Incidental Mutation 'R9324:Ces1g'
ID 706389
Institutional Source Beutler Lab
Gene Symbol Ces1g
Ensembl Gene ENSMUSG00000057074
Gene Name carboxylesterase 1G
Synonyms Ses-1, Ces-1, Ces1
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.064) question?
Stock # R9324 (G1)
Quality Score 225.009
Status Not validated
Chromosome 8
Chromosomal Location 94028997-94063837 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 94055118 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 193 (D193G)
Ref Sequence ENSEMBL: ENSMUSP00000037555 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000044602]
AlphaFold Q8VCC2
Predicted Effect probably damaging
Transcript: ENSMUST00000044602
AA Change: D193G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000037555
Gene: ENSMUSG00000057074
AA Change: D193G

DomainStartEndE-ValueType
Pfam:COesterase 1 545 3.6e-168 PFAM
Pfam:Abhydrolase_3 136 295 5.7e-11 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. The expression and activity of this gene is age-related but independent of growth hormone level. This gene is clustered with Ces7 and Ces3 on chromosome 8. [provided by RefSeq, Jun 2010]
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsm2 A G 7: 119,179,856 (GRCm39) H358R probably benign Het
Arid3c A G 4: 41,730,138 (GRCm39) L19S possibly damaging Het
Arpp21 T A 9: 111,986,765 (GRCm39) D262V probably damaging Het
Atp4a A C 7: 30,415,207 (GRCm39) I276L probably benign Het
Axl C G 7: 25,460,982 (GRCm39) E676Q probably damaging Het
Crym A G 7: 119,789,005 (GRCm39) V274A probably damaging Het
Efcab5 T A 11: 77,004,546 (GRCm39) H924L possibly damaging Het
Eif1ad7 T A 12: 88,238,709 (GRCm39) N17I unknown Het
Eif3l T A 15: 78,978,423 (GRCm39) M560K probably benign Het
Fam234b C A 6: 135,202,793 (GRCm39) Y382* probably null Het
Fbxw19 T C 9: 109,313,440 (GRCm39) K253E possibly damaging Het
Fhip1a T C 3: 85,638,053 (GRCm39) D82G probably benign Het
Flt3 A G 5: 147,313,790 (GRCm39) S87P probably benign Het
Garin3 A T 11: 46,295,810 (GRCm39) I61F Het
Ggnbp2 A G 11: 84,725,174 (GRCm39) L627S probably damaging Het
Gm26661 T G 14: 7,791,765 (GRCm38) V60G unknown Het
Golt1a T C 1: 133,247,094 (GRCm39) L34P probably damaging Het
Gp5 T C 16: 30,127,808 (GRCm39) M289V possibly damaging Het
Gpr63 C G 4: 25,008,432 (GRCm39) H385Q possibly damaging Het
Hcn1 G A 13: 118,111,901 (GRCm39) V622I unknown Het
Hipk4 A G 7: 27,228,834 (GRCm39) D428G probably damaging Het
Hs3st1 T C 5: 39,772,145 (GRCm39) Y166C probably damaging Het
Hsd17b3 A G 13: 64,206,459 (GRCm39) F281S possibly damaging Het
Ifih1 T C 2: 62,475,950 (GRCm39) T109A probably benign Het
Ighv1-64 T A 12: 115,471,645 (GRCm39) probably benign Het
Ina T C 19: 47,003,816 (GRCm39) L208P Het
Iqcn C T 8: 71,161,794 (GRCm39) T329I possibly damaging Het
Irak2 T C 6: 113,615,604 (GRCm39) probably null Het
Klhl10 G A 11: 100,338,481 (GRCm39) E407K probably benign Het
