Incidental Mutation 'R9308:Vmn2r17'
| ID |
705327 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r17
|
| Ensembl Gene |
ENSMUSG00000091879 |
| Gene Name |
vomeronasal 2, receptor 17 |
| Synonyms |
EG384221 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.112)
|
| Stock # |
R9308 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
5 |
| Chromosomal Location |
109567879-109601253 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 109600505 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 601
(V601A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000131450
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000171841]
|
| AlphaFold |
E9PYF5 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000171841
AA Change: V601A
PolyPhen 2
Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000131450
Gene: ENSMUSG00000091879
AA Change: V601A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
76 |
465 |
7e-26 |
PFAM |
|
Pfam:NCD3G
|
508 |
562 |
3.5e-18 |
PFAM |
|
Pfam:7tm_3
|
593 |
830 |
4.8e-55 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.4%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 66 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700010I14Rik |
G |
T |
17: 9,220,667 (GRCm39) |
E389* |
probably null |
Het |
| 2700049A03Rik |
T |
C |
12: 71,231,233 (GRCm39) |
V997A |
probably benign |
Het |
| 9930012K11Rik |
A |
G |
14: 70,393,863 (GRCm39) |
|
probably null |
Het |
| Acss3 |
C |
G |
10: 106,959,282 (GRCm39) |
G55R |
possibly damaging |
Het |
| Acte1 |
G |
T |
7: 143,434,902 (GRCm39) |
|
probably null |
Het |
| Acy3 |
C |
T |
19: 4,038,451 (GRCm39) |
R193W |
probably damaging |
Het |
| Adam15 |
T |
C |
3: 89,254,790 (GRCm39) |
D90G |
possibly damaging |
Het |
| Adamts9 |
T |
C |
6: 92,857,875 (GRCm39) |
D833G |
probably benign |
Het |
| Apoa2 |
A |
G |
1: 171,053,300 (GRCm39) |
S40G |
probably benign |
Het |
| Arhgap21 |
A |
T |
2: 20,854,061 (GRCm39) |
M1777K |
probably damaging |
Het |
| BC004004 |
A |
G |
17: 29,513,089 (GRCm39) |
E171G |
probably benign |
Het |
| Cblb |
A |
G |
16: 52,009,374 (GRCm39) |
|
probably null |
Het |
| Cdk5rap2 |
T |
C |
4: 70,328,504 (GRCm39) |
M1V |
probably null |
Het |
| Clca4a |
T |
G |
3: 144,676,183 (GRCm39) |
E117A |
probably damaging |
Het |
| Cps1 |
T |
C |
1: 67,200,118 (GRCm39) |
|
probably null |
Het |
| Crygd |
T |
C |
1: 65,101,220 (GRCm39) |
N125S |
probably benign |
Het |
| Csf1 |
T |
A |
3: 107,655,585 (GRCm39) |
H482L |
probably benign |
Het |
| Cyp3a41a |
A |
G |
5: 145,656,858 (GRCm39) |
M1T |
probably null |
Het |
| Dgkg |
C |
A |
16: 22,429,528 (GRCm39) |
|
probably null |
Het |
| Dnhd1 |
T |
C |
7: 105,353,484 (GRCm39) |
V2879A |
probably damaging |
Het |
| Dock6 |
A |
T |
9: 21,728,744 (GRCm39) |
C1307* |
probably null |
Het |
| Exoc1 |
T |
A |
5: 76,706,968 (GRCm39) |
M505K |
probably benign |
Het |
| Fam131a |
A |
G |
16: 20,520,582 (GRCm39) |
D345G |
probably damaging |
Het |
| Fbxw17 |
G |
T |
13: 50,572,004 (GRCm39) |
R24L |
probably benign |
Het |
| Gmcl1 |
A |
C |
6: 86,691,239 (GRCm39) |
I252R |
possibly damaging |
Het |
| Gpr150 |
G |
A |
13: 76,203,701 (GRCm39) |
R415C |
probably damaging |
Het |
| Gtf3c4 |
G |
A |
2: 28,724,982 (GRCm39) |
S250L |
probably damaging |
Het |
| Irs3 |
G |
A |
5: 137,642,343 (GRCm39) |
A365V |
possibly damaging |
Het |
| Jph4 |
