Incidental Mutation 'R9324:Plxnc1'
ID 706396
Institutional Source Beutler Lab
Gene Symbol Plxnc1
Ensembl Gene ENSMUSG00000074785
Gene Name plexin C1
Synonyms 2510048K12Rik, vespr, CD232
MMRRC Submission
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.472) question?
Stock # R9324 (G1)
Quality Score 140.008
Status Not validated
Chromosome 10
Chromosomal Location 94626728-94780697 bp(-) (GRCm39)
Type of Mutation start gained
DNA Base Change (assembly) G to A at 94780685 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000096939 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099337]
AlphaFold Q9QZC2
Predicted Effect probably benign
Transcript: ENSMUST00000099337
SMART Domains Protein: ENSMUSP00000096939
Gene: ENSMUSG00000074785

DomainStartEndE-ValueType
signal peptide 1 34 N/A INTRINSIC
Pfam:Sema 87 431 5.5e-10 PFAM
PSI 454 507 5.28e-12 SMART
PSI 590 634 1.07e-3 SMART
Pfam:TIG 665 752 3.7e-9 PFAM
IPT 755 847 5.14e-7 SMART
IPT 849 954 1.8e-2 SMART
low complexity region 978 997 N/A INTRINSIC
Pfam:Plexin_cytopl 1018 1541 1.4e-199 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the plexin family. Plexins are transmembrane receptors for semaphorins, a large family of proteins that regulate axon guidance, cell motility and migration, and the immune response. The encoded protein and its ligand regulate melanocyte adhesion, and viral semaphorins may modulate the immune response by binding to this receptor. The encoded protein may be a tumor suppressor protein for melanoma. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2011]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit abnormal neuron morphology and migration. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsm2 A G 7: 119,179,856 (GRCm39) H358R probably benign Het
Arid3c A G 4: 41,730,138 (GRCm39) L19S possibly damaging Het
Arpp21 T A 9: 111,986,765 (GRCm39) D262V probably damaging Het
Atp4a A C 7: 30,415,207 (GRCm39) I276L probably benign Het
Axl C G 7: 25,460,982 (GRCm39) E676Q probably damaging Het
Ces1g T C 8: 94,055,118 (GRCm39) D193G probably damaging Het
Crym A G 7: 119,789,005 (GRCm39) V274A probably damaging Het
Efcab5 T A 11: 77,004,546 (GRCm39) H924L possibly damaging Het
Eif1ad7 T A 12: 88,238,709 (GRCm39) N17I unknown Het
Eif3l T A 15: 78,978,423 (GRCm39) M560K probably benign Het
Fam234b C A 6: 135,202,793 (GRCm39) Y382* probably null Het
Fbxw19 T C 9: 109,313,440 (GRCm39) K253E possibly damaging Het
Fhip1a T C 3: 85,638,053 (GRCm39) D82G probably benign Het
Flt3 A G 5: 147,313,790 (GRCm39) S87P probably benign Het
Garin3 A T 11: 46,295,810 (GRCm39) I61F Het
Ggnbp2 A G 11: 84,725,174 (GRCm39) L627S probably damaging Het
Gm26661 T G 14: 7,791,765 (GRCm38) V60G unknown Het
Golt1a T C 1: 133,247,094 (GRCm39) L34P probably damaging Het
Gp5 T C 16: 30,127,808 (GRCm39) M289V possibly damaging Het
Gpr63 C G 4: 25,008,432 (GRCm39) H385Q possibly damaging Het
Hcn1 G A 13: 118,111,901 (GRCm39) V622I unknown Het
Hipk4 A G 7: 27,228,834 (GRCm39) D428G probably damaging Het
Hs3st1 T C 5: 39,772,145 (GRCm39) Y166C probably damaging Het
