Mutagenetix > Incidental Mutation

Incidental Mutation 'R9323:Or10g7'

706327

Institutional Source

Beutler Lab

Gene Symbol

Or10g7

Ensembl Gene

ENSMUSG00000044292

Gene Name

olfactory receptor family 10 subfamily G member 7

Synonyms

GA_x6K02T2PVTD-33692287-33693222, MOR223-3, Olfr978

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.149) question?

Stock #

R9323 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

39905108-39906043 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 39905360 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 85 (S85P)

Ref Sequence

ENSEMBL: ENSMUSP00000151115 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000057161] [ENSMUST00000215523] [ENSMUST00000217600]

AlphaFold

E9Q985

Predicted Effect

possibly damaging
Transcript: ENSMUST00000057161
AA Change: S85P

PolyPhen 2 Score 0.878 (Sensitivity: 0.82; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000060106
Gene: ENSMUSG00000044292
AA Change: S85P

Domain	Start	End	E-Value	Type
Pfam:7tm_4	29	303	3.2e-56	PFAM
Pfam:7tm_1	39	287	1.4e-24	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000215523

Predicted Effect

possibly damaging
Transcript: ENSMUST00000217600
AA Change: S85P

PolyPhen 2 Score 0.878 (Sensitivity: 0.82; Specificity: 0.94)

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.0%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 62 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abat	G	A	16: 8,420,235 (GRCm39)	W178*	probably null	Het
Alx1	G	A	10: 102,858,124 (GRCm39)	R192*	probably null	Het
Apom	A	G	17: 35,350,633 (GRCm39)	C23R	probably damaging	Het
Asap2	A	G	12: 21,162,148 (GRCm39)	N35S	probably benign	Het
Atf6	A	T	1: 170,682,682 (GRCm39)	Y43*	probably null	Het
Atosa	C	T	9: 74,883,415 (GRCm39)		probably benign	Het
Bag4	T	C	8: 26,261,361 (GRCm39)	S127G	possibly damaging	Het
Bag4	G	T	8: 26,275,180 (GRCm39)	S7*	probably null	Het
Ccdc88b	A	G	19: 6,826,475 (GRCm39)	L1080P	probably damaging	Het
Cdcp3	T	A	7: 130,828,401 (GRCm39)	N285K	probably damaging	Het
Cdkl2	A	T	5: 92,168,107 (GRCm39)	D362E	probably benign	Het
Cep170	A	G	1: 176,586,068 (GRCm39)	S575P	probably benign	Het
Col4a2	C	T	8: 11,493,413 (GRCm39)	P1374L	possibly damaging	Het
Cpt2	T	C	4: 107,761,556 (GRCm39)	H617R	probably benign	Het
Cyp2d22	A	G	15: 82,258,207 (GRCm39)	S138P	probably damaging	Het
Cyp2j11	T	C	4: 96,195,619 (GRCm39)	D359G	probably benign	Het
Ddb2	T	C	2: 91,042,337 (GRCm39)	S419G	possibly damaging	Het
Dmrtc2	A	T	7: 24,572,341 (GRCm39)	I121F	probably benign	Het
Dus1l	C	T	11: 120,684,724 (GRCm39)	R149H	probably damaging	Het
Fam90a1a	T	A	8: 22,453,640 (GRCm39)	Y332N	probably benign	Het
Fbxo47	A	T	11: 97,770,254 (GRCm39)	V46D	probably benign	Het
Grep1	A	G	17: 23,937,387 (GRCm39)	S54P	unknown	Het
Grpel1	T	A	5: 36,628,007 (GRCm39)	V96E	possibly damaging	Het
Ifi207	A	T	1: 173,555,143 (GRCm39)	N853K	probably damaging	Het
Igkv4-80	C	T	6: 68,993,751 (GRCm39)	A47T	probably damaging	Het
Il1a	T	A	2: 129,149,826 (GRCm39)	I25F	probably benign	Het
Ireb2	T	A	9: 54,811,523 (GRCm39)		probably null	Het
Itpr1	A	G	6: 108,328,979 (GRCm39)	Y131C	probably damaging	Het
Kmt2a	T	C	9: 44,731,261 (GRCm39)		probably benign	Het
Lancl1	T	A	1: 67,077,794 (GRCm39)		probably benign	Het
Lpl	G	A	8: 69,340,196 (GRCm39)	V64M	possibly damaging	Het
Marchf10	T	C	11: 105,280,581 (GRCm39)	H568R	probably damaging	Het
Mib1	G	A	18: 10,775,685 (GRCm39)	V546M	probably damaging	Het
Mss51	A	T	14: 20,534,939 (GRCm39)	I277N	probably benign	Het
Mybpc1	A	G	10: 88,360,829 (GRCm39)		probably null	Het
Myct1	A	C	10: 5,554,195 (GRCm39)	I21L	probably benign	Het
Myo5c	C	A	9: 75,153,531 (GRCm39)	A139E	probably damaging	Het
Nlrp4e	C	G	7: 23,020,755 (GRCm39)	A414G	probably benign	Het
Npy2r	A	T	3: 82,447,728 (GRCm39)	I349N	possibly damaging	Het
Nrap	T	C	19: 56,378,255 (GRCm39)	I19V	probably benign	Het
Or14j2	A	C	17: 37,886,135 (GRCm39)	Y60D	probably damaging	Het
Or52n20	T	C	7: 104,320,220 (GRCm39)	F104L	possibly damaging	Het
Or5p6	C	T	7: 107,631,230 (GRCm39)	V107I	probably benign	Het
Or6c3b	A	T	10: 129,527,829 (GRCm39)	V27D	probably benign	Het
Or8d23	T	C	9: 38,841,818 (GRCm39)	V117A	probably benign	Het
Pde6b	A	T	5: 108,551,298 (GRCm39)	N194I	probably damaging	Het
Polg	TCTGGATGA	TCTGGATGACTGGATGA	7: 79,114,779 (GRCm39)		probably null	Het
Polg	GA	GACTGGAGCA	7: 79,114,786 (GRCm39)		probably null	Het
Ptpn9	T	C	9: 56,934,701 (GRCm39)	M155T	possibly damaging	Het
Ret	A	G	6: 118,158,975 (GRCm39)	Y146H	probably benign	Het
Sdf2l1	T	C	16: 16,949,498 (GRCm39)	H116R	probably damaging	Het
Shld2	A	G	14: 33,981,596 (GRCm39)	V514A	probably damaging	Het
Slc37a1	T	C	17: 31,552,643 (GRCm39)	I316T	probably damaging	Het
Slc4a11	A	C	2: 130,528,830 (GRCm39)	L473R	possibly damaging	Het
Smg7	A	G	1: 152,731,753 (GRCm39)	M344T	probably benign	Het
Smg9	T	C	7: 24,114,465 (GRCm39)	L268P	probably damaging	Het
Tiparp	C	T	3: 65,439,272 (GRCm39)	T196I	probably benign	Het
Trappc12	A	G	12: 28,742,491 (GRCm39)		probably null	Het
Trappc9	A	T	15: 72,565,431 (GRCm39)	N953K	probably benign	Het
Trpa1	A	G	1: 14,968,564 (GRCm39)	V428A	probably benign	Het
Utp20	T	C	10: 88,583,170 (GRCm39)	R2728G	probably damaging	Het
Zfp612	A	G	8: 110,815,372 (GRCm39)	E193G	probably benign	Het

