Incidental Mutation 'R9301:Cic'
ID |
704940 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Cic
|
Ensembl Gene |
ENSMUSG00000005442 |
Gene Name |
capicua transcriptional repressor |
Synonyms |
1200010B10Rik |
MMRRC Submission |
|
Accession Numbers |
|
Essential gene? |
Probably essential
(E-score: 0.949)
|
Stock # |
R9301 (G1)
|
Quality Score |
211.009 |
Status
|
Not validated
|
Chromosome |
7 |
Chromosomal Location |
24967129-24993584 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to C
at 24991117 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Tryptophan to Arginine
at position 2141
(W2141R)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000132351
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000005578]
[ENSMUST00000005583]
[ENSMUST00000108410]
[ENSMUST00000148150]
[ENSMUST00000155118]
[ENSMUST00000163320]
[ENSMUST00000169266]
[ENSMUST00000164820]
[ENSMUST00000165239]
|
AlphaFold |
Q924A2 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000005578
AA Change: W1235R
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
SMART Domains |
Protein: ENSMUSP00000005578 Gene: ENSMUSG00000005442 AA Change: W1235R
Domain | Start | End | E-Value | Type |
PDB:4J2L|D
|
21 |
48 |
6e-12 |
PDB |
low complexity region
|
106 |
120 |
N/A |
INTRINSIC |
low complexity region
|
124 |
138 |
N/A |
INTRINSIC |
HMG
|
199 |
269 |
1.24e-17 |
SMART |
low complexity region
|
415 |
431 |
N/A |
INTRINSIC |
low complexity region
|
473 |
486 |
N/A |
INTRINSIC |
low complexity region
|
508 |
521 |
N/A |
INTRINSIC |
low complexity region
|
525 |
555 |
N/A |
INTRINSIC |
low complexity region
|
567 |
583 |
N/A |
INTRINSIC |
low complexity region
|
645 |
660 |
N/A |
INTRINSIC |
low complexity region
|
729 |
740 |
N/A |
INTRINSIC |
low complexity region
|
782 |
803 |
N/A |
INTRINSIC |
low complexity region
|
837 |
859 |
N/A |
INTRINSIC |
low complexity region
|
939 |
951 |
N/A |
INTRINSIC |
low complexity region
|
1065 |
1080 |
N/A |
INTRINSIC |
low complexity region
|
1118 |
1132 |
N/A |
INTRINSIC |
low complexity region
|
1135 |
1155 |
N/A |
INTRINSIC |
low complexity region
|
1223 |
1253 |
N/A |
INTRINSIC |
low complexity region
|
1280 |
1313 |
N/A |
INTRINSIC |
low complexity region
|
1405 |
1418 |
N/A |
INTRINSIC |
low complexity region
|
1483 |
1494 |
N/A |
INTRINSIC |
low complexity region
|
1524 |
1547 |
N/A |
INTRINSIC |
low complexity region
|
1568 |
1603 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000005583
|
SMART Domains |
Protein: ENSMUSP00000005583 Gene: ENSMUSG00000005447
Domain | Start | End | E-Value | Type |
Pfam:Lipase_GDSL_2
|
12 |
203 |
3.8e-13 |
PFAM |
Pfam:Lipase_GDSL
|
42 |
209 |
1.2e-8 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000108410
|
SMART Domains |
Protein: ENSMUSP00000104048 Gene: ENSMUSG00000005447
Domain | Start | End | E-Value | Type |
Pfam:Lipase_GDSL_2
|
4 |
151 |
1.2e-23 |
PFAM |
low complexity region
|
155 |
