: 86,911,625 (GRCm39) A100S probably damaging Het
Dctn1 C T 6: 83,166,059 (GRCm39) P115S probably damaging Het
Dhrs2 C T 14: 55,472,247 (GRCm39) T46M probably damaging Het
Disp2 T C 2: 118,620,243 (GRCm39) F325S probably benign Het
Dnah11 T G 12: 117,918,564 (GRCm39) T3456P possibly damaging Het
Dnah11 C A 12: 118,162,360 (GRCm39) V70F probably benign Het
Duoxa1 T A 2: 122,135,161 (GRCm39) T195S probably benign Het
Dync2i1 T C 12: 116,175,412 (GRCm39) I922V probably benign Het
Eif2ak1 T A 5: 143,821,742 (GRCm39) F353I possibly damaging Het
Esam A G 9: 37,447,998 (GRCm39) T211A probably damaging Het
Faf1 A G 4: 109,819,036 (GRCm39) N636S probably benign Het
Fbxo25 A G 8: 13,985,219 (GRCm39) Y305C probably benign Het
Fchsd1 C T 18: 38,101,803 (GRCm39) probably null Het
Fdxacb1 T A 9: 50,683,025 (GRCm39) D329E possibly damaging Het
Gvin2 A T 7: 105,545,892 (GRCm39) F2387I possibly damaging Het
Hbq1b A T 11: 32,237,104 (GRCm39) probably null Het
Hmcn2 T A 2: 31,343,172 (GRCm39) V4566E probably damaging Het
Igkv6-29 G A 6: 70,116,053 (GRCm39) T5I probably benign Het
Itfg1 A T 8: 86,452,834 (GRCm39) D511E possibly damaging Het
Jmjd1c C T 10: 66,932,378 (GRCm39) probably benign Het
Kat6b T A 14: 21,687,661 (GRCm39) M570K probably damaging Het
Kdm4d T A 9: 14,375,591 (GRCm39) K89M probably damaging Het
Krt19 A T 11: 100,032,965 (GRCm39) D194E possibly damaging Het
Lamc1 A T 1: 153,123,196 (GRCm39) Y665N possibly damaging Het
Lct A T 1: 128,221,872 (GRCm39) S1556T possibly damaging Het
Macf1 A G 4: 123,263,719 (GRCm39) L4924P probably damaging Het
Mef2c G A 13: 83,804,472 (GRCm39) probably null Het
Mff G A 1: 82,728,326 (GRCm39) probably null Het
Mycbp2 A T 14: 103,412,230 (GRCm39) L2581Q probably damaging Het
Mylk G C 16: 34,699,845 (GRCm39) E403Q possibly damaging Het
Nos3 T A 5: 24,572,295 (GRCm39) L123M probably damaging Het
Ntn5 C T 7: 45,335,952 (GRCm39) P128S probably benign Het
Nudt9 T C 5: 104,212,920 (GRCm39) V331A probably damaging Het
Or2y3 A T 17: 38,393,085 (GRCm39) Y261* probably null Het
Or7g34 T C 9: 19,478,415 (GRCm39) I88M possibly damaging Het
Pcdh7 A T 5: 57,877,664 (GRCm39) K406N possibly damaging Het
Pkdrej T A 15: 85,700,336 (GRCm39) I1867L probably benign Het
Plppr4 C T 3: 117,116,319 (GRCm39) G455R possibly damaging Het
Pramel11 A G 4: 143,624,299 (GRCm39) V66A probably damaging Het
Prkag2 G C 5: 25,152,629 (GRCm39) S158R probably benign Het
Ptprq T G 10: 107,418,400 (GRCm39) T1659P probably benign Het
Rasl12 A G 9: 65,318,241 (GRCm39) K202E probably benign Het
Rb1 A C 14: 73,434,653 (GRCm39) *922G probably null Het
Rsf1 C T 7: 97,229,174 (GRCm39) P22S probably damaging Het
Scn1a T G 2: 66,151,379 (GRCm39) T797P probably damaging Het
Sgsm2 A G 11: 74,756,323 (GRCm39) V342A probably damaging Het
Slc22a7 T G 17: 46,749,113 (GRCm39) H68P possibly damaging Het
Slc4a2 G A 5: 24,640,575 (GRCm39) A652T probably benign Het
Slc5a1 T A 5: 33,290,733 (GRCm39) L106M probably benign Het
Slco1c1 C T 6: 141,477,258 (GRCm39) P19S probably damaging Het
Snx1 A G 9: 66,005,738 (GRCm39) F127S probably damaging Het
Snx31 A T 15: 36,534,576 (GRCm39) I199N probably damaging Het
Snx33 T C 9: 56,832,741 (GRCm39) I443V possibly damaging Het
Sptbn1 A G 11: 30,089,016 (GRCm39) F749L probably damaging Het
