Incidental Mutation 'R0738:Or5b102'
ID 70595
Institutional Source Beutler Lab
Gene Symbol Or5b102
Ensembl Gene ENSMUSG00000094986
Gene Name olfactory receptor family 5 subfamily B member 102
Synonyms MOR202-14, GA_x6K02T2RE5P-3390804-3391727, Olfr1454
MMRRC Submission 038919-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.079) question?
Stock # R0738 (G1)
Quality Score 225
Status Validated
Chromosome 19
Chromosomal Location 13040777-13041700 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 13041102 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Valine at position 109 (E109V)
Ref Sequence ENSEMBL: ENSMUSP00000148859 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073732] [ENSMUST00000213806] [ENSMUST00000214695] [ENSMUST00000217568]
AlphaFold Q8VFW2
Predicted Effect probably damaging
Transcript: ENSMUST00000073732
AA Change: E109V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000073409
Gene: ENSMUSG00000094986
AA Change: E109V

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 1.1e-50 PFAM
Pfam:7tm_1 39 288 2.7e-18 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213806
AA Change: E109V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000214695
AA Change: E109V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000217568
AA Change: E109V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 96.6%
  • 20x: 92.3%
Validation Efficiency 98% (46/47)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A930011G23Rik A T 5: 99,388,812 (GRCm39) M189K probably benign Het
Ank1 A T 8: 23,604,130 (GRCm39) E964D probably damaging Het
Ankhd1 A G 18: 36,778,302 (GRCm39) probably benign Het
Cd9 G T 6: 125,439,103 (GRCm39) Q169K probably benign Het
Cdc42bpa T A 1: 179,827,027 (GRCm39) probably benign Het
Ch25h T C 19: 34,451,787 (GRCm39) N247S possibly damaging Het
Dctn1 T C 6: 83,167,089 (GRCm39) probably null Het
Defa22 C T 8: 21,652,391 (GRCm39) T19I probably benign Het
Dscam T C 16: 96,620,981 (GRCm39) N576D possibly damaging Het
Epha3 T C 16: 63,415,975 (GRCm39) M675V probably damaging Het
Fam241a C A 3: 127,664,442 (GRCm39) A120S possibly damaging Het
Fkbp8 T A 8: 70,982,320 (GRCm39) I86N probably damaging Het
Herc4 C T 10: 63,124,928 (GRCm39) P514L possibly damaging Het
Ide A T 19: 37,255,364 (GRCm39) L813* probably null Het
Igkv12-41 G A 6: 69,835,675 (GRCm39) Q26* probably null Het
Itsn2 T C 12: 4,685,681 (GRCm39) V483A probably benign Het
Kcp A T 6: 29,490,438 (GRCm39) I1002N probably benign Het
Lrfn5 G T 12: 61,887,378 (GRCm39) E389* probably null Het
Lrp6 G T 6: 134,519,008 (GRCm39) A19E probably benign Het
Mad1l1 A G 5: 140,286,315 (GRCm39) L228P probably damaging Het
Map2 T C 1: 66,464,348 (GRCm39) probably benign Het
Med13l T A 5: 118,889,698 (GRCm39) Y1820N probably damaging Het
Mgam A G 6: 40,731,869 (GRCm39) N735S probably benign Het
Mid2 A G X: 139,664,425 (GRCm39) Y618C probably damaging Het
Mllt11 G A 3: 95,127,597 (GRCm39) Q58* probably null Het
Mttp A G 3: 137,809,074 (GRCm39) V678A probably damaging Het
Nfatc1 A G 18: 80,741,125 (GRCm39) S278P probably damaging Het
