Incidental Mutation 'R9300:Magi1'
| ID |
704856 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Magi1
|
| Ensembl Gene |
ENSMUSG00000045095 |
| Gene Name |
membrane associated guanylate kinase, WW and PDZ domain containing 1 |
| Synonyms |
Baiap1, Gukmi1, AIP3, BAP1, WWP3 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.561)
|
| Stock # |
R9300 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
6 |
| Chromosomal Location |
93652436-94260898 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to A
at 93724209 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Tyrosine
at position 496
(D496Y)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000086730
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000055224]
[ENSMUST00000089317]
[ENSMUST00000093769]
[ENSMUST00000203519]
[ENSMUST00000203688]
[ENSMUST00000204347]
[ENSMUST00000204532]
|
| AlphaFold |
Q6RHR9 |
| PDB Structure |
X-ray crystal structure of MAGI-1 PDZ1 bound to the C-terminal peptide of HPV18 E6 [X-RAY DIFFRACTION]
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000055224
AA Change: D484Y
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000062085
Gene: ENSMUSG00000045095
AA Change: D484Y
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
26 |
105 |
8.04e-5 |
SMART |
|
GuKc
|
111 |
295 |
2.55e-49 |
SMART |
|
WW
|
301 |
333 |
9.65e-11 |
SMART |
|
WW
|
348 |
380 |
2.88e-9 |
SMART |
|
low complexity region
|
390 |
402 |
N/A |
INTRINSIC |
|
low complexity region
|
410 |
428 |
N/A |
INTRINSIC |
|
PDZ
|
460 |
536 |
3.71e-18 |
SMART |
|
PDZ
|
631 |
703 |
4.68e-15 |
SMART |
|
low complexity region
|
707 |
714 |
N/A |
INTRINSIC |
|
low complexity region
|
720 |
733 |
N/A |
INTRINSIC |
|
PDZ
|
800 |
876 |
4.64e-19 |
SMART |
|
low complexity region
|
920 |
942 |
N/A |
INTRINSIC |
|
PDB:1UEW|A
|
945 |
977 |
2e-6 |
PDB |
|
PDZ
|
1043 |
1117 |
1.26e-20 |
SMART |
|
low complexity region
|
1152 |
1164 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000089317
AA Change: D496Y
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000086730
Gene: ENSMUSG00000045095
AA Change: D496Y
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
26 |
105 |
4e-7 |
SMART |
|
GuKc
|
111 |
295 |
1.3e-51 |
SMART |
|
WW
|
301 |
333 |
5.8e-13 |
SMART |
|
WW
|
360 |
392 |
1.7e-11 |
SMART |
|
low complexity region
|
402 |
414 |
N/A |
INTRINSIC |
|
low complexity region
|
422 |
440 |
N/A |
INTRINSIC |
|
PDZ
|
472 |
548 |
1.9e-20 |
SMART |
|
PDZ
|
643 |
715 |
2.3e-17 |
SMART |
|
low complexity region
|
733 |
746 |
N/A |
INTRINSIC |
|
PDZ
|
841 |
917 |
2.4e-21 |
SMART |
|
low complexity region
|
961 |
983 |
N/A |
INTRINSIC |
|
PDZ
|
999 |
1074 |
6.1e-25 |
SMART |
|
PDZ
|
1140 |
1214 |
6.1e-23 |
SMART |
|
low complexity region
|
1347 |
1357 |
N/A |
INTRINSIC |
|
low complexity region
|
1366 |
1423 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000093769
AA Change: D269Y
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000091283
Gene: ENSMUSG00000045095
AA Change: D269Y
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
10 |
15 |
N/A |
INTRINSIC |
|
WW
|
74 |
106 |
9.65e-11 |
SMART |
|
WW
|
133 |
165 |
2.88e-9 |
SMART |
|
low complexity region
|
175 |
187 |
N/A |
INTRINSIC |
|
low complexity region
|
195 |
213 |
N/A |
INTRINSIC |
|
PDZ
|
245 |
321 |
3.71e-18 |
SMART |
|
PDZ
|
416 |
488 |
4.68e-15 |
SMART |
|
low complexity region
|
492 |
