Mutagenetix > Incidental Mutation

Incidental Mutation 'R9302:Lyst'

705027

Institutional Source

Beutler Lab

Gene Symbol

Lyst

Ensembl Gene

ENSMUSG00000019726

Gene Name

lysosomal trafficking regulator

Synonyms

D13Sfk13

MMRRC Submission

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.414) question?

Stock #

R9302 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

13764982-13953388 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 13904947 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 3208 (D3208G)

Ref Sequence

ENSEMBL: ENSMUSP00000106188 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000110559]

AlphaFold

no structure available at present

Predicted Effect

possibly damaging
Transcript: ENSMUST00000110559
AA Change: D3208G

PolyPhen 2 Score 0.461 (Sensitivity: 0.89; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000106188
Gene: ENSMUSG00000019726
AA Change: D3208G

Domain	Start	End	E-Value	Type
low complexity region	26	36	N/A	INTRINSIC
low complexity region	72	82	N/A	INTRINSIC
low complexity region	399	412	N/A	INTRINSIC
low complexity region	1333	1344	N/A	INTRINSIC
low complexity region	2295	2307	N/A	INTRINSIC
low complexity region	2427	2445	N/A	INTRINSIC
low complexity region	2534	2546	N/A	INTRINSIC
Pfam:PH_BEACH	3006	3101	5.8e-25	PFAM
Beach	3118	3408	1.25e-193	SMART
Blast:Beach	3441	3478	9e-13	BLAST
WD40	3539	3579	5.75e-1	SMART
WD40	3591	3630	2.89e-5	SMART
WD40	3633	3676	1.38e0	SMART
WD40	3724	3765	1.27e-1	SMART

Meta Mutation Damage Score

0.2023

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.4%

Validation Efficiency

100% (54/54)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that regulates intracellular protein trafficking in endosomes, and may be involved in pigmentation. Mutations in this gene are associated with Chediak-Higashi syndrome, a lysosomal storage disorder. Alternative splicing results in multiple transcript variants, though the full-length nature of some of these variants has not been determined. [provided by RefSeq, Apr 2013]
PHENOTYPE: Homozygous mice have a phenotype similar to human Chediak-Higashi syndrome patients, exhibiting lysosomal dysfunction with resultant protein storage; diluted coat color; abnormal melanogenesis; immune cell dysfunction resulting in increased susceptibility to bacterial, viral, and parasitic infections and decreased cytotoxic activity against tumor cells. [provided by MGI curators]

Allele List at MGI

All alleles(52) : Targeted(3) Gene trapped(34) Spontaneous(8) Chemically induced(6) Radiation induced(1)

