Mutagenetix > Incidental Mutation

Incidental Mutation 'R0738:Map2'

70554

Institutional Source

Beutler Lab

Gene Symbol

Map2

Ensembl Gene

ENSMUSG00000015222

Gene Name

microtubule-associated protein 2

Synonyms

G1-397-34, MAP-2, Mtap2, repro4

MMRRC Submission

038919-MU

Accession Numbers

Essential gene?

Probably essential (E-score: 0.751) question?

Stock #

R0738 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

66214432-66481742 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

T to C at 66464348 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000134518 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000024639] [ENSMUST00000077355] [ENSMUST00000114012] [ENSMUST00000114013] [ENSMUST00000114015] [ENSMUST00000114017] [ENSMUST00000114018] [ENSMUST00000172886] [ENSMUST00000173778] [ENSMUST00000173800]

AlphaFold

P20357

Predicted Effect

probably benign
Transcript: ENSMUST00000024639

SMART Domains

Protein: ENSMUSP00000024639
Gene: ENSMUSG00000015222

Domain	Start	End	E-Value	Type
low complexity region	120	141	N/A	INTRINSIC
low complexity region	182	196	N/A	INTRINSIC
low complexity region	206	222	N/A	INTRINSIC
low complexity region	229	251	N/A	INTRINSIC
Pfam:Tubulin-binding	300	331	2.1e-18	PFAM
Pfam:Tubulin-binding	332	362	9.1e-20	PFAM
Pfam:Tubulin-binding	363	394	1.7e-17	PFAM
low complexity region	422	435	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000077355

SMART Domains

Protein: ENSMUSP00000076577
Gene: ENSMUSG00000015222

Domain	Start	End	E-Value	Type
low complexity region	120	141	N/A	INTRINSIC
low complexity region	182	196	N/A	INTRINSIC
low complexity region	206	222	N/A	INTRINSIC
low complexity region	229	251	N/A	INTRINSIC
Pfam:Tubulin-binding	300	331	2.1e-18	PFAM
Pfam:Tubulin-binding	332	362	9.1e-20	PFAM
Pfam:Tubulin-binding	363	394	1.7e-17	PFAM
low complexity region	422	435	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000114012

SMART Domains

Protein: ENSMUSP00000109645
Gene: ENSMUSG00000015222

Domain	Start	End	E-Value	Type
low complexity region	133	140	N/A	INTRINSIC
low complexity region	181	195	N/A	INTRINSIC
low complexity region	205	221	N/A	INTRINSIC
low complexity region	228	250	N/A	INTRINSIC
Pfam:Tubulin-binding	299	330	2.1e-18	PFAM
Pfam:Tubulin-binding	331	361	9.1e-20	PFAM
Pfam:Tubulin-binding	362	393	1.7e-17	PFAM
low complexity region	421	434	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000114013

SMART Domains

Protein: ENSMUSP00000109646
Gene: ENSMUSG00000015222

Domain	Start	End	E-Value	Type
Pfam:RII_binding_1	86	103	1.2e-5	PFAM
low complexity region	120	141	N/A	INTRINSIC
Pfam:MAP2_projctn	376	1510	N/A	PFAM
low complexity region	1543	1557	N/A	INTRINSIC
low complexity region	1567	1583	N/A	INTRINSIC
low complexity region	1590	1612	N/A	INTRINSIC
Pfam:Tubulin-binding	1662	1692	1.7e-13	PFAM
Pfam:Tubulin-binding	1693	1723	5.8e-18	PFAM
Pfam:Tubulin-binding	1724	1755	5.9e-18	PFAM
low complexity region	1783	1796	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000114015

SMART Domains

Protein: ENSMUSP00000109648
Gene: ENSMUSG00000015222

Domain	Start	End	E-Value	Type
low complexity region	120	141	N/A	INTRINSIC
low complexity region	182	196	N/A	INTRINSIC
low complexity region	206	222	N/A	INTRINSIC
low complexity region	229	251	N/A	INTRINSIC
Pfam:Tubulin-binding	300	331	2.1e-18	PFAM
Pfam:Tubulin-binding	332	362	9.1e-20	PFAM
Pfam:Tubulin-binding	363	394	1.7e-17	PFAM
low complexity region	422	435	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000114017