C |
A |
14: 55,346,981 (GRCm39) |
G522V |
probably damaging |
Het |
| Kcnn1 |
C |
T |
8: 71,305,434 (GRCm39) |
G302R |
probably damaging |
Het |
| Ksr1 |
A |
T |
11: 78,918,291 (GRCm39) |
L621H |
probably damaging |
Het |
| Lrrn3 |
T |
C |
12: 41,503,945 (GRCm39) |
E124G |
probably damaging |
Het |
| Map3k6 |
T |
C |
4: 132,970,722 (GRCm39) |
L203P |
probably damaging |
Het |
| Mapk15 |
T |
A |
15: 75,865,714 (GRCm39) |
C2* |
probably null |
Het |
| Mga |
T |
A |
2: 119,754,369 (GRCm39) |
N959K |
possibly damaging |
Het |
| Mrgprb2 |
A |
T |
7: 48,202,655 (GRCm39) |
N23K |
possibly damaging |
Het |
| Myo10 |
G |
T |
15: 25,781,862 (GRCm39) |
S1119I |
probably damaging |
Het |
| Or12e13 |
G |
A |
2: 87,663,523 (GRCm39) |
G47R |
probably damaging |
Het |
| Or14j4 |
A |
G |
17: 37,921,246 (GRCm39) |
V132A |
possibly damaging |
Het |
| Or2a12 |
G |
T |
6: 42,904,749 (GRCm39) |
V195F |
probably benign |
Het |
| Or2a25 |
A |
T |
6: 42,888,931 (GRCm39) |
H158L |
probably damaging |
Het |
| Or6k6 |
A |
G |
1: 173,945,501 (GRCm39) |
V27A |
probably benign |
Het |
| Ovch2 |
T |
C |
7: 107,389,560 (GRCm39) |
E329G |
probably benign |
Het |
| Pkn2 |
C |
T |
3: 142,517,724 (GRCm39) |
R458Q |
probably benign |
Het |
| Pnpt1 |
T |
C |
11: 29,097,535 (GRCm39) |
|
probably null |
Het |
| Ppfia4 |
A |
G |
1: 134,245,556 (GRCm39) |
V666A |
probably benign |
Het |
| Psmb10 |
T |
C |
8: 106,662,662 (GRCm39) |
R226G |
probably damaging |
Het |
| Ptpn5 |
A |
G |
7: 46,740,569 (GRCm39) |
V78A |
probably benign |
Het |
| Ptprk |
A |
G |
10: 28,450,850 (GRCm39) |
M1004V |
probably benign |
Het |
| Pygb |
T |
A |
2: 150,668,297 (GRCm39) |
S626T |
probably benign |
Het |
| Rad21l |
T |
C |
2: 151,491,049 (GRCm39) |
T473A |
probably benign |
Het |
| Rassf7 |
T |
C |
7: 140,798,063 (GRCm39) |
S344P |
probably benign |
Het |
| Rbbp6 |
T |
C |
7: 122,596,221 (GRCm39) |
S550P |
probably damaging |
Het |
| Rhpn2 |
T |
C |
7: 35,033,805 (GRCm39) |
L13P |
possibly damaging |
Het |
| Rps11 |
C |
T |
7: 44,772,614 (GRCm39) |
V66I |
probably benign |
Het |
| Slc22a18 |
T |
C |
7: 143,044,617 (GRCm39) |
V190A |
probably benign |
Het |
| Smad1 |
T |
C |
8: 80,098,899 (GRCm39) |
|
probably benign |
Het |
| Spock2 |
A |
G |
10: 59,965,556 (GRCm39) |
K327E |
possibly damaging |
Het |
| Tmem135 |
G |
C |
7: 88,797,186 (GRCm39) |
L357V |
probably benign |
Het |
| Tom1l1 |
TTGCTGCTGCTGCTGCTG |
TTGCTGCTGCTGCTG |
11: 90,540,648 (GRCm39) |
|
probably benign |
Het |
| Traj22 |
T |
C |
14: 54,434,729 (GRCm39) |
I8T |
|
Het |
| Txnl1 |
T |
C |
18: 63,812,446 (GRCm39) |
D116G |
probably benign |
Het |
| Ush1g |
A |
T |
11: 115,209,534 (GRCm39) |
L220Q |
probably damaging |
Het |
| Vmn2r10 |
C |
A |
5: 109,145,476 (GRCm39) |
E544* |
probably null |
Het |
| Zc3h13 |
C |
T |
14: 75,565,418 (GRCm39) |
R844W |
unknown |
Het |
| Zfpm1 |
A |
C |
8: 123,034,231 (GRCm39) |
D55A |
probably benign |
Het |
|
| Other mutations in Vmn2r17 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00325:Vmn2r17
|
APN |
5 |
109,575,858 (GRCm39) |
missense |
probably benign |
0.15 |
|
IGL01457:Vmn2r17
|
APN |
5 |
109,600,898 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01527:Vmn2r17
|
APN |
5 |
109,601,006 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01693:Vmn2r17
|
APN |
5 |
109,600,384 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01738:Vmn2r17