Other mutations in this stock

Total: 58 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aar2	T	C	2: 156,392,956 (GRCm39)	L115P	probably damaging	Het
Acsl1	T	A	8: 46,983,470 (GRCm39)	D494E	probably damaging	Het
Adgrl1	T	C	8: 84,656,426 (GRCm39)	V243A	possibly damaging	Het
Ak9	A	T	10: 41,196,486 (GRCm39)	I103F		Het
Ank3	C	T	10: 69,761,849 (GRCm39)		probably benign	Het
Ano4	T	A	10: 88,831,220 (GRCm39)	I468L	probably benign	Het
Anxa2r1	A	G	13: 120,496,626 (GRCm39)	I81T	probably benign	Het
Arhgef10l	G	A	4: 140,242,548 (GRCm39)	S959L	probably benign	Het
Cdh23	G	A	10: 60,143,306 (GRCm39)	A3005V	possibly damaging	Het
Cfap221	T	C	1: 119,853,365 (GRCm39)	I776M	probably benign	Het
Col3a1	C	T	1: 45,350,980 (GRCm39)	Q25*	probably null	Het
Crabp2	C	A	3: 87,859,833 (GRCm39)	L100I	probably benign	Het
Dnah5	A	G	15: 28,240,032 (GRCm39)	D463G	probably benign	Het
Dst	T	C	1: 34,264,636 (GRCm39)	L2602P	probably damaging	Het
Dusp1	A	G	17: 26,726,148 (GRCm39)	Y182H	probably damaging	Het
Fhip1a	C	A	3: 85,579,941 (GRCm39)	D755Y	probably damaging	Het
Fras1	T	A	5: 96,682,751 (GRCm39)	C83S	probably damaging	Het
Frrs1	G	T	3: 116,692,899 (GRCm39)		probably null	Het
Gcnt3	A	G	9: 69,942,529 (GRCm39)	L13P	possibly damaging	Het
Gm8094	T	C	14: 42,932,834 (GRCm39)	D88G	probably benign	Het
Hfe	C	T	13: 23,890,025 (GRCm39)	M249I	probably benign	Het
Hipk1	T	C	3: 103,685,099 (GRCm39)	E172G	probably benign	Het
Iws1	G	A	18: 32,213,213 (GRCm39)	E214K	possibly damaging	Het
Ltb4r2	A	T	14: 55,999,733 (GRCm39)	Q118L	probably damaging	Het
Ltbp4	A	T	7: 27,008,481 (GRCm39)	C1342S	possibly damaging	Het
Mbnl2	A	G	14: 120,622,950 (GRCm39)	T163A	probably benign	Het
Mre11a	T	A	9: 14,696,826 (GRCm39)		probably null	Het
Myo15b	A	G	11: 115,776,238 (GRCm39)	N610D	possibly damaging	Het
Nt5c1b	T	C	12: 10,430,882 (GRCm39)	S390P	probably damaging	Het
Or10ag53	T	A	2: 87,082,906 (GRCm39)	F208L	probably benign	Het
Pde3b	A	G	7: 114,122,621 (GRCm39)	T730A	probably damaging	Het
Pdzd2	G	T	15: 12,374,342 (GRCm39)	T1931N	possibly damaging	Het
Pla2g15	C	T	8: 106,877,201 (GRCm39)	A28V	probably benign	Het
Pmfbp1	A	T	8: 110,268,474 (GRCm39)	D1007V	probably damaging	Het
Polr1a	T	A	6: 71,901,683 (GRCm39)		probably null	Het
Ppp1r3a	T	C	6: 14,721,891 (GRCm39)	K312E	probably benign	Het
Prmt5	G	A	14: 54,749,583 (GRCm39)	T269I	probably benign	Het
Pwp2	A	G	10: 78,009,540 (GRCm39)	S793P	probably benign	Het
Rbm12b1	C	A	4: 12,146,181 (GRCm39)	H718N	probably benign	Het
Rfx1	T	A	8: 84,817,662 (GRCm39)	M512K	possibly damaging	Het
Rp1	T	C	1: 4,416,789 (GRCm39)	E1441G	probably damaging	Het
Slc16a6	C	T	11: 109,350,634 (GRCm39)	V207I	probably benign	Het
Slc6a9	G	A	4: 117,706,596 (GRCm39)	R7H	possibly damaging	Het
Sptlc1	A	T	13: 53,528,047 (GRCm39)	V39D	probably benign	Het
Strc	A	T	2: 121,211,336 (GRCm39)	L3Q	unknown	Het
Svep1	C	T	4: 58,120,565 (GRCm39)	E823K	possibly damaging	Het
Tat	A	G	8: 110,725,031 (GRCm39)		probably benign	Het
Thoc1	T	A	18: 9,968,800 (GRCm39)	N190K	possibly damaging	Het
Tomt	T	C	7: 101,549,826 (GRCm39)	E154G	probably damaging	Het
Topaz1	T	A	9: 122,617,887 (GRCm39)	V1228E	possibly damaging	Het
Trim55	G	A	3: 19,727,153 (GRCm39)	V407M	probably benign	Het
Ttll5	T	A	12: 85,873,338 (GRCm39)	M5K	possibly damaging	Het
Ugt2a2	A	C	5: 87,609,940 (GRCm39)	Y380*	probably null	Het
Usp46	A	G	5: 74,163,922 (GRCm39)	Y272H	probably benign	Het
Vps39	A	T	2: 120,151,525 (GRCm39)		probably benign	Het
Zfp12	T	A	5: 143,230,421 (GRCm39)	H281Q	probably damaging	Het
Zfp142	C	A	1: 74,606,302 (GRCm39)	R1756L	probably damaging	Het
Zmynd10	T	A	9: 107,426,516 (GRCm39)	I183K	possibly damaging	Het

