Incidental Mutation 'R9326:Nxt2'
ID 706554
Institutional Source Beutler Lab
Gene Symbol Nxt2
Ensembl Gene ENSMUSG00000042271
Gene Name nuclear transport factor 2-like export factor 2
Synonyms P15-2, 6330587F24Rik
MMRRC Submission
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.279) question?
Stock # R9326 (G1)
Quality Score 221.999
Status Validated
Chromosome X
Chromosomal Location 141009766-141022688 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 141020747 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Valine at position 118 (A118V)
Ref Sequence ENSEMBL: ENSMUSP00000108536 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000042329] [ENSMUST00000112913] [ENSMUST00000112914] [ENSMUST00000112916]
AlphaFold Q3UNA4
Predicted Effect possibly damaging
Transcript: ENSMUST00000042329
AA Change: A118V

PolyPhen 2 Score 0.779 (Sensitivity: 0.85; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000048221
Gene: ENSMUSG00000042271
AA Change: A118V

DomainStartEndE-ValueType
Pfam:NTF2 17 136 3.5e-31 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000112913
AA Change: A90V

PolyPhen 2 Score 0.779 (Sensitivity: 0.85; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000108535
Gene: ENSMUSG00000042271
AA Change: A90V

DomainStartEndE-ValueType
Pfam:NTF2 1 108 1.4e-25 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000112914
AA Change: A118V

PolyPhen 2 Score 0.779 (Sensitivity: 0.85; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000108536
Gene: ENSMUSG00000042271
AA Change: A118V

DomainStartEndE-ValueType
Pfam:NTF2 17 136 3.5e-31 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000112916
AA Change: A174V

PolyPhen 2 Score 0.754 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000108538
Gene: ENSMUSG00000042271
AA Change: A174V

