Incidental Mutation 'R9298:Iigp1'
ID 704758
Institutional Source Beutler Lab
Gene Symbol Iigp1
Ensembl Gene ENSMUSG00000054072
Gene Name interferon inducible GTPase 1
Synonyms 2900074L10Rik, Irga6
MMRRC Submission 068963-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.052) question?
Stock # R9298 (G1)
Quality Score 225.009
Status Not validated
Chromosome 18
Chromosomal Location 60509099-60525706 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 60523063 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 60 (D60E)
Ref Sequence ENSEMBL: ENSMUSP00000063390 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000032473] [ENSMUST00000066912]
AlphaFold Q9QZ85
Predicted Effect probably benign
Transcript: ENSMUST00000032473
AA Change: D60E

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000032473
Gene: ENSMUSG00000054072
AA Change: D60E

DomainStartEndE-ValueType
Pfam:IIGP 35 409 5.5e-182 PFAM
Pfam:MMR_HSR1 71 210 1.4e-7 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000066912
AA Change: D60E

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000063390
Gene: ENSMUSG00000054072
AA Change: D60E

DomainStartEndE-ValueType
Pfam:IIGP 35 409 7.9e-182 PFAM
Pfam:MMR_HSR1 71 212 8.2e-9 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.4%
Validation Efficiency
MGI Phenotype PHENOTYPE: Targeted deletion of this gene results in partial loss of IFN-gamma-mediated Toxoplasma gondii growth restriction in primary mouse astrocytes. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700030K09Rik C A 8: 73,198,923 (GRCm39) A110D probably benign Het
4930407I10Rik A G 15: 81,947,615 (GRCm39) E504G probably benign Het
Apbb2 T C 5: 66,609,018 (GRCm39) K210E probably benign Het
Arhgef37 G T 18: 61,651,072 (GRCm39) A151D probably damaging Het
Btaf1 A G 19: 36,964,114 (GRCm39) Y895C probably benign Het
Catsperb A G 12: 101,560,600 (GRCm39) I864V possibly damaging Het
Cdhr17 T A 5: 16,996,855 (GRCm39) C10* probably null Het
Cmklr1 G C 5: 113,752,043 (GRCm39) H319Q probably benign Het
Col18a1 G A 10: 76,893,204 (GRCm39) T1057M probably damaging Het
Col1a2 T A 6: 4,515,260 (GRCm39) probably null Het
Col6a4 A G 9: 105,945,534 (GRCm39) I860T probably damaging Het
Csmd3 A C 15: 47,617,187 (GRCm39) H1000Q Het
Cyp4a29 T A 4: 115,108,395 (GRCm39) M373K probably damaging Het
Dnhd1 A G 7: 105,333,173 (GRCm39) E215G probably damaging Het
Dop1b A G 16: 93,597,087 (GRCm39) E1972G probably damaging Het
Dusp19 T C 2: 80,447,729 (GRCm39) M1T probably null Het
Eif4b A G 15: 101,990,449 (GRCm39) T18A possibly damaging Het
Exosc6 G A 8: 111,783,513 (GRCm39) A171T probably damaging Het
Fau G A 19: 6,108,297 (GRCm39) R6H probably benign Het
Flrt3 T C 2: 140,501,879 (GRCm39) D583G probably damaging Het
Fpgt A T 3: 154,792,695 (GRCm39) L444* probably null Het
Gm10226 A G 17: 21,910,768 (GRCm39) E1G probably null Het
Gm14443 A T 2: 175,011,869 (GRCm39) C192* probably null Het
Gm4353 T A 7: 115,682,843 (GRCm39) N246I probably benign Het
Igfn1 A G 1: 135,926,327 (GRCm39) L41P probably benign Het
Kcnt2 T A 1: 140,353,035 (GRCm39) V248D probably damaging Het
Kctd14 A G 7: 97,107,243 (GRCm39) K166R probably benign Het
Kdm4d G A 9: 14,375,336 (GRCm39) T174M probably damaging Het
Kdm5b T C 1: 134,528,493 (GRCm39) probably null Het
