Incidental Mutation 'R9308:Dgkg'
ID 705368
Institutional Source Beutler Lab
Gene Symbol Dgkg
Ensembl Gene ENSMUSG00000022861
Gene Name diacylglycerol kinase, gamma
Synonyms 2900055E17Rik, E430001K23Rik, Dagk3
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.100) question?
Stock # R9308 (G1)
Quality Score 225.009
Status Not validated
Chromosome 16
Chromosomal Location 22287211-22475971 bp(-) (GRCm39)
Type of Mutation critical splice donor site (1 bp from exon)
DNA Base Change (assembly) C to A at 22429528 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000087371 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023578] [ENSMUST00000089925] [ENSMUST00000137311]
AlphaFold Q91WG7
Predicted Effect probably benign
Transcript: ENSMUST00000023578
SMART Domains Protein: ENSMUSP00000023578
Gene: ENSMUSG00000022861

DomainStartEndE-ValueType
Pfam:DAG_kinase_N 2 172 9.3e-66 PFAM
EFh 176 204 8.13e-2 SMART
EFh 221 249 1.07e-1 SMART
C1 269 318 1.23e-10 SMART
DAGKc 392 516 5.29e-65 SMART
DAGKa 536 710 1.25e-116 SMART
low complexity region 735 748 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000089925
SMART Domains Protein: ENSMUSP00000087371
Gene: ENSMUSG00000022861

DomainStartEndE-ValueType
Pfam:DAG_kinase_N 5 172 3.9e-54 PFAM
EFh 176 204 8.13e-2 SMART
EFh 221 249 1.07e-1 SMART
C1 269 318 1.23e-10 SMART
C1 334 380 3.35e-3 SMART
DAGKc 431 555 5.29e-65 SMART
DAGKa 575 749 1.25e-116 SMART
low complexity region 774 787 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000137311
SMART Domains Protein: ENSMUSP00000114441
Gene: ENSMUSG00000022861

DomainStartEndE-ValueType
Pfam:DAG_kinase_N 2 172 3.8e-67 PFAM
EFh 176 204 8.13e-2 SMART
EFh 221 249 1.07e-1 SMART
C1 269 318 1.23e-10 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.4%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an enzyme that is a member of the type I subfamily of diacylglycerol kinases, which are involved in lipid metabolism. These enzymes generate phosphatidic acid by catalyzing the phosphorylation of diacylglycerol, a fundamental lipid second messenger that activates numerous proteins, including protein kinase C isoforms, Ras guanyl nucleotide-releasing proteins and some transient receptor potential channels. Diacylglycerol kinase gamma has been implicated in cell cycle regulation and in the negative regulation of macrophage differentiation in leukemia cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700010I14Rik G T 17: 9,220,667 (GRCm39) E389* probably null Het
2700049A03Rik T C 12: 71,231,233 (GRCm39) V997A probably benign Het
9930012K11Rik A G 14: 70,393,863 (GRCm39) probably null Het
Acss3 C G 10: 106,959,282 (GRCm39) G55R possibly damaging Het
Acte1 G T 7: 143,434,902 (GRCm39) probably null Het
Acy3 C T 19: 4,038,451 (GRCm39) R193W probably damaging Het
Adam15 T C 3: 89,254,790 (GRCm39) D90G possibly damaging Het
Adamts9 T C 6: 92,857,875 (GRCm39) D833G probably benign Het
Apoa2 A G 1: 171,053,300 (GRCm39) S40G probably benign Het
Arhgap21 A T 2: 20,854,061 (GRCm39) M1777K probably damaging Het
BC004004 A G 17: 29,513,089 (GRCm39) E171G probably benign Het
Cblb A G 16: 52,009,374 (GRCm39) probably null Het
Cdk5rap2 T C 4: 70,328,504 (GRCm39) M1V probably null Het
Clca4a T G 3: 144,676,183 (GRCm39) E117A probably damaging Het
Cps1 T C 1: 67,200,118 (GRCm39) probably null Het
Crygd T C 1: 65,101,220 (GRCm39) N125S probably benign Het
