Mutagenetix > Incidental Mutation

Incidental Mutation 'R9310:Mtor'

705455

Institutional Source

Beutler Lab

Gene Symbol

Mtor

Ensembl Gene

ENSMUSG00000028991

Gene Name

mechanistic target of rapamycin kinase

Synonyms

flat, 2610315D21Rik, RAPT1, RAFT1, mechanistic target of rapamycin (serine/threonine kinase), FKBP-rapamycin-associated protein FRAP, Frap1

MMRRC Submission

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R9310 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

148533068-148642140 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 148553834 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Glutamine at position 811 (L811Q)

Ref Sequence

ENSEMBL: ENSMUSP00000099510 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000103221]

AlphaFold

Q9JLN9

Predicted Effect

probably benign
Transcript: ENSMUST00000103221
AA Change: L811Q

PolyPhen 2 Score 0.029 (Sensitivity: 0.95; Specificity: 0.82)

SMART Domains

Protein: ENSMUSP00000099510
Gene: ENSMUSG00000028991
AA Change: L811Q

Domain	Start	End	E-Value	Type
low complexity region	7	21	N/A	INTRINSIC
low complexity region	179	191	N/A	INTRINSIC
low complexity region	277	288	N/A	INTRINSIC
low complexity region	774	790	N/A	INTRINSIC
DUF3385	854	1024	1.51e-93	SMART
low complexity region	1279	1300	N/A	INTRINSIC
Pfam:FAT	1513	1908	2.3e-134	PFAM
Rapamycin_bind	2015	2114	7.94e-61	SMART
PI3Kc	2183	2484	8.84e-121	SMART
FATC	2517	2549	2.11e-15	SMART

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.7%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Sep 2008]
PHENOTYPE: Mice homozygous for targeted, gene trap and ENU-induced null alleles exhibit embryonic lethality by E12.5 with abnormal embryogenesis. Mice homozygous for the ENU mutation further exhibit abnormal brain development. [provided by MGI curators]

Allele List at MGI

All alleles(25) : Targeted(12) Gene trapped(12) Chemically induced(1)

