Incidental Mutation 'R9305:Krt32'
ID 705178
Institutional Source Beutler Lab
Gene Symbol Krt32
Ensembl Gene ENSMUSG00000046095
Gene Name keratin 32
Synonyms mHa2, Krt1-2
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.072) question?
Stock # R9305 (G1)
Quality Score 225.009
Status Not validated
Chromosome 11
Chromosomal Location 99971674-99979095 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 99972029 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 440 (T440A)
Ref Sequence ENSEMBL: ENSMUSP00000103042 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000107419]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000107419
AA Change: T440A

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000103042
Gene: ENSMUSG00000046095
AA Change: T440A

DomainStartEndE-ValueType
low complexity region 11 23 N/A INTRINSIC
Filament 100 411 5.4e-150 SMART
low complexity region 435 448 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.6%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca16 A G 7: 120,126,989 (GRCm39) I1227V probably benign Het
Abhd8 A G 8: 71,911,148 (GRCm39) V261A possibly damaging Het
Adam34 A T 8: 44,104,416 (GRCm39) C410S probably damaging Het
Adamts17 T C 7: 66,489,645 (GRCm39) L21P probably damaging Het
Adgre1 A G 17: 57,748,275 (GRCm39) N492D probably benign Het
Aldh1b1 G A 4: 45,803,811 (GRCm39) V450M probably damaging Het
Apob A G 12: 8,058,053 (GRCm39) I2178M probably benign Het
Atp9a A T 2: 168,517,163 (GRCm39) I390N probably benign Het
Bltp1 A G 3: 37,098,969 (GRCm39) I1277V Het
Cacng2 T G 15: 77,897,542 (GRCm39) Y89S possibly damaging Het
Capn10 T C 1: 92,871,665 (GRCm39) probably null Het
Casq2 A G 3: 102,052,700 (GRCm39) D404G unknown Het
Cdh9 T A 15: 16,832,138 (GRCm39) Y342N probably damaging Het
Cenpf T C 1: 189,392,271 (GRCm39) probably null Het
Cep295nl G A 11: 118,224,766 (GRCm39) P26L possibly damaging Het
Chmp4c T G 3: 10,454,974 (GRCm39) S214A probably benign Het
Clstn2 T A 9: 97,343,537 (GRCm39) I637F probably damaging Het
Csmd1 G T 8: 16,011,532 (GRCm39) T2507K probably benign Het
Ddx55 C T 5: 124,705,012 (GRCm39) S427F probably damaging Het
Dpysl5 T C 5: 30,948,959 (GRCm39) W405R probably damaging Het
Esyt1 A G 10: 128,355,388 (GRCm39) V451A possibly damaging Het
Fads2b A T 2: 85,330,649 (GRCm39) C219* probably null Het
Fam186b G A 15: 99,177,616 (GRCm39) A570V probably damaging Het
Foxa3 A G 7: 18,748,961 (GRCm39) L55P possibly damaging Het
Gng2 G T 14: 19,925,961 (GRCm39) H44N probably damaging Het
Hps5 G A 7: 46,438,619 (GRCm39) T38I possibly damaging Het
Igf2 G A 7: 142,208,153 (GRCm39) R64C probably damaging Het
Klb T A 5: 65,505,988 (GRCm39) Y78* probably null Het
Kynu T A 2: 43,569,768 (GRCm39) F350Y probably damaging Het
Lrp1b A T 2: 41,618,574 (GRCm39) S281T Het
Lrrc43 C T 5: 123,646,219 (GRCm39) A657V unknown Het
Mief2 C A 11: 60,622,042 (GRCm39) P204Q possibly damaging Het
Morc3 G T 16: 93,667,302 (GRCm39) R560L probably benign Het
Or2y3 A T 17: 38,393,629 (GRCm39) V80D probably damaging Het
Or8c20 A C 9: 38,260,381 (GRCm39) M1L probably benign Het
Orc3 G A 4: 34,607,181 (GRCm39) R50* probably null Het
Osbpl6 T A 2: 76,378,716 (GRCm39) D124E probably damaging Het
Parp4 TG T 14: 56,832,790 (GRCm39) probably null Het
