Incidental Mutation 'R9299:Cyp4a10'
ID 704775
Institutional Source Beutler Lab
Gene Symbol Cyp4a10
Ensembl Gene ENSMUSG00000066072
Gene Name cytochrome P450, family 4, subfamily a, polypeptide 10
Synonyms Msp-3, Cyp4a, RP1, D4Rp1
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.056) question?
Stock # R9299 (G1)
Quality Score 225.009
Status Validated
Chromosome 4
Chromosomal Location 115375484-115390846 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 115376947 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Valine at position 104 (M104V)
Ref Sequence ENSEMBL: ENSMUSP00000061126 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058785] [ENSMUST00000094886]
AlphaFold O88833
Predicted Effect probably benign
Transcript: ENSMUST00000058785
AA Change: M104V

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000061126
Gene: ENSMUSG00000066072
AA Change: M104V

DomainStartEndE-ValueType
transmembrane domain 15 32 N/A INTRINSIC
Pfam:p450 51 504 2.3e-133 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000094886
AA Change: M104V

PolyPhen 2 Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000092486
Gene: ENSMUSG00000066072
AA Change: M104V

DomainStartEndE-ValueType
transmembrane domain 17 39 N/A INTRINSIC
Pfam:p450 51 494 4.5e-129 PFAM
Meta Mutation Damage Score 0.1053 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 100% (60/60)
MGI Phenotype PHENOTYPE: Mice homozygous for a null mutation display salt-sensitive hypertension, decrease sodium excretion, and decreased urine output. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700017B05Rik G T 9: 57,163,792 (GRCm39) R861S possibly damaging Het
Abca12 T A 1: 71,359,042 (GRCm39) N588I possibly damaging Het
Adamts9 A G 6: 92,773,976 (GRCm39) Y1727H probably benign Het
Ahnak G A 19: 8,989,824 (GRCm39) probably benign Het
Alad C T 4: 62,429,760 (GRCm39) probably null Het
Anapc15-ps C A 10: 95,509,077 (GRCm39) D68Y probably damaging Het
Arhgap45 T C 10: 79,862,565 (GRCm39) S645P possibly damaging Het
Atp9a A T 2: 168,554,666 (GRCm39) M1K probably null Het
B020004C17Rik A T 14: 57,254,230 (GRCm39) I118F probably damaging Het
Capn13 T A 17: 73,633,467 (GRCm39) probably null Het
Ccdc7a T C 8: 129,616,319 (GRCm39) Q928R probably benign Het
Cdc42bpa C A 1: 179,972,073 (GRCm39) L1292I probably damaging Het
Clec2e A C 6: 129,072,092 (GRCm39) F96V probably benign Het
Cmklr1 G C 5: 113,752,043 (GRCm39) H319Q probably benign Het
Cnot1 T C 8: 96,468,448 (GRCm39) I1460M probably damaging Het
Cyc1 T C 15: 76,228,506 (GRCm39) V45A probably benign Het
Cyth1 C T 11: 118,059,837 (GRCm39) probably benign Het
Dnhd1 T A 7: 105,369,806 (GRCm39) N4410K probably benign Het
Dok4 T A 8: 95,593,469 (GRCm39) T106S probably benign Het
Dpcd C A 19: 45,566,009 (GRCm39) Q203K probably damaging Het