Other mutations in this stock

Total: 95 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700030J22Rik	T	C	8: 117,698,859 (GRCm39)	I83V	possibly damaging	Het
Abcf1	G	A	17: 36,272,621 (GRCm39)	A288V	probably null	Het
Acer1	A	T	17: 57,262,598 (GRCm39)	V184D	probably damaging	Het
Apoh	T	C	11: 108,298,307 (GRCm39)		probably null	Het
Arid1a	T	C	4: 133,413,625 (GRCm39)	Y959C	unknown	Het
Asb3	A	T	11: 30,978,962 (GRCm39)	H84L	probably benign	Het
Atxn1	A	C	13: 45,721,494 (GRCm39)	Y134D	probably damaging	Het
Btbd1	T	C	7: 81,478,985 (GRCm39)	Y52C	probably damaging	Het
Cabp2	A	G	19: 4,136,464 (GRCm39)	D170G	probably damaging	Het
Cacna1a	C	A	8: 85,263,046 (GRCm39)	A407E	probably damaging	Het
Cacna2d4	T	A	6: 119,248,914 (GRCm39)		probably null	Het
Cc2d2a	T	C	5: 43,852,488 (GRCm39)	F404S	probably damaging	Het
Cdh20	T	C	1: 104,875,061 (GRCm39)	M281T	probably damaging	Het
Cfap54	A	T	10: 92,798,177 (GRCm39)	M1694K	unknown	Het
Chd6	G	T	2: 160,881,181 (GRCm39)	T261K	probably damaging	Het
Cnksr1	T	C	4: 133,956,330 (GRCm39)	S585G	probably damaging	Het
Cntnap2	A	T	6: 45,978,281 (GRCm39)	Y312F	probably damaging	Het
Coa7	T	A	4: 108,195,510 (GRCm39)	Y146*	probably null	Het
Col28a1	T	C	6: 8,175,414 (GRCm39)	K145E	unknown	Het
Coq8b	T	A	7: 26,941,486 (GRCm39)	I221N	probably damaging	Het
Cpd	A	T	11: 76,705,607 (GRCm39)	L375*	probably null	Het
Dnah5	T	C	15: 28,448,579 (GRCm39)	F4214S	probably damaging	Het
Dnai3	C	T	3: 145,802,895 (GRCm39)		probably null	Het
Dock2	A	G	11: 34,244,139 (GRCm39)	F1067S	possibly damaging	Het
Dpp6	G	A	5: 27,836,439 (GRCm39)	A310T	probably damaging	Het
Dpp6	C	A	5: 27,930,642 (GRCm39)	L825I	probably benign	Het
Efcab5	A	G	11: 77,004,531 (GRCm39)	V929A	probably benign	Het
Ephx3	C	G	17: 32,408,290 (GRCm39)	D45H	probably benign	Het
Espl1	G	A	15: 102,205,285 (GRCm39)		probably null	Het
Firrm	A	G	1: 163,792,089 (GRCm39)	C610R	probably damaging	Het
Gm4847	T	C	1: 166,460,281 (GRCm39)	R402G	probably benign	Het
Grid1	T	C	14: 34,748,762 (GRCm39)	L194S	probably damaging	Het
Heatr1	A	T	13: 12,453,491 (GRCm39)	H2122L	probably benign	Het
Il17b	T	A	18: 61,825,334 (GRCm39)	C123*	probably null	Het
Il17rc	T	C	6: 113,451,210 (GRCm39)	L181P	probably damaging	Het
Inpp5e	T	A	2: 26,287,940 (GRCm39)	I619L	probably benign	Het
Itgax	C	A	7: 127,741,432 (GRCm39)	Y814*	probably null	Het
Marcks	C	T	10: 37,012,487 (GRCm39)	E183K	unknown	Het
Mefv	T	C	16: 3,533,252 (GRCm39)	T340A	probably benign	Het
Mical2	A	G	7: 111,950,920 (GRCm39)	K958R	probably benign	Het
Mrtfb	T	A	16: 13,218,954 (GRCm39)	D533E	probably benign	Het
Myh4	A	G	11: 67,145,570 (GRCm39)	Y1351C	probably damaging	Het
Neb	T	C	2: 52,153,708 (GRCm39)	M2406V	probably benign	Het
Nebl	T	C	2: 17,353,678 (GRCm39)	T214A	probably benign	Het
Nlrx1	A	T	9: 44,164,705 (GRCm39)	I913N	probably damaging	Het
Npr2	G	T	4: 43,632,404 (GRCm39)	A74S	probably benign	Het
Or4c115	T	A	2: 88,928,257 (GRCm39)	S5C	probably damaging	Het
