Incidental Mutation 'R9314:Tbcd'
ID 705800
Institutional Source Beutler Lab
Gene Symbol Tbcd
Ensembl Gene ENSMUSG00000039230
Gene Name tubulin-specific chaperone d
Synonyms 2310057L06Rik, A030005L14Rik
MMRRC Submission
Accession Numbers
Essential gene? Probably essential (E-score: 0.957) question?
Stock # R9314 (G1)
Quality Score 225.009
Status Not validated
Chromosome 11
Chromosomal Location 121342817-121507996 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 121487297 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 803 (V803A)
Ref Sequence ENSEMBL: ENSMUSP00000099302 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103013]
AlphaFold Q8BYA0
Predicted Effect probably benign
Transcript: ENSMUST00000103013
AA Change: V803A

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000099302
Gene: ENSMUSG00000039230
AA Change: V803A

DomainStartEndE-ValueType
low complexity region 6 20 N/A INTRINSIC
low complexity region 45 62 N/A INTRINSIC
SCOP:d1b3ua_ 357 742 4e-20 SMART
Pfam:TFCD_C 900 1090 1.4e-74 PFAM
low complexity region 1113 1120 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Cofactor D is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. [provided by RefSeq, Jul 2008]
Allele List at MGI

All alleles(23) : Gene trapped(23)

Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca17 A C 17: 24,547,593 (GRCm39) N260K possibly damaging Het
Anapc1 G A 2: 128,464,420 (GRCm39) S1692L possibly damaging Het
Brca2 A G 5: 150,474,359 (GRCm39) R2421G probably damaging Het
Cad A G 5: 31,234,988 (GRCm39) Y2143C probably damaging Het
Calr3 T A 8: 73,178,535 (GRCm39) D356V possibly damaging Het
Cd207 T A 6: 83,652,699 (GRCm39) T144S probably damaging Het
Cntln T C 4: 84,924,719 (GRCm39) L608P probably damaging Het
Dnah8 A T 17: 30,990,857 (GRCm39) Y3300F probably benign Het
Emb T C 13: 117,408,604 (GRCm39) I315T probably damaging Het
Esr1 T A 10: 4,916,181 (GRCm39) V456E possibly damaging Het
Evpl A T 11: 116,118,503 (GRCm39) H701Q probably benign Het
F5 C T 1: 164,029,146 (GRCm39) T1715I probably benign Het
Fut10 T A 8: 31,691,504 (GRCm39) H116Q probably damaging Het
Gm40460 ACAACCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAG ACAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAG 7: 141,794,447 (GRCm39) probably benign Het
Gm5591 T C 7: 38,221,884 (GRCm39) T62A probably benign Het
Hectd4 T C 5: 121,437,708 (GRCm39) probably null Het
Ifit1bl1 G C 19: 34,576,693 (GRCm39) Q3E probably benign Het
Ighg3 A T 12: 113,323,946 (GRCm39) D147E Het
Ighv8-13 A G 12: 115,728,996 (GRCm39) V87A possibly damaging Het
Kdelr1 A G 7: 45,531,050 (GRCm39) T160A probably benign Het
Kdm2a A G 19: 4,372,510 (GRCm39) L945P probably damaging Het
Krt36 C T 11: 99,994,227 (GRCm39) W283* probably null Het
Lamp3 T C 16: 19,492,192 (GRCm39) M351V probably benign Het
Lox C G 18: 52,653,911 (GRCm39) R395P probably damaging Het
Lrrtm3 T C 10: 63,925,499 (GRCm39) probably benign Het
Madcam1 C A 10: 79,501,481 (GRCm39) T182K probably damaging Het
Megf8 T A 7: 25,029,297 (GRCm39) H280Q probably damaging Het
Mrgprb5 A G 7: 47,818,174 (GRCm39) I187T probably benign Het
Muc1 T C 3: 89,138,825 (GRCm39) V478A probably damaging Het
Mug1 T G 6: 121,834,296 (GRCm39) V359G probably damaging Het
Myh4 A G 11: 67,151,141 (GRCm39) H1932R probably benign Het
Naaladl1 A C 19: 6,162,401 (GRCm39) N448H probably damaging Het
Or52b1 A T 7: 104,979,081 (GRCm39) I106N probably damaging Het
Or5a1 C T 19: 12,097,144 (GRCm39) E311K probably benign Het
Pkd1l1 A T 11: 8,829,153 (GRCm39) Y1480N Het
Poll T C 19: 45,547,091 (GRCm39) E127G probably benign Het
Ppl T C 16: 4,922,367 (GRCm39) N305S possibly damaging Het
Prss53 A G 7: 127,490,039 (GRCm39) V17A probably benign Het
Ptprj A G 2: 90,301,631 (GRCm39) V74A possibly damaging Het
Rapgef4 A T 2: 72,064,983 (GRCm39) H804L possibly damaging Het
Rassf8 A G 6: 145,762,296 (GRCm39) T356A probably damaging Het
Rptor T C 11: 119,786,772 (GRCm39) S1246P probably benign Het
Setdb2 A T 14: 59,650,240 (GRCm39) I458N probably benign Het
Sgtb A G 13: 104,254,933 (GRCm39) K68E possibly damaging Het
Slc19a3 T G 1: 83,000,094 (GRCm39) I308L possibly damaging Het
Slc22a5 T C 11: 53,762,487 (GRCm39) D320G possibly damaging Het
Slc34a2 T C 5: 53,218,143 (GRCm39) S141P possibly damaging Het
Slc37a2 T C 9: 37,150,482 (GRCm39) T158A possibly damaging Het
Slc7a1 T C 5: 148,269,327 (GRCm39) I598V probably benign Het
Sphk2 T C 7: 45,361,158 (GRCm39) D282G probably damaging Het
Spty2d1 G T 7: 46,648,486 (GRCm39) P148T probably damaging Het
Supt3 A G 17: 45,352,250 (GRCm39) T310A probably benign Het
Supt5 T A 7: 28,019,799 (GRCm39) D457V probably damaging Het
Svep1 C T 4: 58,070,347 (GRCm39) G2480R probably damaging Het
Tex2 A T 11: 106,435,075 (GRCm39) C784S unknown Het
Thrb A G 14: 17,963,208 (GRCm38) H57R probably benign Het
Tmc4 T C 7: 3,679,723 (GRCm39) T34A possibly damaging Het
Tmprss2 T C 16: 97,400,459 (GRCm39) N4S probably benign Het
Trank1 A G 9: 111,195,049 (GRCm39) I1024M probably damaging Het
Trnau1ap C A 4: 132,056,697 (GRCm39) probably benign Het
Ttn A G 2: 76,566,710 (GRCm39) V28061A probably damaging Het
Txnl4b C A 8: 110,299,331 (GRCm39) P97Q probably benign Het
Ube4a T C 9: 44,854,023 (GRCm39) T573A probably benign Het
Vit A T 17: 78,927,044 (GRCm39) T330S probably benign Het
Wdr3 T C 3: 100,050,288 (GRCm39) I750V probably benign Het
Zfp59 C T 7: 27,554,029 (GRCm39) L494F possibly damaging Het
Other mutations in Tbcd
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00519:Tbcd APN 11 121,466,147 (GRCm39) missense probably damaging 0.96
IGL00795:Tbcd APN 11 121,507,758 (GRCm39) missense probably benign
IGL00802:Tbcd APN 11 121,499,436 (GRCm39) missense possibly damaging 0.55
IGL01286:Tbcd APN 11 121,384,719 (GRCm39) critical splice donor site probably null