SMART Domains

Protein: ENSMUSP00000109650
Gene: ENSMUSG00000015222

Domain	Start	End	E-Value	Type
low complexity region	120	141	N/A	INTRINSIC
low complexity region	182	196	N/A	INTRINSIC
low complexity region	206	222	N/A	INTRINSIC
low complexity region	229	251	N/A	INTRINSIC
Pfam:Tubulin-binding	300	331	2.3e-18	PFAM
Pfam:Tubulin-binding	332	362	2.3e-19	PFAM
Pfam:Tubulin-binding	363	393	9.9e-20	PFAM
Pfam:Tubulin-binding	394	425	1.9e-17	PFAM
low complexity region	453	466	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000114018

SMART Domains

Protein: ENSMUSP00000109651
Gene: ENSMUSG00000015222

Domain	Start	End	E-Value	Type
low complexity region	120	141	N/A	INTRINSIC
low complexity region	182	196	N/A	INTRINSIC
low complexity region	206	222	N/A	INTRINSIC
low complexity region	229	251	N/A	INTRINSIC
Pfam:Tubulin-binding	300	331	2.3e-18	PFAM
Pfam:Tubulin-binding	332	362	2.3e-19	PFAM
Pfam:Tubulin-binding	363	393	9.9e-20	PFAM
Pfam:Tubulin-binding	394	425	1.9e-17	PFAM
low complexity region	453	466	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000172886

SMART Domains

Protein: ENSMUSP00000133446
Gene: ENSMUSG00000015222

Domain	Start	End	E-Value	Type
Pfam:MAP2_projctn	1	107	3.9e-54	PFAM
low complexity region	112	126	N/A	INTRINSIC
low complexity region	136	152	N/A	INTRINSIC
low complexity region	159	181	N/A	INTRINSIC
Pfam:Tubulin-binding	230	261	1.4e-18	PFAM
Pfam:Tubulin-binding	262	292	1.4e-19	PFAM
Pfam:Tubulin-binding	293	323	6e-20	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000173778

SMART Domains

Protein: ENSMUSP00000134651
Gene: ENSMUSG00000015222

Domain	Start	End	E-Value	Type
Pfam:MAP2_projctn	1	124	4.8e-84	PFAM
low complexity region	157	171	N/A	INTRINSIC
low complexity region	181	197	N/A	INTRINSIC
low complexity region	204	226	N/A	INTRINSIC
Pfam:Tubulin-binding	275	306	1.6e-18	PFAM
Pfam:Tubulin-binding	307	337	1.6e-19	PFAM
Pfam:Tubulin-binding	338	368	7e-20	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000151423

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000133522

Predicted Effect

probably benign
Transcript: ENSMUST00000173800

SMART Domains

Protein: ENSMUSP00000134518
Gene: ENSMUSG00000015222

Domain	Start	End	E-Value	Type
Pfam:MAP2_projctn	1	23	2.2e-11	PFAM
low complexity region	55	69	N/A	INTRINSIC
low complexity region	79	95	N/A	INTRINSIC
low complexity region	102	124	N/A	INTRINSIC
Pfam:Tubulin-binding	173	204	8.7e-19	PFAM
Pfam:Tubulin-binding	205	235	3.8e-20	PFAM