Or6b6	C	A	7: 106,570,678 (GRCm39)	C291F	probably damaging	Het
Or6c88	T	A	10: 129,406,687 (GRCm39)	N54K	probably benign	Het
Pard3b	G	T	1: 62,205,528 (GRCm39)	V441F	probably damaging	Het
Pcsk1	G	A	13: 75,238,191 (GRCm39)	R4K	probably benign	Het
Pisd	G	T	5: 32,894,784 (GRCm39)	N337K	possibly damaging	Het
Pml	T	C	9: 58,156,945 (GRCm39)	K10R	probably benign	Het
Prkci	T	C	3: 31,083,664 (GRCm39)	W132R	probably damaging	Het
Prrc2a	A	T	17: 35,374,975 (GRCm39)	M1225K	probably benign	Het
Prss23	T	C	7: 89,159,142 (GRCm39)	D309G	probably damaging	Het
Pxdn	G	A	12: 30,052,051 (GRCm39)	G743S	probably damaging	Het
Rab29	A	T	1: 131,799,860 (GRCm39)	E145V	probably damaging	Het
Rasef	C	T	4: 73,653,956 (GRCm39)		probably null	Het
Rcbtb1	T	G	14: 59,472,699 (GRCm39)	I496S	probably benign	Het
Rcor1	T	C	12: 111,066,393 (GRCm39)	Y228H		Het
Reep5	C	T	18: 34,490,222 (GRCm39)	V92I	probably damaging	Het
Rfx3	T	C	19: 27,827,329 (GRCm39)	S86G	probably benign	Het
Rptn	T	A	3: 93,304,384 (GRCm39)	D572E	probably benign	Het
Rsl1	A	T	13: 67,324,510 (GRCm39)		probably null	Het
Sbf2	T	C	7: 109,914,292 (GRCm39)	E1630G	possibly damaging	Het
Sele	G	A	1: 163,876,975 (GRCm39)	V84I	probably benign	Het
Serpina1b	T	C	12: 103,698,756 (GRCm39)	D31G	probably benign	Het
Serpina3c	T	C	12: 104,115,813 (GRCm39)	I244V	probably benign	Het
Serpinb6e	A	G	13: 34,017,204 (GRCm39)	V272A	probably benign	Het
Serpinb9b	A	G	13: 33,219,523 (GRCm39)	D150G	probably benign	Het
Sgpp1	T	C	12: 75,769,374 (GRCm39)	T265A	probably benign	Het
Slc9a1	T	A	4: 133,143,681 (GRCm39)	M389K	probably damaging	Het
Slco3a1	A	T	7: 74,204,236 (GRCm39)	C35S	probably damaging	Het
Slco6d1	T	A	1: 98,427,619 (GRCm39)	V650E	possibly damaging	Het
Slit2	T	C	5: 48,349,568 (GRCm39)	V274A	possibly damaging	Het
Snd1	A	G	6: 28,795,936 (GRCm39)	E593G	probably null	Het
Spata2l	C	T	8: 123,960,873 (GRCm39)	V139M	probably benign	Het
Suco	T	C	1: 161,684,427 (GRCm39)	K231R	probably damaging	Het
Tenm3	C	A	8: 49,008,935 (GRCm39)		probably benign	Het
Tg	T	C	15: 66,699,118 (GRCm39)	S2415P	possibly damaging	Het
Traf6	C	A	2: 101,527,072 (GRCm39)	A274D	possibly damaging	Het
Usp14	A	G	18: 9,996,239 (GRCm39)	I447T	possibly damaging	Het
Usp32	G	A	11: 84,942,028 (GRCm39)	L355F	probably benign	Het
Vcpip1	T	C	1: 9,817,927 (GRCm39)	N152S	possibly damaging	Het
Vgf	A	G	5: 137,061,110 (GRCm39)	Q424R	probably benign	Het
Vmn2r84	A	T	10: 130,227,993 (GRCm39)	M81K	possibly damaging	Het
Washc5	G	A	15: 59,218,067 (GRCm39)	A732V	possibly damaging	Het
Xrcc3	T	G	12: 111,771,485 (GRCm39)	D213A	probably damaging	Het
Zeb2	T	C	2: 44,886,988 (GRCm39)	T690A	probably benign	Het
Zfat	G	A	15: 67,956,250 (GRCm39)	S1212L	probably damaging	Het
Zfp623	C	T	15: 75,819,949 (GRCm39)	L302F	probably damaging	Het
Zfp799	A	C	17: 33,039,733 (GRCm39)	C178G	possibly damaging	Het
Zfy1	T	C	Y: 727,634 (GRCm39)	E348G	unknown	Het
Zhx3	A	G	2: 160,621,393 (GRCm39)	W925R	possibly damaging	Het

