Incidental Mutation 'R9331:Npy2r'
ID 706832
Institutional Source Beutler Lab
Gene Symbol Npy2r
Ensembl Gene ENSMUSG00000028004
Gene Name neuropeptide Y receptor Y2
Synonyms NPY-Y2 receptor
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.090) question?
Stock # R9331 (G1)
Quality Score 225.009
Status Not validated
Chromosome 3
Chromosomal Location 82445690-82455391 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 82448068 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 236 (S236P)
Ref Sequence ENSEMBL: ENSMUSP00000096595 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029633] [ENSMUST00000098997] [ENSMUST00000182181] [ENSMUST00000182831]
AlphaFold P97295
Predicted Effect probably damaging
Transcript: ENSMUST00000029633
AA Change: S236P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000029633
Gene: ENSMUSG00000028004
AA Change: S236P

DomainStartEndE-ValueType
low complexity region 35 44 N/A INTRINSIC
Pfam:7TM_GPCR_Srsx 65 344 1.7e-13 PFAM
Pfam:7tm_1 71 329 7.9e-52 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000098997
AA Change: S236P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000096595
Gene: ENSMUSG00000028004
AA Change: S236P

DomainStartEndE-ValueType
Pfam:7tm_1 27 212 1.2e-26 PFAM
Pfam:7TM_GPCR_Srsx 30 227 8.5e-6 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000182181
AA Change: S123P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000138559
Gene: ENSMUSG00000028004
AA Change: S123P

DomainStartEndE-ValueType
Pfam:7tm_1 27 212 1.2e-26 PFAM
Pfam:7TM_GPCR_Srsx 30 227 8.5e-6 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000182831
AA Change: S236P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000138282
Gene: ENSMUSG00000028004
AA Change: S236P