Stoml3 T A 3: 53,405,559 (GRCm39) Y53* probably null Het
Stxbp2 A G 8: 3,692,019 (GRCm39) T554A probably benign Het
Tal1 T C 4: 114,925,573 (GRCm39) I214T probably damaging Het
Tas2r140 T A 6: 40,468,344 (GRCm39) I58N probably damaging Het
Thap1 A G 8: 26,648,501 (GRCm39) Y8C probably damaging Het
Thsd7a A T 6: 12,555,368 (GRCm39) L172Q probably damaging Het
Ube3c T A 5: 29,842,740 (GRCm39) D735E probably damaging Het
Unc80 G A 1: 66,544,082 (GRCm39) D402N probably damaging Het
Upf1 G T 8: 70,786,779 (GRCm39) R902S probably benign Het
Urb1 A G 16: 90,570,982 (GRCm39) Y1276H probably damaging Het
Urb1 A T 16: 90,576,026 (GRCm39) F843L probably benign Het
Vmn1r198 C T 13: 22,539,402 (GRCm39) T296I probably benign Het
Vmn1r33 A T 6: 66,588,892 (GRCm39) S221T probably damaging Het
Vmn2r103 A G 17: 19,993,830 (GRCm39) D69G probably benign Het
Vmn2r14 T G 5: 109,364,226 (GRCm39) L563F possibly damaging Het
Vmn2r60 G A 7: 41,844,869 (GRCm39) G744D probably damaging Het
Wdr72 G A 9: 74,052,376 (GRCm39) V136I probably benign Het
Zfp236 T A 18: 82,638,457 (GRCm39) N1388Y probably damaging Het
Zfp53 T A 17: 21,728,839 (GRCm39) F291I probably damaging Het
Zfp944 A T 17: 22,558,889 (GRCm39) H119Q possibly damaging Het
Other mutations in Vstm4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01354:Vstm4 APN 14 32,641,202 (GRCm39) missense probably benign 0.08
IGL02720:Vstm4 APN 14 32,585,574 (GRCm39) missense probably damaging 0.99
IGL02927:Vstm4 APN 14 32,659,745 (GRCm39) missense probably damaging 0.99
R0122:Vstm4 UTSW 14 32,585,768 (GRCm39) splice site probably null
R1508:Vstm4 UTSW 14 32,585,511 (GRCm39) missense probably damaging 1.00
R2075:Vstm4 UTSW 14 32,639,811 (GRCm39) missense probably damaging 1.00
R2517:Vstm4 UTSW 14 32,585,664 (GRCm39) missense probably benign 0.02
R3087:Vstm4 UTSW 14 32,614,592 (GRCm39) missense possibly damaging 0.46
R3870:Vstm4 UTSW 14 32,585,712 (GRCm39) missense probably benign 0.43
R4463:Vstm4 UTSW 14 32,639,833 (GRCm39) missense probably damaging 1.00
R4731:Vstm4 UTSW 14 32,639,859 (GRCm39) missense possibly damaging 0.60
R4732:Vstm4 UTSW 14 32,639,859 (GRCm39) missense possibly damaging 0.60
R4733:Vstm4 UTSW 14 32,639,859 (GRCm39) missense possibly damaging 0.60
R4860:Vstm4 UTSW 14 32,585,742 (GRCm39) missense possibly damaging 0.84
R4860:Vstm4 UTSW 14 32,585,742 (GRCm39) missense possibly damaging 0.84
R4983:Vstm4 UTSW 14 32,641,202 (GRCm39) missense probably benign 0.08
R5059:Vstm4 UTSW 14 32,585,687 (GRCm39) missense probably damaging 0.98
R5455:Vstm4 UTSW 14 32,585,835 (GRCm39) missense possibly damaging 0.94
R5593:Vstm4 UTSW 14 32,641,247 (GRCm39) missense probably benign 0.08
R5771:Vstm4 UTSW 14 32,626,526 (GRCm39) missense probably benign 0.28
R6018:Vstm4 UTSW 14 32,585,627 (GRCm39) missense probably benign 0.25
R6927:Vstm4 UTSW 14 32,585,959 (GRCm39) splice site probably null
R8920:Vstm4 UTSW 14 32,585,615 (GRCm39) missense probably damaging 1.00
X0064:Vstm4 UTSW 14 32,585,678 (GRCm39) missense probably benign 0.01
Z1177:Vstm4 UTSW 14 32,585,784 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- ACACAAAGGGAGGATGCTTCTGATG -3'
(R):5'- GCGATCACTTTATTGCAGCAACACC -3'

Sequencing Primer
(F):5'- AGGAtgcttctgatgacaagtc -3'
(R):5'- AATTGCTGACCCAGGATGC -3'
Posted On 2013-09-30