Csf1 T A 3: 107,655,585 (GRCm39) H482L probably benign Het
Cyp3a41a A G 5: 145,656,858 (GRCm39) M1T probably null Het
Dnhd1 T C 7: 105,353,484 (GRCm39) V2879A probably damaging Het
Dock6 A T 9: 21,728,744 (GRCm39) C1307* probably null Het
Exoc1 T A 5: 76,706,968 (GRCm39) M505K probably benign Het
Fam131a A G 16: 20,520,582 (GRCm39) D345G probably damaging Het
Fbxw17 G T 13: 50,572,004 (GRCm39) R24L probably benign Het
Gmcl1 A C 6: 86,691,239 (GRCm39) I252R possibly damaging Het
Gpr150 G A 13: 76,203,701 (GRCm39) R415C probably damaging Het
Gtf3c4 G A 2: 28,724,982 (GRCm39) S250L probably damaging Het
Irs3 G A 5: 137,642,343 (GRCm39) A365V possibly damaging Het
Jph4 C A 14: 55,346,981 (GRCm39) G522V probably damaging Het
Kcnn1 C T 8: 71,305,434 (GRCm39) G302R probably damaging Het
Ksr1 A T 11: 78,918,291 (GRCm39) L621H probably damaging Het
Lrrn3 T C 12: 41,503,945 (GRCm39) E124G probably damaging Het
Map3k6 T C 4: 132,970,722 (GRCm39) L203P probably damaging Het
Mapk15 T A 15: 75,865,714 (GRCm39) C2* probably null Het
Mga T A 2: 119,754,369 (GRCm39) N959K possibly damaging Het
Mrgprb2 A T 7: 48,202,655 (GRCm39) N23K possibly damaging Het
Myo10 G T 15: 25,781,862 (GRCm39) S1119I probably damaging Het
Or12e13 G A 2: 87,663,523 (GRCm39) G47R probably damaging Het
Or14j4 A G 17: 37,921,246 (GRCm39) V132A possibly damaging Het
Or2a12 G T 6: 42,904,749 (GRCm39) V195F probably benign Het
Or2a25 A T 6: 42,888,931 (GRCm39) H158L probably damaging Het
Or6k6 A G 1: 173,945,501 (GRCm39) V27A probably benign Het
Ovch2 T C 7: 107,389,560 (GRCm39) E329G probably benign Het
Pkn2 C T 3: 142,517,724 (GRCm39) R458Q probably benign Het
Pnpt1 T C 11: 29,097,535 (GRCm39) probably null Het
Ppfia4 A G 1: 134,245,556 (GRCm39) V666A probably benign Het
Psmb10 T C 8: 106,662,662 (GRCm39) R226G probably damaging Het
Ptpn5 A G 7: 46,740,569 (GRCm39) V78A probably benign Het
Ptprk A G 10: 28,450,850 (GRCm39) M1004V probably benign Het
Pygb T A 2: 150,668,297 (GRCm39) S626T probably benign Het
Rad21l T C 2: 151,491,049 (GRCm39) T473A probably benign Het
Rassf7 T C 7: 140,798,063 (GRCm39) S344P probably benign Het
Rbbp6 T C 7: 122,596,221 (GRCm39) S550P probably damaging Het
Rhpn2 T C 7: 35,033,805 (GRCm39) L13P possibly damaging Het
Rps11 C T 7: 44,772,614 (GRCm39) V66I probably benign Het
Slc22a18 T C 7: 143,044,617 (GRCm39) V190A probably benign Het
Smad1 T C 8: 80,098,899 (GRCm39) probably benign Het
Spock2 A G 10: 59,965,556 (GRCm39) K327E possibly damaging Het
Tmem135 G C 7: 88,797,186 (GRCm39) L357V probably benign Het
Tom1l1 TTGCTGCTGCTGCTGCTG TTGCTGCTGCTGCTG 11: 90,540,648 (GRCm39) probably benign Het
Traj22 T C 14: 54,434,729 (GRCm39) I8T Het
Txnl1 T C 18: 63,812,446 (GRCm39) D116G probably benign Het
Ush1g A T 11: 115,209,534 (GRCm39) L220Q probably damaging Het
Vmn2r10 C A 5: 109,145,476 (GRCm39) E544* probably null Het
Vmn2r17 T C 5: 109,600,505 (GRCm39) V601A probably damaging Het
Zc3h13 C T 14: 75,565,418 (GRCm39) R844W unknown Het
Zfpm1 A C 8: 123,034,231 (GRCm39) D55A probably benign Het
Other mutations in Dgkg
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00592:Dgkg APN 16 22,298,112 (GRCm39) splice site probably benign
IGL01347:Dgkg APN 16 22,419,340 (GRCm39) missense probably benign 0.13
IGL02313:Dgkg APN 16 22,388,980 (GRCm39) splice site probably benign
IGL02498:Dgkg APN 16 22,367,441 (GRCm39) missense probably damaging 1.00