Coding Region Coverage

1x: 99.1%
3x: 98.5%
10x: 96.6%
20x: 92.3%

Validation Efficiency

98% (46/47)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2010]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit altered contextual memory. Mice homozygous for another knock-out allele display decreased body weight, altered microtubule density and organization in Purkinje cell dendrites, and reduced dendritic length inhippocampal neurons. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A930011G23Rik	A	T	5: 99,388,812 (GRCm39)	M189K	probably benign	Het
Ank1	A	T	8: 23,604,130 (GRCm39)	E964D	probably damaging	Het
Ankhd1	A	G	18: 36,778,302 (GRCm39)		probably benign	Het
Cd9	G	T	6: 125,439,103 (GRCm39)	Q169K	probably benign	Het
Cdc42bpa	T	A	1: 179,827,027 (GRCm39)		probably benign	Het
Ch25h	T	C	19: 34,451,787 (GRCm39)	N247S	possibly damaging	Het
Dctn1	T	C	6: 83,167,089 (GRCm39)		probably null	Het
Defa22	C	T	8: 21,652,391 (GRCm39)	T19I	probably benign	Het
Dscam	T	C	16: 96,620,981 (GRCm39)	N576D	possibly damaging	Het
Epha3	T	C	16: 63,415,975 (GRCm39)	M675V	probably damaging	Het
Fam241a	C	A	3: 127,664,442 (GRCm39)	A120S	possibly damaging	Het
Fkbp8	T	A	8: 70,982,320 (GRCm39)	I86N	probably damaging	Het
Herc4	C	T	10: 63,124,928 (GRCm39)	P514L	possibly damaging	Het
Ide	A	T	19: 37,255,364 (GRCm39)	L813*	probably null	Het
Igkv12-41	G	A	6: 69,835,675 (GRCm39)	Q26*	probably null	Het
Itsn2	T	C	12: 4,685,681 (GRCm39)	V483A	probably benign	Het
Kcp	A	T	6: 29,490,438 (GRCm39)	I1002N	probably benign	Het
Lrfn5	G	T	12: 61,887,378 (GRCm39)	E389*	probably null	Het
Lrp6	G	T	6: 134,519,008 (GRCm39)	A19E	probably benign	Het
Mad1l1	A	G	5: 140,286,315 (GRCm39)	L228P	probably damaging	Het
Med13l	T	A	5: 118,889,698 (GRCm39)	Y1820N	probably damaging	Het
Mgam	A	G	6: 40,731,869 (GRCm39)	N735S	probably benign	Het
Mid2	A	G	X: 139,664,425 (GRCm39)	Y618C	probably damaging	Het
Mllt11	G	A	3: 95,127,597 (GRCm39)	Q58*	probably null	Het
Mttp	A	G	3: 137,809,074 (GRCm39)	V678A	probably damaging	Het
Nfatc1	A	G	18: 80,741,125 (GRCm39)	S278P	probably damaging	Het
Ninj2	A	G	6: 120,175,098 (GRCm39)		probably benign	Het
Nsd3	T	A	8: 26,168,725 (GRCm39)		probably null	Het
Or5b102	A	T	19: 13,041,102 (GRCm39)	E109V	probably damaging	Het
Or8c17	T	C	9: 38,180,421 (GRCm39)	V204A	possibly damaging	Het
Pcdhb4	A	G	18: 37,441,764 (GRCm39)	N358S	probably damaging	Het
Plch1	T	C	3: 63,609,974 (GRCm39)		probably benign	Het
Popdc3	T	C	10: 45,191,354 (GRCm39)	L155P	probably damaging	Het
Ptpro	T	A	6: 137,420,592 (GRCm39)	V1007D	probably damaging	Het
Rbm26	A	T	14: 105,414,218 (GRCm39)	I24N	unknown	Het
Rc3h2	T	A	2: 37,295,386 (GRCm39)	D210V	probably damaging	Het
Samd1	CGAGGAGGAGGAGGAGGAGGA	CGAGGAGGAGGAGGAGGA	8: 84,725,625 (GRCm39)		probably benign	Het
Spopl	T	C	2: 23,427,533 (GRCm39)	T200A	probably benign	Het
Tarbp1	A	G	8: 127,165,540 (GRCm39)		probably null	Het
Thnsl1	T	A	2: 21,218,173 (GRCm39)	H121Q	probably damaging	Het
Tll1	T	C	8: 64,554,984 (GRCm39)	D233G	probably damaging	Het
Vmn2r27	A	T	6: 124,200,661 (GRCm39)	V432E	possibly damaging	Het
Wdr5	T	C	2: 27,409,424 (GRCm39)	S49P	probably damaging	Het
Zfyve26	A	T	12: 79,342,308 (GRCm39)	I46N	probably damaging	Het