Other mutations in Lyst

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00156:Lyst	APN	13	13,823,463 (GRCm39)	missense	probably benign
IGL00474:Lyst	APN	13	13,818,121 (GRCm39)	missense	possibly damaging	0.48
IGL00484:Lyst	APN	13	13,884,188 (GRCm39)	missense	probably benign	0.02
IGL00492:Lyst	APN	13	13,852,760 (GRCm39)	missense	possibly damaging	0.54
IGL00807:Lyst	APN	13	13,825,008 (GRCm39)	missense	possibly damaging	0.91
IGL00949:Lyst	APN	13	13,810,070 (GRCm39)	missense	possibly damaging	0.87
IGL00952:Lyst	APN	13	13,852,692 (GRCm39)	missense	probably benign	0.05
IGL01305:Lyst	APN	13	13,852,641 (GRCm39)	missense	probably benign	0.01
IGL01317:Lyst	APN	13	13,845,455 (GRCm39)	missense	probably benign
IGL01419:Lyst	APN	13	13,810,423 (GRCm39)	missense	probably benign	0.00
IGL01445:Lyst	APN	13	13,826,299 (GRCm39)	missense	probably benign	0.00
IGL01690:Lyst	APN	13	13,917,831 (GRCm39)	missense	probably damaging	1.00
IGL01791:Lyst	APN	13	13,809,887 (GRCm39)	missense	probably damaging	1.00
IGL01809:Lyst	APN	13	13,812,388 (GRCm39)	missense	probably damaging	1.00
IGL01896:Lyst	APN	13	13,810,162 (GRCm39)	missense	probably benign	0.04
IGL01938:Lyst	APN	13	13,812,009 (GRCm39)	missense	possibly damaging	0.93
IGL01986:Lyst	APN	13	13,950,212 (GRCm39)	critical splice donor site	probably null
IGL02022:Lyst	APN	13	13,838,629 (GRCm39)	nonsense	probably null
IGL02044:Lyst	APN	13	13,887,431 (GRCm39)	missense	probably damaging	1.00
IGL02157:Lyst	APN	13	13,835,541 (GRCm39)	missense	probably benign
IGL02185:Lyst	APN	13	13,835,678 (GRCm39)	nonsense	probably null
IGL02215:Lyst	APN	13	13,835,541 (GRCm39)	missense	probably benign
IGL02245:Lyst	APN	13	13,835,541 (GRCm39)	missense	probably benign
IGL02246:Lyst	APN	13	13,835,541 (GRCm39)	missense	probably benign
IGL02247:Lyst	APN	13	13,835,541 (GRCm39)	missense	probably benign
IGL02297:Lyst	APN	13	13,812,677 (GRCm39)	nonsense	probably null
IGL02411:Lyst	APN	13	13,835,541 (GRCm39)	missense	probably benign
IGL02415:Lyst	APN	13	13,835,541 (GRCm39)	missense	probably benign
IGL02419:Lyst	APN	13	13,835,541 (GRCm39)	missense	probably benign
IGL02420:Lyst	APN	13	13,835,541 (GRCm39)	missense	probably benign
IGL02429:Lyst	APN	13	13,835,541 (GRCm39)	missense	probably benign
IGL02501:Lyst	APN	13	13,886,230 (GRCm39)	missense	probably benign	0.02
IGL02522:Lyst	APN	13	13,809,290 (GRCm39)	missense	possibly damaging	0.81
IGL02535:Lyst	APN	13	13,824,927 (GRCm39)	missense	probably benign	0.00
IGL02596:Lyst	APN	13	13,835,541 (GRCm39)	missense	probably benign
IGL02601:Lyst	APN	13	13,835,541 (GRCm39)	missense	probably benign
IGL02603:Lyst	APN	13	13,835,541 (GRCm39)	missense	probably benign
IGL02608:Lyst	APN	13	13,887,339 (GRCm39)	missense	probably damaging	0.98
IGL02622:Lyst	APN	13	13,855,975 (GRCm39)	missense	probably damaging	1.00
IGL02690:Lyst	APN	13	13,815,710 (GRCm39)	missense	possibly damaging	0.58
IGL02715:Lyst	APN	13	13,848,905 (GRCm39)	splice site	probably null
IGL02725:Lyst	APN	13	13,935,412 (GRCm39)	missense	probably damaging	1.00