Dph1 T A 11: 75,070,622 (GRCm39) Q339L possibly damaging Het
Dpy19l3 G T 7: 35,424,752 (GRCm39) S187* probably null Het
Eva1a G T 6: 82,069,047 (GRCm39) A125S probably damaging Het
Fam24b T A 7: 130,927,949 (GRCm39) Y80F probably benign Het
Frem2 T C 3: 53,563,980 (GRCm39) T176A probably benign Het
Gal3st3 A T 19: 5,356,868 (GRCm39) N81I probably damaging Het
Gm12888 G A 4: 121,182,044 (GRCm39) S16F unknown Het
Hsf5 T A 11: 87,526,770 (GRCm39) C481S probably benign Het
Ifi211 T A 1: 173,735,288 (GRCm39) Q47L probably damaging Het
Il17re A T 6: 113,440,971 (GRCm39) M202L probably benign Het
Krtap5-3 T A 7: 141,756,267 (GRCm39) H175Q unknown Het
Ksr2 G A 5: 117,885,399 (GRCm39) probably null Het
Lrtm1 C T 14: 28,743,714 (GRCm39) P61S probably damaging Het
Ltk A T 2: 119,584,721 (GRCm39) S487R possibly damaging Het
Mis18bp1 A T 12: 65,185,538 (GRCm39) D876E possibly damaging Het
Nalf1 T C 8: 9,820,156 (GRCm39) Y288C probably damaging Het
Or8b39 A G 9: 37,996,785 (GRCm39) T218A probably benign Het
Paqr7 A G 4: 134,234,311 (GRCm39) N56S probably benign Het
Pcdhb22 G T 18: 37,651,885 (GRCm39) E118* probably null Het
Pcdhb4 G A 18: 37,442,264 (GRCm39) A525T probably benign Het
Pik3cb A G 9: 98,943,844 (GRCm39) F653S probably damaging Het
Pla2g4e T A 2: 120,002,204 (GRCm39) D617V probably damaging Het
Plekha1 T A 7: 130,511,348 (GRCm39) C311S possibly damaging Het
Poteg A G 8: 27,940,287 (GRCm39) Y156C probably benign Het
Rev3l T C 10: 39,723,999 (GRCm39) S2644P probably damaging Het
Rnf40 T A 7: 127,188,172 (GRCm39) S2T probably benign Het
Rrp8 T C 7: 105,383,384 (GRCm39) D294G probably damaging Het
Slc6a21 T C 7: 44,937,130 (GRCm39) V252A Het
Slx9 C A 10: 77,351,535 (GRCm39) A14S possibly damaging Het
Socs1 T C 16: 10,602,578 (GRCm39) D53G possibly damaging Het
St6galnac6 G T 2: 32,502,345 (GRCm39) R78L probably benign Het
Tbce T C 13: 14,194,398 (GRCm39) K87R probably benign Het
Tep1 T C 14: 51,081,988 (GRCm39) probably benign Het
Thada T C 17: 84,749,205 (GRCm39) M589V probably benign Het
Thsd7a A G 6: 12,504,131 (GRCm39) F341S Het
Tmem82 A T 4: 141,343,861 (GRCm39) C136* probably null Het
Tmprss11a A T 5: 86,570,361 (GRCm39) C199* probably null Het
Zbtb48 T C 4: 152,105,147 (GRCm39) N505S possibly damaging Het
Zfp385b A T 2: 77,246,115 (GRCm39) V304E probably damaging Het
Other mutations in Cyp4a10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00774:Cyp4a10 APN 4 115,389,735 (GRCm39) missense probably damaging 1.00
IGL01301:Cyp4a10 APN 4 115,375,652 (GRCm39) missense probably damaging 1.00
IGL02081:Cyp4a10 APN 4 115,378,369 (GRCm39) missense possibly damaging 0.87
IGL02373:Cyp4a10 APN 4 115,378,274 (GRCm39) nonsense probably null
IGL03411:Cyp4a10 APN 4 115,382,890 (GRCm39) splice site probably null
ANU18:Cyp4a10 UTSW 4 115,375,652 (GRCm39) missense probably damaging 1.00