DomainStartEndE-ValueType
Pfam:NTF2 73 192 1.5e-31 PFAM
Meta Mutation Damage Score 0.4261 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency 100% (66/66)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene contains a nuclear transport factor 2 (NTF2) domain, which plays an important role in the trafficking of macromolecules, ions, and small molecules between the cytoplasm and nucleus. This protein may also have a role in mRNA nuclear export. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jun 2011]
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310057J18Rik A T 10: 28,849,882 (GRCm39) Y230* probably null Het
Adamts14 A G 10: 61,036,238 (GRCm39) S1015P probably benign Het
Adamts8 A G 9: 30,854,886 (GRCm39) T252A probably benign Het
Adamtsl1 T A 4: 86,150,804 (GRCm39) S149T possibly damaging Het
Afp A G 5: 90,652,205 (GRCm39) K399E probably damaging Het
Atp8b1 T A 18: 64,706,344 (GRCm39) S222C probably damaging Het
Ccdc88c C A 12: 100,995,109 (GRCm39) probably benign Het
Cfap276 C T 3: 108,451,931 (GRCm39) R159W probably damaging Het
Cip2a G A 16: 48,834,235 (GRCm39) probably null Het
Cluh A G 11: 74,554,902 (GRCm39) K780R probably benign Het
Cope C A 8: 70,755,516 (GRCm39) F20L possibly damaging Het
Cps1 G T 1: 67,248,795 (GRCm39) R1174L probably damaging Het
Csmd1 G A 8: 16,049,803 (GRCm39) T2271I probably benign Het
Ctbp2 A G 7: 132,616,359 (GRCm39) I192T probably benign Het
Dcun1d4 A G 5: 73,680,018 (GRCm39) T106A probably benign Het
Ddb2 A T 2: 91,047,559 (GRCm39) M240K probably benign Het
Ddx20 A T 3: 105,591,735 (GRCm39) V145D probably damaging Het
Ddx31 A G 2: 28,749,008 (GRCm39) D268G probably damaging Het
Drc7 A G 8: 95,801,886 (GRCm39) I716V probably benign Het
Epb41l4a G T 18: 33,961,261 (GRCm39) Y424* probably null Het
Exog A G 9: 119,291,554 (GRCm39) N277S probably damaging Het
Fzd7 T C 1: 59,522,837 (GRCm39) L240P possibly damaging Het
Gpr87 T C 3: 59,086,609 (GRCm39) T299A probably damaging Het
Hecw2 A G 1: 54,079,369 (GRCm39) Y95H probably damaging Het
Idh1 T C 1: 65,205,416 (GRCm39) Y183C probably damaging Het
Ighv14-4 T A 12: 114,140,469 (GRCm39) I7F possibly damaging Het
Il1rap A T 16: 26,495,641 (GRCm39) I83F probably damaging Het
Jag1 A G 2: 136,931,745 (GRCm39) S609P probably benign Het
Klhl33 T C 14: 51,134,615 (GRCm39) E9G possibly damaging Het
Lama2 A G 10: 26,906,193 (GRCm39) F2421L probably benign Het
Lmod2 A T 6: 24,597,999 (GRCm39) I40F probably damaging Het
Lsm5 A T 6: 56,681,616 (GRCm39) L13Q possibly damaging Het
Man2c1 G T 9: 57,042,904 (GRCm39) C258F probably damaging Het
Mgst1 T C 6: 138,120,023 (GRCm39) S28P probably benign Het
Msh3 A T 13: 92,400,307 (GRCm39) V744E probably benign Het
Mtx2 C T 2: 74,656,287 (GRCm39) probably benign Het
N4bp3 C T 11: 51,535,313 (GRCm39) R292H probably benign Het
Neto2 A T 8: 86,369,063 (GRCm39) W354R probably damaging Het
Nicn1 C T 9: 108,171,708 (GRCm39) R163C possibly damaging Het
Nos1 G C 5: 118,017,402 (GRCm39) R255P probably benign Het
Nup98 C A 7: 101,788,037 (GRCm39) R1011L probably benign Het
Nutm1 A T 2: 112,078,692 (GRCm39) S1074R possibly damaging Het
Or10ag56 T A 2: 87,139,730 (GRCm39) M219K probably benign Het
Or5aq1 T C 2: 86,966,647 (GRCm39) H6R probably benign Het
Or7g29 A T 9: 19,286,346 (GRCm39) M277K probably damaging Het
Or8s8 T C 15: 98,354,935 (GRCm39) V248A probably damaging Het
Pi4kb T A 3: 94,900,506 (GRCm39) probably null Het
Rgsl1 C T 1: 153,679,768 (GRCm39) D103N probably benign Het
Rrbp1 G A 2: 143,806,744 (GRCm39) T958M probably damaging Het
S100a13 G T 3: 90,423,170 (GRCm39) D54Y unknown Het
Setd2 T C 9: 110,378,671 (GRCm39) C829R probably benign Het
Snd1 A T 6: 28,795,842 (GRCm39) R562* probably null Het
Snx27 A T 3: 94,409,369 (GRCm39) Y526N probably damaging Het
Stab2 A G 10: 86,791,010 (GRCm39) L483P probably damaging Het
Sybu A G 15: 44,537,019 (GRCm39) S436P probably damaging Het
Thy1 A G 9: 43,957,983 (GRCm39) D37G probably damaging Het
Tmed8 A T 12: 87,221,395 (GRCm39) I126N probably damaging Het
Tmem161b T A 13: 84,440,602 (GRCm39) L340* probably null Het
Tpr C T 1: 150,301,407 (GRCm39) A1331V possibly damaging Het
Tprg1 G A 16: 25,136,107 (GRCm39) E33K probably benign Het
Vps26b T C 9: 26,930,627 (GRCm39) N123D probably damaging Het
Wdr7 G A 18: 63,872,260 (GRCm39) S398N probably benign Het
Zbtb48 T C 4: 152,111,509 (GRCm39) D2G probably damaging Het
Zfp975 G A 7: 42,311,837 (GRCm39) R259* probably null Het
Zfp986 T A 4: 145,626,451 (GRCm39) H370Q probably damaging Het
Other mutations in Nxt2
AlleleSourceChrCoordTypePredicted EffectPPH Score
R9016:Nxt2 UTSW X 141,020,747 (GRCm39) missense possibly damaging 0.78
R9018:Nxt2 UTSW X 141,020,747 (GRCm39) missense possibly damaging 0.78
R9064:Nxt2 UTSW X 141,020,747 (GRCm39) missense possibly damaging 0.78
R9065:Nxt2 UTSW X 141,020,747 (GRCm39) missense possibly damaging 0.78
R9066:Nxt2 UTSW X 141,020,747 (GRCm39) missense possibly damaging 0.78
R9114:Nxt2 UTSW X 141,020,747 (GRCm39) missense possibly damaging 0.78
R9115:Nxt2 UTSW X 141,020,747 (GRCm39) missense possibly damaging 0.78
R9144:Nxt2 UTSW X 141,020,747 (GRCm39) missense possibly damaging 0.78
R9145:Nxt2 UTSW X 141,020,747 (GRCm39) missense possibly damaging 0.78
R9146:Nxt2 UTSW X 141,020,747 (GRCm39) missense possibly damaging 0.78
R9147:Nxt2 UTSW X 141,020,747 (GRCm39) missense possibly damaging 0.78
R9148:Nxt2 UTSW X 141,020,747 (GRCm39) missense possibly damaging 0.78
R9149:Nxt2 UTSW X 141,020,747 (GRCm39) missense possibly damaging 0.78
R9327:Nxt2 UTSW X 141,020,747 (GRCm39) missense possibly damaging 0.78
R9480:Nxt2 UTSW X 141,020,747 (GRCm39) missense possibly damaging 0.78
R9521:Nxt2 UTSW X 141,020,747 (GRCm39) missense possibly damaging 0.78
X0064:Nxt2 UTSW X 141,012,590 (GRCm39) start codon destroyed probably null 1.00
Predicted Primers PCR Primer
(F):5'- GGATGCCTGCTTAAAGTACAGAATAG -3'
(R):5'- CCAAACTGGCAGCTGATCTAG -3'

Sequencing Primer
(F):5'- GCTAAAGAGCAAGCTACCC -3'
(R):5'- TGGACCAATAGAGTGGGT -3'
Posted On 2022-04-18