Incidental Mutation 'R9301:Plcb1'
| ID |
704923 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Plcb1
|
| Ensembl Gene |
ENSMUSG00000051177 |
| Gene Name |
phospholipase C, beta 1 |
| Synonyms |
3110043I21Rik |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.166)
|
| Stock # |
R9301 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
2 |
| Chromosomal Location |
134628084-135317178 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 135167610 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Lysine to Arginine
at position 468
(K468R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000105743
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000070724]
[ENSMUST00000110116]
[ENSMUST00000131552]
|
| AlphaFold |
Q9Z1B3 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000070724
AA Change: K468R
PolyPhen 2
Score 0.784 (Sensitivity: 0.85; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000064844
Gene: ENSMUSG00000051177
AA Change: K468R
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:EF-hand_like
|
224 |
315 |
2.2e-26 |
PFAM |
|
PLCXc
|
316 |
467 |
2.85e-74 |
SMART |
|
low complexity region
|
491 |
501 |
N/A |
INTRINSIC |
|
PLCYc
|
540 |
656 |
2e-69 |
SMART |
|
C2
|
677 |
776 |
1.55e-12 |
SMART |
|
low complexity region
|
871 |
885 |
N/A |
INTRINSIC |
|
Pfam:DUF1154
|
903 |
946 |
1.3e-7 |
PFAM |
|
low complexity region
|
967 |
984 |
N/A |
INTRINSIC |
|
Pfam:PLC-beta_C
|
997 |
1155 |
1.9e-64 |
PFAM |
|
low complexity region
|
1157 |
1168 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000110116
AA Change: K468R
PolyPhen 2
Score 0.956 (Sensitivity: 0.79; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000105743
Gene: ENSMUSG00000051177
AA Change: K468R
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:EF-hand_like
|
224 |
315 |
4.1e-26 |
PFAM |
|
PLCXc
|
316 |
467 |
2.85e-74 |
SMART |
|
low complexity region
|
491 |
501 |
N/A |
INTRINSIC |
|
PLCYc
|
540 |
656 |
2e-69 |
SMART |
|
C2
|
677 |
776 |
1.55e-12 |
SMART |
|
low complexity region
|
871 |
885 |
N/A |
INTRINSIC |
|
Pfam:DUF1154
|
903 |
946 |
1.1e-9 |
PFAM |
|
low complexity region
|
967 |
984 |
N/A |
INTRINSIC |
|
Pfam:PLC-beta_C
|
1003 |
1176 |
2.9e-61 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000131552
AA Change: K468R
PolyPhen 2
Score 0.784 (Sensitivity: 0.85; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000118756
Gene: ENSMUSG00000051177
AA Change: K468R
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:EF-hand_like
|
224 |
315 |
3.9e-26 |
PFAM |
|
PLCXc
|
316 |
467 |
2.85e-74 |
SMART |
|
low complexity region
|
491 |
501 |
N/A |
INTRINSIC |
|
PLCYc
|
540 |
656 |
2e-69 |
SMART |
|
C2
|
677 |
776 |
1.55e-12 |
SMART |
|
low complexity region
|
871 |
885 |
N/A |
INTRINSIC |
|
Pfam:DUF1154
|
903 |
946 |
1e-9 |
PFAM |
|
low complexity region
|
967 |
984 |
N/A |
INTRINSIC |
|
Pfam:PLC-beta_C
|
1003 |
1148 |
8e-51 |
PFAM |
|
low complexity region
|
1157 |
1168 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.4%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for a targeted null mutation exhibit spontaneous seizures and high mortality around 3 weeks of age. Mutant males show exhibit sperm with a reduced acrosome reaction rate and fertilizing capacity in vitro and decreased fertility in vivo. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 70 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca4 |