Other mutations in Map2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01518:Map2	APN	1	66,464,490 (GRCm39)	missense	probably damaging	1.00
IGL02135:Map2	APN	1	66,419,920 (GRCm39)	nonsense	probably null
IGL02526:Map2	APN	1	66,419,876 (GRCm39)	missense	possibly damaging	0.94
Annas	UTSW	1	66,472,756 (GRCm39)	critical splice donor site	probably null
calliope	UTSW	1	66,464,457 (GRCm39)	missense	probably damaging	1.00
carthage	UTSW	1	66,453,807 (GRCm39)	missense	probably damaging	1.00
costas	UTSW	1	66,451,812 (GRCm39)	missense	possibly damaging	0.94
Jacobin	UTSW	1	66,438,578 (GRCm39)	missense	probably damaging	1.00
Nectar	UTSW	1	66,454,522 (GRCm39)	nonsense	probably null
ruby_throat	UTSW	1	66,454,043 (GRCm39)	missense	possibly damaging	0.67
Rufous	UTSW	1	66,419,927 (GRCm39)	missense	probably damaging	1.00
Speckled	UTSW	1	66,451,886 (GRCm39)	nonsense	probably null
Sunbird	UTSW	1	66,454,646 (GRCm39)	missense	probably benign	0.01
swift	UTSW	1	66,455,523 (GRCm39)	missense	probably damaging	1.00
E0370:Map2	UTSW	1	66,455,883 (GRCm39)	unclassified	probably benign
PIT4362001:Map2	UTSW	1	66,451,677 (GRCm39)	missense	probably benign	0.05
R0067:Map2	UTSW	1	66,452,322 (GRCm39)	missense	probably benign	0.04
R0238:Map2	UTSW	1	66,455,265 (GRCm39)	missense	probably damaging	1.00
R0238:Map2	UTSW	1	66,455,265 (GRCm39)	missense	probably damaging	1.00
R0239:Map2	UTSW	1	66,455,265 (GRCm39)	missense	probably damaging	1.00
R0239:Map2	UTSW	1	66,455,265 (GRCm39)	missense	probably damaging	1.00
R0268:Map2	UTSW	1	66,419,881 (GRCm39)	nonsense	probably null
R0302:Map2	UTSW	1	66,453,987 (GRCm39)	missense	probably benign	0.15
R0305:Map2	UTSW	1	66,452,253 (GRCm39)	missense	probably benign	0.00
R0409:Map2	UTSW	1	66,472,739 (GRCm39)	missense	probably damaging	1.00
R0561:Map2	UTSW	1	66,464,656 (GRCm39)	missense	probably damaging	1.00
R0674:Map2	UTSW	1	66,452,361 (GRCm39)	missense	probably damaging	1.00
R0893:Map2	UTSW	1	66,419,927 (GRCm39)	missense	probably damaging	1.00
R1305:Map2	UTSW	1	66,464,554 (GRCm39)	missense	probably damaging	1.00
R1534:Map2	UTSW	1	66,452,339 (GRCm39)	missense	probably benign	0.33
R1632:Map2	UTSW	1	66,454,245 (GRCm39)	missense	possibly damaging	0.60
R1682:Map2	UTSW	1	66,454,781 (GRCm39)	splice site	probably null
R1774:Map2	UTSW	1	66,453,233 (GRCm39)	missense	probably damaging	1.00
R2014:Map2	UTSW	1	66,455,295 (GRCm39)	missense	possibly damaging	0.55
R2017:Map2	UTSW	1	66,451,958 (GRCm39)	missense	probably damaging	1.00
R2050:Map2	UTSW	1	66,453,473 (GRCm39)	missense	probably damaging	0.98
R2093:Map2	UTSW	1	66,438,599 (GRCm39)	missense	probably damaging	1.00
R2214:Map2	UTSW	1	66,459,345 (GRCm39)	missense	probably damaging	0.99
R2284:Map2	UTSW	1	66,453,227 (GRCm39)	missense	probably damaging	1.00
R3011:Map2	UTSW	1	66,453,771 (GRCm39)	missense	probably damaging	1.00
R3105:Map2	UTSW	1	66,472,756 (GRCm39)	critical splice donor site	probably null
R3708:Map2	UTSW	1	66,455,714 (GRCm39)	unclassified	probably benign
R3709:Map2	UTSW	1	66,455,015 (GRCm39)	nonsense	probably null
