Incidental Mutation 'R9302:Zmynd10'
ID 705016
Institutional Source Beutler Lab
Gene Symbol Zmynd10
Ensembl Gene ENSMUSG00000010044
Gene Name zinc finger, MYND domain containing 10
Synonyms Blu
MMRRC Submission
Accession Numbers
Essential gene? Possibly essential (E-score: 0.725) question?
Stock # R9302 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 107424497-107428518 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 107426516 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Lysine at position 183 (I183K)
Ref Sequence ENSEMBL: ENSMUSP00000010188 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000010188] [ENSMUST00000010201] [ENSMUST00000093786] [ENSMUST00000122225] [ENSMUST00000156198] [ENSMUST00000193303] [ENSMUST00000195370]
AlphaFold Q99ML0
Predicted Effect possibly damaging
Transcript: ENSMUST00000010188
AA Change: I183K

PolyPhen 2 Score 0.843 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000010188
Gene: ENSMUSG00000010044
AA Change: I183K

DomainStartEndE-ValueType
Pfam:zf-MYND 394 430 1.1e-10 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000010201
SMART Domains Protein: ENSMUSP00000010201
Gene: ENSMUSG00000010057

DomainStartEndE-ValueType
Pfam:NPR2 5 279 1.7e-75 PFAM
Pfam:NPR2 269 373 1.1e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000093786
SMART Domains Protein: ENSMUSP00000091301
Gene: ENSMUSG00000010067

DomainStartEndE-ValueType
C1 44 101 4.7e-7 SMART
low complexity region 168 185 N/A INTRINSIC
RA 194 288 6.26e-24 SMART
PDB:4LGD|H 289 334 3e-12 PDB
Predicted Effect probably benign
Transcript: ENSMUST00000122225
SMART Domains Protein: ENSMUSP00000113252
Gene: ENSMUSG00000010067

DomainStartEndE-ValueType
C1 44 105 1.92e-3 SMART
low complexity region 172 189 N/A INTRINSIC
RA 198 292 6.26e-24 SMART
Pfam:Nore1-SARAH 299 338 4.2e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000156198
SMART Domains Protein: ENSMUSP00000117722
Gene: ENSMUSG00000010067

DomainStartEndE-ValueType
Blast:C1 44 83 6e-24 BLAST
SCOP:d1ptq__ 52 82 5e-10 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000193303
Predicted Effect probably benign
Transcript: ENSMUST00000195370
SMART Domains Protein: ENSMUSP00000141746
Gene: ENSMUSG00000010057