166 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000148150
|
SMART Domains |
Protein: ENSMUSP00000121250 Gene: ENSMUSG00000005447
Domain | Start | End | E-Value | Type |
Pfam:Lipase_GDSL_2
|
43 |
143 |
5.5e-14 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000155118
|
SMART Domains |
Protein: ENSMUSP00000120379 Gene: ENSMUSG00000005447
Domain | Start | End | E-Value | Type |
Pfam:Lipase_GDSL_2
|
43 |
149 |
2.2e-12 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000163320
AA Change: W1234R
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
SMART Domains |
Protein: ENSMUSP00000126659 Gene: ENSMUSG00000005442 AA Change: W1234R
Domain | Start | End | E-Value | Type |
PDB:4J2L|D
|
21 |
48 |
6e-12 |
PDB |
low complexity region
|
106 |
120 |
N/A |
INTRINSIC |
low complexity region
|
124 |
138 |
N/A |
INTRINSIC |
HMG
|
199 |
269 |
1.24e-17 |
SMART |
low complexity region
|
415 |
431 |
N/A |
INTRINSIC |
low complexity region
|
473 |
486 |
N/A |
INTRINSIC |
low complexity region
|
508 |
521 |
N/A |
INTRINSIC |
low complexity region
|
525 |
555 |
N/A |
INTRINSIC |
low complexity region
|
567 |
583 |
N/A |
INTRINSIC |
low complexity region
|
645 |
660 |
N/A |
INTRINSIC |
low complexity region
|
729 |
740 |
N/A |
INTRINSIC |
low complexity region
|
782 |
803 |
N/A |
INTRINSIC |
low complexity region
|
837 |
859 |
N/A |
INTRINSIC |
low complexity region
|
939 |
951 |
N/A |
INTRINSIC |
low complexity region
|
1064 |
1079 |
N/A |
INTRINSIC |
low complexity region
|
1117 |
1131 |
N/A |
INTRINSIC |
low complexity region
|
1134 |
1154 |
N/A |
INTRINSIC |
low complexity region
|
1222 |
1252 |
N/A |
INTRINSIC |
low complexity region
|
1279 |
1312 |
N/A |
INTRINSIC |
low complexity region
|
1405 |
1418 |
N/A |
INTRINSIC |
low complexity region
|
1483 |
1494 |
N/A |
INTRINSIC |
low complexity region
|
1524 |
1547 |
N/A |
INTRINSIC |
low complexity region
|
1568 |
1603 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000169266
AA Change: W2141R
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
SMART Domains |
Protein: ENSMUSP00000132351 Gene: ENSMUSG00000005442 AA Change: W2141R
Domain | Start | End | E-Value | Type |
low complexity region
|
9 |
23 |
N/A |
INTRINSIC |
low complexity region
|
33 |
73 |
N/A |
INTRINSIC |
low complexity region
|
151 |
165 |
N/A |
INTRINSIC |
Pfam:DUF4819
|
249 |
346 |
1.8e-23 |
PFAM |
low complexity region
|
351 |
367 |
N/A |
INTRINSIC |
low complexity region
|
403 |
427 |
N/A |
INTRINSIC |
low complexity region
|
445 |
457 |
N/A |
INTRINSIC |
low complexity region
|
462 |
475 |
N/A |
INTRINSIC |
low complexity region
|
618 |
633 |
N/A |
INTRINSIC |
low complexity region
|
673 |
685 |
N/A |
INTRINSIC |
low complexity region
|
724 |
734 |
N/A |
INTRINSIC |
low complexity region
|
740 |
751 |
N/A |
INTRINSIC |
low complexity region
|
779 |
786 |
N/A |
INTRINSIC |
low complexity region
|
858 |
883 |
N/A |
INTRINSIC |
low complexity region
|
898 |