R3729:Map2	UTSW	1	66,451,605 (GRCm39)	missense	possibly damaging	0.80
R3760:Map2	UTSW	1	66,478,077 (GRCm39)	missense	probably damaging	1.00
R3788:Map2	UTSW	1	66,456,022 (GRCm39)	missense	probably damaging	0.99
R3789:Map2	UTSW	1	66,456,022 (GRCm39)	missense	probably damaging	0.99
R4003:Map2	UTSW	1	66,454,899 (GRCm39)	missense	probably damaging	1.00
R4120:Map2	UTSW	1	66,455,063 (GRCm39)	missense	probably damaging	1.00
R4172:Map2	UTSW	1	66,452,759 (GRCm39)	missense	possibly damaging	0.89
R4198:Map2	UTSW	1	66,464,457 (GRCm39)	missense	probably damaging	1.00
R4200:Map2	UTSW	1	66,464,457 (GRCm39)	missense	probably damaging	1.00
R4205:Map2	UTSW	1	66,464,449 (GRCm39)	missense	probably damaging	1.00
R4613:Map2	UTSW	1	66,464,628 (GRCm39)	missense	probably damaging	1.00
R4700:Map2	UTSW	1	66,449,796 (GRCm39)	missense	probably damaging	0.96
R4974:Map2	UTSW	1	66,452,664 (GRCm39)	missense	probably benign	0.15
R5007:Map2	UTSW	1	66,452,448 (GRCm39)	missense	possibly damaging	0.86
R5039:Map2	UTSW	1	66,477,955 (GRCm39)	missense	probably damaging	1.00
R5237:Map2	UTSW	1	66,478,169 (GRCm39)	unclassified	probably benign
R5313:Map2	UTSW	1	66,464,538 (GRCm39)	missense	probably damaging	1.00
R5455:Map2	UTSW	1	66,438,550 (GRCm39)	missense	probably damaging	1.00
R5490:Map2	UTSW	1	66,452,292 (GRCm39)	missense	probably damaging	1.00
R5517:Map2	UTSW	1	66,454,415 (GRCm39)	missense	probably benign	0.00
R5532:Map2	UTSW	1	66,453,779 (GRCm39)	missense	probably damaging	1.00
R5583:Map2	UTSW	1	66,455,196 (GRCm39)	missense	probably damaging	1.00
R5764:Map2	UTSW	1	66,454,034 (GRCm39)	missense	probably damaging	0.99
R5996:Map2	UTSW	1	66,454,043 (GRCm39)	missense	possibly damaging	0.67
R6058:Map2	UTSW	1	66,454,573 (GRCm39)	missense	probably benign	0.05
R6199:Map2	UTSW	1	66,464,637 (GRCm39)	missense	probably damaging	1.00
R6208:Map2	UTSW	1	66,470,749 (GRCm39)	missense	probably damaging	1.00
R6276:Map2	UTSW	1	66,438,578 (GRCm39)	missense	probably damaging	1.00
R6378:Map2	UTSW	1	66,454,488 (GRCm39)	missense	probably damaging	1.00
R6424:Map2	UTSW	1	66,453,946 (GRCm39)	missense	possibly damaging	0.67
R6743:Map2	UTSW	1	66,454,766 (GRCm39)	missense	probably benign	0.04
R6837:Map2	UTSW	1	66,453,731 (GRCm39)	missense	probably damaging	1.00
R6901:Map2	UTSW	1	66,460,932 (GRCm39)	missense	possibly damaging	0.94
R6984:Map2	UTSW	1	66,454,395 (GRCm39)	missense	possibly damaging	0.90
R6989:Map2	UTSW	1	66,454,065 (GRCm39)	missense	probably benign	0.00
R7001:Map2	UTSW	1	66,454,646 (GRCm39)	missense	probably benign	0.01
R7055:Map2	UTSW	1	66,455,983 (GRCm39)	missense	probably damaging	1.00
R7094:Map2	UTSW	1	66,451,886 (GRCm39)	nonsense	probably null
R7106:Map2	UTSW	1	66,449,903 (GRCm39)	missense	possibly damaging	0.92
R7182:Map2	UTSW	1	66,451,812 (GRCm39)	missense	possibly damaging	0.94
R7235:Map2	UTSW	1	66,453,807 (GRCm39)	missense	probably damaging	1.00
R7424:Map2	UTSW	1	66,453,983 (GRCm39)	missense	possibly damaging	0.69
R7473:Map2	UTSW	1	66,454,617 (GRCm39)	missense	probably damaging	1.00
