Incidental Mutation 'R9310:Myh4'
| ID |
705487 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Myh4
|
| Ensembl Gene |
ENSMUSG00000057003 |
| Gene Name |
myosin, heavy polypeptide 4, skeletal muscle |
| Synonyms |
MYH-2B, MM, MHC2B, MyHC-IIb, Myhsf, Minimsc, Minmus |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.410)
|
| Stock # |
R9310 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
11 |
| Chromosomal Location |
67128855-67151272 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 67145570 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Cysteine
at position 1351
(Y1351C)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000127514
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000018632]
[ENSMUST00000170942]
|
| AlphaFold |
Q5SX39 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000018632
AA Change: Y1351C
PolyPhen 2
Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000018632
Gene: ENSMUSG00000057003
AA Change: Y1351C
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Myosin_N
|
35 |
74 |
4.7e-14 |
PFAM |
|
MYSc
|
80 |
783 |
N/A |
SMART |
|
IQ
|
784 |
806 |
8.84e-3 |
SMART |
|
Pfam:Myosin_tail_1
|
847 |
1928 |
2.5e-168 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000170942
AA Change: Y1351C
PolyPhen 2
Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000127514
Gene: ENSMUSG00000057003
AA Change: Y1351C
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Myosin_N
|
35 |
76 |
1.1e-15 |
PFAM |
|
MYSc
|
80 |
783 |
N/A |
SMART |
|
IQ
|
784 |
806 |
8.84e-3 |
SMART |
|
low complexity region
|
928 |
942 |
N/A |
INTRINSIC |
|
Pfam:Myosin_tail_1
|
1072 |
1930 |
N/A |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.7%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Homozygotes for a targeted null mutation exhibit decreased growth and muscle defects including reduced muscle mass, muscle fiber loss, compensatory fiber hypertrophy, and impaired strength. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(3) : Targeted, knock-out(1) Targeted, other(2) |
| Other mutations in this stock |
Total: 95 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700030J22Rik |
T |
C |
8: 117,698,859 (GRCm39) |
I83V |
possibly damaging |
Het |
| Abcf1 |
G |
A |
17: 36,272,621 (GRCm39) |
A288V |
probably null |
Het |
| Acer1 |
A |
T |
17: 57,262,598 (GRCm39) |
V184D |
probably damaging |
Het |
| Apoh |
T |
C |
11: 108,298,307 (GRCm39) |
|
probably null |
Het |
| Arid1a |
T |
C |
4: 133,413,625 (GRCm39) |
Y959C |
unknown |
Het |
| Asb3 |
A |
T |
11: 30,978,962 (GRCm39) |
H84L |
probably benign |
Het |
| Atxn1 |
A |
C |
13: 45,721,494 (GRCm39) |
Y134D |
probably damaging |
Het |
| Btbd1 |
T |
C |
7: 81,478,985 (GRCm39) |
Y52C |
probably damaging |
Het |
| Cabp2 |
A |
G |
19: 4,136,464 (GRCm39) |
D170G |
probably damaging |
Het |
| Cacna1a |
C |
A |
8: 85,263,046 (GRCm39) |
A407E |
probably damaging |
Het |
| Cacna2d4 |
T |
A |
6: 119,248,914 (GRCm39) |
|
probably null |
Het |
| Cc2d2a |
T |
C |
5: 43,852,488 (GRCm39) |
F404S |
probably damaging |
Het |
| Cdh20 |
T |
C |
1: 104,875,061 (GRCm39) |
M281T |
probably damaging |
Het |
| Cfap54 |
A |
T |
10: 92,798,177 (GRCm39) |
M1694K |
unknown |
Het |
| Chd6 |
G |
T |
2: 160,881,181 (GRCm39) |
T261K |
probably damaging |
Het |
| Cnksr1 |
T |
C |
4: 133,956,330 (GRCm39) |
S585G |
probably damaging |
Het |