Hsd17b3 A G 13: 64,206,459 (GRCm39) F281S possibly damaging Het
Ifih1 T C 2: 62,475,950 (GRCm39) T109A probably benign Het
Ighv1-64 T A 12: 115,471,645 (GRCm39) probably benign Het
Ina T C 19: 47,003,816 (GRCm39) L208P Het
Iqcn C T 8: 71,161,794 (GRCm39) T329I possibly damaging Het
Irak2 T C 6: 113,615,604 (GRCm39) probably null Het
Klhl10 G A 11: 100,338,481 (GRCm39) E407K probably benign Het
Krt81 A G 15: 101,361,335 (GRCm39) S82P probably damaging Het
Ktn1 C A 14: 47,948,353 (GRCm39) Q963K probably benign Het
Lgalsl2 G A 7: 5,362,527 (GRCm39) V53I possibly damaging Het
Lrrc42 A T 4: 107,104,913 (GRCm39) Y17* probably null Het
Lrrc9 A C 12: 72,496,171 (GRCm39) E15D probably damaging Het
Mak G A 13: 41,202,839 (GRCm39) T203I probably benign Het
Masp2 T C 4: 148,692,485 (GRCm39) V326A possibly damaging Het
Mdc1 T C 17: 36,164,258 (GRCm39) S1269P probably benign Het
Mink1 G A 11: 70,502,477 (GRCm39) V1027M probably damaging Het
Mrps10 C A 17: 47,686,903 (GRCm39) S123* probably null Het
Myl10 C T 5: 136,729,787 (GRCm39) H142Y probably damaging Het
Ncan T C 8: 70,560,648 (GRCm39) Q773R possibly damaging Het
Nlrp3 T A 11: 59,434,141 (GRCm39) M68K probably damaging Het
Ntrk1 C T 3: 87,698,745 (GRCm39) V99M possibly damaging Het
Odad3 T C 9: 21,903,207 (GRCm39) E402G probably damaging Het
Or4p22 C T 2: 88,317,787 (GRCm39) T237I probably damaging Het
Or5an1 A G 19: 12,260,939 (GRCm39) R176G probably benign Het
Or8c8 A G 9: 38,164,962 (GRCm39) K80R probably benign Het
Phldb2 A G 16: 45,595,437 (GRCm39) V830A probably damaging Het
Phospho2 T C 2: 69,625,913 (GRCm39) V23A probably damaging Het
Ppcdc T C 9: 57,342,280 (GRCm39) E14G probably benign Het
Ralgapa2 T C 2: 146,302,645 (GRCm39) Y106C probably damaging Het
Rgs22 T C 15: 36,087,544 (GRCm39) Q582R probably benign Het
Rngtt T A 4: 33,320,613 (GRCm39) Y53* probably null Het
Slc12a3 T G 8: 95,083,028 (GRCm39) probably null Het
Slc26a11 A G 11: 119,267,730 (GRCm39) T456A probably benign Het
Slc26a5 G T 5: 22,018,334 (GRCm39) A677E possibly damaging Het
Smurf1 T C 5: 144,817,463 (GRCm39) T690A probably benign Het
Spata24 A T 18: 35,790,064 (GRCm39) N142K probably damaging Het
Ubqlnl A T 7: 103,798,962 (GRCm39) N178K possibly damaging Het
Uggt2 A G 14: 119,312,741 (GRCm39) probably null Het
Vmn1r2 C A 4: 3,172,678 (GRCm39) A199D probably damaging Het
Vmn2r39 T C 7: 9,030,684 (GRCm39) N128S probably damaging Het
Vmn2r61 G T 7: 41,916,619 (GRCm39) V411F probably benign Het
Vmn2r-ps117 T A 17: 19,042,911 (GRCm39) F106L probably benign Het
Zfp503 A T 14: 22,035,353 (GRCm39) I521N possibly damaging Het
Zfp831 T C 2: 174,547,113 (GRCm39) V1432A probably benign Het
Zfp981 T A 4: 146,619,884 (GRCm39) L13I possibly damaging Het
Other mutations in Plxnc1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00843:Plxnc1 APN 10 94,683,411 (GRCm39) missense probably benign 0.25
IGL01285:Plxnc1 APN 10 94,635,230 (GRCm39) missense probably damaging 0.99
IGL01867:Plxnc1 APN 10 94,634,008 (GRCm39) missense possibly damaging 0.61
IGL01994:Plxnc1 APN 10 94,685,801 (GRCm39) missense probably damaging 1.00