T |
A |
3: 121,881,128 (GRCm39) |
N514K |
probably benign |
Het |
| Adss1 |
A |
T |
12: 112,602,882 (GRCm39) |
R358W |
probably damaging |
Het |
| Anxa8 |
T |
A |
14: 33,819,932 (GRCm39) |
I307N |
probably damaging |
Het |
| Atad5 |
T |
A |
11: 79,986,845 (GRCm39) |
I644N |
probably damaging |
Het |
| Atp5f1a |
G |
T |
18: 77,868,938 (GRCm39) |
L437F |
probably damaging |
Het |
| Babam1 |
A |
G |
8: 71,855,684 (GRCm39) |
K259R |
possibly damaging |
Het |
| BC048562 |
T |
G |
9: 108,323,054 (GRCm39) |
F130V |
probably damaging |
Het |
| Btf3l4b |
T |
A |
13: 96,217,621 (GRCm39) |
K73* |
probably null |
Het |
| Camsap2 |
T |
A |
1: 136,202,640 (GRCm39) |
|
probably null |
Het |
| Ccne2 |
A |
G |
4: 11,192,881 (GRCm39) |
I27M |
probably benign |
Het |
| Cd302 |
A |
G |
2: 60,082,793 (GRCm39) |
V177A |
possibly damaging |
Het |
| Cfap46 |
T |
C |
7: 139,222,461 (GRCm39) |
K1172R |
|
Het |
| Cic |
T |
C |
7: 24,991,117 (GRCm39) |
W2141R |
probably damaging |
Het |
| Cpeb3 |
A |
G |
19: 37,151,473 (GRCm39) |
V301A |
possibly damaging |
Het |
| Cpsf3 |
A |
G |
12: 21,350,112 (GRCm39) |
K277R |
possibly damaging |
Het |
| Cstl1 |
A |
G |
2: 148,592,926 (GRCm39) |
H27R |
possibly damaging |
Het |
| Dapk1 |
T |
A |
13: 60,866,125 (GRCm39) |
I188K |
possibly damaging |
Het |
| Dock6 |
T |
C |
9: 21,729,111 (GRCm39) |
T1301A |
probably benign |
Het |
| Eml5 |
A |
T |
12: 98,848,292 (GRCm39) |
C133* |
probably null |
Het |
| Ermap |
T |
A |
4: 119,042,744 (GRCm39) |
I260F |
probably damaging |
Het |
| Fbxw22 |
T |
G |
9: 109,215,653 (GRCm39) |
E198D |
possibly damaging |
Het |
| Flt4 |
T |
C |
11: 49,516,241 (GRCm39) |
Y115H |
possibly damaging |
Het |
| Fmo9 |
A |
C |
1: 166,494,794 (GRCm39) |
I369S |
probably damaging |
Het |
| Frmd4a |
T |
A |
2: 4,157,904 (GRCm39) |
S6T |
probably benign |
Het |
| Golga5 |
A |
T |
12: 102,443,057 (GRCm39) |
I330L |
probably benign |
Het |
| Helq |
C |
A |
5: 100,927,158 (GRCm39) |
V643F |
probably damaging |
Het |
| Ino80d |
A |
T |
1: 63,104,969 (GRCm39) |
L369H |
probably damaging |
Het |
| Kank1 |
A |
T |
19: 25,388,798 (GRCm39) |
M824L |
probably benign |
Het |
| Lilrb4b |
T |
C |
10: 51,356,801 (GRCm39) |
|
probably benign |
Het |
| Ltbp4 |
T |
A |
7: 27,021,578 (GRCm39) |
D1003V |
probably damaging |
Het |
| Mapk8ip2 |
T |
C |
15: 89,341,886 (GRCm39) |
S366P |
probably damaging |
Het |
| Mdga1 |
T |
C |
17: 30,069,512 (GRCm39) |
H178R |
probably benign |
Het |
| Mlh3 |
A |
G |
12: 85,292,613 (GRCm39) |
V1266A |
possibly damaging |
Het |
| Nrp1 |
A |
G |
8: 129,089,859 (GRCm39) |
E78G |
probably damaging |
Het |
| Or1l4 |
A |
T |
2: 37,091,255 (GRCm39) |
M1L |
probably benign |
Het |
| Or4z4 |
A |
T |
19: 12,076,826 (GRCm39) |
M59K |
probably damaging |
Het |
| Or5d16 |
A |
G |
2: 87,773,297 (GRCm39) |
V225A |
probably benign |
Het |
| Or8k33 |
A |
G |
2: 86,383,818 (GRCm39) |
S217P |
possibly damaging |
Het |
| Ovch2 |
A |
G |
7: 107,395,815 (GRCm39) |
S68P |
probably damaging |
Het |
| Pappa2 |
T |
A |
1: 158,672,614 (GRCm39) |
I1110F |
probably damaging |
Het |
| Pcyox1 |
A |
C |
6: 86,369,241 (GRCm39) |
L195R |
possibly damaging |
Het |
| Pde11a |
A |
G |
2: 75,848,217 (GRCm39) |
L870P |
probably damaging |
Het |
| Pgpep1 |
G |
A |
8: 71,103,418 (GRCm39) |
T152M |
probably damaging |
Het |
| Pik3c2a |
A |
T |
7: 115,945,413 (GRCm39) |
D1464E |