Krt81 A G 15: 101,361,335 (GRCm39) S82P probably damaging Het
Ktn1 C A 14: 47,948,353 (GRCm39) Q963K probably benign Het
Lgalsl2 G A 7: 5,362,527 (GRCm39) V53I possibly damaging Het
Lrrc42 A T 4: 107,104,913 (GRCm39) Y17* probably null Het
Lrrc9 A C 12: 72,496,171 (GRCm39) E15D probably damaging Het
Mak G A 13: 41,202,839 (GRCm39) T203I probably benign Het
Masp2 T C 4: 148,692,485 (GRCm39) V326A possibly damaging Het
Mdc1 T C 17: 36,164,258 (GRCm39) S1269P probably benign Het
Mink1 G A 11: 70,502,477 (GRCm39) V1027M probably damaging Het
Mrps10 C A 17: 47,686,903 (GRCm39) S123* probably null Het
Myl10 C T 5: 136,729,787 (GRCm39) H142Y probably damaging Het
Ncan T C 8: 70,560,648 (GRCm39) Q773R possibly damaging Het
Nlrp3 T A 11: 59,434,141 (GRCm39) M68K probably damaging Het
Ntrk1 C T 3: 87,698,745 (GRCm39) V99M possibly damaging Het
Odad3 T C 9: 21,903,207 (GRCm39) E402G probably damaging Het
Or4p22 C T 2: 88,317,787 (GRCm39) T237I probably damaging Het
Or5an1 A G 19: 12,260,939 (GRCm39) R176G probably benign Het
Or8c8 A G 9: 38,164,962 (GRCm39) K80R probably benign Het
Phldb2 A G 16: 45,595,437 (GRCm39) V830A probably damaging Het
Phospho2 T C 2: 69,625,913 (GRCm39) V23A probably damaging Het
Plxnc1 G A 10: 94,780,685 (GRCm39) probably benign Het
Ppcdc T C 9: 57,342,280 (GRCm39) E14G probably benign Het
Ralgapa2 T C 2: 146,302,645 (GRCm39) Y106C probably damaging Het
Rgs22 T C 15: 36,087,544 (GRCm39) Q582R probably benign Het
Rngtt T A 4: 33,320,613 (GRCm39) Y53* probably null Het
Slc12a3 T G 8: 95,083,028 (GRCm39) probably null Het
Slc26a11 A G 11: 119,267,730 (GRCm39) T456A probably benign Het
Slc26a5 G T 5: 22,018,334 (GRCm39) A677E possibly damaging Het
Smurf1 T C 5: 144,817,463 (GRCm39) T690A probably benign Het
Spata24 A T 18: 35,790,064 (GRCm39) N142K probably damaging Het
Ubqlnl A T 7: 103,798,962 (GRCm39) N178K possibly damaging Het
Uggt2 A G 14: 119,312,741 (GRCm39) probably null Het
Vmn1r2 C A 4: 3,172,678 (GRCm39) A199D probably damaging Het
Vmn2r39 T C 7: 9,030,684 (GRCm39) N128S probably damaging Het
Vmn2r61 G T 7: 41,916,619 (GRCm39) V411F probably benign Het
Vmn2r-ps117 T A 17: 19,042,911 (GRCm39) F106L probably benign Het
Zfp503 A T 14: 22,035,353 (GRCm39) I521N possibly damaging Het
Zfp831 T C 2: 174,547,113 (GRCm39) V1432A probably benign Het
Zfp981 T A 4: 146,619,884 (GRCm39) L13I possibly damaging Het
Other mutations in Ces1g
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00841:Ces1g APN 8 94,029,615 (GRCm39) missense possibly damaging 0.61
IGL00971:Ces1g APN 8 94,029,660 (GRCm39) missense probably damaging 1.00
IGL01583:Ces1g APN 8 94,033,587 (GRCm39) missense probably damaging 1.00
IGL02993:Ces1g APN 8 94,043,707 (GRCm39) missense probably benign 0.00
IGL03386:Ces1g APN 8 94,052,440 (GRCm39) missense probably benign 0.00
R0359:Ces1g UTSW 8 94,055,163 (GRCm39) splice site probably benign
R0373:Ces1g UTSW 8 94,057,821 (GRCm39) missense probably benign 0.06
