Mutagenetix > Incidental Mutation

Incidental Mutation 'R9300:Olfr119'

704904

Institutional Source

Beutler Lab

Gene Symbol

Olfr119

Ensembl Gene

ENSMUSG00000059964

Gene Name

olfactory receptor 119

Synonyms

MOR263-7, GA_x6K02T2PSCP-2159633-2160598

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.054) question?

Stock #

R9300 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

37696564-37702124 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 37700924 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Proline to Serine at position 85 (P85S)

Ref Sequence

ENSEMBL: ENSMUSP00000092919 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000080483] [ENSMUST00000213732]

AlphaFold

Q7TRJ5

Predicted Effect

probably damaging
Transcript: ENSMUST00000080483
AA Change: P85S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000092919
Gene: ENSMUSG00000059964
AA Change: P85S

Domain	Start	End	E-Value	Type
Pfam:7tm_4	37	314	5.6e-59	PFAM
Pfam:7TM_GPCR_Srsx	41	311	1.7e-5	PFAM
Pfam:7tm_1	47	296	3.1e-23	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000213732
AA Change: P85S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 99.1%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 88 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcb1b	G	A	5: 8,825,614	V596I	probably benign	Het
Acad8	A	T	9: 26,977,632	H371Q	probably damaging	Het
Actn3	G	T	19: 4,871,628	R175S	probably benign	Het
Adamts9	G	T	6: 92,887,390	D780E	probably benign	Het
AK157302	C	A	13: 21,495,367	T21K	probably benign	Het
Ank3	A	T	10: 69,871,042	H329L	unknown	Het
Ankrd36	A	G	11: 5,569,979	H18R	possibly damaging	Het
Anks1b	T	A	10: 90,577,104	V38D	possibly damaging	Het
Apbb2	A	T	5: 66,313,334	L520H	probably damaging	Het
Arid1b	C	A	17: 5,242,999	P731T	probably damaging	Het
Atp1a4	A	G	1: 172,239,831	F578S	probably damaging	Het
Atp6v0a2	A	T	5: 124,712,248	I360F	probably damaging	Het
Bcas3	A	T	11: 85,557,358	I600F	probably damaging	Het
C1qtnf7	T	G	5: 43,609,099	C20W	possibly damaging	Het
Cadm1	A	T	9: 47,797,523	K184*	probably null	Het
Ccdc138	A	T	10: 58,507,626	H101L	probably benign	Het
Cep120	T	A	18: 53,719,297	N503I	probably damaging	Het
Chil4	T	C	3: 106,202,558	T380A	probably benign	Het
Clip2	A	G	5: 134,498,088		probably null	Het
Cyhr1	C	A	15: 76,646,341	V260L	probably benign	Het
Cyp3a11	G	A	5: 145,862,354	P341L	possibly damaging	Het
Cyp3a41a	G	C	5: 145,720,096		probably benign	Het
Dcaf1	A	G	9: 106,847,843	I509M	possibly damaging	Het
Dcaf13	T	C	15: 39,146,707	S429P	probably damaging	Het
Eln	A	G	5: 134,729,366	V151A	unknown	Het
Endou	T	G	15: 97,713,073	M377L	probably benign	Het
Etfa	A	G	9: 55,488,868	I138T	probably damaging	Het
Fbxw10	T	A	11: 62,877,283	S982T	probably benign	Het
Gm9602	A	T	14: 4,777,288	R47*	probably null	Het
Hectd4	G	A	5: 121,348,889	V3316I	probably benign	Het
Hif1a	T	C	12: 73,940,528	L477S	probably benign	Het
Icam5	G	C	9: 21,035,550	G458A	probably benign	Het
Itm2b	A	T	14: 73,366,456	D106E	probably benign	Het
Kdelc1	A	G	1: 44,117,202	I75T	possibly damaging	Het
Kdm4d	G	A	9: 14,464,040	T174M	probably damaging	Het
Kif16b	G	T	2: 142,699,287	D1364E	probably benign	Het
Lbhd1	G	A	19: 8,884,186	V61M	probably damaging	Het
Lclat1	T	A	17: 73,239,924	S279T	probably benign	Het
Lhx4	G	A	1: 155,705,210	L190F	probably damaging	Het
Lima1	C	T	15: 99,806,439	S283N	probably benign	Het
Magi1	C	A	6: 93,747,228	D496Y	probably damaging	Het
Map1a	T	C	2: 121,302,965	S1421P	probably damaging	Het
Map3k20	C	T	2: 72,371,913	H163Y	probably damaging	Het
Mier3	T	G	13: 111,686,356		probably null	Het
Mllt3	G	A	4: 87,774,047	Q560*	probably null	Het
Mmp25	T	A	17: 23,632,754	D327V	probably benign	Het
Nckap5	G	A	1: 125,981,686	Q1603*	probably null	Het
Nell1	G	A	7: 50,062,620	V63I	probably benign	Het
Olfr151	A	C	9: 37,730,282	S234A	probably benign	Het
Olfr701	A	T	7: 106,818,904	I274F	probably benign	Het
Pde12	C	T	14: 26,665,776	E526K	probably damaging	Het
Pfn4	T	C	12: 4,775,442	V93A	possibly damaging	Het
Ppp2r3d	A	G	9: 124,423,977	S60P	unknown	Het
Prelp	T	C	1: 133,914,519	H296R	probably damaging	Het
Prickle1	T	C	15: 93,500,868	E693G	possibly damaging	Het
Rars	A	G	11: 35,815,661	L477P	probably damaging	Het
Rasal1	G	A	5: 120,664,107	R328H	probably damaging	Het
Rasef	A	G	4: 73,741,156	F220S	probably benign	Het
Rif1	C	T	2: 52,111,139	S1535L	probably damaging	Het
Rnf17	T	C	14: 56,460,038	I463T	possibly damaging	Het
Ryr3	A	T	2: 112,860,350	D1138E	probably benign	Het
Scn9a	T	A	2: 66,504,892	Y1251F	probably benign	Het
Sdk2	A	G	11: 113,825,030	W1568R	possibly damaging	Het
Senp6	A	G	9: 80,142,151	E1019G	probably damaging	Het
Shh	A	G	5: 28,458,463	Y236H	probably damaging	Het
Sin3a	A	G	9: 57,107,460	D655G	probably damaging	Het
Slc35a4	C	T	18: 36,682,221	P35S	probably damaging	Het
Slc35g1	T	C	19: 38,396,185	L24P	probably benign	Het
Slc39a4	G	T	15: 76,614,559	Q312K	probably damaging	Het
Slc6a5	A	T	7: 49,951,427	I659F	probably damaging	Het
Slc7a4	T	C	16: 17,574,535	Y345C	probably benign	Het
Slco6c1	G	T	1: 97,066,084	R645S	probably benign	Het
Soat1	T	C	1: 156,441,353	Y209C	probably benign	Het
Tbc1d9b	T	C	11: 50,163,887	S953P	probably benign	Het
Tgm1	G	A	14: 55,704,846	H683Y	probably benign	Het
Tmem98	G	A	11: 80,817,606	R134Q	probably damaging	Het
Trpm3	A	C	19: 22,978,381	M1107L	possibly damaging	Het
Vmn1r11	G	A	6: 57,137,887	V179I	probably benign	Het
Vmn1r119	G	T	7: 21,011,713	T248K	probably damaging	Het
Vmn1r236	T	A	17: 21,286,683	I21N	possibly damaging	Het
Vmn2r24	A	G	6: 123,816,071	T786A	possibly damaging	Het
Vstm5	A	T	9: 15,257,289	I50F	probably damaging	Het
Wdr1	T	C	5: 38,527,912	D572G	probably damaging	Het
Xaf1	T	C	11: 72,301,691	F5S	probably benign	Het
Zan	A	T	5: 137,470,257		probably null	Het
Zfp697	T	C	3: 98,427,663	V248A	possibly damaging	Het
Zkscan3	T	A	13: 21,393,497	T249S	unknown	Het
Znfx1	A	G	2: 167,055,940	Y355H	probably damaging	Het