PIT4142001:Cyp4a10 UTSW 4 115,382,072 (GRCm39) missense probably damaging 0.99
PIT4151001:Cyp4a10 UTSW 4 115,382,072 (GRCm39) missense probably damaging 0.99
R0016:Cyp4a10 UTSW 4 115,378,304 (GRCm39) missense probably damaging 1.00
R0368:Cyp4a10 UTSW 4 115,382,574 (GRCm39) nonsense probably null
R1319:Cyp4a10 UTSW 4 115,378,342 (GRCm39) missense probably damaging 0.98
R1440:Cyp4a10 UTSW 4 115,386,646 (GRCm39) missense probably damaging 1.00
R1531:Cyp4a10 UTSW 4 115,375,632 (GRCm39) nonsense probably null
R2008:Cyp4a10 UTSW 4 115,382,589 (GRCm39) missense probably damaging 0.98
R2064:Cyp4a10 UTSW 4 115,381,917 (GRCm39) splice site probably benign
R2083:Cyp4a10 UTSW 4 115,382,505 (GRCm39) missense possibly damaging 0.86
R2961:Cyp4a10 UTSW 4 115,377,467 (GRCm39) missense probably benign 0.02
R3028:Cyp4a10 UTSW 4 115,375,628 (GRCm39) missense possibly damaging 0.64
R3839:Cyp4a10 UTSW 4 115,382,544 (GRCm39) missense possibly damaging 0.85
R3930:Cyp4a10 UTSW 4 115,381,980 (GRCm39) missense probably benign 0.00
R4062:Cyp4a10 UTSW 4 115,376,898 (GRCm39) missense probably benign 0.06
R4097:Cyp4a10 UTSW 4 115,386,480 (GRCm39) missense probably damaging 0.99
R4298:Cyp4a10 UTSW 4 115,389,889 (GRCm39) missense probably damaging 1.00
R4482:Cyp4a10 UTSW 4 115,389,795 (GRCm39) missense probably damaging 1.00
R4592:Cyp4a10 UTSW 4 115,386,690 (GRCm39) missense probably damaging 0.99
R4715:Cyp4a10 UTSW 4 115,382,535 (GRCm39) missense probably benign 0.44
R4826:Cyp4a10 UTSW 4 115,375,541 (GRCm39) missense probably benign 0.00
R4834:Cyp4a10 UTSW 4 115,383,005 (GRCm39) missense probably damaging 1.00
R4922:Cyp4a10 UTSW 4 115,378,291 (GRCm39) missense probably benign 0.01
R5202:Cyp4a10 UTSW 4 115,389,812 (GRCm39) missense probably damaging 1.00
R5502:Cyp4a10 UTSW 4 115,382,702 (GRCm39) missense probably benign 0.21
R6269:Cyp4a10 UTSW 4 115,381,509 (GRCm39) missense probably damaging 1.00
R6349:Cyp4a10 UTSW 4 115,382,555 (GRCm39) missense probably benign 0.00
R7684:Cyp4a10 UTSW 4 115,375,549 (GRCm39) missense probably benign 0.18
R7863:Cyp4a10 UTSW 4 115,375,622 (GRCm39) missense probably benign 0.00
R8392:Cyp4a10 UTSW 4 115,386,675 (GRCm39) nonsense probably null
R8445:Cyp4a10 UTSW 4 115,382,791 (GRCm39) missense probably damaging 1.00
R8744:Cyp4a10 UTSW 4 115,386,667 (GRCm39) missense probably benign 0.00
R9264:Cyp4a10 UTSW 4 115,381,475 (GRCm39) missense probably benign 0.03
R9297:Cyp4a10 UTSW 4 115,378,375 (GRCm39) missense probably damaging 1.00
R9393:Cyp4a10 UTSW 4 115,382,566 (GRCm39) missense probably damaging 1.00
Z1176:Cyp4a10 UTSW 4 115,375,523 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGCTATGTTCCTGTGCTTGC -3'
(R):5'- TCCTATGTGTTCTGGAAGGAAAC -3'

Sequencing Primer
(F):5'- ACTCTTGTCTCCAGTCCAAAAACTAG -3'
(R):5'- TGTGTTCTGGAAGGAAACAATTAG -3'
Posted On 2022-03-25