| Cntnap2 |
A |
T |
6: 45,978,281 (GRCm39) |
Y312F |
probably damaging |
Het |
| Coa7 |
T |
A |
4: 108,195,510 (GRCm39) |
Y146* |
probably null |
Het |
| Col28a1 |
T |
C |
6: 8,175,414 (GRCm39) |
K145E |
unknown |
Het |
| Coq8b |
T |
A |
7: 26,941,486 (GRCm39) |
I221N |
probably damaging |
Het |
| Cpd |
A |
T |
11: 76,705,607 (GRCm39) |
L375* |
probably null |
Het |
| Dnah5 |
T |
C |
15: 28,448,579 (GRCm39) |
F4214S |
probably damaging |
Het |
| Dnai3 |
C |
T |
3: 145,802,895 (GRCm39) |
|
probably null |
Het |
| Dock2 |
A |
G |
11: 34,244,139 (GRCm39) |
F1067S |
possibly damaging |
Het |
| Dpp6 |
G |
A |
5: 27,836,439 (GRCm39) |
A310T |
probably damaging |
Het |
| Dpp6 |
C |
A |
5: 27,930,642 (GRCm39) |
L825I |
probably benign |
Het |
| Efcab5 |
A |
G |
11: 77,004,531 (GRCm39) |
V929A |
probably benign |
Het |
| Ephx3 |
C |
G |
17: 32,408,290 (GRCm39) |
D45H |
probably benign |
Het |
| Espl1 |
G |
A |
15: 102,205,285 (GRCm39) |
|
probably null |
Het |
| Firrm |
A |
G |
1: 163,792,089 (GRCm39) |
C610R |
probably damaging |
Het |
| Gm4847 |
T |
C |
1: 166,460,281 (GRCm39) |
R402G |
probably benign |
Het |
| Grid1 |
T |
C |
14: 34,748,762 (GRCm39) |
L194S |
probably damaging |
Het |
| Heatr1 |
A |
T |
13: 12,453,491 (GRCm39) |
H2122L |
probably benign |
Het |
| Il17b |
T |
A |
18: 61,825,334 (GRCm39) |
C123* |
probably null |
Het |
| Il17rc |
T |
C |
6: 113,451,210 (GRCm39) |
L181P |
probably damaging |
Het |
| Inpp5e |
T |
A |
2: 26,287,940 (GRCm39) |
I619L |
probably benign |
Het |
| Itgax |
C |
A |
7: 127,741,432 (GRCm39) |
Y814* |
probably null |
Het |
| Marcks |
C |
T |
10: 37,012,487 (GRCm39) |
E183K |
unknown |
Het |
| Mefv |
T |
C |
16: 3,533,252 (GRCm39) |
T340A |
probably benign |
Het |
| Mical2 |
A |
G |
7: 111,950,920 (GRCm39) |
K958R |
probably benign |
Het |
| Mrtfb |
T |
A |
16: 13,218,954 (GRCm39) |
D533E |
probably benign |
Het |
| Mtor |
T |
A |
4: 148,553,834 (GRCm39) |
L811Q |
probably benign |
Het |
| Neb |
T |
C |
2: 52,153,708 (GRCm39) |
M2406V |
probably benign |
Het |
| Nebl |
T |
C |
2: 17,353,678 (GRCm39) |
T214A |
probably benign |
Het |
| Nlrx1 |
A |
T |
9: 44,164,705 (GRCm39) |
I913N |
probably damaging |
Het |
| Npr2 |
G |
T |
4: 43,632,404 (GRCm39) |
A74S |
probably benign |
Het |
| Or4c115 |
T |
A |
2: 88,928,257 (GRCm39) |
S5C |
probably damaging |
Het |
| Or6b6 |
C |
A |
7: 106,570,678 (GRCm39) |
C291F |
probably damaging |
Het |
| Or6c88 |
T |
A |
10: 129,406,687 (GRCm39) |
N54K |
probably benign |
Het |
| Pard3b |
G |
T |
1: 62,205,528 (GRCm39) |
V441F |
probably damaging |
Het |
| Pcsk1 |
G |
A |
13: 75,238,191 (GRCm39) |
R4K |
probably benign |
Het |
| Pisd |
G |
T |
5: 32,894,784 (GRCm39) |
N337K |
possibly damaging |
Het |
| Pml |
T |
C |
9: 58,156,945 (GRCm39) |
K10R |
probably benign |
Het |
| Prkci |
T |
C |
3: 31,083,664 (GRCm39) |
W132R |
probably damaging |
Het |
| Prrc2a |
A |
T |
17: 35,374,975 (GRCm39) |
M1225K |
probably benign |
Het |
| Prss23 |
T |
C |
7: 89,159,142 (GRCm39) |
D309G |
probably damaging |
Het |
| Pxdn |
G |
A |
12: 30,052,051 (GRCm39) |
G743S |
probably damaging |
Het |
| Rab29 |
A |
T |
1: 131,799,860 (GRCm39) |
E145V |
probably damaging |
Het |
| Rasef |
C |
T |
4: 73,653,956 (GRCm39) |
|
probably null |
Het |
| Rcbtb1 |
T |
G |
14: 59,472,699 (GRCm39) |
I496S |
probably benign |
Het |
| Rcor1 |
T |
C |