IGL01325:Tbcd APN 11 121,431,819 (GRCm39) missense probably damaging 0.99
IGL01348:Tbcd APN 11 121,387,902 (GRCm39) missense probably benign
IGL01432:Tbcd APN 11 121,366,506 (GRCm39) splice site probably benign
IGL01577:Tbcd APN 11 121,387,838 (GRCm39) missense probably damaging 1.00
IGL01660:Tbcd APN 11 121,496,153 (GRCm39) missense probably benign 0.01
IGL01865:Tbcd APN 11 121,481,206 (GRCm39) missense possibly damaging 0.81
IGL02260:Tbcd APN 11 121,494,104 (GRCm39) missense probably damaging 1.00
IGL02492:Tbcd APN 11 121,387,960 (GRCm39) missense probably benign 0.06
IGL02620:Tbcd APN 11 121,352,081 (GRCm39) missense probably damaging 1.00
IGL02950:Tbcd APN 11 121,494,535 (GRCm39) missense probably damaging 0.99
R6859_Tbcd_818 UTSW 11 121,387,937 (GRCm39) missense possibly damaging 0.81
R0066:Tbcd UTSW 11 121,394,590 (GRCm39) nonsense probably null
R0066:Tbcd UTSW 11 121,394,590 (GRCm39) nonsense probably null
R0077:Tbcd UTSW 11 121,485,100 (GRCm39) missense probably benign 0.00
R0349:Tbcd UTSW 11 121,493,809 (GRCm39) splice site probably null
R0865:Tbcd UTSW 11 121,493,815 (GRCm39) missense possibly damaging 0.88
R1203:Tbcd UTSW 11 121,366,451 (GRCm39) missense probably benign 0.00
R1221:Tbcd UTSW 11 121,387,909 (GRCm39) missense probably benign 0.00
R1549:Tbcd UTSW 11 121,451,579 (GRCm39) missense probably benign
R1586:Tbcd UTSW 11 121,387,886 (GRCm39) missense probably benign 0.13
R1671:Tbcd UTSW 11 121,488,120 (GRCm39) missense probably benign 0.00
R2048:Tbcd UTSW 11 121,431,762 (GRCm39) missense probably damaging 1.00
R2051:Tbcd UTSW 11 121,344,496 (GRCm39) missense probably damaging 1.00
R2124:Tbcd UTSW 11 121,494,146 (GRCm39) missense probably damaging 1.00
R2151:Tbcd UTSW 11 121,494,457 (GRCm39) missense possibly damaging 0.95
R2153:Tbcd UTSW 11 121,494,457 (GRCm39) missense possibly damaging 0.95
R3120:Tbcd UTSW 11 121,499,474 (GRCm39) missense probably damaging 0.97
R4108:Tbcd UTSW 11 121,384,637 (GRCm39) missense probably benign 0.00
R4244:Tbcd UTSW 11 121,485,107 (GRCm39) missense probably damaging 1.00
R4587:Tbcd UTSW 11 121,496,097 (GRCm39) missense possibly damaging 0.75
R4684:Tbcd UTSW 11 121,384,597 (GRCm39) missense probably damaging 1.00
R4837:Tbcd UTSW 11 121,473,611 (GRCm39) critical splice donor site probably null
R4861:Tbcd UTSW 11 121,492,787 (GRCm39) missense probably damaging 1.00
R4861:Tbcd UTSW 11 121,492,787 (GRCm39) missense probably damaging 1.00
R4960:Tbcd UTSW 11 121,464,681 (GRCm39) missense probably benign 0.03
R5157:Tbcd UTSW 11 121,500,853 (GRCm39) missense probably benign 0.14
R5166:Tbcd UTSW 11 121,500,216 (GRCm39) missense possibly damaging 0.87
R5403:Tbcd UTSW 11 121,451,569 (GRCm39) missense probably damaging 0.99
R5406:Tbcd UTSW 11 121,342,927 (GRCm39) missense probably benign
R5509:Tbcd UTSW 11 121,492,838 (GRCm39) missense probably benign 0.00
R5767:Tbcd UTSW 11 121,483,518 (GRCm39) missense probably benign 0.00
R5923:Tbcd UTSW 11 121,470,978 (GRCm39) missense probably benign
R5966:Tbcd UTSW 11 121,492,737 (GRCm39) intron probably benign
R6330:Tbcd UTSW 11 121,387,912 (GRCm39) missense probably benign
R6539:Tbcd UTSW 11 121,447,813 (GRCm39) critical splice donor site probably null
R6852:Tbcd UTSW 11 121,500,206 (GRCm39) missense probably benign 0.36
R6859:Tbcd UTSW 11 121,387,937 (GRCm39) missense possibly damaging 0.81
R7348:Tbcd UTSW 11 121,485,137 (GRCm39) missense probably benign 0.22
R7479:Tbcd UTSW 11 121,383,431 (GRCm39) critical splice donor site probably null
R7679:Tbcd UTSW 11 121,494,534 (GRCm39) missense probably benign 0.01
R8121:Tbcd UTSW 11 121,487,969 (GRCm39) splice site probably null
R8163:Tbcd UTSW 11 121,384,711 (GRCm39) missense probably benign 0.00
R8165:Tbcd UTSW 11 121,384,711 (GRCm39) missense probably benign 0.00
R8172:Tbcd UTSW 11 121,384,711 (GRCm39) missense probably benign 0.00
R8973:Tbcd UTSW 11 121,387,679 (GRCm39) unclassified probably benign
R8975:Tbcd UTSW 11 121,387,679 (GRCm39) unclassified probably benign
R9345:Tbcd UTSW 11 121,464,648 (GRCm39) missense probably damaging 1.00
R9556:Tbcd UTSW 11 121,467,053 (GRCm39) missense probably damaging 0.96
R9673:Tbcd UTSW 11 121,464,647 (GRCm39) missense probably damaging 1.00
Z1177:Tbcd UTSW 11 121,481,232 (GRCm39) missense probably null 0.14
Predicted Primers PCR Primer
(F):5'- CATGGCTACTGTGCTCTGTG -3'
(R):5'- ATGTTCCCTGACATTGCACTG -3'

Sequencing Primer
(F):5'- GAAGCGTGTTGATAGCCACACTC -3'
(R):5'- TGTTCCCTGACATTGCACTGAAAAC -3'
Posted On 2022-03-25