Mutagenetix > Incidental Mutation

Incidental Mutation 'R9318:Olfr804'

705981

Institutional Source

Beutler Lab

Gene Symbol

Olfr804

Ensembl Gene

ENSMUSG00000095401

Gene Name

olfactory receptor 804

Synonyms

MOR110-7, GA_x6K02T2PULF-11383575-11384519

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.092) question?

Stock #

R9318 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

129703210-129710018 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 129705414 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 179 (T179A)

Ref Sequence

ENSEMBL: ENSMUSP00000150132 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000077312] [ENSMUST00000213331]

AlphaFold

Q7TRH7

Predicted Effect

probably benign
Transcript: ENSMUST00000077312
AA Change: T179A

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000076540
Gene: ENSMUSG00000095401
AA Change: T179A

Domain	Start	End	E-Value	Type
Pfam:7tm_4	29	306	6e-48	PFAM
Pfam:7tm_1	39	288	3.3e-23	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000213331
AA Change: T179A

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.8%

Validation Efficiency

99% (76/77)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 79 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamts20	A	G	15: 94,403,440	S68P	possibly damaging	Het
Adcy6	A	T	15: 98,593,585	N1044K	possibly damaging	Het
Ak9	T	G	10: 41,423,085	M1594R	unknown	Het
Angpt1	A	G	15: 42,438,355	I419T	probably benign	Het
Ankrd31	A	T	13: 96,878,577	L1451F	probably benign	Het
Ap1b1	T	C	11: 5,040,157	I860T	probably benign	Het
Apc	G	A	18: 34,313,987	R1312Q	possibly damaging	Het
Cadps2	A	G	6: 23,496,888	Y453H	probably benign	Het
Carmil2	A	G	8: 105,687,854	T148A	probably benign	Het
Ccdc125	A	G	13: 100,696,412	Y499C	probably damaging	Het
Ccdc14	A	G	16: 34,704,918	M194V	possibly damaging	Het
Ccdc162	C	A	10: 41,630,114	M893I	probably benign	Het
Ccdc33	C	A	9: 58,086,593	W335L	possibly damaging	Het
Chn2	T	A	6: 54,295,855	Y355N	probably damaging	Het
Chst13	G	A	6: 90,309,524	P152L	probably damaging	Het
Clec4g	A	G	8: 3,716,500	M267T	probably damaging	Het
Clybl	G	A	14: 122,371,403	V136I	probably damaging	Het
Ctnnd1	G	T	2: 84,608,338	Q877K	probably benign	Het
Derl3	A	G	10: 75,894,014	K94R	probably null	Het
Dnah2	T	C	11: 69,484,329	E1356G	probably benign	Het
Dnah5	A	C	15: 28,203,908		probably benign	Het
Dusp19	T	A	2: 80,631,000	V211E	probably benign	Het
Entpd7	T	A	19: 43,704,270	V88E	possibly damaging	Het
Fam114a1	T	A	5: 64,995,884	S140T	possibly damaging	Het
Fbxw13	A	G	9: 109,179,314	F456L	probably benign	Het
Fpr-rs4	A	T	17: 18,021,955	M75L	probably benign	Het
Gm11639	T	C	11: 104,965,822		probably null	Het
Grb14	T	G	2: 65,022,641	T2P	probably damaging	Het
Hace1	T	A	10: 45,652,673	S337T	probably benign	Het
Heatr5b	C	T	17: 78,765,402	V1611I	probably benign	Het
Hist2h2be	T	C	3: 96,221,365	V67A	probably benign	Het
Ints6	A	T	14: 62,696,698	S787T	probably benign	Het
Itga9	A	G	9: 118,626,468	K70R	probably benign	Het
Kcnt2	T	C	1: 140,425,195	I214T	probably damaging	Het
Kdelr3	C	A	15: 79,527,074	L203I	probably benign	Het
Kpnb1	A	G	11: 97,163,458	M842T	probably benign	Het
Lamc1	G	T	1: 153,252,000	R386S	probably damaging	Het
Lctl	A	G	9: 64,119,257		probably benign	Het
Lrrn3	G	A	12: 41,453,244	P358L	probably damaging	Het
Mag	T	C	7: 30,900,368	H582R	possibly damaging	Het
Megf9	A	T	4: 70,435,454	C372S	probably damaging	Het
Mfsd11	T	C	11: 116,859,572	F139S	probably damaging	Het
Mpst	G	T	15: 78,410,442	V125L	probably damaging	Het
Myo15b	T	C	11: 115,885,139	V587A	probably benign	Het
Myod1	A	T	7: 46,376,932	H87L	probably damaging	Het
Oacyl	G	T	18: 65,725,344	V247L	probably benign	Het
Olfr1116	A	C	2: 87,268,927	T49P	possibly damaging	Het
Olfr136	A	T	17: 38,335,429	T91S	possibly damaging	Het
Olfr177	A	G	16: 58,872,385	L255P	probably damaging	Het
Olfr181	A	T	16: 58,925,908	I221N	probably damaging	Het
Olfr350	G	A	2: 36,850,553	C169Y	probably benign	Het
Olfr598	T	A	7: 103,329,376	Y297N	probably damaging	Het
Olfr676	T	C	7: 105,035,623	Y142H	probably damaging	Het
Olfr917	A	G	9: 38,665,284	S187P	possibly damaging	Het
Olfr983	A	C	9: 40,092,816	I50S	possibly damaging	Het
Pde3a	T	C	6: 141,479,476	F666S	probably benign	Het
Phf20	G	A	2: 156,273,770	R337H	probably benign	Het
Plcg2	G	A	8: 117,596,368	E721K	probably benign	Het
Prkg1	T	A	19: 30,571,638	T646S	probably benign	Het
Prr27	C	A	5: 87,843,135	P202Q	probably benign	Het
Prss16	C	A	13: 22,006,938	A206S	possibly damaging	Het
Prss37	A	T	6: 40,514,975	Y224N	probably damaging	Het
Ptprt	A	G	2: 161,575,778	L926S	probably benign	Het
Rgl1	G	A	1: 152,524,703	T649I	possibly damaging	Het
Rgs3	C	A	4: 62,640,782	D504E	probably benign	Het
Rp1	C	T	1: 4,348,265	A875T	probably benign	Het
Rpl9-ps1	T	A	11: 83,645,351	K91*	probably null	Het
Slc44a2	A	G	9: 21,341,972	Y65C	probably damaging	Het
Snw1	T	C	12: 87,458,904	K255E	probably damaging	Het
Sox6	T	C	7: 115,662,322	I220V	probably benign	Het
Synpo2	A	T	3: 123,080,056	I1146N	probably damaging	Het
Tas2r115	T	C	6: 132,737,509	R160G	probably benign	Het
Tchh	T	C	3: 93,446,744	F1164L	unknown	Het
Tmem110	T	A	14: 30,866,682	V122E	probably damaging	Het
Trim58	T	C	11: 58,651,267	V351A	probably damaging	Het
Ttf1	T	C	2: 29,074,654	S663P	possibly damaging	Het
Wdr59	A	G	8: 111,451,068	Y920H		Het
Zfp418	A	G	7: 7,182,436	Y466C	probably damaging	Het
Zfp827	A	T	8: 79,118,353	R717S	possibly damaging	Het