probably damaging |
Het |
| Postn |
C |
T |
3: 54,292,659 (GRCm39) |
T742I |
probably benign |
Het |
| Ppm1j |
T |
A |
3: 104,691,057 (GRCm39) |
Y274N |
probably damaging |
Het |
| Ppp2cb |
T |
C |
8: 34,090,038 (GRCm39) |
C32R |
possibly damaging |
Het |
| Prmt9 |
T |
A |
8: 78,282,374 (GRCm39) |
Y90* |
probably null |
Het |
| Ptk2 |
T |
C |
15: 73,146,346 (GRCm39) |
Y441C |
probably damaging |
Het |
| Rabggta |
T |
A |
14: 55,957,083 (GRCm39) |
I266L |
probably benign |
Het |
| Rft1 |
C |
T |
14: 30,398,812 (GRCm39) |
R261W |
probably damaging |
Het |
| Rsrc1 |
C |
T |
3: 67,197,680 (GRCm39) |
A195V |
probably damaging |
Het |
| Rtkn2 |
T |
G |
10: 67,871,677 (GRCm39) |
L355R |
possibly damaging |
Het |
| Runx1t1 |
A |
T |
4: 13,875,477 (GRCm39) |
D427V |
possibly damaging |
Het |
| Slc15a4 |
T |
G |
5: 127,673,812 (GRCm39) |
H534P |
probably benign |
Het |
| Slc16a7 |
T |
C |
10: 125,066,880 (GRCm39) |
N253S |
probably damaging |
Het |
| Slc29a1 |
A |
G |
17: 45,897,063 (GRCm39) |
S408P |
probably damaging |
Het |
| Slc52a2 |
G |
A |
15: 76,424,406 (GRCm39) |
A215T |
probably damaging |
Het |
| Smc1b |
T |
A |
15: 85,011,995 (GRCm39) |
I126L |
probably damaging |
Het |
| Sycp2 |
A |
T |
2: 178,023,650 (GRCm39) |
N455K |
probably benign |
Het |
| Tbck |
T |
C |
3: 132,543,738 (GRCm39) |
V863A |
probably benign |
Het |
| Tfap2c |
A |
G |
2: 172,395,347 (GRCm39) |
M263V |
probably benign |
Het |
| Tmem45a |
A |
G |
16: 56,627,134 (GRCm39) |
V245A |
probably damaging |
Het |
| Top2a |
C |
T |
11: 98,897,790 (GRCm39) |
G759D |
probably damaging |
Het |
| Traf5 |
A |
G |
1: 191,729,489 (GRCm39) |
S218P |
|
Het |
| Tsfm |
T |
C |
10: 126,866,502 (GRCm39) |
R20G |
probably benign |
Het |
| Ugt2a2 |
G |
T |
5: 87,608,382 (GRCm39) |
Q486K |
probably damaging |
Het |
| Usp34 |
T |
A |
11: 23,422,951 (GRCm39) |
D3108E |
|
Het |
| Wnt11 |
A |
G |
7: 98,495,796 (GRCm39) |
Y100C |
probably damaging |
Het |
| Zbtb49 |
A |
G |
5: 38,370,931 (GRCm39) |
C317R |
probably benign |
Het |
|
| Other mutations in Plcb1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00510:Plcb1
|
APN |
2 |
135,093,676 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
IGL01152:Plcb1
|
APN |
2 |
134,655,579 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01945:Plcb1
|
APN |
2 |
135,062,711 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01999:Plcb1
|
APN |
2 |
135,188,238 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02109:Plcb1
|
APN |
2 |
134,628,479 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02153:Plcb1
|
APN |
2 |
135,229,773 (GRCm39) |
missense |
probably benign |
0.08 |
|
IGL02207:Plcb1
|
APN |
2 |
135,229,091 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02566:Plcb1
|
APN |
2 |
135,314,183 (GRCm39) |
missense |
probably benign |
0.17 |
|
IGL02590:Plcb1
|
APN |
2 |
135,136,784 (GRCm39) |
missense |
probably benign |
0.08 |
|
IGL02640:Plcb1
|
APN |
2 |
135,062,779 (GRCm39) |
splice site |
probably benign |
|
|
IGL02926:Plcb1
|
APN |
2 |
135,206,682 (GRCm39) |
splice site |
probably benign |
|
|
IGL03071:Plcb1
|
APN |
2 |
135,229,722 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03236:Plcb1
|
APN |
2 |
135,188,226 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03252:Plcb1
|
APN |
2 |
135,212,348 (GRCm39) |
missense |
probably benign |
|
|
IGL03387:Plcb1
|
APN |
2 |
134,655,606 (GRCm39) |