Other mutations in Mtor

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01123:Mtor	APN	4	148,537,494 (GRCm39)	missense	probably benign	0.06
IGL01447:Mtor	APN	4	148,615,214 (GRCm39)	missense	possibly damaging	0.62
IGL01551:Mtor	APN	4	148,556,494 (GRCm39)	missense	probably damaging	0.99
IGL01661:Mtor	APN	4	148,599,308 (GRCm39)	missense	possibly damaging	0.61
IGL01675:Mtor	APN	4	148,569,111 (GRCm39)	missense	probably benign	0.00
IGL01743:Mtor	APN	4	148,615,070 (GRCm39)	splice site	probably benign
IGL02015:Mtor	APN	4	148,624,570 (GRCm39)	nonsense	probably null
IGL02084:Mtor	APN	4	148,555,137 (GRCm39)	missense	probably damaging	0.98
IGL02095:Mtor	APN	4	148,628,998 (GRCm39)	missense	probably damaging	1.00
IGL02129:Mtor	APN	4	148,634,302 (GRCm39)	missense	possibly damaging	0.91
IGL02260:Mtor	APN	4	148,622,758 (GRCm39)	missense	probably damaging	1.00
IGL02329:Mtor	APN	4	148,619,396 (GRCm39)	missense	probably benign	0.16
IGL02440:Mtor	APN	4	148,576,104 (GRCm39)	missense	probably benign	0.04
IGL02440:Mtor	APN	4	148,630,886 (GRCm39)	missense	probably benign	0.24
IGL02449:Mtor	APN	4	148,618,378 (GRCm39)	missense	possibly damaging	0.65
IGL02479:Mtor	APN	4	148,555,041 (GRCm39)	missense	probably damaging	1.00
IGL02904:Mtor	APN	4	148,576,069 (GRCm39)	splice site	probably benign
IGL02904:Mtor	APN	4	148,536,851 (GRCm39)	missense	possibly damaging	0.55
IGL02931:Mtor	APN	4	148,549,421 (GRCm39)	missense	probably benign	0.22
IGL03048:Mtor	APN	4	148,630,847 (GRCm39)	splice site	probably benign
IGL03133:Mtor	APN	4	148,568,776 (GRCm39)	missense	probably benign	0.01
IGL03142:Mtor	APN	4	148,538,356 (GRCm39)	missense	probably benign	0.00
Brushes	UTSW	4	148,548,205 (GRCm39)	missense	probably benign	0.00
Dynamo	UTSW	4	148,547,367 (GRCm39)	missense	probably benign	0.00
engine	UTSW	4	148,641,312 (GRCm39)	splice site	probably null
Erg	UTSW	4	148,630,053 (GRCm39)	missense	probably damaging	1.00
Lindor	UTSW	4	148,539,103 (GRCm39)	missense	probably damaging	1.00
motor	UTSW	4	148,575,817 (GRCm39)	missense	possibly damaging	0.76
R4858_Mtor_211	UTSW	4	148,539,273 (GRCm39)	makesense	probably null
Vigor	UTSW	4	148,623,356 (GRCm39)	missense	probably damaging	1.00
Vim	UTSW	4	148,610,260 (GRCm39)	critical splice donor site	probably null
PIT4519001:Mtor	UTSW	4	148,608,957 (GRCm39)	missense	probably damaging	1.00
R0045:Mtor	UTSW	4	148,549,406 (GRCm39)	missense	probably benign	0.42
R0048:Mtor	UTSW	4	148,623,338 (GRCm39)	nonsense	probably null
R0048:Mtor	UTSW	4	148,623,338 (GRCm39)	nonsense	probably null
R0103:Mtor	UTSW	4	148,618,359 (GRCm39)	missense	probably benign	0.05