IGL02729:Lyst	APN	13	13,921,194 (GRCm39)	missense	possibly damaging	0.95
IGL02729:Lyst	APN	13	13,848,924 (GRCm39)	missense	possibly damaging	0.81
IGL02820:Lyst	APN	13	13,812,643 (GRCm39)	missense	probably benign	0.03
IGL02945:Lyst	APN	13	13,935,783 (GRCm39)	missense	possibly damaging	0.48
IGL02981:Lyst	APN	13	13,809,496 (GRCm39)	missense	probably damaging	0.99
IGL03087:Lyst	APN	13	13,809,641 (GRCm39)	missense	probably damaging	1.00
IGL03149:Lyst	APN	13	13,856,029 (GRCm39)	missense	probably benign	0.14
IGL03158:Lyst	APN	13	13,826,337 (GRCm39)	critical splice donor site	probably null
IGL03226:Lyst	APN	13	13,884,144 (GRCm39)	missense	probably benign	0.01
IGL03242:Lyst	APN	13	13,831,466 (GRCm39)	nonsense	probably null
IGL03385:Lyst	APN	13	13,831,565 (GRCm39)	nonsense	probably null
50-cal	UTSW	13	13,882,797 (GRCm39)	critical splice donor site	probably null
charcoal	UTSW	13	13,871,346 (GRCm39)	nonsense	probably null
charlotte_gray	UTSW	13	13,602,026 (GRCm38)	intron	probably benign
charzard	UTSW	13	13,821,668 (GRCm39)	nonsense	probably null
grey_wolf	UTSW	13	0 ()	unclassified
lightspeed	UTSW	13	13,915,121 (GRCm39)	missense	possibly damaging	0.91
pardon	UTSW	13	13,852,537 (GRCm39)	missense	probably benign	0.00
robin	UTSW	13	13,823,387 (GRCm39)	nonsense	probably null
sooty	UTSW	13	0 ()	unclassified
souris	UTSW	13	13,857,808 (GRCm39)	unclassified	probably benign
Swallow	UTSW	13	13,932,007 (GRCm39)	missense	probably benign	0.00
vulpix	UTSW	13	13,871,379 (GRCm39)	splice site	probably null
ANU22:Lyst	UTSW	13	13,852,641 (GRCm39)	missense	probably benign	0.01
IGL02835:Lyst	UTSW	13	13,835,685 (GRCm39)	missense	possibly damaging	0.82
P0031:Lyst	UTSW	13	13,838,616 (GRCm39)	missense	probably damaging	1.00
R0012:Lyst	UTSW	13	13,862,279 (GRCm39)	missense	probably benign	0.10
R0012:Lyst	UTSW	13	13,862,279 (GRCm39)	missense	probably benign	0.10
R0031:Lyst	UTSW	13	13,882,741 (GRCm39)	missense	probably benign	0.14
R0115:Lyst	UTSW	13	13,852,537 (GRCm39)	missense	probably benign	0.00
R0212:Lyst	UTSW	13	13,810,570 (GRCm39)	missense	possibly damaging	0.93
R0386:Lyst	UTSW	13	13,882,799 (GRCm39)	splice site	probably benign
R0393:Lyst	UTSW	13	13,821,664 (GRCm39)	missense	probably benign	0.01
R0415:Lyst	UTSW	13	13,886,195 (GRCm39)	splice site	probably benign
R0446:Lyst	UTSW	13	13,812,633 (GRCm39)	missense	probably benign	0.00
R0481:Lyst	UTSW	13	13,852,537 (GRCm39)	missense	probably benign	0.00
R0499:Lyst	UTSW	13	13,791,298 (GRCm39)	missense	probably damaging	1.00
R0506:Lyst	UTSW	13	13,812,600 (GRCm39)	missense	probably benign
R0530:Lyst	UTSW	13	13,931,891 (GRCm39)	splice site	probably benign
R0541:Lyst	UTSW	13	13,855,878 (GRCm39)	missense	probably benign	0.00
R0570:Lyst	UTSW	13	13,883,971 (GRCm39)	missense	probably benign	0.26
R0680:Lyst	UTSW	13	13,824,926 (GRCm39)	missense	probably benign	0.01
R0842:Lyst	UTSW	13	13,852,826 (GRCm39)	nonsense	probably null
R0848:Lyst	UTSW	13	13,809,515 (GRCm39)	missense	probably benign	0.00
R1014:Lyst	UTSW	13	13,808,645 (GRCm39)	missense	possibly damaging	0.49