splice site |
probably benign |
|
|
BB001:Plcb1
|
UTSW |
2 |
135,201,613 (GRCm39) |
missense |
probably benign |
0.00 |
|
BB011:Plcb1
|
UTSW |
2 |
135,201,613 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0024:Plcb1
|
UTSW |
2 |
135,204,345 (GRCm39) |
missense |
probably benign |
0.06 |
|
R0024:Plcb1
|
UTSW |
2 |
135,204,345 (GRCm39) |
missense |
probably benign |
0.06 |
|
R0053:Plcb1
|
UTSW |
2 |
135,136,835 (GRCm39) |
missense |
probably benign |
0.33 |
|
R0053:Plcb1
|
UTSW |
2 |
135,136,835 (GRCm39) |
missense |
probably benign |
0.33 |
|
R0308:Plcb1
|
UTSW |
2 |
134,655,534 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0415:Plcb1
|
UTSW |
2 |
135,179,419 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0624:Plcb1
|
UTSW |
2 |
135,136,831 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R0898:Plcb1
|
UTSW |
2 |
135,229,063 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R1071:Plcb1
|
UTSW |
2 |
135,167,577 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R1615:Plcb1
|
UTSW |
2 |
135,204,364 (GRCm39) |
splice site |
probably benign |
|
|
R1617:Plcb1
|
UTSW |
2 |
135,179,361 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1785:Plcb1
|
UTSW |
2 |
135,167,587 (GRCm39) |
nonsense |
probably null |
|
|
R1866:Plcb1
|
UTSW |
2 |
135,186,093 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1869:Plcb1
|
UTSW |
2 |
135,152,934 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1902:Plcb1
|
UTSW |
2 |
134,655,533 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1938:Plcb1
|
UTSW |
2 |
135,228,222 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2016:Plcb1
|
UTSW |
2 |
135,204,340 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2017:Plcb1
|
UTSW |
2 |
135,204,340 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2131:Plcb1
|
UTSW |
2 |
135,167,587 (GRCm39) |
nonsense |
probably null |
|
|
R2132:Plcb1
|
UTSW |
2 |
135,167,587 (GRCm39) |
nonsense |
probably null |
|
|
R2133:Plcb1
|
UTSW |
2 |
135,167,587 (GRCm39) |
nonsense |
probably null |
|
|
R2164:Plcb1
|
UTSW |
2 |
135,188,250 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R2419:Plcb1
|
UTSW |
2 |
135,104,020 (GRCm39) |
splice site |
probably benign |
|
|
R2429:Plcb1
|
UTSW |
2 |
135,179,362 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2508:Plcb1
|
UTSW |
2 |
135,102,428 (GRCm39) |
missense |
probably benign |
0.27 |
|
R3161:Plcb1
|
UTSW |
2 |
135,177,402 (GRCm39) |
missense |
probably benign |
0.03 |
|
R3870:Plcb1
|
UTSW |
2 |
135,167,591 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4191:Plcb1
|
UTSW |
2 |
135,187,010 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4239:Plcb1
|
UTSW |
2 |
135,186,078 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4552:Plcb1
|
UTSW |
2 |
135,177,413 (GRCm39) |
missense |
probably benign |
0.44 |
|
R4553:Plcb1
|
UTSW |
2 |
135,177,413 (GRCm39) |
missense |
probably benign |
0.44 |
|
R4720:Plcb1
|
UTSW |
2 |
135,093,667 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R4946:Plcb1
|
UTSW |
2 |
135,187,015 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5012:Plcb1
|
UTSW |
2 |
135,175,320 (GRCm39) |
missense |
probably null |
0.97 |
|
R5151:Plcb1
|
UTSW |
2 |
135,104,165 (GRCm39) |
missense |
probably benign |
0.28 |
|
R5320:Plcb1
|
UTSW |
2 |
135,094,696 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R5415:Plcb1
|
UTSW |
2 |
