Mutagenetix > Incidental Mutation

Incidental Mutation 'R9316:Vmn2r75'

705879

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r75

Ensembl Gene

ENSMUSG00000090436

Gene Name

vomeronasal 2, receptor 75

Synonyms

EG546981

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.080) question?

Stock #

R9316 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

85797250-85820932 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 85797313 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Serine at position 833 (R833S)

Ref Sequence

ENSEMBL: ENSMUSP00000126973 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000167830]

AlphaFold

G5E8Z7

Predicted Effect

possibly damaging
Transcript: ENSMUST00000167830
AA Change: R833S

PolyPhen 2 Score 0.626 (Sensitivity: 0.87; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000126973
Gene: ENSMUSG00000090436
AA Change: R833S

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
Pfam:ANF_receptor	80	466	2.8e-31	PFAM
Pfam:NCD3G	510	562	4.6e-20	PFAM
Pfam:7tm_3	593	829	7.7e-51	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.7%

Validation Efficiency

91% (32/35)

Allele List at MGI

Other mutations in this stock

Total: 35 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Actr5	C	A	2: 158,477,274 (GRCm39)	N408K	probably benign	Het
AI661453	A	G	17: 47,747,832 (GRCm39)	I35V	probably benign	Het
Asb10	G	T	5: 24,745,045 (GRCm39)	N101K	possibly damaging	Het
Bpifa6	T	C	2: 153,828,383 (GRCm39)	V163A	possibly damaging	Het
Dmp1	G	T	5: 104,357,767 (GRCm39)	D36Y	probably benign	Het
Eef1d	T	A	15: 75,781,130 (GRCm39)		probably benign	Het
Gcm2	C	T	13: 41,259,328 (GRCm39)	R47H	probably damaging	Het
Gm7145	A	G	1: 117,896,174 (GRCm39)	N72S	probably benign	Het
Gpr45	T	A	1: 43,071,534 (GRCm39)	V59E	probably damaging	Het
Gucy1a1	T	C	3: 82,016,250 (GRCm39)	E246G	possibly damaging	Het
Hspa12a	C	T	19: 58,793,079 (GRCm39)	E369K	probably benign	Het
Iho1	T	C	9: 108,298,726 (GRCm39)	T31A	possibly damaging	Het
Il6st	T	A	13: 112,639,349 (GRCm39)	N652K	possibly damaging	Het
Kdm5a	T	A	6: 120,381,973 (GRCm39)	D672E	probably damaging	Het
Klk6	T	C	7: 43,477,912 (GRCm39)	S95P	probably benign	Het
Lrrc51	C	T	7: 101,562,351 (GRCm39)	R169H	probably damaging	Het
Or14c41	T	C	7: 86,235,134 (GRCm39)	V217A	probably benign	Het
Or3a4	A	T	11: 73,944,892 (GRCm39)	I231N	probably damaging	Het
Pacsin1	A	G	17: 27,924,707 (GRCm39)	K186E	possibly damaging	Het
Pate3	C	T	9: 35,557,374 (GRCm39)	C94Y	probably damaging	Het
Pcdh18	G	A	3: 49,709,089 (GRCm39)	T742M	probably damaging	Het
Pogz	T	A	3: 94,784,659 (GRCm39)	S779T	probably damaging	Het
Prep	A	T	10: 44,967,192 (GRCm39)	K75M	probably damaging	Het
Qsox2	T	G	2: 26,101,084 (GRCm39)	K475T	probably benign	Het
Qsox2	T	A	2: 26,101,085 (GRCm39)	K475*	probably null	Het
Rfng	A	T	11: 120,674,863 (GRCm39)	D42E	unknown	Het
Ripor2	C	T	13: 24,905,719 (GRCm39)	T955M	probably benign	Het
Ryr1	C	T	7: 28,717,387 (GRCm39)	E4554K	unknown	Het
Slco1a5	A	T	6: 142,195,935 (GRCm39)	L356H	probably damaging	Het
Tbc1d21	G	A	9: 58,274,215 (GRCm39)	A30V	probably benign	Het
Tmem161b	C	A	13: 84,430,855 (GRCm39)	H158N	possibly damaging	Het
Tmem217	A	G	17: 29,745,383 (GRCm39)	F116L	probably benign	Het
Tnfrsf13c	A	G	15: 82,108,021 (GRCm39)	I119T	probably benign	Het
Tpp2	G	A	1: 44,017,604 (GRCm39)	R736H	probably damaging	Het
Zfp330	A	G	8: 83,491,487 (GRCm39)	S229P	probably damaging	Het