12: 111,066,393 (GRCm39) |
Y228H |
|
Het |
| Reep5 |
C |
T |
18: 34,490,222 (GRCm39) |
V92I |
probably damaging |
Het |
| Rfx3 |
T |
C |
19: 27,827,329 (GRCm39) |
S86G |
probably benign |
Het |
| Rptn |
T |
A |
3: 93,304,384 (GRCm39) |
D572E |
probably benign |
Het |
| Rsl1 |
A |
T |
13: 67,324,510 (GRCm39) |
|
probably null |
Het |
| Sbf2 |
T |
C |
7: 109,914,292 (GRCm39) |
E1630G |
possibly damaging |
Het |
| Sele |
G |
A |
1: 163,876,975 (GRCm39) |
V84I |
probably benign |
Het |
| Serpina1b |
T |
C |
12: 103,698,756 (GRCm39) |
D31G |
probably benign |
Het |
| Serpina3c |
T |
C |
12: 104,115,813 (GRCm39) |
I244V |
probably benign |
Het |
| Serpinb6e |
A |
G |
13: 34,017,204 (GRCm39) |
V272A |
probably benign |
Het |
| Serpinb9b |
A |
G |
13: 33,219,523 (GRCm39) |
D150G |
probably benign |
Het |
| Sgpp1 |
T |
C |
12: 75,769,374 (GRCm39) |
T265A |
probably benign |
Het |
| Slc9a1 |
T |
A |
4: 133,143,681 (GRCm39) |
M389K |
probably damaging |
Het |
| Slco3a1 |
A |
T |
7: 74,204,236 (GRCm39) |
C35S |
probably damaging |
Het |
| Slco6d1 |
T |
A |
1: 98,427,619 (GRCm39) |
V650E |
possibly damaging |
Het |
| Slit2 |
T |
C |
5: 48,349,568 (GRCm39) |
V274A |
possibly damaging |
Het |
| Snd1 |
A |
G |
6: 28,795,936 (GRCm39) |
E593G |
probably null |
Het |
| Spata2l |
C |
T |
8: 123,960,873 (GRCm39) |
V139M |
probably benign |
Het |
| Suco |
T |
C |
1: 161,684,427 (GRCm39) |
K231R |
probably damaging |
Het |
| Tenm3 |
C |
A |
8: 49,008,935 (GRCm39) |
|
probably benign |
Het |
| Tg |
T |
C |
15: 66,699,118 (GRCm39) |
S2415P |
possibly damaging |
Het |
| Traf6 |
C |
A |
2: 101,527,072 (GRCm39) |
A274D |
possibly damaging |
Het |
| Usp14 |
A |
G |
18: 9,996,239 (GRCm39) |
I447T |
possibly damaging |
Het |
| Usp32 |
G |
A |
11: 84,942,028 (GRCm39) |
L355F |
probably benign |
Het |
| Vcpip1 |
T |
C |
1: 9,817,927 (GRCm39) |
N152S |
possibly damaging |
Het |
| Vgf |
A |
G |
5: 137,061,110 (GRCm39) |
Q424R |
probably benign |
Het |
| Vmn2r84 |
A |
T |
10: 130,227,993 (GRCm39) |
M81K |
possibly damaging |
Het |
| Washc5 |
G |
A |
15: 59,218,067 (GRCm39) |
A732V |
possibly damaging |
Het |
| Xrcc3 |
T |
G |
12: 111,771,485 (GRCm39) |
D213A |
probably damaging |
Het |
| Zeb2 |
T |
C |
2: 44,886,988 (GRCm39) |
T690A |
probably benign |
Het |
| Zfat |
G |
A |
15: 67,956,250 (GRCm39) |
S1212L |
probably damaging |
Het |
| Zfp623 |
C |
T |
15: 75,819,949 (GRCm39) |
L302F |
probably damaging |
Het |
| Zfp799 |
A |
C |
17: 33,039,733 (GRCm39) |
C178G |
possibly damaging |
Het |
| Zfy1 |
T |
C |
Y: 727,634 (GRCm39) |
E348G |
unknown |
Het |
| Zhx3 |
A |
G |
2: 160,621,393 (GRCm39) |
W925R |
possibly damaging |
Het |
|
| Other mutations in Myh4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01471:Myh4
|
APN |
11 |
67,146,205 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01600:Myh4
|
APN |
11 |
67,151,015 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
IGL01737:Myh4
|
APN |
11 |
67,134,245 (GRCm39) |
splice site |
probably benign |
|
|
IGL02208:Myh4
|
APN |
11 |
67,142,760 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
IGL02334:Myh4
|
APN |
11 |
67,136,373 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02376:Myh4
|
APN |
11 |
67,136,554 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02429:Myh4
|
APN |
11 |
67,149,808 (GRCm39) |
nonsense |
probably null |
|
|
IGL02450:Myh4
|