499 |
N/A |
INTRINSIC |
|
low complexity region
|
505 |
518 |
N/A |
INTRINSIC |
|
PDZ
|
613 |
689 |
4.64e-19 |
SMART |
|
low complexity region
|
733 |
755 |
N/A |
INTRINSIC |
|
PDZ
|
771 |
858 |
2.3e-23 |
SMART |
|
PDZ
|
924 |
998 |
1.26e-20 |
SMART |
|
low complexity region
|
1131 |
1141 |
N/A |
INTRINSIC |
|
low complexity region
|
1150 |
1207 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000203519
AA Change: D496Y
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000145244
Gene: ENSMUSG00000045095
AA Change: D496Y
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
26 |
105 |
8.04e-5 |
SMART |
|
GuKc
|
111 |
295 |
2.55e-49 |
SMART |
|
WW
|
301 |
333 |
9.65e-11 |
SMART |
|
WW
|
360 |
392 |
2.88e-9 |
SMART |
|
low complexity region
|
402 |
414 |
N/A |
INTRINSIC |
|
low complexity region
|
422 |
440 |
N/A |
INTRINSIC |
|
PDZ
|
472 |
548 |
3.71e-18 |
SMART |
|
PDZ
|
643 |
715 |
4.68e-15 |
SMART |
|
low complexity region
|
719 |
726 |
N/A |
INTRINSIC |
|
low complexity region
|
732 |
745 |
N/A |
INTRINSIC |
|
PDZ
|
812 |
888 |
4.64e-19 |
SMART |
|
low complexity region
|
932 |
954 |
N/A |
INTRINSIC |
|
PDB:1UEW|A
|
957 |
989 |
2e-6 |
PDB |
|
PDZ
|
1055 |
1115 |
1.13e-8 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000203688
AA Change: D269Y
PolyPhen 2
Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000145515
Gene: ENSMUSG00000045095
AA Change: D269Y
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:MAGI_u1
|
1 |
34 |
2.9e-17 |
PFAM |
|
WW
|
74 |
106 |
9.65e-11 |
SMART |
|
WW
|
133 |
165 |
2.88e-9 |
SMART |
|
low complexity region
|
175 |
187 |
N/A |
INTRINSIC |
|
low complexity region
|
195 |
213 |
N/A |
INTRINSIC |
|
PDZ
|
245 |
321 |
3.71e-18 |
SMART |
|
PDZ
|
416 |
488 |
4.68e-15 |
SMART |
|
low complexity region
|
506 |
519 |
N/A |
INTRINSIC |
|
PDZ
|
614 |
690 |
4.64e-19 |
SMART |
|
low complexity region
|
734 |
756 |
N/A |
INTRINSIC |
|
PDZ
|
772 |
858 |
1.74e-23 |
SMART |
|
PDZ
|
924 |
998 |
1.26e-20 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000204347
AA Change: D496Y
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000144881
Gene: ENSMUSG00000045095
AA Change: D496Y
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
26 |
105 |
4e-7 |
SMART |
|
GuKc
|
111 |
295 |
1.3e-51 |
SMART |
|
WW
|
301 |
333 |
5.8e-13 |
SMART |
|
WW
|
360 |
392 |
1.7e-11 |
SMART |
|
low complexity region
|
402 |
414 |
N/A |
INTRINSIC |
|
low complexity region
|
422 |
440 |
N/A |
INTRINSIC |
|
PDZ
|
472 |
548 |
1.9e-20 |
SMART |
|
PDZ
|
643 |
715 |
2.3e-17 |
SMART |
|
low complexity region
|
733 |
746 |
N/A |
INTRINSIC |
|
PDZ
|
841 |
917 |
2.4e-21 |
SMART |
|
low complexity region
|
961 |
983 |
N/A |
INTRINSIC |
|
PDZ
|
999 |
1086 |
1.1e-25 |
SMART |
|
PDZ
|
1152 |
1226 |
6.1e-23 |
SMART |
|
low complexity region
|
1261 |
1273 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000204532
AA Change: D269Y
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000144769
Gene: ENSMUSG00000045095
AA Change: D269Y
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:MAGI_u1
|
1 |
34 |
1.8e-14 |
PFAM |
|
WW
|
74 |
106 |
5.8e-13 |
SMART |
|
WW
|
133 |
165 |
1.7e-11 |
SMART |
|
low complexity region
|
175 |
187 |
N/A |
INTRINSIC |
|
low complexity region
|
195 |
213 |
N/A |
INTRINSIC |
|
PDZ
|
245 |
321 |
1.9e-20 |
SMART |
|
PDZ
|
416 |
488 |