R1205:Lyst	UTSW	13	13,854,787 (GRCm39)	missense	probably benign
R1251:Lyst	UTSW	13	13,809,068 (GRCm39)	missense	probably benign	0.00
R1304:Lyst	UTSW	13	13,926,569 (GRCm39)	nonsense	probably null
R1398:Lyst	UTSW	13	13,915,121 (GRCm39)	missense	possibly damaging	0.91
R1445:Lyst	UTSW	13	13,814,639 (GRCm39)	missense	possibly damaging	0.94
R1475:Lyst	UTSW	13	13,882,797 (GRCm39)	critical splice donor site	probably null
R1479:Lyst	UTSW	13	13,809,067 (GRCm39)	missense	probably benign	0.00
R1484:Lyst	UTSW	13	13,852,775 (GRCm39)	missense	probably benign	0.01
R1498:Lyst	UTSW	13	13,824,960 (GRCm39)	missense	possibly damaging	0.49
R1540:Lyst	UTSW	13	13,809,686 (GRCm39)	missense	possibly damaging	0.81
R1611:Lyst	UTSW	13	13,809,482 (GRCm39)	missense	probably damaging	0.97
R1653:Lyst	UTSW	13	13,809,811 (GRCm39)	missense	probably damaging	1.00
R1669:Lyst	UTSW	13	13,818,672 (GRCm39)	missense	possibly damaging	0.90
R1686:Lyst	UTSW	13	13,809,290 (GRCm39)	missense	possibly damaging	0.81
R1694:Lyst	UTSW	13	13,835,746 (GRCm39)	missense	probably damaging	0.98
R1747:Lyst	UTSW	13	13,932,007 (GRCm39)	missense	probably benign	0.00
R1793:Lyst	UTSW	13	13,821,668 (GRCm39)	nonsense	probably null
R1871:Lyst	UTSW	13	13,826,297 (GRCm39)	missense	probably benign	0.00
R1905:Lyst	UTSW	13	13,808,719 (GRCm39)	missense	probably benign
R1958:Lyst	UTSW	13	13,791,203 (GRCm39)	missense	probably damaging	1.00
R1969:Lyst	UTSW	13	13,904,929 (GRCm39)	missense	probably damaging	0.99
R2040:Lyst	UTSW	13	13,815,807 (GRCm39)	missense	probably benign	0.00
R2109:Lyst	UTSW	13	13,887,405 (GRCm39)	missense	possibly damaging	0.46
R2116:Lyst	UTSW	13	13,810,286 (GRCm39)	missense	probably damaging	0.99
R2121:Lyst	UTSW	13	13,835,556 (GRCm39)	missense	probably damaging	1.00
R2127:Lyst	UTSW	13	13,809,847 (GRCm39)	missense	probably damaging	1.00
R2187:Lyst	UTSW	13	13,883,926 (GRCm39)	missense	possibly damaging	0.61
R2238:Lyst	UTSW	13	13,917,848 (GRCm39)	missense	probably benign	0.41
R2258:Lyst	UTSW	13	13,812,243 (GRCm39)	missense	probably benign	0.00
R2292:Lyst	UTSW	13	13,915,080 (GRCm39)	missense	probably damaging	1.00
R2368:Lyst	UTSW	13	13,871,248 (GRCm39)	missense	probably damaging	0.96
R2908:Lyst	UTSW	13	13,844,458 (GRCm39)	missense	probably benign	0.03
R3001:Lyst	UTSW	13	13,871,290 (GRCm39)	missense	probably benign
R3002:Lyst	UTSW	13	13,871,290 (GRCm39)	missense	probably benign
R3024:Lyst	UTSW	13	13,833,272 (GRCm39)	missense	probably benign
R3113:Lyst	UTSW	13	13,844,512 (GRCm39)	missense	probably benign	0.12
R3406:Lyst	UTSW	13	13,809,815 (GRCm39)	missense	possibly damaging	0.56
R3972:Lyst	UTSW	13	13,881,210 (GRCm39)	missense	possibly damaging	0.67
R3978:Lyst	UTSW	13	13,808,753 (GRCm39)	missense	possibly damaging	0.82
R4032:Lyst	UTSW	13	13,791,250 (GRCm39)	missense	probably damaging	1.00
R4192:Lyst	UTSW	13	13,915,098 (GRCm39)	missense	probably damaging	1.00
R4206:Lyst	UTSW	13	13,810,574 (GRCm39)	missense	probably benign	0.03
R4298:Lyst	UTSW	13	13,809,472 (GRCm39)	missense	probably damaging	1.00