APN |
11 |
67,142,635 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02524:Myh4
|
APN |
11 |
67,140,066 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL02612:Myh4
|
APN |
11 |
67,147,305 (GRCm39) |
missense |
probably benign |
|
|
IGL03024:Myh4
|
APN |
11 |
67,139,305 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03065:Myh4
|
APN |
11 |
67,149,982 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL03084:Myh4
|
APN |
11 |
67,142,777 (GRCm39) |
splice site |
probably null |
|
|
IGL03188:Myh4
|
APN |
11 |
67,137,369 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03204:Myh4
|
APN |
11 |
67,141,122 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
IGL03252:Myh4
|
APN |
11 |
67,143,042 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03345:Myh4
|
APN |
11 |
67,146,304 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Mr_chicken
|
UTSW |
11 |
67,140,711 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
Mrs_muir
|
UTSW |
11 |
67,136,339 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Willies
|
UTSW |
11 |
67,132,335 (GRCm39) |
missense |
probably damaging |
1.00 |
|
F6893:Myh4
|
UTSW |
11 |
67,146,283 (GRCm39) |
missense |
probably null |
0.12 |
|
PIT1430001:Myh4
|
UTSW |
11 |
67,149,658 (GRCm39) |
missense |
probably benign |
0.01 |
|
PIT4458001:Myh4
|
UTSW |
11 |
67,131,821 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R0099:Myh4
|
UTSW |
11 |
67,150,173 (GRCm39) |
missense |
probably benign |
|
|
R0194:Myh4
|
UTSW |
11 |
67,143,162 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0346:Myh4
|
UTSW |
11 |
67,151,152 (GRCm39) |
missense |
probably benign |
|
|
R0427:Myh4
|
UTSW |
11 |
67,149,479 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0483:Myh4
|
UTSW |
11 |
67,143,123 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0571:Myh4
|
UTSW |
11 |
67,141,157 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R0854:Myh4
|
UTSW |
11 |
67,149,973 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0940:Myh4
|
UTSW |
11 |
67,133,689 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0946:Myh4
|
UTSW |
11 |
67,142,577 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R1108:Myh4
|
UTSW |
11 |
67,146,532 (GRCm39) |
missense |
probably null |
0.01 |
|
R1162:Myh4
|
UTSW |
11 |
67,149,439 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1194:Myh4
|
UTSW |
11 |
67,146,560 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1347:Myh4
|
UTSW |
11 |
67,135,567 (GRCm39) |
splice site |
probably benign |
|
|
R1457:Myh4
|
UTSW |
11 |
67,139,287 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1531:Myh4
|
UTSW |
11 |
67,141,366 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1716:Myh4
|
UTSW |
11 |
67,141,135 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1766:Myh4
|
UTSW |
11 |
67,147,121 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R1796:Myh4
|
UTSW |
11 |
67,151,150 (GRCm39) |
missense |
probably benign |
|
|
R1856:Myh4
|
UTSW |
11 |
67,146,508 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1873:Myh4
|
UTSW |
11 |
67,145,569 (GRCm39) |
missense |
probably benign |
0.16 |
|
R2069:Myh4
|
UTSW |
11 |
67,137,192 (GRCm39) |
splice site |
probably benign |
|
|
R2370:Myh4
|
UTSW |
11 |
67,146,454 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2406:Myh4
|
UTSW |
11 |