R0112:Mtor	UTSW	4	148,565,380 (GRCm39)	missense	probably damaging	1.00
R0137:Mtor	UTSW	4	148,555,081 (GRCm39)	missense	possibly damaging	0.78
R0184:Mtor	UTSW	4	148,549,428 (GRCm39)	missense	probably benign	0.05
R0208:Mtor	UTSW	4	148,549,432 (GRCm39)	missense	probably benign	0.43
R0329:Mtor	UTSW	4	148,568,837 (GRCm39)	missense	probably benign
R0330:Mtor	UTSW	4	148,568,837 (GRCm39)	missense	probably benign
R0365:Mtor	UTSW	4	148,570,507 (GRCm39)	missense	probably benign	0.01
R0537:Mtor	UTSW	4	148,622,817 (GRCm39)	missense	probably damaging	1.00
R0542:Mtor	UTSW	4	148,624,907 (GRCm39)	missense	probably benign	0.02
R0556:Mtor	UTSW	4	148,553,837 (GRCm39)	missense	possibly damaging	0.88
R0613:Mtor	UTSW	4	148,610,503 (GRCm39)	missense	possibly damaging	0.95
R0646:Mtor	UTSW	4	148,568,811 (GRCm39)	nonsense	probably null
R0710:Mtor	UTSW	4	148,548,848 (GRCm39)	missense	possibly damaging	0.73
R0791:Mtor	UTSW	4	148,547,367 (GRCm39)	missense	probably benign	0.00
R0792:Mtor	UTSW	4	148,547,367 (GRCm39)	missense	probably benign	0.00
R0866:Mtor	UTSW	4	148,570,513 (GRCm39)	missense	probably benign	0.04
R0973:Mtor	UTSW	4	148,634,645 (GRCm39)	missense	probably damaging	1.00
R1027:Mtor	UTSW	4	148,624,456 (GRCm39)	missense	probably benign	0.03
R1028:Mtor	UTSW	4	148,623,287 (GRCm39)	missense	possibly damaging	0.88
R1289:Mtor	UTSW	4	148,554,764 (GRCm39)	missense	probably benign	0.10
R1416:Mtor	UTSW	4	148,575,871 (GRCm39)	nonsense	probably null
R1465:Mtor	UTSW	4	148,610,450 (GRCm39)	splice site	probably benign
R1506:Mtor	UTSW	4	148,620,962 (GRCm39)	splice site	probably benign
R1624:Mtor	UTSW	4	148,632,133 (GRCm39)	missense	probably damaging	1.00
R1695:Mtor	UTSW	4	148,623,364 (GRCm39)	missense	probably benign	0.08
R1771:Mtor	UTSW	4	148,555,081 (GRCm39)	missense	possibly damaging	0.78
R1800:Mtor	UTSW	4	148,547,349 (GRCm39)	missense	probably benign	0.00
R1855:Mtor	UTSW	4	148,637,546 (GRCm39)	missense	probably benign	0.02
R1857:Mtor	UTSW	4	148,565,336 (GRCm39)	missense	probably damaging	1.00
R1867:Mtor	UTSW	4	148,539,089 (GRCm39)	missense	probably damaging	0.97
R1954:Mtor	UTSW	4	148,552,730 (GRCm39)	missense	probably damaging	1.00
R2054:Mtor	UTSW	4	148,550,482 (GRCm39)	missense	probably benign	0.00
R2054:Mtor	UTSW	4	148,547,309 (GRCm39)	missense	probably benign	0.05
R2099:Mtor	UTSW	4	148,634,649 (GRCm39)	nonsense	probably null
R2148:Mtor	UTSW	4	148,540,469 (GRCm39)	missense	possibly damaging	0.56
R2214:Mtor	UTSW	4	148,623,327 (GRCm39)	missense	probably benign	0.39
R2281:Mtor	UTSW	4	148,574,012 (GRCm39)	missense	probably benign	0.02
R2512:Mtor	UTSW	4	148,614,948 (GRCm39)	missense	possibly damaging	0.95