7.3e-17 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue (MAGUK) family. MAGUK proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane at regions of cell-cell contact. The product of this gene may play a role as scaffolding protein at cell-cell junctions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
All alleles(165) : Targeted(2) Gene trapped(163)
|
| Other mutations in this stock |
Total: 88 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcb1b |
G |
A |
5: 8,875,614 (GRCm39) |
V596I |
probably benign |
Het |
| Acad8 |
A |
T |
9: 26,888,928 (GRCm39) |
H371Q |
probably damaging |
Het |
| Actn3 |
G |
T |
19: 4,921,656 (GRCm39) |
R175S |
probably benign |
Het |
| Adamts9 |
G |
T |
6: 92,864,371 (GRCm39) |
D780E |
probably benign |
Het |
| AK157302 |
C |
A |
13: 21,679,537 (GRCm39) |
T21K |
probably benign |
Het |
| Ank3 |
A |
T |
10: 69,706,872 (GRCm39) |
H329L |
unknown |
Het |
| Ankrd36 |
A |
G |
11: 5,519,979 (GRCm39) |
H18R |
possibly damaging |
Het |
| Anks1b |
T |
A |
10: 90,412,966 (GRCm39) |
V38D |
possibly damaging |
Het |
| Apbb2 |
A |
T |
5: 66,470,677 (GRCm39) |
L520H |
probably damaging |
Het |
| Arid1b |
C |
A |
17: 5,293,274 (GRCm39) |
P731T |
probably damaging |
Het |
| Atp1a4 |
A |
G |
1: 172,067,398 (GRCm39) |
F578S |
probably damaging |
Het |
| Atp6v0a2 |
A |
T |
5: 124,789,312 (GRCm39) |
I360F |
probably damaging |
Het |
| Bcas3 |
A |
T |
11: 85,448,184 (GRCm39) |
I600F |
probably damaging |
Het |
| C1qtnf7 |
T |
G |
5: 43,766,441 (GRCm39) |
C20W |
possibly damaging |
Het |
| Cadm1 |
A |
T |
9: 47,708,821 (GRCm39) |
K184* |
probably null |
Het |
| Ccdc138 |
A |
T |
10: 58,343,448 (GRCm39) |
H101L |
probably benign |
Het |
| Cep120 |
T |
A |
18: 53,852,369 (GRCm39) |
N503I |
probably damaging |
Het |
| Chil4 |
T |
C |
3: 106,109,874 (GRCm39) |
T380A |
probably benign |
Het |
| Clip2 |
A |
G |
5: 134,526,942 (GRCm39) |
|
probably null |
Het |
| Cyp3a11 |
G |
A |
5: 145,799,164 (GRCm39) |
P341L |
possibly damaging |
Het |
| Cyp3a41a |
G |
C |
5: 145,656,906 (GRCm39) |
|
probably benign |
Het |
| Dcaf1 |
A |
G |
9: 106,725,042 (GRCm39) |
I509M |
possibly damaging |
Het |
| Dcaf13 |
T |
C |
15: 39,010,102 (GRCm39) |
S429P |
probably damaging |
Het |
| Eln |
A |
G |
5: 134,758,220 (GRCm39) |
V151A |
unknown |
Het |
| Endou |
T |
G |
15: 97,610,954 (GRCm39) |
M377L |
probably benign |
Het |
| Etfa |
A |
G |
9: 55,396,152 (GRCm39) |
I138T |
probably damaging |
Het |
| Fbxw10 |
T |
A |
11: 62,768,109 (GRCm39) |
S982T |
probably benign |
Het |
| Gm9602 |
A |
T |
14: 15,933,435 (GRCm39) |
R47* |
probably null |
Het |
| Hectd4 |
G |
A |
5: 121,486,952 (GRCm39) |
V3316I |
probably benign |
Het |
| Hif1a |
T |
C |
12: 73,987,302 (GRCm39) |
L477S |
probably benign |
Het |
| Icam5 |
G |
C |
9: 20,946,846 (GRCm39) |
G458A |
probably benign |
Het |
| Itm2b |
A |
T |
14: 73,603,896 (GRCm39) |
D106E |
probably benign |
Het |
| Kdm4d |
G |
A |
9: 14,375,336 (GRCm39) |
T174M |
probably damaging |
Het |
| Kif16b |
G |
T |
2: 142,541,207 (GRCm39) |
D1364E |
probably benign |
Het |
| Lbhd1 |
G |
A |
19: 8,861,550 (GRCm39) |
V61M |
probably damaging |
Het |
| Lclat1 |
T |
A |
17: 73,546,919 (GRCm39) |
S279T |
probably benign |
Het |
| Lhx4 |
G |
A |
1: 155,580,956 (GRCm39) |
L190F |
probably damaging |
Het |
| Lima1 |
C |
T |
15: 99,704,320 (GRCm39) |
S283N |
probably benign |
Het |
| Map1a |
T |
C |
2: 121,133,446 (GRCm39) |