|
APN |
5 |
109,577,364 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01767:Vmn2r17
|
APN |
5 |
109,567,903 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01932:Vmn2r17
|
APN |
5 |
109,574,916 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01970:Vmn2r17
|
APN |
5 |
109,575,813 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02009:Vmn2r17
|
APN |
5 |
109,600,714 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
IGL02365:Vmn2r17
|
APN |
5 |
109,601,175 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02385:Vmn2r17
|
APN |
5 |
109,582,247 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02457:Vmn2r17
|
APN |
5 |
109,601,012 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02646:Vmn2r17
|
APN |
5 |
109,600,946 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02741:Vmn2r17
|
APN |
5 |
109,568,077 (GRCm39) |
missense |
probably benign |
|
|
IGL03213:Vmn2r17
|
APN |
5 |
109,582,256 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03216:Vmn2r17
|
APN |
5 |
109,600,756 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03342:Vmn2r17
|
APN |
5 |
109,575,782 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03408:Vmn2r17
|
APN |
5 |
109,577,238 (GRCm39) |
splice site |
probably benign |
|
|
R0349:Vmn2r17
|
UTSW |
5 |
109,576,202 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0418:Vmn2r17
|
UTSW |
5 |
109,600,747 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0800:Vmn2r17
|
UTSW |
5 |
109,575,192 (GRCm39) |
splice site |
probably benign |
|
|
R0836:Vmn2r17
|
UTSW |
5 |
109,575,822 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R1715:Vmn2r17
|
UTSW |
5 |
109,576,110 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1738:Vmn2r17
|
UTSW |
5 |
109,576,377 (GRCm39) |
missense |
probably benign |
0.10 |
|
R1801:Vmn2r17
|
UTSW |
5 |
109,576,344 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2054:Vmn2r17
|
UTSW |
5 |
109,600,352 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2060:Vmn2r17
|
UTSW |
5 |
109,575,075 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2192:Vmn2r17
|
UTSW |
5 |
109,582,144 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R2315:Vmn2r17
|
UTSW |
5 |
109,575,897 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2374:Vmn2r17
|
UTSW |
5 |
109,575,104 (GRCm39) |
missense |
probably benign |
|
|
R3612:Vmn2r17
|
UTSW |
5 |
109,577,463 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3832:Vmn2r17
|
UTSW |
5 |
109,576,262 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4273:Vmn2r17
|
UTSW |
5 |
109,600,832 (GRCm39) |
missense |
probably benign |
0.44 |
|
R4494:Vmn2r17
|
UTSW |
5 |
109,576,335 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4597:Vmn2r17
|
UTSW |
5 |
109,577,428 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4675:Vmn2r17
|
UTSW |
5 |
109,575,049 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4701:Vmn2r17
|
UTSW |
5 |
109,575,849 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4754:Vmn2r17
|
UTSW |
5 |
109,600,715 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4841:Vmn2r17
|
UTSW |
5 |
109,582,246 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4842:Vmn2r17
|
UTSW |
5 |
109,582,246 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4865:Vmn2r17
|
UTSW |
5 |