911 |
N/A |
INTRINSIC |
PDB:4J2L|D
|
930 |
955 |
5e-10 |
PDB |
low complexity region
|
1013 |
1027 |
N/A |
INTRINSIC |
low complexity region
|
1031 |
1045 |
N/A |
INTRINSIC |
HMG
|
1106 |
1176 |
1.24e-17 |
SMART |
low complexity region
|
1322 |
1338 |
N/A |
INTRINSIC |
low complexity region
|
1380 |
1393 |
N/A |
INTRINSIC |
low complexity region
|
1415 |
1428 |
N/A |
INTRINSIC |
low complexity region
|
1432 |
1462 |
N/A |
INTRINSIC |
low complexity region
|
1474 |
1490 |
N/A |
INTRINSIC |
low complexity region
|
1552 |
1567 |
N/A |
INTRINSIC |
low complexity region
|
1636 |
1647 |
N/A |
INTRINSIC |
low complexity region
|
1689 |
1710 |
N/A |
INTRINSIC |
low complexity region
|
1744 |
1766 |
N/A |
INTRINSIC |
low complexity region
|
1846 |
1858 |
N/A |
INTRINSIC |
low complexity region
|
1971 |
1986 |
N/A |
INTRINSIC |
low complexity region
|
2024 |
2038 |
N/A |
INTRINSIC |
low complexity region
|
2041 |
2061 |
N/A |
INTRINSIC |
low complexity region
|
2129 |
2159 |
N/A |
INTRINSIC |
low complexity region
|
2186 |
2219 |
N/A |
INTRINSIC |
low complexity region
|
2311 |
2324 |
N/A |
INTRINSIC |
low complexity region
|
2389 |
2400 |
N/A |
INTRINSIC |
low complexity region
|
2430 |
2453 |
N/A |
INTRINSIC |
low complexity region
|
2474 |
2509 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000163901
|
SMART Domains |
Protein: ENSMUSP00000127858 Gene: ENSMUSG00000005442
Domain | Start | End | E-Value | Type |
low complexity region
|
24 |
35 |
N/A |
INTRINSIC |
low complexity region
|
114 |
128 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000164820
|
SMART Domains |
Protein: ENSMUSP00000130146 Gene: ENSMUSG00000005442
Domain | Start | End | E-Value | Type |
low complexity region
|
22 |
36 |
N/A |
INTRINSIC |
low complexity region
|
39 |
57 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000165239
|
SMART Domains |
Protein: ENSMUSP00000128071 Gene: ENSMUSG00000005442
Domain | Start | End | E-Value | Type |
PDB:4J2L|D
|
21 |
48 |
5e-12 |
PDB |
low complexity region
|
106 |
120 |
N/A |
INTRINSIC |
low complexity region
|
124 |
138 |
N/A |
INTRINSIC |
HMG
|
199 |
269 |
1.24e-17 |
SMART |
low complexity region
|
415 |
431 |
N/A |
INTRINSIC |
low complexity region
|
473 |
486 |
N/A |
INTRINSIC |
low complexity region
|
508 |
521 |
N/A |
INTRINSIC |
low complexity region
|
525 |
555 |
N/A |
INTRINSIC |
low complexity region
|
567 |
583 |
N/A |
INTRINSIC |
low complexity region
|
645 |
660 |
N/A |
INTRINSIC |
low complexity region
|
729 |
740 |
N/A |
INTRINSIC |
low complexity region
|
782 |
803 |
N/A |
INTRINSIC |
low complexity region
|
837 |
859 |
N/A |
INTRINSIC |
low complexity region
|
939 |
951 |
N/A |
INTRINSIC |
low complexity region
|
1065 |
1080 |
N/A |
INTRINSIC |
low complexity region
|
1118 |
1132 |
N/A |
INTRINSIC |
low complexity region
|
1135 |
1153 |
N/A |
INTRINSIC |
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.4%
|
Validation Efficiency |
|