R0499:Ces1g UTSW 8 94,060,317 (GRCm39) missense probably benign 0.01
R0689:Ces1g UTSW 8 94,055,035 (GRCm39) missense probably damaging 1.00
R1756:Ces1g UTSW 8 94,033,582 (GRCm39) missense probably benign 0.03
R3052:Ces1g UTSW 8 94,061,676 (GRCm39) missense possibly damaging 0.50
R3150:Ces1g UTSW 8 94,052,444 (GRCm39) missense probably benign 0.45
R3899:Ces1g UTSW 8 94,029,678 (GRCm39) missense probably damaging 1.00
R3966:Ces1g UTSW 8 94,055,139 (GRCm39) missense possibly damaging 0.50
R4134:Ces1g UTSW 8 94,046,500 (GRCm39) missense probably benign 0.00
R4198:Ces1g UTSW 8 94,032,496 (GRCm39) missense probably benign 0.11
R4332:Ces1g UTSW 8 94,046,446 (GRCm39) missense probably benign 0.01
R4719:Ces1g UTSW 8 94,043,718 (GRCm39) missense possibly damaging 0.59
R4841:Ces1g UTSW 8 94,060,323 (GRCm39) missense probably benign 0.01
R4842:Ces1g UTSW 8 94,060,323 (GRCm39) missense probably benign 0.01
R4843:Ces1g UTSW 8 94,057,893 (GRCm39) missense probably damaging 1.00
R5344:Ces1g UTSW 8 94,063,821 (GRCm39) start gained probably benign
R5405:Ces1g UTSW 8 94,032,496 (GRCm39) missense probably benign 0.29
R5425:Ces1g UTSW 8 94,052,428 (GRCm39) missense probably benign 0.20
R5884:Ces1g UTSW 8 94,033,558 (GRCm39) missense probably benign 0.24
R6022:Ces1g UTSW 8 94,055,085 (GRCm39) missense probably damaging 1.00
R6183:Ces1g UTSW 8 94,057,867 (GRCm39) missense possibly damaging 0.48
R6197:Ces1g UTSW 8 94,063,764 (GRCm39) missense probably benign 0.01
R6307:Ces1g UTSW 8 94,057,820 (GRCm39) missense possibly damaging 0.60
R6688:Ces1g UTSW 8 94,033,600 (GRCm39) missense possibly damaging 0.92
R6863:Ces1g UTSW 8 94,043,647 (GRCm39) missense possibly damaging 0.92
R7097:Ces1g UTSW 8 94,043,665 (GRCm39) missense possibly damaging 0.89
R7122:Ces1g UTSW 8 94,043,665 (GRCm39) missense possibly damaging 0.89
R7180:Ces1g UTSW 8 94,029,576 (GRCm39) missense probably benign 0.04
R7202:Ces1g UTSW 8 94,029,595 (GRCm39) missense probably benign 0.01
R7361:Ces1g UTSW 8 94,060,307 (GRCm39) missense not run
R7537:Ces1g UTSW 8 94,046,455 (GRCm39) missense probably benign 0.01
R7621:Ces1g UTSW 8 94,055,094 (GRCm39) missense probably damaging 1.00
R8200:Ces1g UTSW 8 94,055,085 (GRCm39) missense probably damaging 1.00
R8895:Ces1g UTSW 8 94,046,512 (GRCm39) missense possibly damaging 0.83
R9248:Ces1g UTSW 8 94,060,319 (GRCm39) missense possibly damaging 0.62
R9290:Ces1g UTSW 8 94,029,545 (GRCm39) missense probably benign 0.07
R9361:Ces1g UTSW 8 94,061,646 (GRCm39) critical splice donor site probably null
R9565:Ces1g UTSW 8 94,061,792 (GRCm39) missense probably benign 0.06
R9615:Ces1g UTSW 8 94,061,807 (GRCm39) missense probably damaging 1.00
Z1176:Ces1g UTSW 8 94,052,439 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- TGAACCCAGGTCATGAGAGC -3'
(R):5'- AGAGCTGCAGGTGAACACTC -3'

Sequencing Primer
(F):5'- CAGGTCATGAGAGCAAAGGTTCC -3'
(R):5'- ACACTCTCATCAGTGATGTGGAGC -3'
Posted On 2022-04-18