Other mutations in Vmn2r75

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01133:Vmn2r75	APN	7	85,797,240 (GRCm39)	unclassified	probably benign
IGL01287:Vmn2r75	APN	7	85,797,801 (GRCm39)	missense	probably damaging	0.97
IGL01318:Vmn2r75	APN	7	85,814,774 (GRCm39)	missense	probably benign	0.06
IGL01331:Vmn2r75	APN	7	85,820,870 (GRCm39)	nonsense	probably null
IGL01406:Vmn2r75	APN	7	85,812,500 (GRCm39)	splice site	probably benign
IGL01615:Vmn2r75	APN	7	85,797,681 (GRCm39)	missense	probably benign	0.03
IGL01657:Vmn2r75	APN	7	85,813,455 (GRCm39)	missense	probably damaging	1.00
IGL02237:Vmn2r75	APN	7	85,814,786 (GRCm39)	missense	possibly damaging	0.88
IGL02275:Vmn2r75	APN	7	85,814,348 (GRCm39)	missense	probably benign	0.04
IGL02307:Vmn2r75	APN	7	85,814,974 (GRCm39)	missense	probably benign	0.00
IGL03136:Vmn2r75	APN	7	85,797,911 (GRCm39)	missense	possibly damaging	0.89
IGL03160:Vmn2r75	APN	7	85,797,644 (GRCm39)	missense	probably damaging	1.00
IGL03244:Vmn2r75	APN	7	85,820,933 (GRCm39)	unclassified	probably benign
PIT4449001:Vmn2r75	UTSW	7	85,814,791 (GRCm39)	missense	probably damaging	1.00
R0049:Vmn2r75	UTSW	7	85,797,309 (GRCm39)	nonsense	probably null
R0049:Vmn2r75	UTSW	7	85,797,309 (GRCm39)	nonsense	probably null
R0083:Vmn2r75	UTSW	7	85,814,866 (GRCm39)	missense	probably benign	0.00
R0108:Vmn2r75	UTSW	7	85,814,866 (GRCm39)	missense	probably benign	0.00
R0276:Vmn2r75	UTSW	7	85,797,515 (GRCm39)	missense	probably benign	0.01
R0320:Vmn2r75	UTSW	7	85,814,288 (GRCm39)	missense	probably benign	0.36
R0471:Vmn2r75	UTSW	7	85,814,721 (GRCm39)	missense	probably benign	0.01
R0562:Vmn2r75	UTSW	7	85,797,449 (GRCm39)	nonsense	probably null
R0631:Vmn2r75	UTSW	7	85,812,478 (GRCm39)	missense	probably null	1.00
R0661:Vmn2r75	UTSW	7	85,814,866 (GRCm39)	missense	probably benign	0.00
R0811:Vmn2r75	UTSW	7	85,814,575 (GRCm39)	missense	probably benign	0.38
R0812:Vmn2r75	UTSW	7	85,814,575 (GRCm39)	missense	probably benign	0.38
R0891:Vmn2r75	UTSW	7	85,813,476 (GRCm39)	missense	possibly damaging	0.81
R1340:Vmn2r75	UTSW	7	85,797,798 (GRCm39)	missense	probably damaging	0.98
R1501:Vmn2r75	UTSW	7	85,814,850 (GRCm39)	missense	possibly damaging	0.85
R1760:Vmn2r75	UTSW	7	85,798,019 (GRCm39)	missense	probably damaging	1.00
R1970:Vmn2r75	UTSW	7	85,797,470 (GRCm39)	missense	probably damaging	1.00
R2060:Vmn2r75	UTSW	7	85,814,372 (GRCm39)	missense	probably benign	0.00
R2292:Vmn2r75	UTSW	7	85,798,144 (GRCm39)	missense	probably damaging	1.00
R3688:Vmn2r75	UTSW	7	85,797,629 (GRCm39)	missense	probably damaging	0.99
R3892:Vmn2r75	UTSW	7	85,813,494 (GRCm39)	missense	probably null	1.00
R4532:Vmn2r75	UTSW	7	85,797,349 (GRCm39)	nonsense	probably null
R4583:Vmn2r75	UTSW	7	85,813,290 (GRCm39)	missense	possibly damaging	0.81