R4344:Lyst	UTSW	13	13,873,051 (GRCm39)	missense	probably benign	0.06
R4441:Lyst	UTSW	13	13,809,968 (GRCm39)	missense	probably damaging	1.00
R4445:Lyst	UTSW	13	13,884,149 (GRCm39)	missense	probably benign	0.42
R4477:Lyst	UTSW	13	13,809,968 (GRCm39)	missense	probably damaging	1.00
R4493:Lyst	UTSW	13	13,809,968 (GRCm39)	missense	probably damaging	1.00
R4494:Lyst	UTSW	13	13,809,968 (GRCm39)	missense	probably damaging	1.00
R4495:Lyst	UTSW	13	13,809,968 (GRCm39)	missense	probably damaging	1.00
R4622:Lyst	UTSW	13	13,848,983 (GRCm39)	missense	probably benign	0.01
R4638:Lyst	UTSW	13	13,871,379 (GRCm39)	splice site	probably null
R4658:Lyst	UTSW	13	13,809,968 (GRCm39)	missense	probably damaging	1.00
R4675:Lyst	UTSW	13	13,809,968 (GRCm39)	missense	probably damaging	1.00
R4719:Lyst	UTSW	13	13,824,935 (GRCm39)	missense	probably benign
R4729:Lyst	UTSW	13	13,812,486 (GRCm39)	missense	probably damaging	1.00
R4774:Lyst	UTSW	13	13,915,182 (GRCm39)	missense	probably damaging	1.00
R4811:Lyst	UTSW	13	13,951,685 (GRCm39)	missense	probably benign	0.33
R4877:Lyst	UTSW	13	13,857,734 (GRCm39)	missense	probably damaging	1.00
R4920:Lyst	UTSW	13	13,821,645 (GRCm39)	missense	possibly damaging	0.79
R4933:Lyst	UTSW	13	13,933,963 (GRCm39)	missense	probably benign	0.12
R4933:Lyst	UTSW	13	13,812,349 (GRCm39)	missense	probably damaging	0.98
R4958:Lyst	UTSW	13	13,810,048 (GRCm39)	missense	probably benign	0.00
R4982:Lyst	UTSW	13	13,900,539 (GRCm39)	missense	probably damaging	1.00
R4992:Lyst	UTSW	13	13,835,748 (GRCm39)	missense	probably damaging	1.00
R5024:Lyst	UTSW	13	13,808,989 (GRCm39)	missense	probably benign
R5049:Lyst	UTSW	13	13,810,649 (GRCm39)	missense	probably damaging	1.00
R5079:Lyst	UTSW	13	13,931,938 (GRCm39)	missense	probably benign	0.08
R5254:Lyst	UTSW	13	13,857,655 (GRCm39)	missense	probably benign	0.00
R5266:Lyst	UTSW	13	13,835,555 (GRCm39)	missense	probably damaging	1.00
R5279:Lyst	UTSW	13	13,823,387 (GRCm39)	nonsense	probably null
R5285:Lyst	UTSW	13	13,809,011 (GRCm39)	missense	probably benign	0.01
R5364:Lyst	UTSW	13	13,831,439 (GRCm39)	missense	probably benign	0.35
R5435:Lyst	UTSW	13	13,951,649 (GRCm39)	missense	possibly damaging	0.64
R5516:Lyst	UTSW	13	13,818,707 (GRCm39)	missense	probably benign	0.10
R5524:Lyst	UTSW	13	13,921,364 (GRCm39)	missense	probably benign	0.03
R5591:Lyst	UTSW	13	13,917,918 (GRCm39)	missense	probably damaging	0.99
R5592:Lyst	UTSW	13	13,917,918 (GRCm39)	missense	probably damaging	0.99
R5593:Lyst	UTSW	13	13,917,918 (GRCm39)	missense	probably damaging	0.99
R5594:Lyst	UTSW	13	13,917,918 (GRCm39)	missense	probably damaging	0.99
R5594:Lyst	UTSW	13	13,933,982 (GRCm39)	missense	probably benign	0.00
R5644:Lyst	UTSW	13	13,812,081 (GRCm39)	missense	possibly damaging	0.58
R5659:Lyst	UTSW	13	13,809,212 (GRCm39)	missense	possibly damaging	0.58
R5741:Lyst	UTSW	13	13,808,615 (GRCm39)	missense	probably benign	0.44
R5908:Lyst	UTSW	13	13,871,346 (GRCm39)	nonsense	probably null
R5969:Lyst	UTSW	13	13,862,398 (GRCm39)	splice site	probably null
