Mutagenetix > Incidental Mutation

Incidental Mutation 'R0737:Vmn2r94'

70541

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r94

Ensembl Gene

ENSMUSG00000090417

Gene Name

vomeronasal 2, receptor 94

Synonyms

EG665227

MMRRC Submission

038918-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.079) question?

Stock #

R0737 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

18240994-18277756 bp(-) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

G to A at 18277433 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Stop codon at position 26 (Q26*)

Ref Sequence

ENSEMBL: ENSMUSP00000156288 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000172190] [ENSMUST00000231457] [ENSMUST00000231815]

AlphaFold

E9PZK8

Predicted Effect

probably null
Transcript: ENSMUST00000172190
AA Change: Q26*

SMART Domains

Protein: ENSMUSP00000126386
Gene: ENSMUSG00000090417
AA Change: Q26*

Domain	Start	End	E-Value	Type
Pfam:ANF_receptor	42	425	1.7e-35	PFAM
Pfam:NCD3G	469	522	3.5e-21	PFAM
Pfam:7tm_3	553	790	1.7e-51	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000231390

Predicted Effect

probably null
Transcript: ENSMUST00000231457
AA Change: Q26*

Predicted Effect

probably null
Transcript: ENSMUST00000231815
AA Change: Q26*

Coding Region Coverage

1x: 99.3%
3x: 98.7%
10x: 97.4%
20x: 94.8%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930567H17Rik	T	A	X: 70,394,207		probably benign	Het
4932429P05Rik	A	G	X: 89,754,320	H586R	probably benign	Het
9130409I23Rik	G	A	1: 181,055,379	M235I	probably benign	Het
Aff4	T	A	11: 53,410,953	L1043*	probably null	Het
Ankrd11	G	T	8: 122,895,836	R426S	probably damaging	Het
Atm	T	A	9: 53,456,566	N2422I	probably damaging	Het
Bahcc1	C	A	11: 120,272,841	P655Q	probably damaging	Het
Baz2a	A	G	10: 128,116,080	I556V	possibly damaging	Het
BC017643	C	T	11: 121,227,242		probably null	Het
Ccdc33	T	C	9: 58,082,048	D114G	probably damaging	Het
Cdk5rap2	T	C	4: 70,337,375	H424R	probably benign	Het
Cfap57	T	C	4: 118,581,102	E864G	possibly damaging	Het
Cit	T	A	5: 115,946,919	S836R	probably damaging	Het
Clip4	C	T	17: 71,837,699	Q95*	probably null	Het
Col17a1	C	T	19: 47,669,433	G433S	possibly damaging	Het
Col6a3	A	G	1: 90,828,298	F90L	probably damaging	Het
Dnah9	T	C	11: 66,107,898	H1108R	probably damaging	Het
Elac1	A	T	18: 73,739,039	M295K	probably damaging	Het
Epas1	G	T	17: 86,829,456	G816C	possibly damaging	Het
Ermap	C	A	4: 119,178,510	C427F	probably damaging	Het
Fbxo44	T	C	4: 148,158,809		probably benign	Het
Fmo4	T	A	1: 162,808,392	K14*	probably null	Het
Gadl1	G	A	9: 116,073,987	M461I	probably damaging	Het
Garnl3	T	A	2: 32,990,642	I868F	probably damaging	Het
Gm6614	G	T	6: 142,003,428	A74E	possibly damaging	Het
Gm7168	A	G	17: 13,948,983	D204G	probably damaging	Het
Hs6st3	T	C	14: 119,869,383	F401S	possibly damaging	Het
Kcnmb1	A	T	11: 33,964,701	M1L	probably benign	Het
Krt35	T	C	11: 100,093,794	T292A	probably benign	Het
Krt81	C	A	15: 101,463,627	R24L	possibly damaging	Het
Lamb2	T	A	9: 108,483,794	W572R	probably benign	Het
Letmd1	A	G	15: 100,469,821	T87A	probably damaging	Het
Lrp2	A	G	2: 69,448,169	Y3947H	probably damaging	Het
Mocos	T	C	18: 24,688,987	F685L	probably damaging	Het
Nsun6	A	T	2: 14,996,474	F424I	probably damaging	Het
Nup88	A	G	11: 70,969,950	M1T	probably null	Het
Olfr1209	T	C	2: 88,910,273	N40S	probably damaging	Het
Olfr1339	C	T	4: 118,735,224	R232C	probably benign	Het
Olfr297	C	T	7: 86,526,987	P77S	probably damaging	Het
Pcdhb12	T	A	18: 37,437,709	V636D	probably damaging	Het
Pclo	C	A	5: 14,515,439	A73E	probably damaging	Het
Pdlim7	A	T	13: 55,504,880		probably null	Het
Phldb1	G	A	9: 44,699,636	P67S	possibly damaging	Het
Ppp2r2b	T	C	18: 43,059,192	T17A	probably benign	Het
Rab11fip4	T	C	11: 79,683,502	V241A	probably benign	Het
Slc41a1	T	C	1: 131,840,952	L216P	probably damaging	Het
Smg6	T	A	11: 75,159,836	D1352E	probably damaging	Het
Tbc1d9	A	T	8: 83,259,313	I816F	probably damaging	Het
Tex264	T	C	9: 106,659,299	T220A	probably benign	Het
Tmco6	G	A	18: 36,741,776	V439I	probably damaging	Het
Tmem64	A	G	4: 15,266,717	I256V	probably damaging	Het
Tnks1bp1	A	G	2: 85,052,536	S236G	possibly damaging	Het
Tsc1	A	G	2: 28,670,930	T267A	possibly damaging	Het
Txndc2	A	G	17: 65,639,553		probably null	Het
Zan	T	C	5: 137,389,249	D4900G	unknown	Het
Zkscan3	T	C	13: 21,388,596	T122A	probably benign	Het