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes 1, 4, 6, 7, 16, 20, and the Y chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015] PHENOTYPE: Mice homozygous for a gene trapped allele exhibit partial postnatal lethality, decreased body size, and severe lung alveolarization defects. [provided by MGI curators]
|
Allele List at MGI |
All alleles(61) : Targeted, other(4) Gene trapped(57)
|
Other mutations in this stock |
Total: 70 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Abca4 |
T |
A |
3: 121,881,128 (GRCm39) |
N514K |
probably benign |
Het |
Adss1 |
A |
T |
12: 112,602,882 (GRCm39) |
R358W |
probably damaging |
Het |
Anxa8 |
T |
A |
14: 33,819,932 (GRCm39) |
I307N |
probably damaging |
Het |
Atad5 |
T |
A |
11: 79,986,845 (GRCm39) |
I644N |
probably damaging |
Het |
Atp5f1a |
G |
T |
18: 77,868,938 (GRCm39) |
L437F |
probably damaging |
Het |
Babam1 |
A |
G |
8: 71,855,684 (GRCm39) |
K259R |
possibly damaging |
Het |
BC048562 |
T |
G |
9: 108,323,054 (GRCm39) |
F130V |
probably damaging |
Het |
Btf3l4b |
T |
A |
13: 96,217,621 (GRCm39) |
K73* |
probably null |
Het |
Camsap2 |
T |
A |
1: 136,202,640 (GRCm39) |
|
probably null |
Het |
Ccne2 |
A |
G |
4: 11,192,881 (GRCm39) |
I27M |
probably benign |
Het |
Cd302 |
A |
G |
2: 60,082,793 (GRCm39) |
V177A |
possibly damaging |
Het |
Cfap46 |
T |
C |
7: 139,222,461 (GRCm39) |
K1172R |
|
Het |
Cpeb3 |
A |
G |
19: 37,151,473 (GRCm39) |
V301A |
possibly damaging |
Het |
Cpsf3 |
A |
G |
12: 21,350,112 (GRCm39) |
K277R |
possibly damaging |
Het |
Cstl1 |
A |
G |
2: 148,592,926 (GRCm39) |
H27R |
possibly damaging |
Het |
Dapk1 |
T |
A |
13: 60,866,125 (GRCm39) |
I188K |
possibly damaging |
Het |
Dock6 |
T |
C |
9: 21,729,111 (GRCm39) |
T1301A |
probably benign |
Het |
Eml5 |
A |
T |
12: 98,848,292 (GRCm39) |
C133* |
probably null |
Het |
Ermap |
T |
A |
4: 119,042,744 (GRCm39) |
I260F |
probably damaging |
Het |
Fbxw22 |
T |
G |
9: 109,215,653 (GRCm39) |
E198D |
possibly damaging |
Het |
Flt4 |
T |
C |
11: 49,516,241 (GRCm39) |
Y115H |
possibly damaging |
Het |
Fmo9 |
A |
C |
1: 166,494,794 (GRCm39) |
I369S |
probably damaging |
Het |
Frmd4a |
T |
A |
2: 4,157,904 (GRCm39) |
S6T |
probably benign |
Het |
Golga5 |
A |
T |
12: 102,443,057 (GRCm39) |
I330L |
probably benign |
Het |
Helq |
C |
A |
5: 100,927,158 (GRCm39) |
V643F |
probably damaging |
Het |
Ino80d |
A |
T |
1: 63,104,969 (GRCm39) |
L369H |
probably damaging |
Het |
Kank1 |
A |
T |
19: 25,388,798 (GRCm39) |
M824L |
probably benign |
Het |
Lilrb4b |
T |
C |
10: 51,356,801 (GRCm39) |
|
probably benign |
Het |
Ltbp4 |
T |
A |
7: 27,021,578 (GRCm39) |
D1003V |
probably damaging |
Het |
Mapk8ip2 |
T |
C |
15: 89,341,886 (GRCm39) |
S366P |
probably damaging |
Het |
Mdga1 |
T |
C |
17: 30,069,512 (GRCm39) |
H178R |
probably benign |
Het |
Mlh3 |
A |
G |
12: 85,292,613 (GRCm39) |
V1266A |
possibly damaging |
Het |
Nrp1 |
A |
G |
8: 129,089,859 (GRCm39) |