DomainStartEndE-ValueType
low complexity region 31 40 N/A INTRINSIC
Pfam:7TM_GPCR_Srsx 61 340 7.1e-15 PFAM
Pfam:7tm_1 67 325 4.4e-54 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygotes for targeted null mutations exhibit reduced food intake, body weight, and adiposity, elevated plasma pancreatic polypeptide levels, increased cancellous bone volume, and heightened sensitivity to pentobarbital-induced sedation. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca3 A G 17: 24,616,324 (GRCm39) E922G probably benign Het
Abca8a A G 11: 109,917,154 (GRCm39) L1615P probably damaging Het
Actrt3 T C 3: 30,652,050 (GRCm39) D348G probably damaging Het
Adam3 A G 8: 25,177,951 (GRCm39) M654T probably benign Het
Adamts8 A T 9: 30,862,770 (GRCm39) H325L probably damaging Het
Agpat2 A G 2: 26,487,318 (GRCm39) Y72H probably benign Het
Ap3m1 A G 14: 21,095,666 (GRCm39) Y55H possibly damaging Het
Cacna1a C T 8: 85,142,446 (GRCm39) A58V probably damaging Het
Cacna1c C T 6: 119,084,909 (GRCm39) V10I Het
Ccnt1 T A 15: 98,441,097 (GRCm39) K724* probably null Het
Cd72 T A 4: 43,454,320 (GRCm39) T38S possibly damaging Het
Crispld1 T A 1: 17,832,454 (GRCm39) I480K probably damaging Het
Diaph3 G T 14: 87,378,461 (GRCm39) Y30* probably null Het
Ei24 A G 9: 36,701,217 (GRCm39) I34T possibly damaging Het
Fdxacb1 G A 9: 50,681,511 (GRCm39) S144N probably damaging Het
Fgf21 G T 7: 45,263,614 (GRCm39) Q155K probably benign Het
Gdap1l1 A T 2: 163,295,664 (GRCm39) R310S probably benign Het
Gm44501 G A 17: 40,889,620 (GRCm39) V45I probably benign Het
Gne A G 4: 44,066,845 (GRCm39) L56P probably damaging Het
Hcn4 T C 9: 58,767,705 (GRCm39) S1089P probably damaging Het
Hexim1 C T 11: 103,007,974 (GRCm39) T76M probably damaging Het
Hkdc1 A T 10: 62,236,114 (GRCm39) L476* probably null Het
Hoxd8 CGCGGCGGCGGCGGCGGC CGCGGCGGCGGCGGC 2: 74,535,942 (GRCm39) probably benign Het
Hyal4 A T 6: 24,765,866 (GRCm39) I407L probably damaging Het
Ighv5-9-1 T C 12: 113,699,878 (GRCm39) Y78C possibly damaging Het
Kif20a T A 18: 34,762,562 (GRCm39) C478* probably null Het
Klk15 C T 7: 43,587,790 (GRCm39) H73Y possibly damaging Het
Ltbp2 C T 12: 84,922,965 (GRCm39) R34Q probably benign Het
Mccc1 A G 3: 36,014,238 (GRCm39) V693A probably damaging Het
Muc5b C A 7: 141,411,475 (GRCm39) Q1474K unknown Het
Nos1 T C 5: 118,038,589 (GRCm39) V474A possibly damaging Het
Nprl2 G A 9: 107,421,955 (GRCm39) V244M probably damaging Het
Or8b9 G A 9: 37,766,710 (GRCm39) V199I probably benign Het
Or8c10 A G 9: 38,279,003 (GRCm39) S44G probably benign Het
P2rx7 T C 5: 122,818,961 (GRCm39) L461P probably benign Het
Pacc1 T C 1: 191,077,318 (GRCm39) probably null Het
Pde12 T C 14: 26,389,828 (GRCm39) I294V probably benign Het
Plcl1 T C 1: 55,736,030 (GRCm39) L457P possibly damaging Het
Plekho2 C A 9: 65,463,866 (GRCm39) A328S probably benign Het
Polg T C 7: 79,108,148 (GRCm39) K556E probably damaging Het
Prl7a2 A G 13: 27,849,062 (GRCm39) S76P probably damaging Het
Ptar1 T A 19: 23,671,707 (GRCm39) C37S probably benign Het
Pwwp2b G A 7: 138,835,357 (GRCm39) G266D probably damaging Het
Pygm T C 19: 6,448,129 (GRCm39) F812L probably damaging Het
Smarcc2 A T 10: 128,323,310 (GRCm39) T982S unknown Het
Spata31e2 T C 1: 26,722,790 (GRCm39) R797G probably benign Het
Syne1 C G 10: 5,073,666 (GRCm39) V1226L probably benign Het
Tmco1 C T 1: 167,136,132 (GRCm39) probably benign Het
Tmub1 T C 5: 24,650,985 (GRCm39) T225A probably damaging Het
Trmo A C 4: 46,387,642 (GRCm39) C59W possibly damaging Het
Ttc6 C A 12: 57,720,509 (GRCm39) A925D probably damaging Het
Tubb1 A G 2: 174,297,472 (GRCm39) E27G probably damaging Het
Unkl G A 17: 25,450,723 (GRCm39) C503Y probably damaging Het
Usp40 A G 1: 87,901,828 (GRCm39) I785T probably damaging Het
Vmn2r32 G A 7: 7,467,402 (GRCm39) Q709* probably null Het
Xaf1 T C 11: 72,197,470 (GRCm39) S149P probably damaging Het
Ythdc2 T A 18: 44,970,499 (GRCm39) V271E possibly damaging Het
Zfp386 C T 12: 116,011,433 (GRCm39) probably benign Het
Zfp456 T A 13: 67,514,389 (GRCm39) E439V probably damaging Het
Other mutations in Npy2r
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02705:Npy2r APN 3 82,448,056 (GRCm39) missense probably benign 0.07
IGL03013:Npy2r APN 3 82,447,819 (GRCm39) missense probably damaging 1.00
R0616:Npy2r UTSW 3 82,448,670 (GRCm39) missense possibly damaging 0.84
R1460:Npy2r UTSW 3 82,448,251 (GRCm39) missense probably benign
R2013:Npy2r UTSW 3 82,448,487 (GRCm39) missense probably damaging 1.00
R2107:Npy2r UTSW 3 82,448,436 (GRCm39) splice site probably null
R2171:Npy2r UTSW 3 82,447,708 (GRCm39) missense possibly damaging 0.65
R2259:Npy2r UTSW 3 82,448,661 (GRCm39) missense possibly damaging 0.82
R2261:Npy2r UTSW 3 82,448,346 (GRCm39) missense possibly damaging 0.90
R4604:Npy2r UTSW 3 82,448,365 (GRCm39) missense probably damaging 1.00
R5935:Npy2r UTSW 3 82,448,068 (GRCm39) missense possibly damaging 0.83
R7124:Npy2r UTSW 3 82,448,490 (GRCm39) missense probably damaging 1.00
R7143:Npy2r UTSW 3 82,448,250 (GRCm39) missense probably benign 0.02
R7709:Npy2r UTSW 3 82,447,689 (GRCm39) missense probably benign
R7971:Npy2r UTSW 3 82,448,175 (GRCm39) missense probably damaging 0.99
R7986:Npy2r UTSW 3 82,448,803 (GRCm39) critical splice acceptor site probably null
R9323:Npy2r UTSW 3 82,447,728 (GRCm39) missense possibly damaging 0.93
R9381:Npy2r UTSW 3 82,448,356 (GRCm39) missense probably damaging 1.00
X0018:Npy2r UTSW 3 82,447,690 (GRCm39) missense probably benign 0.00
X0062:Npy2r UTSW 3 82,447,900 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGTCCACAGCGAGTTGGAAG -3'
(R):5'- AGAGCAAGATCTCCAAGCG -3'

Sequencing Primer
(F):5'- CAGCGAGTTGGAAGGCGTG -3'
(R):5'- AGCTTCCTGATCATTGGCCTGG -3'
Posted On 2022-04-18