Incidental Mutation 'R9308:Tom1l1'
ID 705355
Institutional Source Beutler Lab
Gene Symbol Tom1l1
Ensembl Gene ENSMUSG00000020541
Gene Name target of myb1-like 1 (chicken)
Synonyms 2310045L10Rik, Srcasm
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.169) question?
Stock # R9308 (G1)
Quality Score 217.468
Status Not validated
Chromosome 11
Chromosomal Location 90536516-90579105 bp(-) (GRCm39)
Type of Mutation small deletion (1 aa in frame mutation)
DNA Base Change (assembly) TTGCTGCTGCTGCTGCTG to TTGCTGCTGCTGCTG at 90540648 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000103501 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000020849] [ENSMUST00000020851] [ENSMUST00000107867] [ENSMUST00000107868] [ENSMUST00000107869]
AlphaFold Q923U0
Predicted Effect probably benign
Transcript: ENSMUST00000020849
SMART Domains Protein: ENSMUSP00000020849
Gene: ENSMUSG00000020541

DomainStartEndE-ValueType
VHS 15 150 7.37e-53 SMART
Pfam:GAT 212 288 5.8e-17 PFAM
low complexity region 340 349 N/A INTRINSIC
low complexity region 409 416 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000020851
SMART Domains Protein: ENSMUSP00000020851
Gene: ENSMUSG00000020544

DomainStartEndE-ValueType
low complexity region 42 54 N/A INTRINSIC
Pfam:CtaG_Cox11 112 262 5.5e-62 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000107867
SMART Domains Protein: ENSMUSP00000103499
Gene: ENSMUSG00000020541

DomainStartEndE-ValueType
Pfam:GAT 1 50 5.4e-12 PFAM
low complexity region 93 102 N/A INTRINSIC
low complexity region 162 169 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000107868
SMART Domains Protein: ENSMUSP00000103500
Gene: ENSMUSG00000020541

DomainStartEndE-ValueType
Pfam:VHS 1 73 4.2e-10 PFAM
Pfam:GAT 119 220 5.5e-29 PFAM
low complexity region 263 272 N/A INTRINSIC
low complexity region 332 339 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000107869
SMART Domains Protein: ENSMUSP00000103501
Gene: ENSMUSG00000020541