Other mutations in Olfr804

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01613:Olfr804	APN	10	129705623	missense	probably benign	0.01
IGL02041:Olfr804	APN	10	129705235	missense	probably damaging	1.00
IGL02245:Olfr804	APN	10	129705739	missense	probably damaging	1.00
IGL02341:Olfr804	APN	10	129705489	missense	probably damaging	0.99
IGL02433:Olfr804	APN	10	129705576	missense	probably benign	0.01
authen	UTSW	10	129705799	missense	probably benign	0.00
R0111:Olfr804	UTSW	10	129705277	missense	probably damaging	1.00
R0309:Olfr804	UTSW	10	129705139	missense	probably benign	0.38
R0326:Olfr804	UTSW	10	129705769	missense	possibly damaging	0.69
R0374:Olfr804	UTSW	10	129705647	missense	probably benign	0.00
R1573:Olfr804	UTSW	10	129705618	missense	probably damaging	1.00
R1663:Olfr804	UTSW	10	129705291	missense	probably benign	0.44
R1778:Olfr804	UTSW	10	129705705	missense	probably benign	0.01
R1789:Olfr804	UTSW	10	129705607	missense	possibly damaging	0.82
R1906:Olfr804	UTSW	10	129705496	missense	probably benign	0.00
R2108:Olfr804	UTSW	10	129705621	missense	probably benign
R2211:Olfr804	UTSW	10	129705451	missense	probably benign
R2432:Olfr804	UTSW	10	129704925	missense	possibly damaging	0.91
R2902:Olfr804	UTSW	10	129705451	missense	probably benign
R4114:Olfr804	UTSW	10	129705799	missense	probably benign	0.00
R5149:Olfr804	UTSW	10	129705508	missense	probably benign	0.00
R5153:Olfr804	UTSW	10	129705157	missense	probably benign	0.05
R5846:Olfr804	UTSW	10	129704887	missense	probably damaging	0.99
R6553:Olfr804	UTSW	10	129705063	missense	probably benign	0.07
R7676:Olfr804	UTSW	10	129705286	missense	possibly damaging	0.63
R8161:Olfr804	UTSW	10	129704884	missense	possibly damaging	0.94
R9266:Olfr804	UTSW	10	129705678	missense	probably benign	0.17
R9334:Olfr804	UTSW	10	129705814	missense	probably benign	0.00
R9746:Olfr804	UTSW	10	129705339	missense	probably damaging	0.97

Predicted Primers

PCR Primer
(F):5'- TGGCTGCCATGTCCTATGAC -3'
(R):5'- ACAACAATCATGTGGGAAGTGC -3'

Sequencing Primer
(F):5'- GCCATGTCCTATGACCGCTATG -3'
(R):5'- CAATCATGTGGGAAGTGCAGGTG -3'

Posted On

2022-03-25