Parp4 T C 14: 56,852,224 (GRCm39) probably null Het
Pcdhb18 A C 18: 37,625,004 (GRCm39) H778P probably benign Het
Polg A T 7: 79,105,860 (GRCm39) Y710N probably benign Het
Ppp2r2b C A 18: 42,779,025 (GRCm39) R370L possibly damaging Het
Prune2 A G 19: 17,097,625 (GRCm39) D1043G probably benign Het
Rpl6 T C 5: 121,346,516 (GRCm39) S206P possibly damaging Het
Serpina3i T C 12: 104,234,881 (GRCm39) V404A probably damaging Het
Serpinb8 T C 1: 107,526,769 (GRCm39) probably null Het
Stx11 A T 10: 12,817,564 (GRCm39) D53E probably benign Het
Thoc3 C T 13: 54,607,998 (GRCm39) W315* probably null Het
Tmem26 G A 10: 68,559,816 (GRCm39) W29* probably null Het
Togaram2 A G 17: 71,996,408 (GRCm39) E137G probably damaging Het
Ttc39b A G 4: 83,151,023 (GRCm39) L524S probably damaging Het
Usp43 T C 11: 67,767,345 (GRCm39) N675S probably damaging Het
Vmn2r104 A G 17: 20,268,439 (GRCm39) L10P possibly damaging Het
Zbtb1 G A 12: 76,432,773 (GRCm39) R253Q probably damaging Het
Zfc3h1 A G 10: 115,255,771 (GRCm39) D1474G probably benign Het
Zfp873 T C 10: 81,896,514 (GRCm39) F415S probably benign Het
Other mutations in Krt32
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01089:Krt32 APN 11 99,978,605 (GRCm39) missense probably benign 0.23
IGL01454:Krt32 APN 11 99,974,907 (GRCm39) missense probably damaging 1.00
IGL02268:Krt32 APN 11 99,978,967 (GRCm39) missense probably benign 0.21
IGL02502:Krt32 APN 11 99,978,749 (GRCm39) missense probably damaging 1.00
IGL02967:Krt32 APN 11 99,974,876 (GRCm39) missense possibly damaging 0.93
IGL02799:Krt32 UTSW 11 99,978,733 (GRCm39) missense possibly damaging 0.54
R0840:Krt32 UTSW 11 99,972,068 (GRCm39) missense probably benign 0.00
R1503:Krt32 UTSW 11 99,974,936 (GRCm39) critical splice acceptor site probably null
R1944:Krt32 UTSW 11 99,975,670 (GRCm39) critical splice acceptor site probably null
R1945:Krt32 UTSW 11 99,975,670 (GRCm39) critical splice acceptor site probably null
R2426:Krt32 UTSW 11 99,977,192 (GRCm39) missense possibly damaging 0.76
R3774:Krt32 UTSW 11 99,978,947 (GRCm39) missense probably benign 0.00
R3775:Krt32 UTSW 11 99,978,947 (GRCm39) missense probably benign 0.00
R3776:Krt32 UTSW 11 99,978,947 (GRCm39) missense probably benign 0.00
R5522:Krt32 UTSW 11 99,977,497 (GRCm39) critical splice donor site probably null
R5794:Krt32 UTSW 11 99,975,812 (GRCm39) missense probably damaging 0.99
R6109:Krt32 UTSW 11 99,978,791 (GRCm39) missense probably benign 0.01
R6994:Krt32 UTSW 11 99,977,271 (GRCm39) missense probably damaging 1.00
R7375:Krt32 UTSW 11 99,972,050 (GRCm39) missense probably benign 0.18
R7577:Krt32 UTSW 11 99,972,047 (GRCm39) missense probably benign 0.00
R8249:Krt32 UTSW 11 99,977,548 (GRCm39) missense probably benign 0.00
R9207:Krt32 UTSW 11 99,977,580 (GRCm39) missense possibly damaging 0.61
R9303:Krt32 UTSW 11 99,972,029 (GRCm39) missense probably benign 0.00
R9684:Krt32 UTSW 11 99,977,308 (GRCm39) missense probably damaging 1.00
Z1088:Krt32 UTSW 11 99,979,042 (GRCm39) missense probably benign
Z1177:Krt32 UTSW 11 99,974,895 (GRCm39) missense possibly damaging 0.95
Predicted Primers PCR Primer
(F):5'- ATCAGGACATGTTGCTAGTGTC -3'
(R):5'- GCAGTGGAGCCATTAACGAG -3'

Sequencing Primer
(F):5'- GTTCTGGTCAGGGCCAACTAAG -3'
(R):5'- AGCCATTAACGAGGCTCCTGAG -3'
Posted On 2022-03-25