Other mutations in Vmn2r94

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01396:Vmn2r94	APN	17	18257039	missense	probably damaging	1.00
IGL01676:Vmn2r94	APN	17	18257010	missense	probably benign
IGL01687:Vmn2r94	APN	17	18253312	missense	possibly damaging	0.64
IGL02113:Vmn2r94	APN	17	18257675	missense	probably damaging	0.99
IGL02408:Vmn2r94	APN	17	18253261	missense	probably benign	0.01
IGL02451:Vmn2r94	APN	17	18258191	missense	possibly damaging	0.95
IGL02755:Vmn2r94	APN	17	18244499	missense	probably benign	0.01
IGL02822:Vmn2r94	APN	17	18243620	missense	probably benign	0.00
IGL02868:Vmn2r94	APN	17	18244054	missense	possibly damaging	0.75
IGL03008:Vmn2r94	APN	17	18257646	missense	probably benign	0.05
R0112:Vmn2r94	UTSW	17	18243604	missense	probably benign
R0371:Vmn2r94	UTSW	17	18257294	missense	probably benign	0.11
R0413:Vmn2r94	UTSW	17	18243818	missense	probably damaging	0.98
R0627:Vmn2r94	UTSW	17	18257165	missense	probably damaging	1.00
R0815:Vmn2r94	UTSW	17	18257711	missense	probably damaging	1.00
R0863:Vmn2r94	UTSW	17	18257711	missense	probably damaging	1.00
R1125:Vmn2r94	UTSW	17	18257455	missense	probably damaging	1.00
R1276:Vmn2r94	UTSW	17	18257082	missense	possibly damaging	0.47
R1491:Vmn2r94	UTSW	17	18257703	missense	probably damaging	1.00
R1500:Vmn2r94	UTSW	17	18256980	missense	probably benign	0.07
R1610:Vmn2r94	UTSW	17	18243733	missense	probably damaging	1.00
R1664:Vmn2r94	UTSW	17	18244144	missense	probably damaging	0.99
R1716:Vmn2r94	UTSW	17	18257373	missense	probably benign	0.01
R1843:Vmn2r94	UTSW	17	18244470	missense	probably benign	0.01
R1882:Vmn2r94	UTSW	17	18244214	missense	probably benign	0.07
R1936:Vmn2r94	UTSW	17	18244292	nonsense	probably null
R2273:Vmn2r94	UTSW	17	18257331	missense	probably benign	0.00
R2508:Vmn2r94	UTSW	17	18257474	missense	probably benign	0.32
R3436:Vmn2r94	UTSW	17	18258388	splice site	probably benign
R3917:Vmn2r94	UTSW	17	18244358	missense	probably benign
R3968:Vmn2r94	UTSW	17	18258385	missense	possibly damaging	0.95
R3969:Vmn2r94	UTSW	17	18258385	missense	possibly damaging	0.95
R4257:Vmn2r94	UTSW	17	18244171	missense	probably damaging	1.00
R4271:Vmn2r94	UTSW	17	18243678	missense	probably damaging	1.00
R4349:Vmn2r94	UTSW	17	18244343	missense	probably benign	0.01