R6128:Lyst	UTSW	13	13,933,964 (GRCm39)	missense	possibly damaging	0.67
R6271:Lyst	UTSW	13	13,833,339 (GRCm39)	missense	probably benign	0.30
R6315:Lyst	UTSW	13	13,818,089 (GRCm39)	missense	probably benign
R6318:Lyst	UTSW	13	13,917,896 (GRCm39)	missense	possibly damaging	0.88
R6555:Lyst	UTSW	13	13,823,510 (GRCm39)	missense	probably benign	0.01
R6663:Lyst	UTSW	13	13,838,701 (GRCm39)	splice site	probably null
R6701:Lyst	UTSW	13	13,856,070 (GRCm39)	missense	probably benign	0.06
R6711:Lyst	UTSW	13	13,809,820 (GRCm39)	missense	possibly damaging	0.80
R6909:Lyst	UTSW	13	13,917,960 (GRCm39)	missense	probably damaging	1.00
R6915:Lyst	UTSW	13	13,900,629 (GRCm39)	missense	probably benign	0.01
R6929:Lyst	UTSW	13	13,917,909 (GRCm39)	missense	probably damaging	1.00
R6960:Lyst	UTSW	13	13,808,663 (GRCm39)	missense	probably benign	0.12
R7018:Lyst	UTSW	13	13,918,044 (GRCm39)	critical splice donor site	probably null
R7037:Lyst	UTSW	13	13,791,251 (GRCm39)	missense	probably damaging	1.00
R7045:Lyst	UTSW	13	13,812,293 (GRCm39)	missense	probably damaging	1.00
R7045:Lyst	UTSW	13	13,809,485 (GRCm39)	missense	probably benign	0.34
R7070:Lyst	UTSW	13	13,932,029 (GRCm39)	missense	probably benign	0.23
R7188:Lyst	UTSW	13	13,926,675 (GRCm39)	missense	possibly damaging	0.66
R7201:Lyst	UTSW	13	13,883,885 (GRCm39)	nonsense	probably null
R7210:Lyst	UTSW	13	13,831,568 (GRCm39)	missense	probably damaging	1.00
R7229:Lyst	UTSW	13	13,818,094 (GRCm39)	missense	probably benign	0.00
R7293:Lyst	UTSW	13	13,854,822 (GRCm39)	missense	probably benign	0.01
R7318:Lyst	UTSW	13	13,932,028 (GRCm39)	missense	probably benign	0.13
R7344:Lyst	UTSW	13	13,881,140 (GRCm39)	missense	probably benign
R7426:Lyst	UTSW	13	13,812,109 (GRCm39)	missense	probably benign
R7522:Lyst	UTSW	13	13,821,668 (GRCm39)	nonsense	probably null
R7583:Lyst	UTSW	13	13,810,472 (GRCm39)	missense	probably damaging	1.00
R7606:Lyst	UTSW	13	13,812,060 (GRCm39)	missense	probably damaging	1.00
R7636:Lyst	UTSW	13	13,791,332 (GRCm39)	critical splice donor site	probably null
R7658:Lyst	UTSW	13	13,905,061 (GRCm39)	missense	possibly damaging	0.63
R7685:Lyst	UTSW	13	13,844,450 (GRCm39)	missense	probably benign	0.00
R7689:Lyst	UTSW	13	13,857,808 (GRCm39)	critical splice donor site	probably null
R7765:Lyst	UTSW	13	13,884,117 (GRCm39)	missense	possibly damaging	0.75
R7779:Lyst	UTSW	13	13,809,128 (GRCm39)	missense	probably damaging	1.00
R7871:Lyst	UTSW	13	13,810,637 (GRCm39)	nonsense	probably null
R7872:Lyst	UTSW	13	13,810,450 (GRCm39)	missense	probably benign	0.14
R7884:Lyst	UTSW	13	13,882,268 (GRCm39)	missense	probably benign	0.09
R7890:Lyst	UTSW	13	13,915,154 (GRCm39)	missense	probably damaging	0.99
R7916:Lyst	UTSW	13	13,821,657 (GRCm39)	missense	possibly damaging	0.64
R7948:Lyst	UTSW	13	13,921,174 (GRCm39)	missense	possibly damaging	0.59
R7956:Lyst	UTSW	13	13,815,788 (GRCm39)	missense	possibly damaging	0.80
R8048:Lyst	UTSW	13	13,862,230 (GRCm39)	missense	probably benign	0.12
R8085:Lyst	UTSW	13	13,808,894 (GRCm39)	missense	probably damaging	0.98