67,150,000 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2414:Myh4
|
UTSW |
11 |
67,141,594 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2848:Myh4
|
UTSW |
11 |
67,139,459 (GRCm39) |
missense |
probably benign |
0.20 |
|
R3111:Myh4
|
UTSW |
11 |
67,137,276 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R3744:Myh4
|
UTSW |
11 |
67,146,141 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3845:Myh4
|
UTSW |
11 |
67,149,931 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R3877:Myh4
|
UTSW |
11 |
67,148,009 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4498:Myh4
|
UTSW |
11 |
67,142,578 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4514:Myh4
|
UTSW |
11 |
67,146,395 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4601:Myh4
|
UTSW |
11 |
67,141,136 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4673:Myh4
|
UTSW |
11 |
67,137,227 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4684:Myh4
|
UTSW |
11 |
67,136,637 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4736:Myh4
|
UTSW |
11 |
67,131,746 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4837:Myh4
|
UTSW |
11 |
67,149,818 (GRCm39) |
missense |
probably benign |
0.38 |
|
R4866:Myh4
|
UTSW |
11 |
67,139,453 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4869:Myh4
|
UTSW |
11 |
67,143,490 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4887:Myh4
|
UTSW |
11 |
67,131,880 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4921:Myh4
|
UTSW |
11 |
67,144,854 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5005:Myh4
|
UTSW |
11 |
67,144,241 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5008:Myh4
|
UTSW |
11 |
67,144,358 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5011:Myh4
|
UTSW |
11 |
67,147,189 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5087:Myh4
|
UTSW |
11 |
67,146,235 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5277:Myh4
|
UTSW |
11 |
67,143,180 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5336:Myh4
|
UTSW |
11 |
67,150,017 (GRCm39) |
splice site |
probably null |
|
|
R5354:Myh4
|
UTSW |
11 |
67,146,551 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R5371:Myh4
|
UTSW |
11 |
67,150,150 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5484:Myh4
|
UTSW |
11 |
67,142,644 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5774:Myh4
|
UTSW |
11 |
67,144,034 (GRCm39) |
nonsense |
probably null |
|
|
R5902:Myh4
|
UTSW |
11 |
67,141,733 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R5941:Myh4
|
UTSW |
11 |
67,150,126 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6045:Myh4
|
UTSW |
11 |
67,135,550 (GRCm39) |
missense |
probably benign |
0.32 |
|
R6156:Myh4
|
UTSW |
11 |
67,141,618 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6301:Myh4
|
UTSW |
11 |
67,146,159 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6318:Myh4
|
UTSW |
11 |
67,134,268 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6352:Myh4
|
UTSW |
11 |
67,143,108 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6385:Myh4
|
UTSW |
11 |
67,146,663 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6493:Myh4
|
UTSW |
11 |
67,149,455 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6666:Myh4
|
UTSW |
11 |
67,142,638 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6826:Myh4
|
UTSW |
11 |
67,137,357 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6852:Myh4