E78G |
probably damaging |
Het |
Or1l4 |
A |
T |
2: 37,091,255 (GRCm39) |
M1L |
probably benign |
Het |
Or4z4 |
A |
T |
19: 12,076,826 (GRCm39) |
M59K |
probably damaging |
Het |
Or5d16 |
A |
G |
2: 87,773,297 (GRCm39) |
V225A |
probably benign |
Het |
Or8k33 |
A |
G |
2: 86,383,818 (GRCm39) |
S217P |
possibly damaging |
Het |
Ovch2 |
A |
G |
7: 107,395,815 (GRCm39) |
S68P |
probably damaging |
Het |
Pappa2 |
T |
A |
1: 158,672,614 (GRCm39) |
I1110F |
probably damaging |
Het |
Pcyox1 |
A |
C |
6: 86,369,241 (GRCm39) |
L195R |
possibly damaging |
Het |
Pde11a |
A |
G |
2: 75,848,217 (GRCm39) |
L870P |
probably damaging |
Het |
Pgpep1 |
G |
A |
8: 71,103,418 (GRCm39) |
T152M |
probably damaging |
Het |
Pik3c2a |
A |
T |
7: 115,945,413 (GRCm39) |
D1464E |
probably damaging |
Het |
Plcb1 |
A |
G |
2: 135,167,610 (GRCm39) |
K468R |
possibly damaging |
Het |
Postn |
C |
T |
3: 54,292,659 (GRCm39) |
T742I |
probably benign |
Het |
Ppm1j |
T |
A |
3: 104,691,057 (GRCm39) |
Y274N |
probably damaging |
Het |
Ppp2cb |
T |
C |
8: 34,090,038 (GRCm39) |
C32R |
possibly damaging |
Het |
Prmt9 |
T |
A |
8: 78,282,374 (GRCm39) |
Y90* |
probably null |
Het |
Ptk2 |
T |
C |
15: 73,146,346 (GRCm39) |
Y441C |
probably damaging |
Het |
Rabggta |
T |
A |
14: 55,957,083 (GRCm39) |
I266L |
probably benign |
Het |
Rft1 |
C |
T |
14: 30,398,812 (GRCm39) |
R261W |
probably damaging |
Het |
Rsrc1 |
C |
T |
3: 67,197,680 (GRCm39) |
A195V |
probably damaging |
Het |
Rtkn2 |
T |
G |
10: 67,871,677 (GRCm39) |
L355R |
possibly damaging |
Het |
Runx1t1 |
A |
T |
4: 13,875,477 (GRCm39) |
D427V |
possibly damaging |
Het |
Slc15a4 |
T |
G |
5: 127,673,812 (GRCm39) |
H534P |
probably benign |
Het |
Slc16a7 |
T |
C |
10: 125,066,880 (GRCm39) |
N253S |
probably damaging |
Het |
Slc29a1 |
A |
G |
17: 45,897,063 (GRCm39) |
S408P |
probably damaging |
Het |
Slc52a2 |
G |
A |
15: 76,424,406 (GRCm39) |
A215T |
probably damaging |
Het |
Smc1b |
T |
A |
15: 85,011,995 (GRCm39) |
I126L |
probably damaging |
Het |
Sycp2 |
A |
T |
2: 178,023,650 (GRCm39) |
N455K |
probably benign |
Het |
Tbck |
T |
C |
3: 132,543,738 (GRCm39) |
V863A |
probably benign |
Het |
Tfap2c |
A |
G |
2: 172,395,347 (GRCm39) |
M263V |
probably benign |
Het |
Tmem45a |
A |
G |
16: 56,627,134 (GRCm39) |
V245A |
probably damaging |
Het |
Top2a |
C |
T |
11: 98,897,790 (GRCm39) |
G759D |
probably damaging |
Het |
Traf5 |
A |
G |
1: 191,729,489 (GRCm39) |
S218P |
|
Het |
Tsfm |
T |
C |
10: 126,866,502 (GRCm39) |
R20G |
probably benign |
Het |
Ugt2a2 |
G |
T |
5: 87,608,382 (GRCm39) |
Q486K |
probably damaging |
Het |
Usp34 |
T |
A |
11: 23,422,951 (GRCm39) |
D3108E |
|
Het |
Wnt11 |
A |
G |
7: 98,495,796 (GRCm39) |
Y100C |
probably damaging |
Het |
Zbtb49 |
A |
G |
5: 38,370,931 (GRCm39) |
C317R |
probably benign |
Het |
|
Other mutations in Cic |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00092:Cic
|
APN |
7 |