R2870:Mtor	UTSW	4	148,624,487 (GRCm39)	missense	probably benign	0.00
R2870:Mtor	UTSW	4	148,624,487 (GRCm39)	missense	probably benign	0.00
R2871:Mtor	UTSW	4	148,624,487 (GRCm39)	missense	probably benign	0.00
R2871:Mtor	UTSW	4	148,624,487 (GRCm39)	missense	probably benign	0.00
R2872:Mtor	UTSW	4	148,624,487 (GRCm39)	missense	probably benign	0.00
R2872:Mtor	UTSW	4	148,624,487 (GRCm39)	missense	probably benign	0.00
R2873:Mtor	UTSW	4	148,624,487 (GRCm39)	missense	probably benign	0.00
R4032:Mtor	UTSW	4	148,621,209 (GRCm39)	missense	probably benign	0.03
R4073:Mtor	UTSW	4	148,633,832 (GRCm39)	missense	probably damaging	0.99
R4273:Mtor	UTSW	4	148,634,609 (GRCm39)	missense	probably benign	0.21
R4611:Mtor	UTSW	4	148,570,576 (GRCm39)	missense	probably benign	0.03
R4858:Mtor	UTSW	4	148,539,273 (GRCm39)	makesense	probably null
R4942:Mtor	UTSW	4	148,556,599 (GRCm39)	missense	probably benign	0.03
R4967:Mtor	UTSW	4	148,575,817 (GRCm39)	missense	possibly damaging	0.76
R4995:Mtor	UTSW	4	148,610,209 (GRCm39)	missense	probably damaging	1.00
R5054:Mtor	UTSW	4	148,641,312 (GRCm39)	splice site	probably null
R5215:Mtor	UTSW	4	148,538,440 (GRCm39)	missense	probably benign
R5249:Mtor	UTSW	4	148,548,189 (GRCm39)	missense	probably damaging	1.00
R5289:Mtor	UTSW	4	148,550,549 (GRCm39)	missense	possibly damaging	0.88
R5365:Mtor	UTSW	4	148,634,587 (GRCm39)	missense	probably damaging	0.99
R5498:Mtor	UTSW	4	148,624,821 (GRCm39)	missense	possibly damaging	0.71
R5514:Mtor	UTSW	4	148,630,901 (GRCm39)	missense	probably damaging	1.00
R5540:Mtor	UTSW	4	148,539,165 (GRCm39)	missense	probably benign	0.01
R5600:Mtor	UTSW	4	148,575,927 (GRCm39)	missense	probably damaging	1.00
R5615:Mtor	UTSW	4	148,622,733 (GRCm39)	missense	possibly damaging	0.95
R5632:Mtor	UTSW	4	148,553,463 (GRCm39)	missense	possibly damaging	0.94
R5641:Mtor	UTSW	4	148,630,882 (GRCm39)	missense	probably damaging	0.98
R5834:Mtor	UTSW	4	148,620,993 (GRCm39)	missense	possibly damaging	0.95
R5984:Mtor	UTSW	4	148,623,284 (GRCm39)	missense	probably benign	0.02
R6056:Mtor	UTSW	4	148,621,892 (GRCm39)	missense	probably benign	0.00
R6225:Mtor	UTSW	4	148,605,794 (GRCm39)	missense	probably benign	0.04
R6262:Mtor	UTSW	4	148,610,552 (GRCm39)	missense	possibly damaging	0.46
R6335:Mtor	UTSW	4	148,550,384 (GRCm39)	missense	probably damaging	1.00
R6479:Mtor	UTSW	4	148,635,457 (GRCm39)	missense	probably benign	0.16
R6543:Mtor	UTSW	4	148,630,053 (GRCm39)	missense	probably damaging	1.00
R6711:Mtor	UTSW	4	148,536,824 (GRCm39)	missense	possibly damaging	0.49
R6715:Mtor	UTSW	4	148,623,004 (GRCm39)	missense	probably benign	0.00