Other mutations in Olfr119

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02209:Olfr119	APN	17	37700992	missense	probably damaging	1.00
IGL03339:Olfr119	APN	17	37700791	missense	probably damaging	0.99
R0092:Olfr119	UTSW	17	37700805	missense	probably damaging	0.98
R0207:Olfr119	UTSW	17	37701058	nonsense	probably null
R0378:Olfr119	UTSW	17	37701041	missense	probably damaging	1.00
R0408:Olfr119	UTSW	17	37701299	missense	probably benign
R0483:Olfr119	UTSW	17	37701297	missense	probably benign	0.01
R1595:Olfr119	UTSW	17	37701113	missense	probably benign	0.03
R1901:Olfr119	UTSW	17	37701421	missense	probably damaging	1.00
R1902:Olfr119	UTSW	17	37701421	missense	probably damaging	1.00
R2845:Olfr119	UTSW	17	37700823	missense	probably damaging	1.00
R2846:Olfr119	UTSW	17	37700823	missense	probably damaging	1.00
R4356:Olfr119	UTSW	17	37700899	missense	probably damaging	0.97
R4381:Olfr119	UTSW	17	37700899	missense	probably damaging	0.97
R6744:Olfr119	UTSW	17	37701445	nonsense	probably null
R7674:Olfr119	UTSW	17	37700682	missense	probably benign	0.03
R7677:Olfr119	UTSW	17	37701066	missense	probably damaging	1.00
R7994:Olfr119	UTSW	17	37701435	missense	probably damaging	0.99
R8305:Olfr119	UTSW	17	37701498	missense	probably benign	0.10
R8512:Olfr119	UTSW	17	37701180	missense	probably damaging	1.00
R9760:Olfr119	UTSW	17	37701543	missense	probably damaging	1.00
Z1177:Olfr119	UTSW	17	37701053	missense	possibly damaging	0.93

Predicted Primers

PCR Primer
(F):5'- TCTGAGGTTCCTGGAGAATGC -3'
(R):5'- CATTCCCCATGAAACTATTGCC -3'

Sequencing Primer
(F):5'- AGGTTCCTGGAGAATGCTTCCTC -3'
(R):5'- CCATGAAACTATTGCCAAATGGG -3'

Posted On

2022-03-25