24,991,549 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01668:Cic
|
APN |
7 |
24,990,629 (GRCm39) |
missense |
possibly damaging |
0.47 |
IGL02229:Cic
|
APN |
7 |
24,990,375 (GRCm39) |
missense |
probably damaging |
0.96 |
IGL02506:Cic
|
APN |
7 |
24,990,282 (GRCm39) |
missense |
probably benign |
|
IGL02794:Cic
|
APN |
7 |
24,985,069 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03065:Cic
|
APN |
7 |
24,985,246 (GRCm39) |
splice site |
probably benign |
|
IGL03304:Cic
|
APN |
7 |
24,984,274 (GRCm39) |
missense |
probably damaging |
1.00 |
Capuccino
|
UTSW |
7 |
24,986,565 (GRCm39) |
missense |
probably damaging |
0.98 |
Cassock
|
UTSW |
7 |
24,988,338 (GRCm39) |
nonsense |
probably null |
|
Monkey
|
UTSW |
7 |
24,986,566 (GRCm39) |
missense |
probably damaging |
1.00 |
R4850_Cic_466
|
UTSW |
7 |
24,972,327 (GRCm39) |
missense |
probably damaging |
0.98 |
1mM(1):Cic
|
UTSW |
7 |
24,990,214 (GRCm39) |
splice site |
probably benign |
|
IGL03046:Cic
|
UTSW |
7 |
24,990,500 (GRCm39) |
missense |
probably damaging |
1.00 |
R0012:Cic
|
UTSW |
7 |
24,986,566 (GRCm39) |
missense |
probably damaging |
1.00 |
R0012:Cic
|
UTSW |
7 |
24,986,565 (GRCm39) |
missense |
probably damaging |
0.98 |
R0027:Cic
|
UTSW |
7 |
24,986,566 (GRCm39) |
missense |
probably damaging |
1.00 |
R0027:Cic
|
UTSW |
7 |
24,986,565 (GRCm39) |
missense |
probably damaging |
0.98 |
R0038:Cic
|
UTSW |
7 |
24,986,566 (GRCm39) |
missense |
probably damaging |
1.00 |
R0038:Cic
|
UTSW |
7 |
24,986,565 (GRCm39) |
missense |
probably damaging |
0.98 |
R0063:Cic
|
UTSW |
7 |
24,986,566 (GRCm39) |
missense |
probably damaging |
1.00 |
R0063:Cic
|
UTSW |
7 |
24,986,565 (GRCm39) |
missense |
probably damaging |
0.98 |
R0064:Cic
|
UTSW |
7 |
24,986,566 (GRCm39) |
missense |
probably damaging |
1.00 |
R0064:Cic
|
UTSW |
7 |
24,986,565 (GRCm39) |
missense |
probably damaging |
0.98 |
R0118:Cic
|
UTSW |
7 |
24,985,459 (GRCm39) |
missense |
probably damaging |
1.00 |
R0193:Cic
|
UTSW |
7 |
24,986,566 (GRCm39) |
missense |
probably damaging |
1.00 |
R0193:Cic
|
UTSW |
7 |
24,986,565 (GRCm39) |
missense |
probably damaging |
0.98 |
R0241:Cic
|
UTSW |
7 |
24,986,566 (GRCm39) |
missense |
probably damaging |
1.00 |
R0241:Cic
|
UTSW |
7 |
24,986,565 (GRCm39) |
missense |
probably damaging |
0.98 |
R0377:Cic
|
UTSW |
7 |
24,985,224 (GRCm39) |
missense |
probably damaging |
0.98 |
R0462:Cic
|
UTSW |
7 |
24,986,565 (GRCm39) |
missense |
probably damaging |
0.98 |
R0462:Cic
|
UTSW |
7 |
24,986,566 (GRCm39) |
missense |
probably damaging |
1.00 |
R0800:Cic
|
UTSW |
7 |
24,984,662 (GRCm39) |
missense |
probably benign |
|
R1253:Cic
|
UTSW |
7 |
24,990,373 (GRCm39) |
missense |
probably damaging |
1.00 |
R1458:Cic
|
UTSW |
7 |
24,979,162 (GRCm39) |
intron |
probably benign |
|
R1462:Cic
|
UTSW |
7 |
24,971,032 (GRCm39) |
missense |
probably damaging |
0.98 |
R1462:Cic
|
UTSW |
7 |
24,971,032 (GRCm39) |
missense |
probably damaging |
0.98 |
R1519:Cic
|
UTSW |