S1421P |
probably damaging |
Het |
| Map3k20 |
C |
T |
2: 72,202,257 (GRCm39) |
H163Y |
probably damaging |
Het |
| Mier3 |
T |
G |
13: 111,822,890 (GRCm39) |
|
probably null |
Het |
| Mllt3 |
G |
A |
4: 87,692,284 (GRCm39) |
Q560* |
probably null |
Het |
| Mmp25 |
T |
A |
17: 23,851,728 (GRCm39) |
D327V |
probably benign |
Het |
| Nckap5 |
G |
A |
1: 125,909,423 (GRCm39) |
Q1603* |
probably null |
Het |
| Nell1 |
G |
A |
7: 49,712,368 (GRCm39) |
V63I |
probably benign |
Het |
| Or10al3 |
C |
T |
17: 38,011,815 (GRCm39) |
P85S |
probably damaging |
Het |
| Or2ag2b |
A |
T |
7: 106,418,111 (GRCm39) |
I274F |
probably benign |
Het |
| Or8a1 |
A |
C |
9: 37,641,578 (GRCm39) |
S234A |
probably benign |
Het |
| Pde12 |
C |
T |
14: 26,386,931 (GRCm39) |
E526K |
probably damaging |
Het |
| Pfn4 |
T |
C |
12: 4,825,442 (GRCm39) |
V93A |
possibly damaging |
Het |
| Poglut2 |
A |
G |
1: 44,156,362 (GRCm39) |
I75T |
possibly damaging |
Het |
| Ppp2r3d |
A |
G |
9: 124,423,977 (GRCm38) |
S60P |
unknown |
Het |
| Prelp |
T |
C |
1: 133,842,257 (GRCm39) |
H296R |
probably damaging |
Het |
| Prickle1 |
T |
C |
15: 93,398,749 (GRCm39) |
E693G |
possibly damaging |
Het |
| Rars1 |
A |
G |
11: 35,706,488 (GRCm39) |
L477P |
probably damaging |
Het |
| Rasal1 |
G |
A |
5: 120,802,172 (GRCm39) |
R328H |
probably damaging |
Het |
| Rasef |
A |
G |
4: 73,659,393 (GRCm39) |
F220S |
probably benign |
Het |
| Rif1 |
C |
T |
2: 52,001,151 (GRCm39) |
S1535L |
probably damaging |
Het |
| Rnf17 |
T |
C |
14: 56,697,495 (GRCm39) |
I463T |
possibly damaging |
Het |
| Ryr3 |
A |
T |
2: 112,690,695 (GRCm39) |
D1138E |
probably benign |
Het |
| Scn9a |
T |
A |
2: 66,335,236 (GRCm39) |
Y1251F |
probably benign |
Het |
| Sdk2 |
A |
G |
11: 113,715,856 (GRCm39) |
W1568R |
possibly damaging |
Het |
| Senp6 |
A |
G |
9: 80,049,433 (GRCm39) |
E1019G |
probably damaging |
Het |
| Shh |
A |
G |
5: 28,663,461 (GRCm39) |
Y236H |
probably damaging |
Het |
| Sin3a |
A |
G |
9: 57,014,744 (GRCm39) |
D655G |
probably damaging |
Het |
| Slc35a4 |
C |
T |
18: 36,815,274 (GRCm39) |
P35S |
probably damaging |
Het |
| Slc35g1 |
T |
C |
19: 38,384,633 (GRCm39) |
L24P |
probably benign |
Het |
| Slc39a4 |
G |
T |
15: 76,498,759 (GRCm39) |
Q312K |
probably damaging |
Het |
| Slc6a5 |
A |
T |
7: 49,601,175 (GRCm39) |
I659F |
probably damaging |
Het |
| Slc7a4 |
T |
C |
16: 17,392,399 (GRCm39) |
Y345C |
probably benign |
Het |
| Slco6c1 |
G |
T |
1: 96,993,809 (GRCm39) |
R645S |
probably benign |
Het |
| Soat1 |
T |
C |
1: 156,268,923 (GRCm39) |
Y209C |
probably benign |
Het |
| Tbc1d9b |
T |
C |
11: 50,054,714 (GRCm39) |
S953P |
probably benign |
Het |
| Tgm1 |
G |
A |
14: 55,942,303 (GRCm39) |
H683Y |
probably benign |
Het |
| Tmem98 |
G |
A |
11: 80,708,432 (GRCm39) |
R134Q |
probably damaging |
Het |
| Trpm3 |
A |
C |
19: 22,955,745 (GRCm39) |
M1107L |
possibly damaging |
Het |
| Vmn1r11 |
G |
A |
6: 57,114,872 (GRCm39) |
V179I |
probably benign |
Het |
| Vmn1r119 |
G |
T |
7: 20,745,638 (GRCm39) |
T248K |
probably damaging |
Het |
| Vmn1r236 |
T |
A |
17: 21,506,945 (GRCm39) |
I21N |
possibly damaging |
Het |
| Vmn2r24 |
A |
G |
6: 123,793,030 (GRCm39) |
T786A |
possibly damaging |
Het |
| Vstm5 |
A |
T |
9: 15,168,585 (GRCm39) |
I50F |
probably damaging |
Het |
| Wdr1 |
T |
C |
5: 38,685,255 (GRCm39) |
D572G |
probably damaging |
Het |
| Xaf1 |
T |
C |
