Incidental Mutation 'R9329:Vmn2r73'
| ID |
706722 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r73
|
| Ensembl Gene |
ENSMUSG00000070458 |
| Gene Name |
vomeronasal 2, receptor 73 |
| Synonyms |
EG620928 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.172)
|
| Stock # |
R9329 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
85506755-85525146 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 85519073 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Serine
at position 516
(R516S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000076687
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000077478]
|
| AlphaFold |
D3Z7M3 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000077478
AA Change: R516S
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000076687
Gene: ENSMUSG00000070458
AA Change: R516S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
465 |
1.4e-30 |
PFAM |
|
Pfam:NCD3G
|
508 |
560 |
5.9e-21 |
PFAM |
|
Pfam:7tm_3
|
590 |
827 |
4.4e-51 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.4%
|
| Validation Efficiency |
99% (73/74) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 72 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700003E16Rik |
T |
G |
6: 83,133,556 (GRCm39) |
M1R |
probably null |
Het |
| Acap2 |
T |
C |
16: 30,946,238 (GRCm39) |
D235G |
probably damaging |
Het |
| Adgrv1 |
C |
A |
13: 81,647,241 (GRCm39) |
V3100F |
probably damaging |
Het |
| Aff4 |
A |
G |
11: 53,288,686 (GRCm39) |
T401A |
probably damaging |
Het |
| Apcs |
T |
C |
1: 172,722,391 (GRCm39) |
T22A |
probably benign |
Het |
| Atf7ip2 |
T |
C |
16: 10,059,738 (GRCm39) |
V426A |
possibly damaging |
Het |
| Bach2 |
A |
G |
4: 32,562,175 (GRCm39) |
D214G |
possibly damaging |
Het |
| Baz2a |
C |
T |
10: 127,960,925 (GRCm39) |
A1578V |
possibly damaging |
Het |
| Camk1d |
T |
C |
2: 5,449,954 (GRCm39) |
I76V |
probably benign |
Het |
| Ccdc182 |
A |
T |
11: 88,185,324 (GRCm39) |
M135L |
probably benign |
Het |
| Cd47 |
C |
T |
16: 49,716,731 (GRCm39) |
T201I |
|
Het |
| Chodl |
T |
C |
16: 78,746,030 (GRCm39) |
S290P |
possibly damaging |
Het |
| Chst15 |
A |
G |
7: 131,868,520 (GRCm39) |
L300P |
possibly damaging |
Het |
| Ciita |
T |
C |
16: 10,324,571 (GRCm39) |
S168P |
probably damaging |
Het |
| Cntn2 |
C |
T |
1: 132,456,678 (GRCm39) |
V123I |
probably benign |
Het |
| Cyld |
T |
A |
8: 89,457,348 (GRCm39) |
L527Q |
probably benign |
Het |
| Dbn1 |
T |
A |
13: 55,631,241 (GRCm39) |
Y34F |
probably damaging |
Het |
| Enc1 |
C |
A |
13: 97,383,018 (GRCm39) |
Y509* |
probably null |
Het |
| Ermard |
A |
T |
17: 15,273,643 (GRCm39) |
E409D |
probably benign |
Het |
| Extl3 |
T |
C |
14: 65,314,765 (GRCm39) |
E139G |
possibly damaging |
Het |
| Fa2h |
A |
T |
8: 112,082,115 (GRCm39) |
V177E |
possibly damaging |
Het |
| Flot2 |
T |
C |
11: 77,949,772 (GRCm39) |
I367T |
probably damaging |
Het |
| Fras1 |
T |
C |
5: 96,884,813 (GRCm39) |
Y2564H |
probably damaging |
Het |
| Fxyd3 |
A |
G |
7: 30,773,018 (GRCm39) |
V10A |
probably benign |
Het |
| Gfra3 |
A |
G |
18: 34,837,560 (GRCm39) |
L146P |
probably damaging |
Het |
| Gm49359 |
T |
C |
13: 62,602,448 (GRCm39) |
N251D |
probably benign |
Het |
| Hps6 |
A |
G |
19: 45,992,542 (GRCm39) |
S160G |
probably benign |
Het |
| Hsd17b7 |
C |
A |
1: 169,794,875 (GRCm39) |
A55S |
probably damaging |
Het |
| Hspa12a |
T |
C |
19: 58,789,298 (GRCm39) |
D446G |
probably benign |
Het |
| Htt |
G |
A |
5: 34,989,957 (GRCm39) |
R1163Q |
possibly damaging |
Het |
| Ift81 |
T |
C |
5: 122,697,833 (GRCm39) |
|
probably null |
Het |
| Ighv5-15 |
T |
G |
12: 113,790,395 (GRCm39) |
Y75S |
probably benign |