Maz CGCGGCCTCGGCGGCTGGTGCGG CGCGG 7: 126,625,075 (GRCm39) probably benign Het
Mrtfb A G 16: 13,202,082 (GRCm39) Q115R probably benign Het
Nox4 G A 7: 87,025,448 (GRCm39) R525Q probably benign Het
Or10a5 A T 7: 106,635,640 (GRCm39) I93F probably damaging Het
Or2h1b A T 17: 37,462,572 (GRCm39) V97D probably damaging Het
Or5b95 T A 19: 12,658,190 (GRCm39) C239* probably null Het
Pigc C T 1: 161,798,032 (GRCm39) R5C probably benign Het
Plekhm2 C A 4: 141,356,829 (GRCm39) M771I probably benign Het
Runx1 T A 16: 92,441,147 (GRCm39) T221S possibly damaging Het
S100pbp A G 4: 129,044,847 (GRCm39) Y363H probably damaging Het
Sema5a A G 15: 32,619,040 (GRCm39) T523A probably benign Het
Slc38a8 A G 8: 120,212,851 (GRCm39) F270S possibly damaging Het
Slc4a1ap T C 5: 31,693,538 (GRCm39) S491P probably damaging Het
Slc66a2 T C 18: 80,300,300 (GRCm39) L57P probably damaging Het
Slc7a6 T C 8: 106,922,534 (GRCm39) V440A probably damaging Het
Sobp A T 10: 42,898,902 (GRCm39) C228S probably damaging Het
Svop G A 5: 114,168,231 (GRCm39) T456M probably benign Het
Synrg A G 11: 83,900,278 (GRCm39) D750G probably damaging Het
Syt14 C A 1: 192,612,944 (GRCm39) E336* probably null Het
Tcp11l1 C T 2: 104,528,897 (GRCm39) V134I possibly damaging Het
Tex51 T C 18: 32,594,029 (GRCm39) R110G possibly damaging Het
Tle3 T A 9: 61,319,562 (GRCm39) H443Q possibly damaging Het
Unc13a C T 8: 72,108,335 (GRCm39) R506Q possibly damaging Het
Vmn1r121 A C 7: 20,832,344 (GRCm39) V32G probably damaging Het
Wiz A G 17: 32,580,714 (GRCm39) F246L probably benign Het
Zfp672 A T 11: 58,220,590 (GRCm39) M3K unknown Het
Zfp709 A T 8: 72,644,648 (GRCm39) E692D possibly damaging Het
Zglp1 A T 9: 20,977,482 (GRCm39) L111Q probably benign Het
Other mutations in Iigp1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00798:Iigp1 APN 18 60,524,073 (GRCm39) missense probably benign 0.01
IGL03323:Iigp1 APN 18 60,522,896 (GRCm39) missense probably benign 0.04
R0025:Iigp1 UTSW 18 60,523,859 (GRCm39) missense possibly damaging 0.53
R0410:Iigp1 UTSW 18 60,523,375 (GRCm39) missense probably benign 0.15
R0564:Iigp1 UTSW 18 60,523,523 (GRCm39) missense probably damaging 0.98
R0609:Iigp1 UTSW 18 60,522,896 (GRCm39) missense probably benign 0.04
R1549:Iigp1 UTSW 18 60,522,948 (GRCm39) missense probably benign
R2226:Iigp1 UTSW 18 60,522,960 (GRCm39) missense possibly damaging 0.55
R2264:Iigp1 UTSW 18 60,523,738 (GRCm39) missense probably benign 0.20
R3110:Iigp1 UTSW 18 60,523,983 (GRCm39) missense probably benign 0.01
R3112:Iigp1 UTSW 18 60,523,983 (GRCm39) missense probably benign 0.01
R4575:Iigp1 UTSW 18 60,523,218 (GRCm39) missense probably benign 0.02
R4795:Iigp1 UTSW 18 60,522,964 (GRCm39) missense probably benign 0.13
R5439:Iigp1 UTSW 18 60,523,329 (GRCm39) missense probably damaging 1.00
R6565:Iigp1 UTSW 18 60,523,839 (GRCm39) missense probably damaging 1.00
R8775:Iigp1 UTSW 18 60,523,596 (GRCm39) missense probably damaging 1.00
R8775-TAIL:Iigp1 UTSW 18 60,523,596 (GRCm39) missense probably damaging 1.00
R9520:Iigp1 UTSW 18 60,523,451 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- ATGGGTCAGCTGTTCTCTTC -3'
(R):5'- TTGTGCTTCCAATCCCAGGC -3'

Sequencing Primer
(F):5'- GGGTCAGCTGTTCTCTTCACCTAAG -3'
(R):5'- TTCCAATCCCAGGCAGGTC -3'
Posted On 2022-03-25