Other mutations in Or10g7

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01570:Or10g7	APN	9	39,905,625 (GRCm39)	missense	probably damaging	0.99
IGL02429:Or10g7	APN	9	39,905,138 (GRCm39)	missense	probably benign
IGL02887:Or10g7	APN	9	39,905,109 (GRCm39)	start codon destroyed	probably null	0.99
R0190:Or10g7	UTSW	9	39,905,840 (GRCm39)	missense	probably benign	0.01
R0355:Or10g7	UTSW	9	39,905,459 (GRCm39)	missense	possibly damaging	0.72
R1348:Or10g7	UTSW	9	39,905,124 (GRCm39)	missense	probably benign
R1856:Or10g7	UTSW	9	39,905,655 (GRCm39)	missense	probably benign	0.29
R3853:Or10g7	UTSW	9	39,905,450 (GRCm39)	missense	probably damaging	0.99
R3886:Or10g7	UTSW	9	39,905,835 (GRCm39)	missense	probably damaging	1.00
R5678:Or10g7	UTSW	9	39,905,199 (GRCm39)	missense	probably benign	0.00
R5994:Or10g7	UTSW	9	39,905,519 (GRCm39)	nonsense	probably null
R6185:Or10g7	UTSW	9	39,905,420 (GRCm39)	missense	probably benign	0.19
R6721:Or10g7	UTSW	9	39,905,603 (GRCm39)	missense	possibly damaging	0.55
R7414:Or10g7	UTSW	9	39,905,349 (GRCm39)	missense	possibly damaging	0.53
R7556:Or10g7	UTSW	9	39,905,978 (GRCm39)	missense	probably damaging	1.00
R8192:Or10g7	UTSW	9	39,905,467 (GRCm39)	missense	probably damaging	1.00
R8422:Or10g7	UTSW	9	39,905,850 (GRCm39)	missense	probably damaging	0.99
X0025:Or10g7	UTSW	9	39,905,240 (GRCm39)	missense	possibly damaging	0.62

Predicted Primers

PCR Primer
(F):5'- GGACTCCATGCTCTTTGGGATC -3'
(R):5'- TGTAGTCTGGACAGCAGAGTG -3'

Sequencing Primer
(F):5'- CATGCTCTTTGGGATCTTCCTTGTG -3'
(R):5'- GGAACCAGTGAACCATGTTCCTG -3'

Posted On

2022-04-18