Het |
| Kcnd2 |
T |
A |
6: 21,725,981 (GRCm39) |
H491Q |
probably damaging |
Het |
| Lamb3 |
C |
A |
1: 193,014,665 (GRCm39) |
T608K |
probably benign |
Het |
| Lrtm2 |
T |
A |
6: 119,297,412 (GRCm39) |
K210* |
probably null |
Het |
| Med13 |
G |
T |
11: 86,189,283 (GRCm39) |
P1209T |
probably benign |
Het |
| Mtus1 |
G |
A |
8: 41,537,239 (GRCm39) |
T159I |
probably damaging |
Het |
| Myt1l |
A |
G |
12: 29,901,659 (GRCm39) |
M805V |
unknown |
Het |
| Neb |
G |
T |
2: 52,160,231 (GRCm39) |
L2261I |
probably benign |
Het |
| Nlrp4c |
G |
A |
7: 6,068,498 (GRCm39) |
R133H |
probably benign |
Het |
| Nol11 |
A |
T |
11: 107,071,765 (GRCm39) |
L276Q |
probably damaging |
Het |
| Nrap |
A |
G |
19: 56,350,277 (GRCm39) |
Y614H |
probably damaging |
Het |
| Or13c9 |
G |
A |
4: 52,936,211 (GRCm39) |
T24M |
probably damaging |
Het |
| Or52p1 |
A |
G |
7: 104,267,705 (GRCm39) |
H273R |
probably damaging |
Het |
| Pou2f3 |
A |
G |
9: 43,040,224 (GRCm39) |
S355P |
probably damaging |
Het |
| Ppm1l |
C |
A |
3: 69,460,453 (GRCm39) |
N343K |
probably damaging |
Het |
| Prh1 |
A |
T |
6: 132,548,573 (GRCm39) |
I27F |
unknown |
Het |
| Prkrip1 |
A |
T |
5: 136,223,203 (GRCm39) |
L85Q |
probably damaging |
Het |
| Pycr3 |
C |
T |
15: 75,790,563 (GRCm39) |
V99I |
probably benign |
Het |
| R3hdm4 |
T |
A |
10: 79,749,393 (GRCm39) |
N72I |
probably damaging |
Het |
| Rab11fip3 |
G |
T |
17: 26,231,032 (GRCm39) |
H738N |
probably benign |
Het |
| Rtl1 |
G |
A |
12: 109,556,673 (GRCm39) |
A1722V |
possibly damaging |
Het |
| Sell |
A |
G |
1: 163,893,122 (GRCm39) |
N113D |
probably damaging |
Het |
| Smarcal1 |
T |
C |
1: 72,665,697 (GRCm39) |
S732P |
probably damaging |
Het |
| Smurf2 |
A |
T |
11: 106,743,424 (GRCm39) |
D207E |
probably benign |
Het |
| Spata31h1 |
G |
A |
10: 82,121,439 (GRCm39) |
S3857L |
probably benign |
Het |
| Tat |
C |
T |
8: 110,723,510 (GRCm39) |
R333C |
probably benign |
Het |
| Tmem121b |
A |
T |
6: 120,469,234 (GRCm39) |
F494L |
probably damaging |
Het |
| Tmem198 |
C |
A |
1: 75,456,522 (GRCm39) |
P89Q |
probably damaging |
Het |
| Tnks2 |
T |
G |
19: 36,835,284 (GRCm39) |
C2G |
probably damaging |
Het |
| Trappc9 |
T |
C |
15: 72,673,202 (GRCm39) |
E869G |
unknown |
Het |
| Trim42 |
T |
A |
9: 97,251,584 (GRCm39) |
K105M |
probably benign |
Het |
| Ttll3 |
T |
C |
6: 113,369,635 (GRCm39) |
S60P |
probably benign |
Het |
| Ttll4 |
T |
A |
1: 74,725,121 (GRCm39) |
I625N |
possibly damaging |
Het |
| Tubgcp5 |
T |
A |
7: 55,479,181 (GRCm39) |
|
probably null |
Het |
| Txlnb |
A |
T |
10: 17,682,594 (GRCm39) |
Y172F |
probably damaging |
Het |
| Ube2e3 |
A |
T |
2: 78,744,035 (GRCm39) |
D88V |
possibly damaging |
Het |
| Vmn1r189 |
T |
A |
13: 22,286,430 (GRCm39) |
I136L |
probably benign |
Het |
| Vmn2r71 |
A |
G |
7: 85,267,950 (GRCm39) |
I135V |
probably benign |
Het |
| Wrn |
C |
T |
8: 33,731,006 (GRCm39) |
E1352K |
probably benign |
Het |
| Zfp318 |
T |
C |
17: 46,722,139 (GRCm39) |
S1381P |
probably damaging |
Het |
| Zfp747 |
A |
T |
7: 126,973,655 (GRCm39) |
Y172N |
probably damaging |
Het |
|
| Other mutations in Vmn2r73 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00158:Vmn2r73
|
APN |
7 |
85,506,795 (GRCm39) |
missense |
|
|
|
IGL01151:Vmn2r73
|
APN |
7 |
85,507,086 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01408:Vmn2r73
|
APN |
7 |
85,521,455 (GRCm39) |
missense |
probably benign |
0.45 |
|
IGL01505:Vmn2r73
|
APN |
7 |
85,507,267 (GRCm39) |
nonsense |
probably null |
|
|
IGL01731:Vmn2r73
|
APN |
7 |
85,506,757 (GRCm39) |
makesense |
probably null |
|
|
IGL01818:Vmn2r73
|
APN |
7 |
85,519,109 (GRCm39) |
splice site |