IGL02083:Plxnc1 APN 10 94,758,587 (GRCm39) missense possibly damaging 0.61
IGL02250:Plxnc1 APN 10 94,706,893 (GRCm39) missense probably benign 0.00
IGL02429:Plxnc1 APN 10 94,718,453 (GRCm39) missense probably benign 0.00
IGL02752:Plxnc1 APN 10 94,630,542 (GRCm39) splice site probably null
IGL02973:Plxnc1 APN 10 94,646,546 (GRCm39) missense probably damaging 1.00
R0230:Plxnc1 UTSW 10 94,635,209 (GRCm39) missense probably benign 0.07
R0265:Plxnc1 UTSW 10 94,648,991 (GRCm39) missense probably benign 0.14
R0271:Plxnc1 UTSW 10 94,673,780 (GRCm39) missense probably null 1.00
R0299:Plxnc1 UTSW 10 94,685,683 (GRCm39) critical splice donor site probably null
R0361:Plxnc1 UTSW 10 94,700,869 (GRCm39) missense probably damaging 1.00
R0441:Plxnc1 UTSW 10 94,632,344 (GRCm39) missense probably damaging 1.00
R0558:Plxnc1 UTSW 10 94,673,797 (GRCm39) missense probably damaging 1.00
R0617:Plxnc1 UTSW 10 94,635,230 (GRCm39) missense probably damaging 1.00
R0671:Plxnc1 UTSW 10 94,635,194 (GRCm39) missense possibly damaging 0.63
R0692:Plxnc1 UTSW 10 94,673,362 (GRCm39) critical splice donor site probably null
R0751:Plxnc1 UTSW 10 94,667,195 (GRCm39) splice site probably benign
R1184:Plxnc1 UTSW 10 94,667,195 (GRCm39) splice site probably benign
R1260:Plxnc1 UTSW 10 94,667,227 (GRCm39) missense probably damaging 0.99
R1680:Plxnc1 UTSW 10 94,677,413 (GRCm39) missense probably benign 0.14
R1746:Plxnc1 UTSW 10 94,680,041 (GRCm39) splice site probably null
R1750:Plxnc1 UTSW 10 94,635,359 (GRCm39) missense probably damaging 1.00
R1751:Plxnc1 UTSW 10 94,685,677 (GRCm39) unclassified probably benign
R1768:Plxnc1 UTSW 10 94,680,184 (GRCm39) missense probably benign 0.05
R1876:Plxnc1 UTSW 10 94,702,803 (GRCm39) missense possibly damaging 0.94
R2004:Plxnc1 UTSW 10 94,688,484 (GRCm39) missense probably damaging 0.98
R2031:Plxnc1 UTSW 10 94,779,529 (GRCm39) missense probably benign 0.26
R2184:Plxnc1 UTSW 10 94,780,131 (GRCm39) missense probably damaging 1.00
R2437:Plxnc1 UTSW 10 94,742,395 (GRCm39) missense probably benign 0.02
R2927:Plxnc1 UTSW 10 94,629,154 (GRCm39) critical splice acceptor site probably null
R3001:Plxnc1 UTSW 10 94,629,080 (GRCm39) missense probably damaging 0.98
R3002:Plxnc1 UTSW 10 94,629,080 (GRCm39) missense probably damaging 0.98
R3003:Plxnc1 UTSW 10 94,629,080 (GRCm39) missense probably damaging 0.98
R3441:Plxnc1 UTSW 10 94,706,872 (GRCm39) missense probably benign 0.00
R3849:Plxnc1 UTSW 10 94,630,294 (GRCm39) missense probably benign 0.01
R3884:Plxnc1 UTSW 10 94,746,549 (GRCm39) splice site probably null
R4004:Plxnc1 UTSW 10 94,630,459 (GRCm39) nonsense probably null
R4679:Plxnc1 UTSW 10 94,630,306 (GRCm39) missense probably damaging 1.00
R4730:Plxnc1 UTSW 10 94,703,330 (GRCm39) intron probably benign
R4937:Plxnc1 UTSW 10 94,677,335 (GRCm39) missense probably damaging 1.00
R5068:Plxnc1 UTSW 10 94,635,239 (GRCm39) missense possibly damaging 0.91
R5345:Plxnc1 UTSW 10 94,685,831 (GRCm39) missense probably benign 0.26
R5397:Plxnc1 UTSW 10 94,679,614 (GRCm39) missense probably benign 0.08
R5416:Plxnc1 UTSW 10 94,673,416 (GRCm39) missense probably damaging 1.00