135,189,322 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R5523:Plcb1
|
UTSW |
2 |
135,102,486 (GRCm39) |
missense |
probably benign |
0.08 |
|
R5568:Plcb1
|
UTSW |
2 |
135,212,513 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5688:Plcb1
|
UTSW |
2 |
135,177,400 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5809:Plcb1
|
UTSW |
2 |
135,104,164 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R6237:Plcb1
|
UTSW |
2 |
135,212,486 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6315:Plcb1
|
UTSW |
2 |
135,188,261 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6478:Plcb1
|
UTSW |
2 |
135,177,371 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6531:Plcb1
|
UTSW |
2 |
135,167,722 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6683:Plcb1
|
UTSW |
2 |
134,628,513 (GRCm39) |
missense |
probably benign |
0.32 |
|
R6760:Plcb1
|
UTSW |
2 |
135,313,980 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R6947:Plcb1
|
UTSW |
2 |
135,228,075 (GRCm39) |
missense |
probably benign |
0.08 |
|
R6976:Plcb1
|
UTSW |
2 |
135,104,159 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R7379:Plcb1
|
UTSW |
2 |
135,212,430 (GRCm39) |
missense |
probably benign |
0.45 |
|
R7473:Plcb1
|
UTSW |
2 |
135,186,196 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7492:Plcb1
|
UTSW |
2 |
135,093,684 (GRCm39) |
nonsense |
probably null |
|
|
R7498:Plcb1
|
UTSW |
2 |
135,104,154 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7498:Plcb1
|
UTSW |
2 |
135,104,153 (GRCm39) |
nonsense |
probably null |
|
|
R7777:Plcb1
|
UTSW |
2 |
135,062,677 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R7924:Plcb1
|
UTSW |
2 |
135,201,613 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8061:Plcb1
|
UTSW |
2 |
135,188,316 (GRCm39) |
missense |
probably benign |
|
|
R8099:Plcb1
|
UTSW |
2 |
135,093,654 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R8299:Plcb1
|
UTSW |
2 |
135,177,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8394:Plcb1
|
UTSW |
2 |
135,159,710 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8439:Plcb1
|
UTSW |
2 |
135,091,972 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8549:Plcb1
|
UTSW |
2 |
135,206,853 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8693:Plcb1
|
UTSW |
2 |
135,094,696 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8750:Plcb1
|
UTSW |
2 |
135,177,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8817:Plcb1
|
UTSW |
2 |
135,175,429 (GRCm39) |
intron |
probably benign |
|
|
R8950:Plcb1
|
UTSW |
2 |
135,179,439 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9146:Plcb1
|
UTSW |
2 |
135,182,615 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9311:Plcb1
|
UTSW |
2 |
135,189,385 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9459:Plcb1
|
UTSW |
2 |
135,164,558 (GRCm39) |
missense |
probably benign |
0.03 |
|
S24628:Plcb1
|
UTSW |
2 |
135,179,419 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0025:Plcb1
|
UTSW |
2 |
135,186,974 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
Z1088:Plcb1
|
UTSW |
2 |
135,062,766 (GRCm39) |
missense |
probably benign |
0.04 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCACAATTAGAATGCTTTCGTGAAC -3'
(R):5'- AAGCTGAAAGCCCTTCTAGG -3'
Sequencing Primer
(F):5'- AGAATGCTTTCGTGAACTATGCTG -3'
(R):5'- CTTCTAGGCCAATTTCAGAGCAG -3'
|
| Posted On |
2022-03-25 |
Incidental Mutation