R6744:Mtor	UTSW	4	148,543,112 (GRCm39)	missense	probably benign	0.01
R6748:Mtor	UTSW	4	148,634,641 (GRCm39)	missense	probably damaging	1.00
R6762:Mtor	UTSW	4	148,622,938 (GRCm39)	missense	possibly damaging	0.47
R6836:Mtor	UTSW	4	148,573,955 (GRCm39)	missense	possibly damaging	0.94
R6948:Mtor	UTSW	4	148,621,209 (GRCm39)	missense	probably benign	0.12
R6979:Mtor	UTSW	4	148,608,930 (GRCm39)	missense	possibly damaging	0.60
R6992:Mtor	UTSW	4	148,548,932 (GRCm39)	missense	probably benign
R7271:Mtor	UTSW	4	148,630,942 (GRCm39)	missense	possibly damaging	0.70
R7423:Mtor	UTSW	4	148,640,801 (GRCm39)	missense	possibly damaging	0.77
R7434:Mtor	UTSW	4	148,549,416 (GRCm39)	missense	probably benign	0.39
R7619:Mtor	UTSW	4	148,547,252 (GRCm39)	missense	probably damaging	0.98
R7634:Mtor	UTSW	4	148,536,807 (GRCm39)	missense	possibly damaging	0.53
R7697:Mtor	UTSW	4	148,624,765 (GRCm39)	nonsense	probably null
R7737:Mtor	UTSW	4	148,623,195 (GRCm39)	missense	possibly damaging	0.95
R7791:Mtor	UTSW	4	148,547,397 (GRCm39)	missense	probably benign	0.00
R7858:Mtor	UTSW	4	148,539,103 (GRCm39)	missense	probably damaging	1.00
R8035:Mtor	UTSW	4	148,630,856 (GRCm39)	missense	probably benign	0.29
R8076:Mtor	UTSW	4	148,610,260 (GRCm39)	critical splice donor site	probably null
R8078:Mtor	UTSW	4	148,552,744 (GRCm39)	missense	probably benign
R8928:Mtor	UTSW	4	148,623,356 (GRCm39)	missense	probably damaging	1.00
R9040:Mtor	UTSW	4	148,548,205 (GRCm39)	missense	probably benign	0.00
R9116:Mtor	UTSW	4	148,637,198 (GRCm39)	missense	probably benign
R9284:Mtor	UTSW	4	148,543,537 (GRCm39)	missense	probably benign	0.03
R9374:Mtor	UTSW	4	148,599,397 (GRCm39)	missense	probably damaging	1.00
R9417:Mtor	UTSW	4	148,622,776 (GRCm39)	nonsense	probably null
R9465:Mtor	UTSW	4	148,624,839 (GRCm39)	missense	possibly damaging	0.92
R9492:Mtor	UTSW	4	148,568,801 (GRCm39)	missense	probably damaging	1.00
R9499:Mtor	UTSW	4	148,599,397 (GRCm39)	missense	probably damaging	1.00
R9516:Mtor	UTSW	4	148,569,103 (GRCm39)	missense	probably benign	0.23
R9600:Mtor	UTSW	4	148,632,092 (GRCm39)	missense	possibly damaging	0.82
R9622:Mtor	UTSW	4	148,568,169 (GRCm39)	missense	probably damaging	0.99
X0025:Mtor	UTSW	4	148,615,171 (GRCm39)	missense	probably benign	0.09
Z1176:Mtor	UTSW	4	148,634,587 (GRCm39)	missense	possibly damaging	0.69
Z1176:Mtor	UTSW	4	148,634,582 (GRCm39)	missense	probably benign	0.08

Predicted Primers

PCR Primer
(F):5'- ACGCTCTTTAGCCTGGGAAAG -3'
(R):5'- AGCTTGTTCCGAGATTCTGTCC -3'

Sequencing Primer
(F):5'- AAAGGCAGAGCACTGGTTTTTCTC -3'
(R):5'- TCCTCTTTCCCCATTCAAAGAAAATG -3'

Posted On

2022-03-25