109,574,985 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4902:Vmn2r17
|
UTSW |
5 |
109,601,220 (GRCm39) |
missense |
probably benign |
0.14 |
|
R4989:Vmn2r17
|
UTSW |
5 |
109,575,739 (GRCm39) |
missense |
probably benign |
0.07 |
|
R5101:Vmn2r17
|
UTSW |
5 |
109,576,217 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5109:Vmn2r17
|
UTSW |
5 |
109,577,342 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5123:Vmn2r17
|
UTSW |
5 |
109,575,774 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R5474:Vmn2r17
|
UTSW |
5 |
109,582,150 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5485:Vmn2r17
|
UTSW |
5 |
109,567,972 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5611:Vmn2r17
|
UTSW |
5 |
109,576,030 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5652:Vmn2r17
|
UTSW |
5 |
109,577,430 (GRCm39) |
missense |
probably benign |
0.10 |
|
R5717:Vmn2r17
|
UTSW |
5 |
109,575,140 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5735:Vmn2r17
|
UTSW |
5 |
109,600,716 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R5766:Vmn2r17
|
UTSW |
5 |
109,575,139 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6645:Vmn2r17
|
UTSW |
5 |
109,576,247 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6786:Vmn2r17
|
UTSW |
5 |
109,575,695 (GRCm39) |
missense |
probably benign |
0.30 |
|
R6821:Vmn2r17
|
UTSW |
5 |
109,577,331 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6979:Vmn2r17
|
UTSW |
5 |
109,576,265 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6984:Vmn2r17
|
UTSW |
5 |
109,600,533 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7269:Vmn2r17
|
UTSW |
5 |
109,576,337 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R7509:Vmn2r17
|
UTSW |
5 |
109,575,695 (GRCm39) |
missense |
probably benign |
0.30 |
|
R7736:Vmn2r17
|
UTSW |
5 |
109,600,757 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7789:Vmn2r17
|
UTSW |
5 |
109,600,831 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R7814:Vmn2r17
|
UTSW |
5 |
109,575,739 (GRCm39) |
missense |
probably benign |
0.07 |
|
R7847:Vmn2r17
|
UTSW |
5 |
109,568,063 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7863:Vmn2r17
|
UTSW |
5 |
109,568,035 (GRCm39) |
missense |
probably benign |
|
|
R7893:Vmn2r17
|
UTSW |
5 |
109,575,944 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8234:Vmn2r17
|
UTSW |
5 |
109,601,235 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8382:Vmn2r17
|
UTSW |
5 |
109,576,387 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8435:Vmn2r17
|
UTSW |
5 |
109,576,172 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8465:Vmn2r17
|
UTSW |
5 |
109,600,691 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8555:Vmn2r17
|
UTSW |
5 |
109,600,810 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8900:Vmn2r17
|
UTSW |
5 |
109,575,863 (GRCm39) |
missense |
probably benign |
0.25 |
|
R9293:Vmn2r17
|
UTSW |
5 |
109,600,712 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9378:Vmn2r17
|
UTSW |
5 |
109,575,732 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9597:Vmn2r17
|
UTSW |
5 |
109,575,669 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GTGATTGTTCACCAGCAGATATGG -3'
(R):5'- GCCATGACCACAGTTATTGTTTTGG -3'
Sequencing Primer
(F):5'- GAACAGTGTGTGAGGTGTCCAG -3'
(R):5'- TTTGGCCAACACTGTAGAAATGGC -3'
|
| Posted On |
2022-03-25 |
Incidental Mutation