11: 72,192,517 (GRCm39) |
F5S |
probably benign |
Het |
| Zan |
A |
T |
5: 137,468,519 (GRCm39) |
|
probably null |
Het |
| Zfp697 |
T |
C |
3: 98,334,979 (GRCm39) |
V248A |
possibly damaging |
Het |
| Zftraf1 |
C |
A |
15: 76,530,541 (GRCm39) |
V260L |
probably benign |
Het |
| Zkscan3 |
T |
A |
13: 21,577,667 (GRCm39) |
T249S |
unknown |
Het |
| Znfx1 |
A |
G |
2: 166,897,860 (GRCm39) |
Y355H |
probably damaging |
Het |
|
| Other mutations in Magi1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01376:Magi1
|
APN |
6 |
94,260,074 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL01457:Magi1
|
APN |
6 |
93,724,205 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01642:Magi1
|
APN |
6 |
93,663,605 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
IGL01724:Magi1
|
APN |
6 |
93,769,381 (GRCm39) |
splice site |
probably null |
|
|
IGL01967:Magi1
|
APN |
6 |
93,685,115 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01984:Magi1
|
APN |
6 |
93,685,155 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02074:Magi1
|
APN |
6 |
93,722,579 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02098:Magi1
|
APN |
6 |
93,655,768 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02225:Magi1
|
APN |
6 |
93,671,007 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02522:Magi1
|
APN |
6 |
93,655,617 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL02659:Magi1
|
APN |
6 |
93,762,591 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
IGL02900:Magi1
|
APN |
6 |
93,663,854 (GRCm39) |
missense |
probably damaging |
1.00 |
|
P0007:Magi1
|
UTSW |
6 |
93,722,969 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0149:Magi1
|
UTSW |
6 |
93,724,226 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0512:Magi1
|
UTSW |
6 |
93,671,045 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1487:Magi1
|
UTSW |
6 |
93,685,060 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1497:Magi1
|
UTSW |
6 |
93,724,310 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1502:Magi1
|
UTSW |
6 |
93,671,151 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1824:Magi1
|
UTSW |
6 |
93,676,620 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2042:Magi1
|
UTSW |
6 |
93,732,026 (GRCm39) |
missense |
probably benign |
|
|
R2132:Magi1
|
UTSW |
6 |
93,674,255 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2331:Magi1
|
UTSW |
6 |
93,662,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2418:Magi1
|
UTSW |
6 |
93,722,891 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3076:Magi1
|
UTSW |
6 |
93,734,668 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R3551:Magi1
|
UTSW |
6 |
93,676,610 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4005:Magi1
|
UTSW |
6 |
93,678,299 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4455:Magi1
|
UTSW |
6 |
93,762,438 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4670:Magi1
|
UTSW |
6 |
93,663,624 (GRCm39) |
splice site |
probably null |
|
|
R4671:Magi1
|
UTSW |
6 |
93,657,768 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4839:Magi1
|
UTSW |
6 |
93,671,177 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5132:Magi1
|
UTSW |
6 |
93,660,072 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R5147:Magi1
|
UTSW |
6 |
93,724,248 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5525:Magi1
|
UTSW |
6 |