R4436:Vmn2r94	UTSW	17	18258383	missense	probably damaging	1.00
R4603:Vmn2r94	UTSW	17	18257385	missense	probably benign	0.33
R4821:Vmn2r94	UTSW	17	18257031	missense	probably benign	0.02
R5288:Vmn2r94	UTSW	17	18244466	missense	probably damaging	1.00
R5725:Vmn2r94	UTSW	17	18256227	missense	possibly damaging	0.88
R5735:Vmn2r94	UTSW	17	18243804	missense	probably damaging	1.00
R6066:Vmn2r94	UTSW	17	18257433	missense	probably damaging	0.99
R6124:Vmn2r94	UTSW	17	18244059	missense	probably benign	0.01
R6189:Vmn2r94	UTSW	17	18257734	missense	probably benign	0.25
R6245:Vmn2r94	UTSW	17	18258123	missense	probably damaging	1.00
R6574:Vmn2r94	UTSW	17	18256159	missense	probably damaging	1.00
R7236:Vmn2r94	UTSW	17	18257549	missense	possibly damaging	0.49
R7317:Vmn2r94	UTSW	17	18243620	missense	probably benign	0.00
R7398:Vmn2r94	UTSW	17	18257341	missense	probably benign	0.00
R7399:Vmn2r94	UTSW	17	18244503	critical splice acceptor site	probably null
R7478:Vmn2r94	UTSW	17	18257505	missense	probably benign
R8099:Vmn2r94	UTSW	17	18257397	missense	probably benign	0.00
R8189:Vmn2r94	UTSW	17	18258356	missense	probably damaging	1.00
R8217:Vmn2r94	UTSW	17	18243724	missense	probably damaging	1.00
R8303:Vmn2r94	UTSW	17	18244171	missense	probably damaging	1.00
R8543:Vmn2r94	UTSW	17	18243722	missense	possibly damaging	0.45
R8684:Vmn2r94	UTSW	17	18277650	start gained	probably benign
R8889:Vmn2r94	UTSW	17	18244073	missense	possibly damaging	0.83
R8892:Vmn2r94	UTSW	17	18244073	missense	possibly damaging	0.83
R9282:Vmn2r94	UTSW	17	18277489	missense	possibly damaging	0.89
R9526:Vmn2r94	UTSW	17	18256999	missense	probably benign
R9647:Vmn2r94	UTSW	17	18243622	missense	probably benign	0.00
R9748:Vmn2r94	UTSW	17	18243727	missense	probably benign	0.21
R9789:Vmn2r94	UTSW	17	18243776	missense	probably damaging	1.00
RF014:Vmn2r94	UTSW	17	18253287	nonsense	probably null
X0011:Vmn2r94	UTSW	17	18244448	missense	possibly damaging	0.76
X0028:Vmn2r94	UTSW	17	18243975	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- ACGTTTATGGTTAACAATCCAACCAGGA -3'
(R):5'- CGGGCATCAGCAGCAGTCTAAAA -3'

Sequencing Primer
(F):5'- GTGAAAGTAGTCAAAGTTTCCACTTG -3'
(R):5'- CAAGCTGACCCATGTATTACTAGG -3'

Posted On

2013-09-30