7 |
24,993,235 (GRCm39) |
critical splice acceptor site |
probably null |
|
R1586:Cic
|
UTSW |
7 |
24,985,386 (GRCm39) |
missense |
probably damaging |
1.00 |
R1824:Cic
|
UTSW |
7 |
24,987,691 (GRCm39) |
missense |
probably damaging |
1.00 |
R1908:Cic
|
UTSW |
7 |
24,986,265 (GRCm39) |
missense |
probably damaging |
1.00 |
R2045:Cic
|
UTSW |
7 |
24,970,961 (GRCm39) |
missense |
possibly damaging |
0.53 |
R2063:Cic
|
UTSW |
7 |
24,972,876 (GRCm39) |
missense |
probably damaging |
0.98 |
R2161:Cic
|
UTSW |
7 |
24,987,559 (GRCm39) |
splice site |
probably null |
|
R2495:Cic
|
UTSW |
7 |
24,991,201 (GRCm39) |
splice site |
probably benign |
|
R2865:Cic
|
UTSW |
7 |
24,972,646 (GRCm39) |
missense |
probably damaging |
0.96 |
R3692:Cic
|
UTSW |
7 |
24,988,338 (GRCm39) |
nonsense |
probably null |
|
R3709:Cic
|
UTSW |
7 |
24,986,406 (GRCm39) |
missense |
probably damaging |
0.99 |
R3710:Cic
|
UTSW |
7 |
24,986,406 (GRCm39) |
missense |
probably damaging |
0.99 |
R3872:Cic
|
UTSW |
7 |
24,971,124 (GRCm39) |
missense |
possibly damaging |
0.92 |
R3946:Cic
|
UTSW |
7 |
24,971,771 (GRCm39) |
missense |
possibly damaging |
0.93 |
R4199:Cic
|
UTSW |
7 |
24,991,095 (GRCm39) |
frame shift |
probably null |
|
R4426:Cic
|
UTSW |
7 |
24,993,433 (GRCm39) |
utr 3 prime |
probably benign |
|
R4502:Cic
|
UTSW |
7 |
24,987,892 (GRCm39) |
missense |
probably damaging |
1.00 |
R4585:Cic
|
UTSW |
7 |
24,972,203 (GRCm39) |
missense |
probably benign |
0.33 |
R4586:Cic
|
UTSW |
7 |
24,972,203 (GRCm39) |
missense |
probably benign |
0.33 |
R4614:Cic
|
UTSW |
7 |
24,991,095 (GRCm39) |
frame shift |
probably null |
|
R4664:Cic
|
UTSW |
7 |
24,990,099 (GRCm39) |
small deletion |
probably benign |
|
R4688:Cic
|
UTSW |
7 |
24,991,095 (GRCm39) |
frame shift |
probably null |
|
R4695:Cic
|
UTSW |
7 |
24,973,013 (GRCm39) |
missense |
possibly damaging |
0.72 |
R4696:Cic
|
UTSW |
7 |
24,987,908 (GRCm39) |
missense |
probably benign |
|
R4746:Cic
|
UTSW |
7 |
24,987,905 (GRCm39) |
missense |
probably damaging |
1.00 |
R4758:Cic
|
UTSW |
7 |
24,991,636 (GRCm39) |
missense |
possibly damaging |
0.62 |
R4767:Cic
|
UTSW |
7 |
24,971,025 (GRCm39) |
missense |
possibly damaging |
0.92 |
R4776:Cic
|
UTSW |
7 |
24,982,308 (GRCm39) |
missense |
possibly damaging |
0.95 |
R4820:Cic
|
UTSW |
7 |
24,971,157 (GRCm39) |
missense |
possibly damaging |
0.92 |
R4850:Cic
|
UTSW |
7 |
24,972,327 (GRCm39) |
missense |
probably damaging |
0.98 |
R4851:Cic
|
UTSW |
7 |
24,972,327 (GRCm39) |
missense |
probably damaging |
0.98 |
R4922:Cic
|
UTSW |
7 |
24,991,095 (GRCm39) |
small insertion |
probably benign |
|
R4989:Cic
|
UTSW |
7 |
24,986,535 (GRCm39) |
missense |
probably damaging |
1.00 |
R5131:Cic
|
UTSW |
7 |
24,991,095 (GRCm39) |
small insertion |
probably benign |
|
R5718:Cic
|
UTSW |
7 |
24,972,203 (GRCm39) |
missense |
probably benign |
0.33 |
R5801:Cic
|
UTSW |
7 |
24,970,863 (GRCm39) |
missense |
possibly damaging |