probably benign |
|
|
IGL02236:Vmn2r73
|
APN |
7 |
85,521,902 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02265:Vmn2r73
|
APN |
7 |
85,520,847 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02266:Vmn2r73
|
APN |
7 |
85,525,007 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
IGL02276:Vmn2r73
|
APN |
7 |
85,518,980 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02284:Vmn2r73
|
APN |
7 |
85,507,123 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL02380:Vmn2r73
|
APN |
7 |
85,507,383 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02466:Vmn2r73
|
APN |
7 |
85,522,084 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03172:Vmn2r73
|
APN |
7 |
85,507,495 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03179:Vmn2r73
|
APN |
7 |
85,519,468 (GRCm39) |
missense |
probably benign |
0.04 |
|
G1Funyon:Vmn2r73
|
UTSW |
7 |
85,507,510 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0077:Vmn2r73
|
UTSW |
7 |
85,525,075 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0311:Vmn2r73
|
UTSW |
7 |
85,520,997 (GRCm39) |
missense |
probably benign |
|
|
R0413:Vmn2r73
|
UTSW |
7 |
85,521,087 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R0494:Vmn2r73
|
UTSW |
7 |
85,522,140 (GRCm39) |
missense |
probably benign |
|
|
R1523:Vmn2r73
|
UTSW |
7 |
85,519,486 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1618:Vmn2r73
|
UTSW |
7 |
85,525,120 (GRCm39) |
nonsense |
probably null |
|
|
R1667:Vmn2r73
|
UTSW |
7 |
85,506,889 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1728:Vmn2r73
|
UTSW |
7 |
85,507,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1729:Vmn2r73
|
UTSW |
7 |
85,507,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1747:Vmn2r73
|
UTSW |
7 |
85,507,375 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1784:Vmn2r73
|
UTSW |
7 |
85,507,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2152:Vmn2r73
|
UTSW |
7 |
85,506,936 (GRCm39) |
missense |
probably benign |
0.03 |
|
R2395:Vmn2r73
|
UTSW |
7 |
85,506,975 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2415:Vmn2r73
|
UTSW |
7 |
85,521,431 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2926:Vmn2r73
|
UTSW |
7 |
85,520,871 (GRCm39) |
missense |
probably benign |
0.17 |
|
R3719:Vmn2r73
|
UTSW |
7 |
85,519,582 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3766:Vmn2r73
|
UTSW |
7 |
85,521,198 (GRCm39) |
missense |
probably benign |
|
|
R3838:Vmn2r73
|
UTSW |
7 |
85,507,258 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3890:Vmn2r73
|
UTSW |
7 |
85,507,144 (GRCm39) |
missense |
probably benign |
|
|
R4030:Vmn2r73
|
UTSW |
7 |
85,521,044 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4247:Vmn2r73
|
UTSW |
7 |
85,521,883 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4409:Vmn2r73
|
UTSW |
7 |
85,520,768 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4427:Vmn2r73
|
UTSW |
7 |
85,506,981 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4430:Vmn2r73
|
UTSW |
7 |
85,519,449 (GRCm39) |
missense |
probably benign |
|
|
R4552:Vmn2r73
|
UTSW |
7 |
85,525,055 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4779:Vmn2r73
|
UTSW |
7 |
85,520,923 (GRCm39) |
nonsense |
probably null |
|
|
R4906:Vmn2r73
|
UTSW |
7 |
85,506,829 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4942:Vmn2r73
|
UTSW |
7 |
85,519,582 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5280:Vmn2r73
|
UTSW |
7 |
85,507,155 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5344:Vmn2r73
|
UTSW |
7 |
85,525,046 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5478:Vmn2r73
|
UTSW |
7 |
85,518,996 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5527:Vmn2r73