93,769,354 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5724:Magi1
|
UTSW |
6 |
93,722,682 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5724:Magi1
|
UTSW |
6 |
93,657,852 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5846:Magi1
|
UTSW |
6 |
93,662,584 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5896:Magi1
|
UTSW |
6 |
93,685,180 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5912:Magi1
|
UTSW |
6 |
93,685,126 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6112:Magi1
|
UTSW |
6 |
93,722,571 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6115:Magi1
|
UTSW |
6 |
93,685,051 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R6351:Magi1
|
UTSW |
6 |
93,920,210 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R6355:Magi1
|
UTSW |
6 |
94,260,177 (GRCm39) |
missense |
probably benign |
0.06 |
|
R6457:Magi1
|
UTSW |
6 |
93,676,620 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6464:Magi1
|
UTSW |
6 |
93,676,770 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6613:Magi1
|
UTSW |
6 |
93,722,654 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6661:Magi1
|
UTSW |
6 |
93,920,289 (GRCm39) |
missense |
probably benign |
0.08 |
|
R6755:Magi1
|
UTSW |
6 |
93,685,158 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6909:Magi1
|
UTSW |
6 |
93,674,301 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7180:Magi1
|
UTSW |
6 |
93,792,731 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7224:Magi1
|
UTSW |
6 |
93,660,070 (GRCm39) |
missense |
probably benign |
0.34 |
|
R7447:Magi1
|
UTSW |
6 |
93,722,562 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R7517:Magi1
|
UTSW |
6 |
93,685,189 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7537:Magi1
|
UTSW |
6 |
93,685,091 (GRCm39) |
nonsense |
probably null |
|
|
R7549:Magi1
|
UTSW |
6 |
93,685,095 (GRCm39) |
missense |
probably benign |
0.19 |
|
R7566:Magi1
|
UTSW |
6 |
93,655,308 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7805:Magi1
|
UTSW |
6 |
93,659,927 (GRCm39) |
missense |
probably benign |
|
|
R8022:Magi1
|
UTSW |
6 |
93,674,346 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8290:Magi1
|
UTSW |
6 |
94,260,066 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8519:Magi1
|
UTSW |
6 |
93,681,330 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R8762:Magi1
|
UTSW |
6 |
93,792,789 (GRCm39) |
nonsense |
probably null |
|
|
R8894:Magi1
|
UTSW |
6 |
93,663,586 (GRCm39) |
missense |
probably benign |
0.12 |
|
R8974:Magi1
|
UTSW |
6 |
93,674,223 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9225:Magi1
|
UTSW |
6 |
93,762,511 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R9277:Magi1
|
UTSW |
6 |
93,920,234 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R9393:Magi1
|
UTSW |
6 |
93,659,890 (GRCm39) |
missense |
probably benign |
0.27 |
|
R9402:Magi1
|
UTSW |
6 |
94,260,278 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9432:Magi1
|
UTSW |
6 |
93,660,058 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9567:Magi1
|
UTSW |
6 |
93,659,931 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9567:Magi1
|
UTSW |
6 |
93,655,431 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GTTTTCATCTGCACTGAGGGAG -3'
(R):5'- GTCTCATAGCATCCTTGGTTCAG -3'
Sequencing Primer
(F):5'- CATCTGCACTGAGGGAGGGATC -3'
(R):5'- ATAGCATCCTTGGTTCAGGTTTAC -3'
|
| Posted On |
2022-03-25 |
Incidental Mutation