0.93 |
R5949:Cic
|
UTSW |
7 |
24,971,730 (GRCm39) |
missense |
probably damaging |
1.00 |
R6000:Cic
|
UTSW |
7 |
24,971,423 (GRCm39) |
missense |
probably benign |
0.33 |
R6246:Cic
|
UTSW |
7 |
24,971,067 (GRCm39) |
missense |
probably damaging |
1.00 |
R6283:Cic
|
UTSW |
7 |
24,985,459 (GRCm39) |
missense |
probably damaging |
1.00 |
R6364:Cic
|
UTSW |
7 |
24,972,248 (GRCm39) |
missense |
possibly damaging |
0.72 |
R6481:Cic
|
UTSW |
7 |
24,987,706 (GRCm39) |
missense |
possibly damaging |
0.56 |
R6919:Cic
|
UTSW |
7 |
24,971,202 (GRCm39) |
missense |
probably benign |
0.04 |
R6920:Cic
|
UTSW |
7 |
24,990,107 (GRCm39) |
missense |
probably damaging |
1.00 |
R6995:Cic
|
UTSW |
7 |
24,970,736 (GRCm39) |
missense |
possibly damaging |
0.53 |
R7002:Cic
|
UTSW |
7 |
24,971,621 (GRCm39) |
missense |
probably damaging |
0.99 |
R7113:Cic
|
UTSW |
7 |
24,972,869 (GRCm39) |
missense |
probably benign |
0.08 |
R7560:Cic
|
UTSW |
7 |
24,972,278 (GRCm39) |
missense |
probably damaging |
0.98 |
R7680:Cic
|
UTSW |
7 |
24,991,856 (GRCm39) |
missense |
probably damaging |
0.96 |
R7698:Cic
|
UTSW |
7 |
24,972,597 (GRCm39) |
missense |
possibly damaging |
0.72 |
R7746:Cic
|
UTSW |
7 |
24,988,207 (GRCm39) |
missense |
probably damaging |
1.00 |
R7841:Cic
|
UTSW |
7 |
24,985,192 (GRCm39) |
missense |
probably damaging |
1.00 |
R7879:Cic
|
UTSW |
7 |
24,984,551 (GRCm39) |
missense |
probably benign |
0.10 |
R7916:Cic
|
UTSW |
7 |
24,987,715 (GRCm39) |
missense |
probably damaging |
0.99 |
R7920:Cic
|
UTSW |
7 |
24,971,384 (GRCm39) |
missense |
probably benign |
|
R8056:Cic
|
UTSW |
7 |
24,990,366 (GRCm39) |
missense |
possibly damaging |
0.90 |
R8226:Cic
|
UTSW |
7 |
24,987,213 (GRCm39) |
missense |
probably damaging |
1.00 |
R8281:Cic
|
UTSW |
7 |
24,971,249 (GRCm39) |
missense |
probably benign |
|
R8847:Cic
|
UTSW |
7 |
24,970,631 (GRCm39) |
missense |
probably damaging |
0.98 |
R8991:Cic
|
UTSW |
7 |
24,988,885 (GRCm39) |
missense |
probably damaging |
1.00 |
R9083:Cic
|
UTSW |
7 |
24,985,470 (GRCm39) |
missense |
probably damaging |
0.99 |
R9140:Cic
|
UTSW |
7 |
24,985,165 (GRCm39) |
missense |
probably damaging |
0.99 |
R9200:Cic
|
UTSW |
7 |
24,971,940 (GRCm39) |
missense |
probably damaging |
0.99 |
R9208:Cic
|
UTSW |
7 |
24,987,502 (GRCm39) |
missense |
probably benign |
0.07 |
R9408:Cic
|
UTSW |
7 |
24,971,414 (GRCm39) |
missense |
possibly damaging |
0.70 |
R9569:Cic
|
UTSW |
7 |
24,972,120 (GRCm39) |
missense |
possibly damaging |
0.85 |
R9752:Cic
|
UTSW |
7 |
24,971,403 (GRCm39) |
missense |
probably damaging |
0.96 |
V7732:Cic
|
UTSW |
7 |
24,991,670 (GRCm39) |
missense |
probably benign |
|
Z1176:Cic
|
UTSW |
7 |
24,970,444 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
Predicted Primers |
PCR Primer
(F):5'- AGCCATTGCCAGCATTCCTG -3'
(R):5'- AAAACCCTTGGCCCCTGAAG -3'
Sequencing Primer
(F):5'- CAGCATTCCTGTGGGGTC -3'
(R):5'- CTGAAGGCCAGGATACCCAG -3'
|
Posted On |
2022-03-25 |