Incidental Mutation 'R9315:Or13a22'
ID 705844
Institutional Source Beutler Lab
Gene Symbol Or13a22
Ensembl Gene ENSMUSG00000063230
Gene Name olfactory receptor family 13 subfamily A member 22
Synonyms Olfr535, GA_x6K02T2PBJ9-42641642-42642574, MOR253-7
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.102) question?
Stock # R9315 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 140072553-140073491 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 140072935 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 128 (I128T)
Ref Sequence ENSEMBL: ENSMUSP00000149320 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074897] [ENSMUST00000213715] [ENSMUST00000214296] [ENSMUST00000216585] [ENSMUST00000217235] [ENSMUST00000217580]
AlphaFold Q8VGL3
Predicted Effect probably damaging
Transcript: ENSMUST00000074897
AA Change: I128T

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000074435
Gene: ENSMUSG00000063230
AA Change: I128T

DomainStartEndE-ValueType
Pfam:7tm_4 33 309 4.5e-50 PFAM
Pfam:7TM_GPCR_Srsx 37 183 1.1e-8 PFAM
Pfam:7tm_1 43 292 5.8e-21 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213715
AA Change: I128T

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000214296
AA Change: I128T

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000216585
AA Change: I128T

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000217235
AA Change: I128T

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000217580
AA Change: I128T

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 98% (43/44)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc3 C T 11: 94,265,576 (GRCm39) R153H possibly damaging Het
Ankrd17 G A 5: 90,398,360 (GRCm39) S1730L probably damaging Het
Ano3 T C 2: 110,528,287 (GRCm39) E509G probably damaging Het
Cacna2d4 G T 6: 119,213,670 (GRCm39) A30S probably benign Het
Clec4e A G 6: 123,263,214 (GRCm39) S109P probably damaging Het
Coa7 T A 4: 108,195,581 (GRCm39) L170Q probably benign Het
Col1a2 T A 6: 4,540,544 (GRCm39) I1334N unknown Het
Col6a3 A G 1: 90,738,979 (GRCm39) probably null Het
Cyp2j6 A G 4: 96,420,035 (GRCm39) I232T probably benign Het
Ddx52 T A 11: 83,837,033 (GRCm39) S175T probably benign Het
Dnah11 G A 12: 118,143,341 (GRCm39) S434F probably benign Het
Epn1 T C 7: 5,096,339 (GRCm39) V211A probably benign Het
Fads2b C A 2: 85,319,188 (GRCm39) K371N probably benign Het
Glb1 A G 9: 114,285,548 (GRCm39) N429S probably benign Het
Ifng A T 10: 118,278,588 (GRCm39) D83V probably damaging Het
Ints4 A G 7: 97,156,840 (GRCm39) probably benign Het
Lamb2 C T 9: 108,364,366 (GRCm39) R1102W possibly damaging Het
Ldlr T A 9: 21,644,782 (GRCm39) probably benign Het
Mdn1 T C 4: 32,760,911 (GRCm39) V4992A probably benign Het
Mrc1 T A 2: 14,248,969 (GRCm39) C168* probably null Het
Msantd5f3 A T 4: 73,575,280 (GRCm39) R320* probably null Het
Mug1 T A 6: 121,850,730 (GRCm39) V742D possibly damaging Het
Mxd1 T C 6: 86,627,926 (GRCm39) D204G probably damaging Het
Myo9b C A 8: 71,801,811 (GRCm39) A1322D possibly damaging Het
Nepn T A 10: 52,267,869 (GRCm39) I45N probably benign Het
Or14c46 A T 7: 85,918,495 (GRCm39) C167* probably null Het
Or4d5 T C 9: 40,012,270 (GRCm39) D172G probably benign Het
Paip1 A G 13: 119,586,516 (GRCm39) E271G probably benign Het
Pcnx2 T C 8: 126,614,119 (GRCm39) N444S probably benign Het
Pdcd6ip T C 9: 113,488,921 (GRCm39) T705A possibly damaging Het
Pik3r1 A G 13: 101,894,166 (GRCm39) M1T probably null Het
Rab33b T G 3: 51,401,000 (GRCm39) V158G probably damaging Het
Rab6a A G 7: 100,281,017 (GRCm39) I120V probably benign Het
Radil G T 5: 142,474,254 (GRCm39) H731N probably damaging Het
Rbm4b T C 19: 4,812,028 (GRCm39) S146P probably damaging Het
Rrn3 T C 16: 13,606,690 (GRCm39) Y99H probably benign Het
Saxo4 T A 19: 10,458,767 (GRCm39) S88C probably damaging Het
Syne1 G T 10: 5,283,553 (GRCm39) T1504K possibly damaging Het
Tas1r2 A G 4: 139,381,046 (GRCm39) Y56C possibly damaging Het
Tmprss3 T C 17: 31,403,644 (GRCm39) I386V probably null Het
Tns1 A G 1: 73,980,141 (GRCm39) C11R Het
Wdr11 A G 7: 129,208,264 (GRCm39) T340A probably benign Het
Zbtb49 A G 5: 38,358,082 (GRCm39) S724P probably benign Het
Zfp446 A G 7: 12,713,397 (GRCm39) K221R probably benign Het
Other mutations in Or13a22
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00979:Or13a22 APN 7 140,072,614 (GRCm39) missense probably benign 0.00
IGL01537:Or13a22 APN 7 140,072,751 (GRCm39) missense probably damaging 1.00
IGL01639:Or13a22 APN 7 140,073,099 (GRCm39) missense probably benign 0.09
IGL02157:Or13a22 APN 7 140,072,847 (GRCm39) missense probably damaging 1.00
IGL02593:Or13a22 APN 7 140,073,244 (GRCm39) missense probably benign 0.04
IGL03108:Or13a22 APN 7 140,073,034 (GRCm39) missense possibly damaging 0.50
R1835:Or13a22 UTSW 7 140,072,622 (GRCm39) missense probably benign
R2040:Or13a22 UTSW 7 140,073,295 (GRCm39) missense probably benign 0.10
R3125:Or13a22 UTSW 7 140,072,764 (GRCm39) missense probably benign 0.01
R4795:Or13a22 UTSW 7 140,072,920 (GRCm39) missense probably damaging 1.00
R6187:Or13a22 UTSW 7 140,072,529 (GRCm39) start gained probably benign
R6285:Or13a22 UTSW 7 140,072,626 (GRCm39) missense possibly damaging 0.71
R6528:Or13a22 UTSW 7 140,072,964 (GRCm39) missense probably damaging 1.00
R7016:Or13a22 UTSW 7 140,073,153 (GRCm39) missense probably benign 0.01
R7573:Or13a22 UTSW 7 140,072,912 (GRCm39) missense probably damaging 1.00
R7867:Or13a22 UTSW 7 140,073,049 (GRCm39) missense probably benign 0.00
R8506:Or13a22 UTSW 7 140,073,336 (GRCm39) missense probably benign
R8822:Or13a22 UTSW 7 140,072,926 (GRCm39) missense possibly damaging 0.93
Predicted Primers PCR Primer
(F):5'- TGGATATTGTGTGCACCTCTTC -3'
(R):5'- GGTCAGCATGAAGTTGATGCC -3'

Sequencing Primer
(F):5'- CTGTGATTCCCAAGGCTCTGATTG -3'
(R):5'- CATGAAGTTGATGCCTCCATAAAAGG -3'
Posted On 2022-03-25