Incidental Mutation 'R9316:Or14c41'
ID 705880
Institutional Source Beutler Lab
Gene Symbol Or14c41
Ensembl Gene ENSMUSG00000059319
Gene Name olfactory receptor family 14 subfamily C member 41
Synonyms Olfr295, GA_x6K02T2NHDJ-9539243-9538314, MOR220-1
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.069) question?
Stock # R9316 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 86234485-86235414 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 86235134 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 217 (V217A)
Ref Sequence ENSEMBL: ENSMUSP00000150377 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078447] [ENSMUST00000215365]
AlphaFold Q7TS08
Predicted Effect probably benign
Transcript: ENSMUST00000078447
AA Change: V217A

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000077542
Gene: ENSMUSG00000059319
AA Change: V217A

DomainStartEndE-ValueType
Pfam:7tm_1 39 288 6.1e-26 PFAM
Pfam:7tm_4 137 281 2.2e-40 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215365
AA Change: V217A

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency 91% (32/35)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actr5 C A 2: 158,477,274 (GRCm39) N408K probably benign Het
AI661453 A G 17: 47,747,832 (GRCm39) I35V probably benign Het
Asb10 G T 5: 24,745,045 (GRCm39) N101K possibly damaging Het
Bpifa6 T C 2: 153,828,383 (GRCm39) V163A possibly damaging Het
Dmp1 G T 5: 104,357,767 (GRCm39) D36Y probably benign Het
Eef1d T A 15: 75,781,130 (GRCm39) probably benign Het
Gcm2 C T 13: 41,259,328 (GRCm39) R47H probably damaging Het
Gm7145 A G 1: 117,896,174 (GRCm39) N72S probably benign Het
Gpr45 T A 1: 43,071,534 (GRCm39) V59E probably damaging Het
Gucy1a1 T C 3: 82,016,250 (GRCm39) E246G possibly damaging Het
Hspa12a C T 19: 58,793,079 (GRCm39) E369K probably benign Het
Iho1 T C 9: 108,298,726 (GRCm39) T31A possibly damaging Het
Il6st T A 13: 112,639,349 (GRCm39) N652K possibly damaging Het
Kdm5a T A 6: 120,381,973 (GRCm39) D672E probably damaging Het
Klk6 T C 7: 43,477,912 (GRCm39) S95P probably benign Het
Lrrc51 C T 7: 101,562,351 (GRCm39) R169H probably damaging Het
Or3a4 A T 11: 73,944,892 (GRCm39) I231N probably damaging Het
Pacsin1 A G 17: 27,924,707 (GRCm39) K186E possibly damaging Het
Pate3 C T 9: 35,557,374 (GRCm39) C94Y probably damaging Het
Pcdh18 G A 3: 49,709,089 (GRCm39) T742M probably damaging Het
Pogz T A 3: 94,784,659 (GRCm39) S779T probably damaging Het
Prep A T 10: 44,967,192 (GRCm39) K75M probably damaging Het
Qsox2 T G 2: 26,101,084 (GRCm39) K475T probably benign Het
Qsox2 T A 2: 26,101,085 (GRCm39) K475* probably null Het
Rfng A T 11: 120,674,863 (GRCm39) D42E unknown Het
Ripor2 C T 13: 24,905,719 (GRCm39) T955M probably benign Het
Ryr1 C T 7: 28,717,387 (GRCm39) E4554K unknown Het
Slco1a5 A T 6: 142,195,935 (GRCm39) L356H probably damaging Het
Tbc1d21 G A 9: 58,274,215 (GRCm39) A30V probably benign Het
Tmem161b C A 13: 84,430,855 (GRCm39) H158N possibly damaging Het
Tmem217 A G 17: 29,745,383 (GRCm39) F116L probably benign Het
Tnfrsf13c A G 15: 82,108,021 (GRCm39) I119T probably benign Het
Tpp2 G A 1: 44,017,604 (GRCm39) R736H probably damaging Het
Vmn2r75 T A 7: 85,797,313 (GRCm39) R833S possibly damaging Het
Zfp330 A G 8: 83,491,487 (GRCm39) S229P probably damaging Het
Other mutations in Or14c41
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01362:Or14c41 APN 7 86,234,647 (GRCm39) missense possibly damaging 0.91
IGL02248:Or14c41 APN 7 86,235,312 (GRCm39) nonsense probably null
IGL02309:Or14c41 APN 7 86,234,705 (GRCm39) missense possibly damaging 0.84
IGL02866:Or14c41 APN 7 86,234,901 (GRCm39) nonsense probably null
IGL03059:Or14c41 APN 7 86,234,779 (GRCm39) missense probably benign 0.00
IGL03134:Or14c41 UTSW 7 86,235,220 (GRCm39) missense probably damaging 0.99
R1311:Or14c41 UTSW 7 86,235,161 (GRCm39) missense probably damaging 0.96
R1777:Or14c41 UTSW 7 86,235,272 (GRCm39) missense probably benign
R2259:Or14c41 UTSW 7 86,235,092 (GRCm39) missense possibly damaging 0.80
R2379:Or14c41 UTSW 7 86,235,400 (GRCm39) missense probably benign
R5944:Or14c41 UTSW 7 86,234,486 (GRCm39) start codon destroyed probably null 1.00
R6213:Or14c41 UTSW 7 86,234,485 (GRCm39) start codon destroyed probably null 1.00
R6241:Or14c41 UTSW 7 86,235,245 (GRCm39) missense probably benign 0.35
R8730:Or14c41 UTSW 7 86,235,259 (GRCm39) missense probably benign 0.20
R9461:Or14c41 UTSW 7 86,235,247 (GRCm39) missense possibly damaging 0.79
Predicted Primers
Posted On 2022-03-25