Ninj2 A G 6: 120,175,098 (GRCm39) probably benign Het
Nsd3 T A 8: 26,168,725 (GRCm39) probably null Het
Or8c17 T C 9: 38,180,421 (GRCm39) V204A possibly damaging Het
Pcdhb4 A G 18: 37,441,764 (GRCm39) N358S probably damaging Het
Plch1 T C 3: 63,609,974 (GRCm39) probably benign Het
Popdc3 T C 10: 45,191,354 (GRCm39) L155P probably damaging Het
Ptpro T A 6: 137,420,592 (GRCm39) V1007D probably damaging Het
Rbm26 A T 14: 105,414,218 (GRCm39) I24N unknown Het
Rc3h2 T A 2: 37,295,386 (GRCm39) D210V probably damaging Het
Samd1 CGAGGAGGAGGAGGAGGAGGA CGAGGAGGAGGAGGAGGA 8: 84,725,625 (GRCm39) probably benign Het
Spopl T C 2: 23,427,533 (GRCm39) T200A probably benign Het
Tarbp1 A G 8: 127,165,540 (GRCm39) probably null Het
Thnsl1 T A 2: 21,218,173 (GRCm39) H121Q probably damaging Het
Tll1 T C 8: 64,554,984 (GRCm39) D233G probably damaging Het
Vmn2r27 A T 6: 124,200,661 (GRCm39) V432E possibly damaging Het
Wdr5 T C 2: 27,409,424 (GRCm39) S49P probably damaging Het
Zfyve26 A T 12: 79,342,308 (GRCm39) I46N probably damaging Het
Other mutations in Or5b102
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01598:Or5b102 APN 19 13,041,513 (GRCm39) missense probably damaging 1.00
IGL02942:Or5b102 APN 19 13,041,552 (GRCm39) missense probably benign 0.45
IGL03331:Or5b102 APN 19 13,041,231 (GRCm39) missense probably damaging 1.00
R0551:Or5b102 UTSW 19 13,041,658 (GRCm39) missense probably benign 0.01
R1532:Or5b102 UTSW 19 13,041,639 (GRCm39) missense probably damaging 1.00
R2072:Or5b102 UTSW 19 13,041,044 (GRCm39) missense probably benign 0.00
R2092:Or5b102 UTSW 19 13,041,166 (GRCm39) nonsense probably null
R2656:Or5b102 UTSW 19 13,041,348 (GRCm39) missense probably benign 0.05
R2850:Or5b102 UTSW 19 13,040,934 (GRCm39) missense probably damaging 1.00
R4212:Or5b102 UTSW 19 13,041,123 (GRCm39) missense probably damaging 0.98
R5303:Or5b102 UTSW 19 13,041,139 (GRCm39) nonsense probably null
R6362:Or5b102 UTSW 19 13,040,709 (GRCm39) start gained probably benign
R6928:Or5b102 UTSW 19 13,041,348 (GRCm39) missense probably benign 0.05
R7183:Or5b102 UTSW 19 13,041,680 (GRCm39) missense probably benign 0.00
R7701:Or5b102 UTSW 19 13,041,445 (GRCm39) missense probably damaging 1.00
R7741:Or5b102 UTSW 19 13,041,423 (GRCm39) missense probably damaging 0.98
R8057:Or5b102 UTSW 19 13,040,638 (GRCm39) start gained probably benign
R8272:Or5b102 UTSW 19 13,040,795 (GRCm39) missense possibly damaging 0.47
R8534:Or5b102 UTSW 19 13,041,432 (GRCm39) missense probably damaging 1.00
R8769:Or5b102 UTSW 19 13,041,307 (GRCm39) nonsense probably null
R9400:Or5b102 UTSW 19 13,041,139 (GRCm39) nonsense probably null
R9511:Or5b102 UTSW 19 13,041,119 (GRCm39) missense probably damaging 0.99
R9651:Or5b102 UTSW 19 13,041,256 (GRCm39) missense probably benign 0.01
Z1176:Or5b102 UTSW 19 13,041,010 (GRCm39) missense probably benign 0.15
Predicted Primers PCR Primer
(F):5'- AGGAAATCTTGGGCTGATCCTGTTG -3'
(R):5'- TGGACTACATTGGACTCACAGAAGGAG -3'

Sequencing Primer
(F):5'- TTGGATTCTCGGCTCCACAC -3'
(R):5'- CAGAAGGAGAGACTTAATGCATCTAC -3'
Posted On 2013-09-30