R8165:Lyst	UTSW	13	13,872,945 (GRCm39)	missense	probably damaging	0.99
R8235:Lyst	UTSW	13	13,935,323 (GRCm39)	missense	possibly damaging	0.69
R8237:Lyst	UTSW	13	13,826,317 (GRCm39)	missense	probably benign	0.00
R8275:Lyst	UTSW	13	13,950,667 (GRCm39)	missense	probably benign	0.02
R8300:Lyst	UTSW	13	13,838,643 (GRCm39)	missense	possibly damaging	0.79
R8350:Lyst	UTSW	13	13,824,973 (GRCm39)	nonsense	probably null
R8526:Lyst	UTSW	13	13,935,391 (GRCm39)	missense	probably damaging	0.99
R8551:Lyst	UTSW	13	13,808,645 (GRCm39)	missense	possibly damaging	0.77
R8723:Lyst	UTSW	13	13,887,342 (GRCm39)	missense	possibly damaging	0.89
R8772:Lyst	UTSW	13	13,812,077 (GRCm39)	nonsense	probably null
R8778:Lyst	UTSW	13	13,903,152 (GRCm39)	missense	possibly damaging	0.89
R8778:Lyst	UTSW	13	13,810,361 (GRCm39)	missense	possibly damaging	0.89
R8801:Lyst	UTSW	13	13,835,595 (GRCm39)	missense	probably benign	0.10
R8837:Lyst	UTSW	13	13,852,548 (GRCm39)	missense	probably benign
R8874:Lyst	UTSW	13	13,812,147 (GRCm39)	missense	probably benign
R8878:Lyst	UTSW	13	13,815,661 (GRCm39)	missense	probably benign	0.00
R8891:Lyst	UTSW	13	13,887,435 (GRCm39)	missense	possibly damaging	0.67
R9077:Lyst	UTSW	13	13,857,693 (GRCm39)	missense	probably benign	0.02
R9127:Lyst	UTSW	13	13,808,827 (GRCm39)	missense	probably damaging	1.00
R9143:Lyst	UTSW	13	13,835,750 (GRCm39)	missense	probably damaging	0.98
R9216:Lyst	UTSW	13	13,823,188 (GRCm39)	missense	probably benign
R9217:Lyst	UTSW	13	13,871,245 (GRCm39)	missense	probably benign	0.01
R9291:Lyst	UTSW	13	13,883,938 (GRCm39)	missense	probably benign	0.01
R9370:Lyst	UTSW	13	13,935,333 (GRCm39)	missense	probably damaging	1.00
R9402:Lyst	UTSW	13	13,812,463 (GRCm39)	missense	probably benign
R9457:Lyst	UTSW	13	13,862,330 (GRCm39)	missense	possibly damaging	0.83
R9481:Lyst	UTSW	13	13,857,653 (GRCm39)	missense	possibly damaging	0.68
R9563:Lyst	UTSW	13	13,812,408 (GRCm39)	missense	probably benign	0.36
R9623:Lyst	UTSW	13	13,852,587 (GRCm39)	missense	probably benign
R9661:Lyst	UTSW	13	13,808,779 (GRCm39)	missense	probably benign	0.01
R9682:Lyst	UTSW	13	13,831,526 (GRCm39)	missense	probably benign	0.21
R9743:Lyst	UTSW	13	13,809,323 (GRCm39)	missense	possibly damaging	0.67
R9801:Lyst	UTSW	13	13,809,290 (GRCm39)	missense	probably damaging	0.97
RF001:Lyst	UTSW	13	13,810,426 (GRCm39)	missense	probably benign
RF002:Lyst	UTSW	13	13,808,948 (GRCm39)	missense	probably benign	0.05
X0024:Lyst	UTSW	13	13,809,033 (GRCm39)	missense	probably benign	0.00
X0026:Lyst	UTSW	13	13,926,555 (GRCm39)	missense	probably damaging	0.99
Z1088:Lyst	UTSW	13	13,918,018 (GRCm39)	missense	probably benign	0.09
Z1176:Lyst	UTSW	13	13,951,664 (GRCm39)	missense	probably benign	0.27
Z1176:Lyst	UTSW	13	13,814,692 (GRCm39)	missense	probably damaging	1.00
Z1177:Lyst	UTSW	13	13,854,719 (GRCm39)	missense	possibly damaging	0.73

Predicted Primers

PCR Primer
(F):5'- TCAAAAGGGCTGGGGATCTG -3'
(R):5'- GACAGGAGCAAGATTTGACTACC -3'

Sequencing Primer
(F):5'- ATCTGGACACTGGTGGGAAGTC -3'
(R):5'- AGGGCTAGTTTTTAAGAAGCTAGTC -3'

Posted On

2022-03-25