IGL02954:Dgkg APN 16 22,441,003 (GRCm39) missense probably benign 0.00
IGL03103:Dgkg APN 16 22,399,275 (GRCm39) missense probably damaging 1.00
R0014:Dgkg UTSW 16 22,384,114 (GRCm39) splice site probably null
R0636:Dgkg UTSW 16 22,398,479 (GRCm39) splice site probably benign
R0666:Dgkg UTSW 16 22,381,480 (GRCm39) missense probably damaging 1.00
R1056:Dgkg UTSW 16 22,419,291 (GRCm39) missense probably damaging 1.00
R1495:Dgkg UTSW 16 22,319,129 (GRCm39) missense probably damaging 1.00
R1603:Dgkg UTSW 16 22,388,909 (GRCm39) splice site probably benign
R1993:Dgkg UTSW 16 22,419,344 (GRCm39) missense probably damaging 1.00
R2073:Dgkg UTSW 16 22,384,067 (GRCm39) missense probably damaging 0.96
R2192:Dgkg UTSW 16 22,407,049 (GRCm39) missense probably damaging 0.98
R2251:Dgkg UTSW 16 22,441,010 (GRCm39) start codon destroyed probably null 0.98
R2252:Dgkg UTSW 16 22,441,010 (GRCm39) start codon destroyed probably null 0.98
R3104:Dgkg UTSW 16 22,394,091 (GRCm39) missense probably damaging 1.00
R3105:Dgkg UTSW 16 22,394,091 (GRCm39) missense probably damaging 1.00
R3106:Dgkg UTSW 16 22,394,091 (GRCm39) missense probably damaging 1.00
R4804:Dgkg UTSW 16 22,393,943 (GRCm39) intron probably benign
R5272:Dgkg UTSW 16 22,407,044 (GRCm39) splice site probably null
R5364:Dgkg UTSW 16 22,419,211 (GRCm39) missense probably benign 0.03
R5417:Dgkg UTSW 16 22,407,081 (GRCm39) missense possibly damaging 0.50
R5677:Dgkg UTSW 16 22,388,921 (GRCm39) missense probably benign 0.00
R5839:Dgkg UTSW 16 22,385,244 (GRCm39) missense possibly damaging 0.91
R5931:Dgkg UTSW 16 22,376,788 (GRCm39) nonsense probably null
R6313:Dgkg UTSW 16 22,338,311 (GRCm39) missense probably damaging 0.96
R7017:Dgkg UTSW 16 22,391,463 (GRCm39) missense probably benign 0.31
R7135:Dgkg UTSW 16 22,319,132 (GRCm39) missense probably damaging 1.00
R7326:Dgkg UTSW 16 22,367,440 (GRCm39) missense probably damaging 1.00
R7476:Dgkg UTSW 16 22,441,054 (GRCm39) start gained probably benign
R7812:Dgkg UTSW 16 22,385,165 (GRCm39) missense probably damaging 1.00
R7971:Dgkg UTSW 16 22,388,966 (GRCm39) nonsense probably null
R8064:Dgkg UTSW 16 22,399,344 (GRCm39) frame shift probably null
R8122:Dgkg UTSW 16 22,385,295 (GRCm39) splice site probably null
R8825:Dgkg UTSW 16 22,381,519 (GRCm39) missense probably benign 0.13
R9049:Dgkg UTSW 16 22,419,338 (GRCm39) missense probably benign 0.01
R9352:Dgkg UTSW 16 22,398,581 (GRCm39) missense probably damaging 0.99
R9433:Dgkg UTSW 16 22,384,065 (GRCm39) missense probably damaging 1.00
R9545:Dgkg UTSW 16 22,385,168 (GRCm39) missense possibly damaging 0.48
R9606:Dgkg UTSW 16 22,441,011 (GRCm39) start codon destroyed probably null 0.51
R9623:Dgkg UTSW 16 22,385,194 (GRCm39) missense
R9634:Dgkg UTSW 16 22,338,387 (GRCm39) critical splice acceptor site probably null
R9765:Dgkg UTSW 16 22,298,157 (GRCm39) missense possibly damaging 0.70
Z1088:Dgkg UTSW 16 22,391,436 (GRCm39) missense probably benign 0.31
Z1088:Dgkg UTSW 16 22,288,078 (GRCm39) missense probably damaging 0.96
Z1176:Dgkg UTSW 16 22,407,148 (GRCm39) missense probably benign 0.00
Z1177:Dgkg UTSW 16 22,376,834 (GRCm39) missense probably benign 0.22
Predicted Primers PCR Primer
(F):5'- TTATAGGACAACACGGGCCTG -3'
(R):5'- GATTGGACACACTCTTCTGACC -3'

Sequencing Primer
(F):5'- AACACGGGCCTGTGAAC -3'
(R):5'- ATTGGACACACTCTTCTGACCTACAC -3'
Posted On 2022-03-25