R4592:Vmn2r75	UTSW	7	85,815,494 (GRCm39)	missense	probably benign	0.00
R4792:Vmn2r75	UTSW	7	85,812,378 (GRCm39)	missense	possibly damaging	0.46
R4859:Vmn2r75	UTSW	7	85,797,611 (GRCm39)	missense	probably benign	0.35
R4896:Vmn2r75	UTSW	7	85,820,787 (GRCm39)	missense	probably benign	0.01
R4943:Vmn2r75	UTSW	7	85,814,705 (GRCm39)	missense	probably damaging	1.00
R4992:Vmn2r75	UTSW	7	85,815,375 (GRCm39)	critical splice donor site	probably null
R5048:Vmn2r75	UTSW	7	85,814,735 (GRCm39)	missense	possibly damaging	0.66
R5063:Vmn2r75	UTSW	7	85,813,372 (GRCm39)	missense	probably benign
R5156:Vmn2r75	UTSW	7	85,813,436 (GRCm39)	missense	possibly damaging	0.51
R5243:Vmn2r75	UTSW	7	85,813,447 (GRCm39)	missense	probably damaging	1.00
R5277:Vmn2r75	UTSW	7	85,815,500 (GRCm39)	missense	probably benign
R5574:Vmn2r75	UTSW	7	85,815,510 (GRCm39)	missense	probably benign	0.22
R5622:Vmn2r75	UTSW	7	85,797,702 (GRCm39)	missense	probably benign	0.15
R5680:Vmn2r75	UTSW	7	85,820,779 (GRCm39)	missense	probably benign	0.10
R5884:Vmn2r75	UTSW	7	85,814,578 (GRCm39)	missense	probably benign
R6021:Vmn2r75	UTSW	7	85,820,820 (GRCm39)	missense	probably benign	0.01
R6217:Vmn2r75	UTSW	7	85,815,375 (GRCm39)	critical splice donor site	probably benign
R6242:Vmn2r75	UTSW	7	85,814,592 (GRCm39)	missense	probably damaging	1.00
R6299:Vmn2r75	UTSW	7	85,814,482 (GRCm39)	missense	probably benign	0.12
R6441:Vmn2r75	UTSW	7	85,820,784 (GRCm39)	missense	probably damaging	0.99
R6495:Vmn2r75	UTSW	7	85,813,287 (GRCm39)	missense	probably benign	0.00
R6553:Vmn2r75	UTSW	7	85,813,453 (GRCm39)	missense	probably benign	0.28
R6670:Vmn2r75	UTSW	7	85,797,644 (GRCm39)	missense	probably damaging	1.00
R7078:Vmn2r75	UTSW	7	85,815,568 (GRCm39)	missense	probably damaging	1.00
R7164:Vmn2r75	UTSW	7	85,814,592 (GRCm39)	missense	probably damaging	1.00
R8411:Vmn2r75	UTSW	7	85,797,722 (GRCm39)	missense	probably damaging	1.00
R8507:Vmn2r75	UTSW	7	85,797,685 (GRCm39)	nonsense	probably null
R8559:Vmn2r75	UTSW	7	85,815,480 (GRCm39)	missense	possibly damaging	0.65
R8677:Vmn2r75	UTSW	7	85,814,410 (GRCm39)	missense	possibly damaging	0.86
R8708:Vmn2r75	UTSW	7	85,812,476 (GRCm39)	missense	probably damaging	0.99
R8778:Vmn2r75	UTSW	7	85,813,497 (GRCm39)	missense	probably benign	0.40
R8968:Vmn2r75	UTSW	7	85,820,765 (GRCm39)	nonsense	probably null
R9145:Vmn2r75	UTSW	7	85,813,447 (GRCm39)	missense	probably damaging	1.00
R9363:Vmn2r75	UTSW	7	85,815,423 (GRCm39)	missense	probably benign	0.03

Predicted Primers

PCR Primer
(F):5'- CCAATAAACTGAAATCCAGGTCATG -3'
(R):5'- AAGCTCTTGACATTTAGCATGC -3'

Sequencing Primer
(F):5'- CTGAAATCCAGGTCATGTGTTAG -3'
(R):5'- ACATTTAGCATGCTGGTGTTC -3'

Posted On

2022-03-25