R7642:Map2	UTSW	1	66,452,466 (GRCm39)	missense	probably benign	0.01
R7660:Map2	UTSW	1	66,453,536 (GRCm39)	missense	probably damaging	1.00
R7673:Map2	UTSW	1	66,452,933 (GRCm39)	missense	probably benign	0.03
R7768:Map2	UTSW	1	66,453,642 (GRCm39)	missense	possibly damaging	0.94
R7796:Map2	UTSW	1	66,455,654 (GRCm39)	splice site	probably null
R7834:Map2	UTSW	1	66,455,647 (GRCm39)	missense	probably damaging	1.00
R7842:Map2	UTSW	1	66,455,570 (GRCm39)	missense	probably benign
R7955:Map2	UTSW	1	66,452,875 (GRCm39)	missense	probably damaging	1.00
R8056:Map2	UTSW	1	66,454,779 (GRCm39)	missense	probably damaging	0.99
R8118:Map2	UTSW	1	66,464,550 (GRCm39)	missense	probably damaging	1.00
R8135:Map2	UTSW	1	66,452,828 (GRCm39)	missense	probably damaging	1.00
R8152:Map2	UTSW	1	66,453,902 (GRCm39)	missense	probably benign	0.00
R8223:Map2	UTSW	1	66,464,649 (GRCm39)	missense	probably damaging	1.00
R8329:Map2	UTSW	1	66,454,272 (GRCm39)	missense	probably benign	0.01
R8344:Map2	UTSW	1	66,460,872 (GRCm39)	missense	probably damaging	1.00
R8475:Map2	UTSW	1	66,453,164 (GRCm39)	missense	probably damaging	1.00
R8548:Map2	UTSW	1	66,452,499 (GRCm39)	missense	probably damaging	1.00
R8680:Map2	UTSW	1	66,460,872 (GRCm39)	missense	probably damaging	1.00
R8713:Map2	UTSW	1	66,453,781 (GRCm39)	missense	probably damaging	1.00
R8745:Map2	UTSW	1	66,452,556 (GRCm39)	missense	probably benign	0.00
R8786:Map2	UTSW	1	66,472,755 (GRCm39)	critical splice donor site	probably benign
R8790:Map2	UTSW	1	66,477,997 (GRCm39)	missense	probably damaging	1.00
R8874:Map2	UTSW	1	66,455,523 (GRCm39)	missense	probably damaging	1.00
R8887:Map2	UTSW	1	66,454,758 (GRCm39)	missense	possibly damaging	0.48
R8948:Map2	UTSW	1	66,419,684 (GRCm39)	missense	probably damaging	1.00
R8950:Map2	UTSW	1	66,419,684 (GRCm39)	missense	probably damaging	1.00
R8998:Map2	UTSW	1	66,452,473 (GRCm39)	missense	possibly damaging	0.91
R8999:Map2	UTSW	1	66,452,473 (GRCm39)	missense	possibly damaging	0.91
R9072:Map2	UTSW	1	66,453,312 (GRCm39)	missense	probably damaging	1.00
R9088:Map2	UTSW	1	66,453,773 (GRCm39)	missense	probably damaging	1.00
R9089:Map2	UTSW	1	66,452,098 (GRCm39)	missense	probably benign	0.09
R9106:Map2	UTSW	1	66,454,522 (GRCm39)	nonsense	probably null
R9112:Map2	UTSW	1	66,472,723 (GRCm39)	nonsense	probably null
R9120:Map2	UTSW	1	66,453,218 (GRCm39)	missense	probably damaging	1.00
R9161:Map2	UTSW	1	66,477,503 (GRCm39)	missense	possibly damaging	0.65
R9464:Map2	UTSW	1	66,454,497 (GRCm39)	missense	probably damaging	1.00
R9589:Map2	UTSW	1	66,449,753 (GRCm39)	missense	probably benign
V8831:Map2	UTSW	1	66,455,004 (GRCm39)	missense	probably damaging	1.00
Z1177:Map2	UTSW	1	66,477,520 (GRCm39)	missense	probably damaging	0.96
Z1177:Map2	UTSW	1	66,419,839 (GRCm39)	missense	probably benign	0.01

Predicted Primers

PCR Primer
(F):5'- GCCATTCAGGAGTCTTCCCACAATC -3'
(R):5'- ACTTTCTTCTCACTGGGCACCAGG -3'

Sequencing Primer
(F):5'- TAACTACAGGTCGTCCATATGACTC -3'
(R):5'- GGGCACCAGGATGCCAG -3'

Posted On

2013-09-30