DomainStartEndE-ValueType
Pfam:NPR2 2 156 1.2e-52 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.4%
Validation Efficiency 100% (54/54)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein containing a MYND-type zinc finger domain that likely functions in assembly of the dynein motor. Mutations in this gene can cause primary ciliary dyskinesia. This gene is also considered a tumor suppressor gene and is often mutated, deleted, or hypermethylated and silenced in cancer cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aar2 T C 2: 156,392,956 (GRCm39) L115P probably damaging Het
Acsl1 T A 8: 46,983,470 (GRCm39) D494E probably damaging Het
Adgrl1 T C 8: 84,656,426 (GRCm39) V243A possibly damaging Het
Ak9 A T 10: 41,196,486 (GRCm39) I103F Het
Ank3 C T 10: 69,761,849 (GRCm39) probably benign Het
Ano4 T A 10: 88,831,220 (GRCm39) I468L probably benign Het
Anxa2r1 A G 13: 120,496,626 (GRCm39) I81T probably benign Het
Arhgef10l G A 4: 140,242,548 (GRCm39) S959L probably benign Het
Cdh23 G A 10: 60,143,306 (GRCm39) A3005V possibly damaging Het
Cfap221 T C 1: 119,853,365 (GRCm39) I776M probably benign Het
Col3a1 C T 1: 45,350,980 (GRCm39) Q25* probably null Het
Crabp2 C A 3: 87,859,833 (GRCm39) L100I probably benign Het
Dnah5 A G 15: 28,240,032 (GRCm39) D463G probably benign Het
Dst T C 1: 34,264,636 (GRCm39) L2602P probably damaging Het
Dusp1 A G 17: 26,726,148 (GRCm39) Y182H probably damaging Het
Fhip1a C A 3: 85,579,941 (GRCm39) D755Y probably damaging Het
Fras1 T A 5: 96,682,751 (GRCm39) C83S probably damaging Het
Frrs1 G T 3: 116,692,899 (GRCm39) probably null Het
Gcnt3 A G 9: 69,942,529 (GRCm39) L13P possibly damaging Het
Gm8094 T C 14: 42,932,834 (GRCm39) D88G probably benign Het
Hfe C T 13: 23,890,025 (GRCm39) M249I probably benign Het
Hipk1 T C 3: 103,685,099 (GRCm39) E172G probably benign Het
Iws1 G A 18: 32,213,213 (GRCm39) E214K possibly damaging Het
Ltb4r2 A T 14: 55,999,733 (GRCm39) Q118L probably damaging Het
Ltbp4 A T 7: 27,008,481 (GRCm39) C1342S possibly damaging Het
Lyst A G 13: 13,904,947 (GRCm39) D3208G possibly damaging Het
Mbnl2 A G 14: 120,622,950 (GRCm39) T163A probably benign Het
Mre11a T A 9: 14,696,826 (GRCm39) probably null Het
Myo15b A G 11: 115,776,238 (GRCm39) N610D possibly damaging Het
Nt5c1b T C 12: 10,430,882 (GRCm39) S390P probably damaging Het
Or10ag53 T A 2: 87,082,906 (GRCm39) F208L probably benign Het
Pde3b A G 7: 114,122,621 (GRCm39) T730A probably damaging Het
Pdzd2 G T 15: 12,374,342 (GRCm39) T1931N possibly damaging Het
Pla2g15 C T 8: 106,877,201 (GRCm39) A28V probably benign Het
Pmfbp1 A T 8: 110,268,474 (GRCm39) D1007V probably damaging Het
Polr1a T A 6: 71,901,683 (GRCm39) probably null Het
Ppp1r3a T C 6: 14,721,891 (GRCm39) K312E probably benign Het
Prmt5 G A 14: 54,749,583 (GRCm39) T269I probably benign Het
Pwp2 A G 10: 78,009,540 (GRCm39) S793P probably benign Het
Rbm12b1 C A 4: 12,146,181 (GRCm39) H718N probably benign Het
Rfx1 T A 8: 84,817,662 (GRCm39) M512K possibly damaging Het
Rp1 T C 1: 4,416,789 (GRCm39) E1441G probably damaging Het
Slc16a6 C T 11: 109,350,634 (GRCm39) V207I probably benign Het
Slc6a9 G A 4: 117,706,596 (GRCm39) R7H possibly damaging Het
Sptlc1 A T 13: 53,528,047 (GRCm39) V39D probably benign Het
Strc A T 2: 121,211,336 (GRCm39) L3Q unknown Het
Svep1 C T 4: 58,120,565 (GRCm39) E823K possibly damaging Het
Tat A G 8: 110,725,031 (GRCm39) probably benign Het
Thoc1 T A 18: 9,968,800 (GRCm39) N190K possibly damaging Het
Tomt T C 7: 101,549,826 (GRCm39) E154G probably damaging Het
Topaz1 T A 9: 122,617,887 (GRCm39) V1228E possibly damaging Het
Trim55 G A 3: 19,727,153 (GRCm39) V407M probably benign Het
Ttll5 T A 12: 85,873,338 (GRCm39) M5K possibly damaging Het
Ugt2a2 A C 5: 87,609,940 (GRCm39) Y380* probably null Het
Usp46 A G 5: 74,163,922 (GRCm39) Y272H probably benign Het
Vps39 A T 2: 120,151,525 (GRCm39) probably benign Het
Zfp12 T A 5: 143,230,421 (GRCm39) H281Q probably damaging Het
Zfp142 C A 1: 74,606,302 (GRCm39) R1756L probably damaging Het
Other mutations in Zmynd10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02007:Zmynd10 APN 9 107,427,731 (GRCm39) missense probably damaging 0.96
R0152:Zmynd10 UTSW 9 107,428,144 (GRCm39) splice site probably null
R0749:Zmynd10 UTSW 9 107,425,882 (GRCm39) missense probably damaging 0.96
R1899:Zmynd10 UTSW 9 107,427,236 (GRCm39) missense probably benign 0.20
R1900:Zmynd10 UTSW 9 107,427,236 (GRCm39) missense probably benign 0.20
R4111:Zmynd10 UTSW 9 107,426,251 (GRCm39) nonsense probably null
R5403:Zmynd10 UTSW 9 107,427,785 (GRCm39) missense possibly damaging 0.59
R5468:Zmynd10 UTSW 9 107,427,536 (GRCm39) missense probably benign 0.00
R6430:Zmynd10 UTSW 9 107,425,911 (GRCm39) nonsense probably null
R6743:Zmynd10 UTSW 9 107,425,079 (GRCm39) missense possibly damaging 0.94
R7117:Zmynd10 UTSW 9 107,424,716 (GRCm39) missense probably benign 0.22
R7247:Zmynd10 UTSW 9 107,425,976 (GRCm39) missense possibly damaging 0.95
R7291:Zmynd10 UTSW 9 107,426,503 (GRCm39) missense probably benign 0.00
R8263:Zmynd10 UTSW 9 107,426,516 (GRCm39) missense possibly damaging 0.84
R9128:Zmynd10 UTSW 9 107,426,326 (GRCm39) missense
R9358:Zmynd10 UTSW 9 107,426,249 (GRCm39) missense possibly damaging 0.91
R9763:Zmynd10 UTSW 9 107,425,965 (GRCm39) missense probably benign 0.11
Predicted Primers PCR Primer
(F):5'- AAGCTGATACTGCTAGTGGC -3'
(R):5'- TCAGTGTGCTCAGGGAAAGG -3'

Sequencing Primer
(F):5'- TGACCTGTCTGAAGAAGAACAGTTCC -3'
(R):5'- TGTGCTCAGGGAAAGGCTAGAG -3'
Posted On 2022-03-25