|
UTSW |
11 |
67,143,794 (GRCm39) |
splice site |
probably null |
|
|
R6857:Myh4
|
UTSW |
11 |
67,140,711 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R7029:Myh4
|
UTSW |
11 |
67,137,251 (GRCm39) |
missense |
probably benign |
0.40 |
|
R7076:Myh4
|
UTSW |
11 |
67,143,999 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R7145:Myh4
|
UTSW |
11 |
67,151,054 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R7179:Myh4
|
UTSW |
11 |
67,135,550 (GRCm39) |
missense |
probably benign |
0.32 |
|
R7365:Myh4
|
UTSW |
11 |
67,133,674 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7514:Myh4
|
UTSW |
11 |
67,134,148 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7553:Myh4
|
UTSW |
11 |
67,147,221 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7666:Myh4
|
UTSW |
11 |
67,147,107 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7673:Myh4
|
UTSW |
11 |
67,136,339 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7685:Myh4
|
UTSW |
11 |
67,131,756 (GRCm39) |
missense |
probably benign |
0.13 |
|
R8154:Myh4
|
UTSW |
11 |
67,144,200 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8343:Myh4
|
UTSW |
11 |
67,143,390 (GRCm39) |
missense |
possibly damaging |
0.45 |
|
R8446:Myh4
|
UTSW |
11 |
67,144,347 (GRCm39) |
missense |
probably benign |
0.14 |
|
R8534:Myh4
|
UTSW |
11 |
67,134,335 (GRCm39) |
missense |
probably benign |
0.17 |
|
R8710:Myh4
|
UTSW |
11 |
67,143,158 (GRCm39) |
missense |
probably benign |
|
|
R8775:Myh4
|
UTSW |
11 |
67,148,006 (GRCm39) |
missense |
probably benign |
0.25 |
|
R8775-TAIL:Myh4
|
UTSW |
11 |
67,148,006 (GRCm39) |
missense |
probably benign |
0.25 |
|
R8852:Myh4
|
UTSW |
11 |
67,132,335 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8860:Myh4
|
UTSW |
11 |
67,132,335 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8897:Myh4
|
UTSW |
11 |
67,137,362 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R8954:Myh4
|
UTSW |
11 |
67,143,806 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8957:Myh4
|
UTSW |
11 |
67,141,780 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R9065:Myh4
|
UTSW |
11 |
67,139,573 (GRCm39) |
missense |
probably benign |
|
|
R9280:Myh4
|
UTSW |
11 |
67,146,135 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9296:Myh4
|
UTSW |
11 |
67,146,130 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9314:Myh4
|
UTSW |
11 |
67,151,141 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9462:Myh4
|
UTSW |
11 |
67,141,811 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R9516:Myh4
|
UTSW |
11 |
67,141,129 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9516:Myh4
|
UTSW |
11 |
67,139,290 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9773:Myh4
|
UTSW |
11 |
67,137,263 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0027:Myh4
|
UTSW |
11 |
67,137,306 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Myh4
|
UTSW |
11 |
67,147,097 (GRCm39) |
missense |
probably benign |
0.02 |
|
Z1176:Myh4
|
UTSW |
11 |
67,144,331 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Myh4
|
UTSW |
11 |
67,139,467 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGTGAGAACCCTCTGTTGAG -3'
(R):5'- TGAGTACATGGTCCTCTTAACTG -3'
Sequencing Primer
(F):5'- GAGAACCCTCTGTTGAGACTTTCATG -3'
(R):5'- GGAAGCTGTGAAATTATTTGATGCTC -3'
|
| Posted On |
2022-03-25 |
Incidental Mutation