|
UTSW |
7 |
85,507,575 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R5691:Vmn2r73
|
UTSW |
7 |
85,507,299 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5826:Vmn2r73
|
UTSW |
7 |
85,524,956 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R6018:Vmn2r73
|
UTSW |
7 |
85,521,875 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R6082:Vmn2r73
|
UTSW |
7 |
85,507,429 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6111:Vmn2r73
|
UTSW |
7 |
85,520,997 (GRCm39) |
missense |
probably benign |
|
|
R6233:Vmn2r73
|
UTSW |
7 |
85,519,099 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6278:Vmn2r73
|
UTSW |
7 |
85,522,140 (GRCm39) |
missense |
probably benign |
|
|
R6283:Vmn2r73
|
UTSW |
7 |
85,521,049 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6307:Vmn2r73
|
UTSW |
7 |
85,506,828 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6413:Vmn2r73
|
UTSW |
7 |
85,519,544 (GRCm39) |
nonsense |
probably null |
|
|
R6782:Vmn2r73
|
UTSW |
7 |
85,519,563 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6884:Vmn2r73
|
UTSW |
7 |
85,507,213 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6921:Vmn2r73
|
UTSW |
7 |
85,507,446 (GRCm39) |
missense |
probably benign |
0.27 |
|
R7169:Vmn2r73
|
UTSW |
7 |
85,507,663 (GRCm39) |
nonsense |
probably null |
|
|
R7206:Vmn2r73
|
UTSW |
7 |
85,522,075 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7311:Vmn2r73
|
UTSW |
7 |
85,521,192 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R7650:Vmn2r73
|
UTSW |
7 |
85,521,147 (GRCm39) |
missense |
probably benign |
|
|
R7811:Vmn2r73
|
UTSW |
7 |
85,524,956 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R8263:Vmn2r73
|
UTSW |
7 |
85,507,619 (GRCm39) |
missense |
probably benign |
|
|
R8301:Vmn2r73
|
UTSW |
7 |
85,507,510 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8341:Vmn2r73
|
UTSW |
7 |
85,507,128 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8500:Vmn2r73
|
UTSW |
7 |
85,519,638 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8673:Vmn2r73
|
UTSW |
7 |
85,521,902 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8719:Vmn2r73
|
UTSW |
7 |
85,521,095 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8783:Vmn2r73
|
UTSW |
7 |
85,507,668 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8828:Vmn2r73
|
UTSW |
7 |
85,521,179 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8860:Vmn2r73
|
UTSW |
7 |
85,522,149 (GRCm39) |
splice site |
probably benign |
|
|
R9002:Vmn2r73
|
UTSW |
7 |
85,507,284 (GRCm39) |
missense |
probably benign |
0.32 |
|
R9008:Vmn2r73
|
UTSW |
7 |
85,521,904 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9159:Vmn2r73
|
UTSW |
7 |
85,521,931 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R9180:Vmn2r73
|
UTSW |
7 |
85,507,123 (GRCm39) |
missense |
probably benign |
0.07 |
|
R9198:Vmn2r73
|
UTSW |
7 |
85,518,987 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9448:Vmn2r73
|
UTSW |
7 |
85,522,027 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9463:Vmn2r73
|
UTSW |
7 |
85,506,795 (GRCm39) |
missense |
|
|
|
R9589:Vmn2r73
|
UTSW |
7 |
85,519,659 (GRCm39) |
missense |
probably benign |
0.03 |
|
X0023:Vmn2r73
|
UTSW |
7 |
85,507,664 (GRCm39) |
missense |
probably benign |
0.31 |
|
Z1176:Vmn2r73
|
UTSW |
7 |
85,521,176 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1177:Vmn2r73
|
UTSW |
7 |
85,521,480 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCCAGGGATTAGAATAACGAGTC -3'
(R):5'- GACTTACTATAAACTGCCCTAGACATC -3'
Sequencing Primer
(F):5'- CTGAAGCTTTTGACTCCTTAACATG -3'
(R):5'- GAGGTCTCTCATTGGATCT -3'
|
| Posted On |
2022-04-18 |
Incidental Mutation