R5485:Plxnc1 UTSW 10 94,758,604 (GRCm39) missense probably benign 0.00
R5543:Plxnc1 UTSW 10 94,700,636 (GRCm39) missense probably benign
R5826:Plxnc1 UTSW 10 94,635,335 (GRCm39) critical splice donor site probably null
R6007:Plxnc1 UTSW 10 94,629,152 (GRCm39) missense possibly damaging 0.88
R6018:Plxnc1 UTSW 10 94,779,710 (GRCm39) missense probably benign 0.21
R6052:Plxnc1 UTSW 10 94,779,635 (GRCm39) missense probably benign 0.13
R6291:Plxnc1 UTSW 10 94,669,504 (GRCm39) splice site probably null
R6653:Plxnc1 UTSW 10 94,779,738 (GRCm39) missense probably damaging 1.00
R6984:Plxnc1 UTSW 10 94,667,392 (GRCm39) missense probably damaging 1.00
R7086:Plxnc1 UTSW 10 94,667,297 (GRCm39) missense probably benign
R7401:Plxnc1 UTSW 10 94,706,867 (GRCm39) missense probably benign
R7727:Plxnc1 UTSW 10 94,779,971 (GRCm39) missense probably damaging 1.00
R7789:Plxnc1 UTSW 10 94,630,339 (GRCm39) missense probably damaging 1.00
R7803:Plxnc1 UTSW 10 94,779,377 (GRCm39) critical splice donor site probably null
R7809:Plxnc1 UTSW 10 94,630,302 (GRCm39) missense probably damaging 1.00
R7882:Plxnc1 UTSW 10 94,679,698 (GRCm39) missense probably benign
R8103:Plxnc1 UTSW 10 94,706,944 (GRCm39) missense probably benign
R8226:Plxnc1 UTSW 10 94,669,230 (GRCm39) missense possibly damaging 0.90
R8273:Plxnc1 UTSW 10 94,649,105 (GRCm39) missense probably benign 0.14
R8299:Plxnc1 UTSW 10 94,663,041 (GRCm39) missense probably benign 0.35
R8392:Plxnc1 UTSW 10 94,637,352 (GRCm39) missense possibly damaging 0.75
R8758:Plxnc1 UTSW 10 94,758,607 (GRCm39) missense possibly damaging 0.91
R8806:Plxnc1 UTSW 10 94,635,140 (GRCm39) missense probably damaging 1.00
R8882:Plxnc1 UTSW 10 94,677,428 (GRCm39) missense probably damaging 1.00
R8893:Plxnc1 UTSW 10 94,685,709 (GRCm39) missense probably benign 0.35
R8956:Plxnc1 UTSW 10 94,746,448 (GRCm39) missense probably benign 0.00
R9040:Plxnc1 UTSW 10 94,779,379 (GRCm39) nonsense probably null
R9102:Plxnc1 UTSW 10 94,663,107 (GRCm39) missense probably damaging 1.00
R9225:Plxnc1 UTSW 10 94,629,061 (GRCm39) missense probably damaging 1.00
R9368:Plxnc1 UTSW 10 94,700,599 (GRCm39) nonsense probably null
R9375:Plxnc1 UTSW 10 94,649,093 (GRCm39) missense probably benign 0.20
R9430:Plxnc1 UTSW 10 94,758,544 (GRCm39) missense probably benign 0.01
R9460:Plxnc1 UTSW 10 94,700,895 (GRCm39) missense probably benign
R9498:Plxnc1 UTSW 10 94,649,004 (GRCm39) missense possibly damaging 0.48
RF003:Plxnc1 UTSW 10 94,630,306 (GRCm39) missense probably damaging 1.00
RF045:Plxnc1 UTSW 10 94,700,869 (GRCm39) missense probably damaging 1.00
RF046:Plxnc1 UTSW 10 94,700,869 (GRCm39) missense probably damaging 1.00
RF047:Plxnc1 UTSW 10 94,700,869 (GRCm39) missense probably damaging 1.00
X0024:Plxnc1 UTSW 10 94,700,577 (GRCm39) critical splice donor site probably null
Z1176:Plxnc1 UTSW 10 94,700,891 (GRCm39) missense probably benign 0.16
Predicted Primers PCR Primer
(F):5'- TCCGATGGCTTGCTCAGATC -3'
(R):5'- TTATGAATAGATGAAAGAGGCCACC -3'

Sequencing Primer
(F):5'- GCTTGCTCAGATCGCCACAC -3'
(R):5'- CGATCTCACCGAATCAAGAAGGG -3'
Posted On 2022-04-18