DomainStartEndE-ValueType
VHS 15 152 7.23e-38 SMART
low complexity region 264 273 N/A INTRINSIC
low complexity region 333 340 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700010I14Rik G T 17: 9,220,667 (GRCm39) E389* probably null Het
2700049A03Rik T C 12: 71,231,233 (GRCm39) V997A probably benign Het
9930012K11Rik A G 14: 70,393,863 (GRCm39) probably null Het
Acss3 C G 10: 106,959,282 (GRCm39) G55R possibly damaging Het
Acte1 G T 7: 143,434,902 (GRCm39) probably null Het
Acy3 C T 19: 4,038,451 (GRCm39) R193W probably damaging Het
Adam15 T C 3: 89,254,790 (GRCm39) D90G possibly damaging Het
Adamts9 T C 6: 92,857,875 (GRCm39) D833G probably benign Het
Apoa2 A G 1: 171,053,300 (GRCm39) S40G probably benign Het
Arhgap21 A T 2: 20,854,061 (GRCm39) M1777K probably damaging Het
BC004004 A G 17: 29,513,089 (GRCm39) E171G probably benign Het
Cblb A G 16: 52,009,374 (GRCm39) probably null Het
Cdk5rap2 T C 4: 70,328,504 (GRCm39) M1V probably null Het
Clca4a T G 3: 144,676,183 (GRCm39) E117A probably damaging Het
Cps1 T C 1: 67,200,118 (GRCm39) probably null Het
Crygd T C 1: 65,101,220 (GRCm39) N125S probably benign Het
Csf1 T A 3: 107,655,585 (GRCm39) H482L probably benign Het
Cyp3a41a A G 5: 145,656,858 (GRCm39) M1T probably null Het
Dgkg C A 16: 22,429,528 (GRCm39) probably null Het
Dnhd1 T C 7: 105,353,484 (GRCm39) V2879A probably damaging Het
Dock6 A T 9: 21,728,744 (GRCm39) C1307* probably null Het
Exoc1 T A 5: 76,706,968 (GRCm39) M505K probably benign Het
Fam131a A G 16: 20,520,582 (GRCm39) D345G probably damaging Het
Fbxw17 G T 13: 50,572,004 (GRCm39) R24L probably benign Het
Gmcl1 A C 6: 86,691,239 (GRCm39) I252R possibly damaging Het
Gpr150 G A 13: 76,203,701 (GRCm39) R415C probably damaging Het
Gtf3c4 G A 2: 28,724,982 (GRCm39) S250L probably damaging Het
Irs3 G A 5: 137,642,343 (GRCm39) A365V possibly damaging Het
Jph4 C A 14: 55,346,981 (GRCm39) G522V probably damaging Het
Kcnn1 C T 8: 71,305,434 (GRCm39) G302R probably damaging Het
Ksr1 A T 11: 78,918,291 (GRCm39) L621H probably damaging Het
Lrrn3 T C 12: 41,503,945 (GRCm39) E124G probably damaging Het
Map3k6 T C 4: 132,970,722 (GRCm39) L203P probably damaging Het
Mapk15 T A 15: 75,865,714 (GRCm39) C2* probably null Het
Mga T A 2: 119,754,369 (GRCm39) N959K possibly damaging Het
Mrgprb2 A T 7: 48,202,655 (GRCm39) N23K possibly damaging Het
Myo10 G T 15: 25,781,862 (GRCm39) S1119I probably damaging Het
Or12e13 G A 2: 87,663,523 (GRCm39) G47R probably damaging Het
Or14j4 A G 17: 37,921,246 (GRCm39) V132A possibly damaging Het
Or2a12 G T 6: 42,904,749 (GRCm39) V195F probably benign Het
Or2a25 A T 6: 42,888,931 (GRCm39) H158L probably damaging Het
Or6k6 A G 1: 173,945,501 (GRCm39) V27A probably benign Het
Ovch2 T C 7: 107,389,560 (GRCm39) E329G probably benign Het
Pkn2 C T 3: 142,517,724 (GRCm39) R458Q probably benign Het
Pnpt1 T C 11: 29,097,535 (GRCm39) probably null Het
Ppfia4 A G 1: 134,245,556 (GRCm39) V666A probably benign Het
Psmb10 T C 8: 106,662,662 (GRCm39) R226G probably damaging Het
Ptpn5 A G 7: 46,740,569 (GRCm39) V78A probably benign Het
Ptprk A G 10: 28,450,850 (GRCm39) M1004V probably benign Het
Pygb T A 2: 150,668,297 (GRCm39) S626T probably benign Het
Rad21l T C 2: 151,491,049 (GRCm39) T473A probably benign Het
Rassf7 T C 7: 140,798,063 (GRCm39) S344P probably benign Het
Rbbp6 T C 7: 122,596,221 (GRCm39) S550P probably damaging Het
Rhpn2 T C 7: 35,033,805 (GRCm39) L13P possibly damaging Het
Rps11 C T 7: 44,772,614 (GRCm39) V66I probably benign Het
Slc22a18 T C 7: 143,044,617 (GRCm39) V190A probably benign Het
Smad1 T C 8: 80,098,899 (GRCm39) probably benign Het
Spock2 A G 10: 59,965,556 (GRCm39) K327E possibly damaging Het
Tmem135 G C 7: 88,797,186 (GRCm39) L357V probably benign Het
Traj22 T C 14: 54,434,729 (GRCm39) I8T Het
Txnl1 T C 18: 63,812,446 (GRCm39) D116G probably benign Het
Ush1g A T 11: 115,209,534 (GRCm39) L220Q probably damaging Het
Vmn2r10 C A 5: 109,145,476 (GRCm39) E544* probably null Het
Vmn2r17 T C 5: 109,600,505 (GRCm39) V601A probably damaging Het
Zc3h13 C T 14: 75,565,418 (GRCm39) R844W unknown Het
Zfpm1 A C 8: 123,034,231 (GRCm39) D55A probably benign Het
Other mutations in Tom1l1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00595:Tom1l1 APN 11 90,565,566 (GRCm39) missense probably damaging 1.00
IGL01995:Tom1l1 APN 11 90,540,687 (GRCm39) missense probably damaging 0.96
R0057:Tom1l1 UTSW 11 90,575,975 (GRCm39) splice site probably benign
R1557:Tom1l1 UTSW 11 90,547,210 (GRCm39) missense possibly damaging 0.92
R1614:Tom1l1 UTSW 11 90,574,080 (GRCm39) missense probably damaging 1.00
R1616:Tom1l1 UTSW 11 90,547,177 (GRCm39) missense possibly damaging 0.92
R2165:Tom1l1 UTSW 11 90,540,721 (GRCm39) splice site probably benign
R2517:Tom1l1 UTSW 11 90,561,951 (GRCm39) missense possibly damaging 0.66
R3745:Tom1l1 UTSW 11 90,548,567 (GRCm39) missense probably benign 0.01
R4614:Tom1l1 UTSW 11 90,561,952 (GRCm39) missense probably damaging 1.00
R4694:Tom1l1 UTSW 11 90,537,675 (GRCm39) missense possibly damaging 0.86
R4755:Tom1l1 UTSW 11 90,575,942 (GRCm39) missense probably damaging 1.00
R5397:Tom1l1 UTSW 11 90,552,600 (GRCm39) missense probably benign 0.02
R6294:Tom1l1 UTSW 11 90,552,587 (GRCm39) nonsense probably null
R6733:Tom1l1 UTSW 11 90,575,886 (GRCm39) critical splice donor site probably null
R6911:Tom1l1 UTSW 11 90,534,987 (GRCm39) splice site probably null
R7103:Tom1l1 UTSW 11 90,561,907 (GRCm39) splice site probably null
R7489:Tom1l1 UTSW 11 90,547,185 (GRCm39) missense probably benign 0.00
R7696:Tom1l1 UTSW 11 90,563,741 (GRCm39) missense probably benign 0.02
R8244:Tom1l1 UTSW 11 90,548,647 (GRCm39) missense probably benign 0.13
R8787:Tom1l1 UTSW 11 90,561,931 (GRCm39) missense probably benign 0.00
R9205:Tom1l1 UTSW 11 90,548,644 (GRCm39) missense probably damaging 1.00
R9307:Tom1l1 UTSW 11 90,540,648 (GRCm39) small deletion probably benign
R9309:Tom1l1 UTSW 11 90,540,648 (GRCm39) small deletion probably benign
Predicted Primers PCR Primer
(F):5'- GGCCTCAACTAATGGGAGTC -3'
(R):5'- GACTGGTTCCTACTCGGTTG -3'

Sequencing Primer
(F):5'- GTGTCATCCCTGAGTTTATTACATG -3'
(R):5'- GAGTGTGTACGGTTATTGGCGC -3'
Posted On 2022-03-25